PULMONARY ARTERIAL HYPERTENSION

This study is testing if a newer drug called sotatercept can improve how well the heart pumps in people with pulmonary arterial hypertension (PAH), a serious lung and heart condition. Twenty adult patients with PAH will receive injections of sotatercept for 24 weeks. Researchers …

This study is observing what happens when adults with pulmonary arterial hypertension (PAH) switch from one standard medication (ambrisentan) to another (bosentan). Researchers will track 121 patients for 3-6 months to see if this change affects their overall risk score, which pr…

This early-stage study is testing if empagliflozin, a medication typically used for diabetes and heart failure, can help control pulmonary arterial hypertension (PAH)—a serious condition causing high blood pressure in the lungs. The trial will involve 72 adults with PAH who will …

This study provides continued access to an inhaled medication called TPIP for people with serious lung and heart conditions. It is for patients who have already successfully completed earlier long-term studies of this drug. The goal is to allow these patients to keep receiving a …

This study is testing if spironolactone, a drug often used for heart failure, can help people with pulmonary arterial hypertension (PAH), a rare and serious condition of high blood pressure in the lungs. Researchers want to see if the drug can improve how far patients can walk an…

This early-stage study is testing the safety of a new inhaled medication called L608 in healthy volunteers. L608 is being developed as a longer-lasting, easier-to-use version of an existing treatment for pulmonary arterial hypertension (PAH), a serious condition affecting blood v…

This early-stage study is testing whether transplanting healthy gut bacteria from donors can help control pulmonary arterial hypertension, a serious lung condition. Researchers will give 24 patients either the bacteria transplant capsules with fiber, the transplant alone, or a pl…

This study is testing a drug called sotatercept in children aged 1 to 18 who have pulmonary arterial hypertension (PAH), a serious condition that causes high blood pressure in the lungs. The main goal is to see if the drug is safe and how the body processes it over 24 weeks while…

This study is testing a new implantable device, the Aria CV Pulmonary Hypertension System, to see if it is safe and can help people with pulmonary hypertension and right heart dysfunction. Up to 30 adults who remain symptomatic despite standard medications will have the device im…

This study is testing whether APL-9796 injections are safe and might help control pulmonary hypertension, a serious condition where blood pressure in the lungs is dangerously high. The trial will involve 48 adults who already have a special heart sensor implanted to monitor their…

This study is checking the long-term safety of a drug called sotatercept for people with pulmonary arterial hypertension (PAH), a serious lung and heart condition. It is enrolling about 815 people who have already taken sotatercept in a previous study. The main goal is to see how…

This study is testing a new type of PET scan to see if it can detect early signs of pulmonary arterial hypertension (PAH), a serious disease of the lung's blood vessels. Researchers will compare scan results from about 71 people, including patients with PAH and healthy volunteers…

This study is testing a special type of MRI scan to see if it can help doctors better identify and track pulmonary arterial hypertension (PAH), a serious condition of high blood pressure in the lungs. Researchers will enroll 20 adults with PAH to see how their scan results change…

This study aims to develop a non-invasive MRI scan to identify patients with certain lung diseases and high blood pressure in the lungs who might respond to specific medications. Researchers will use a special gas-based MRI scan on 30 patients with conditions like COPD or pulmona…

This study is testing whether a supervised group exercise program can help people with pulmonary arterial hypertension (PAH) walk farther and feel better. The program involves 15 weekly group sessions plus home exercises over 12 weeks. Researchers want to see if this outpatient a…

This study aims to understand why it takes so long for patients in Brazil to get diagnosed with pulmonary arterial hypertension (PAH) and other rare diseases. Researchers will review medical records of 139 adults diagnosed within the last five years to track their journey from fi…

This online research study aims to understand how genetics influence a person's risk of developing pulmonary hypertension, a condition affecting blood pressure in the lungs. The study is recruiting 10,000 adults living in the United States, and participants do not need to have a …

This national registry aims to understand how people with pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH) are diagnosed and treated across the United States. It will follow 3,000 patients over time to see if care follows recommended…

This study is testing whether a special type of MRI scan using Xenon gas can provide a clearer picture of lung damage in people with pulmonary hypertension. Researchers will scan 60 patients to see if the images match actual lung tissue damage and if the scans can help predict ho…

This study is testing whether a special type of lung scan using xenon gas can better measure how well a new drug (sotatercept) works for people with pulmonary arterial hypertension (PAH). Researchers will scan the lungs of 14 participants before they start the drug and again afte…