New hope for PAH patients: Long-Term safety study of targeted therapy sotatercept

NCT ID NCT07218029

Recruiting now Disease control Sponsor: Merck Sharp & Dohme LLC Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated May 25, 2026 · Updated 29 times

Summary

This study looks at the long-term safety of the drug sotatercept when added to standard treatments for pulmonary arterial hypertension (PAH), a condition where lung blood vessels narrow, making breathing and activity difficult. About 815 adults who completed earlier sotatercept studies can join. Researchers will monitor side effects, lab results, and how well the drug is tolerated over time.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

A.O.R.N. Ospedale dei Colli - Monaldi V. ( Site 2407)
ACTIVE_NOT_RECRUITING

Naples, 80131, Italy
AHEPA University General Hospital of Thessaloniki-1st Cardiology Clinic ( Site 3601)
RECRUITING

Thessaloniki, 546 36, Greece

Contact Phone: •••-•••-••••
AOU Policlinico Umberto I ( Site 2402)
ACTIVE_NOT_RECRUITING

Rome, Roma, 00161, Italy
ATTIKON GENERAL UNIVERSITY HOSPITAL ( Site 3604)
RECRUITING

Athens, Attica, 124 62, Greece

Contact Phone: •••-•••-••••
Aarhus Universitetshospital, Skejby ( Site 3801)
ACTIVE_NOT_RECRUITING

Aarhus, Central Jutland, 8200, Denmark
AdventHealth Orlando ( Site 1058)
RECRUITING

Orlando, Florida, 32803, United States

Contact Phone: •••-•••-••••
Amsterdam UMC, locatie VUmc ( Site 2601)
ACTIVE_NOT_RECRUITING

Amsterdam, North Holland, 1081 HV, Netherlands
CENTRE HOSPITALIER UNIVERSITAIRE DE LILLE ( Site 1306)
RECRUITING

Lille, Nord, 59037, France

Contact Phone: •••-•••-••••
CHI St. Luke's Health Baylor College of Medicine Medical Center ( Site 1044)
RECRUITING

Houston, Texas, 77030, United States

Contact Phone: •••-•••-••••
CHU Angers ( Site 1313)
RECRUITING

Angers, Maine-et-Loire, 49100, France

Contact Phone: •••-•••-••••
CHU Bordeaux Haut-Leveque ( Site 1312)
RECRUITING

Pessac, Aquitaine, 33604, France

Contact Phone: •••-•••-••••
CHU de Grenoble Hopital Nord ( Site 1303)
ACTIVE_NOT_RECRUITING

La Tronche, Isere, 38700, France
CHU de la Miletrie Poitiers ( Site 1316)
RECRUITING

Poitiers, Vienne, 86021, France

Contact Phone: •••-•••-••••
Carmel Hospital ( Site 1705)
RECRUITING

Haifa, 3436212, Israel

Contact Phone: •••-•••-••••
Centre Hospitalier Universitaire de Nice - Hopital Pasteur ( Site 1311)
RECRUITING

Nice, Alpes-Maritimes, 06300, France

Contact Phone: •••-•••-••••
Centre Hospitalier Universitaire de Saint Étienne- Hôpital Nord-Medecine Vasculaire et Therapeutique ( Site 1302)
RECRUITING

Saint-Étienne-de-Montluc, Pays de la Loire Region, 42055, France

Contact Phone: •••-•••-••••
Clínica Imbanaco S.A.S ( Site 3404)
RECRUITING

Cali, Valle del Cauca Department, 760042, Colombia

Contact Phone: •••-•••-••••
DRK Kliniken Berlin Westend ( Site 1507)
ACTIVE_NOT_RECRUITING

Berlin, 14050, Germany
Duke University Medical Center ( Site 1026)
RECRUITING

Durham, North Carolina, 27710-4000, United States

Contact Phone: •••-•••-••••
Fiona Stanley Hospital ( Site 1103)
RECRUITING

Murdoch, Western Australia, 6150, Australia

Contact Phone: •••-•••-••••
Fondazione IRCCS San Gerardo dei Tintori ( Site 2406)
ACTIVE_NOT_RECRUITING

Monza, Lombardy, 20900, Italy
Freeman Hospital ( Site 1205)
ACTIVE_NOT_RECRUITING

Newcastle upon Tyne, NE7 7DN, United Kingdom
Fundación Neumológica Colombiana ( Site 3403)
RECRUITING

Bogotá, Bogota D.C., 110131, Colombia

Contact Phone: •••-•••-••••
Gachon University Gil Medical Center ( Site 3103)
ACTIVE_NOT_RECRUITING

Incheon, 21565, South Korea
Golden Jubilee National Hospital ( Site 1204)
ACTIVE_NOT_RECRUITING

Glasgow, Glasgow City, G81 4DY, United Kingdom
HOSPITAL GENERAL UNIVERSITARIO DE TOLEDO ( Site 1607)
ACTIVE_NOT_RECRUITING

Toledo, 45007, Spain
Haddasah Medical Center ( Site 1711)
RECRUITING

Jerusalem, 9112001, Israel

Contact Phone: •••-•••-••••
Hammersmith Hospital ( Site 1203)
ACTIVE_NOT_RECRUITING

London, London, City of, W12 0HS, United Kingdom
Hopital Cavale Blanche ( Site 1314)
RECRUITING

Brest, Finistere, 29609, France

Contact Phone: •••-•••-••••
Hopital Larrey ( Site 1315)
ACTIVE_NOT_RECRUITING

Toulouse, Haute-Garonne, 31400, France
Hopital Nord Laennec ( Site 1309)
RECRUITING

Saint-Herblain, Loire-Atlantique, 44800, France

Contact Phone: •••-•••-••••
Hospital Clinic de Barcelona ( Site 1602)
ACTIVE_NOT_RECRUITING

Barcelona, 08036, Spain
Hospital Dia do Pulmao ( Site 1802)
RECRUITING

Blumenau, Santa Catarina, 89010-000, Brazil

Contact Phone: •••-•••-••••
Hospital Garcia de Orta ( Site 3501)
RECRUITING

Almada, Setúbal District, 2805-267, Portugal

Contact Phone: •••-•••-••••
Hospital General Universitario Ramon y Cajal ( Site 1609)
ACTIVE_NOT_RECRUITING

Madrid, 28048, Spain
Hospital Provincial Dr. Jose M. Cullen ( Site 1902)
ACTIVE_NOT_RECRUITING

Santa Fe, S3000EOZ, Argentina
Hospital Provincial del Centenario ( Site 1912)
ACTIVE_NOT_RECRUITING

Rosario, Santa Fe Province, S2002KDS, Argentina
Hospital Pulido Valente ( Site 3503)
RECRUITING

Lisbon, 1769-001, Portugal

Contact Phone: •••-•••-••••
Hospital Universitari Vall D Hebron ( Site 1605)
ACTIVE_NOT_RECRUITING

Barcelona, Catalonia, 08035, Spain
Hospital Universitario 12 de Octubre ( Site 1603)
ACTIVE_NOT_RECRUITING

Madrid, Madrid, Comunidad de, 28041, Spain
Hospital Universitario La Paz ( Site 1610)
ACTIVE_NOT_RECRUITING

Madrid, 28046, Spain
Hospital Universitario Marques de Valdecilla ( Site 1601)
ACTIVE_NOT_RECRUITING

Santander, Cantabria, 39008, Spain
Hospital Universitario Puerta de Hierro-Majadahonda ( Site 1604)
ACTIVE_NOT_RECRUITING

Majadahonda, Madrid, 28222, Spain
Hospital Universitario de Son Espases ( Site 1611)
ACTIVE_NOT_RECRUITING

Palma de Mallorca, Balearic Islands, 07120, Spain
Houston Methodist Hospital ( Site 1009)
RECRUITING

Houston, Texas, 77030, United States

Contact Phone: •••-•••-••••
Hôpital Louis Pradel ( Site 1317)
RECRUITING

Lyon, Rhone, 69677, France

Contact Phone: •••-•••-••••
Hôpitaux Universitaires Paris Sud - Hôpital Bicêtre-Pneumologie ( Site 1304)
RECRUITING

Le Kremlin-Bicêtre, Val-de-Marne, 94275, France

Contact Phone: •••-•••-••••
Institut Klinicke a Experimentalni Mediciny ( Site 2202)
ACTIVE_NOT_RECRUITING

Prague, Praha 4, 140 21, Czechia
Institute for Cardiovascular Diseases Dedinje ( Site 2903)
ACTIVE_NOT_RECRUITING

Belgrade, 11000, Serbia
Institute for pulmonary diseases of Vojvodina ( Site 2906)
ACTIVE_NOT_RECRUITING

Novi Sad, Beograd, 21000, Serbia
Instituto Cardiovascular de Rosario ( Site 1906)
ACTIVE_NOT_RECRUITING

Rosario, Santa Fe Province, S2000DSR, Argentina
Instituto Médico Río Cuarto ( Site 1907)
ACTIVE_NOT_RECRUITING

Río Cuarto, Córdoba Province, X5800AEV, Argentina
Instituto de Investigaciones Clinicas Quilmes ( Site 1903)
ACTIVE_NOT_RECRUITING

Quilmes, Buenos Aires, B1878GEG, Argentina
Jeffrey S. Sager, MD Medical Corporation ( Site 1060)
RECRUITING

Santa Barbara, California, 93105-5316, United States

Contact Phone: •••-•••-••••
John Hunter Hospital ( Site 1101)
ACTIVE_NOT_RECRUITING

New Lambton Heights, New South Wales, 2305, Australia
Johns Hopkins University ( Site 1036)
RECRUITING

Baltimore, Maryland, 21287, United States

Contact Phone: •••-•••-••••
Kaohsiung Veteran General Hospital ( Site 3702)
ACTIVE_NOT_RECRUITING

Kaohsiung City, 813, Taiwan
Klinicki Bolnicki Centar Split ( Site 3901)
ACTIVE_NOT_RECRUITING

Split, Split-Dalmatia County, 21000, Croatia
Krakowski Szpital Specjalistyczny im. Jana Pawla II ( Site 2801)
RECRUITING

Krakow, Lesser Poland Voivodeship, 31-202, Poland

Contact Phone: •••-•••-••••
Krankenhaus Neuwittelsbach ( Site 1510)
ACTIVE_NOT_RECRUITING

München, Bavaria, 80639, Germany
Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center ( Site 1028)
ACTIVE_NOT_RECRUITING

Torrance, California, 90502, United States
Mayo Clinic Jacksonville ( Site 1045)
ACTIVE_NOT_RECRUITING

Jacksonville, Florida, 32224, United States
Medical University of South Carolina ( Site 1003)
RECRUITING

Charleston, South Carolina, 29425, United States

Contact Phone: •••-•••-••••
Medizinische Hochschule Hannover ( Site 1505)
RECRUITING

Hanover, Lower Saxony, 30625, Germany

Contact Phone: •••-•••-••••
National Cheng Kung University Hospital ( Site 3703)
ACTIVE_NOT_RECRUITING

Tainan, 704302, Taiwan
Norton Pulmonary Specialists ( Site 1066)
RECRUITING

Louisville, Kentucky, 40202, United States

Contact Phone: •••-•••-••••
Nouvel Hôpital Civil (NHC) ( Site 1307)
RECRUITING

Strasbourg, Bas-Rhin, 67000, France

Contact Phone: •••-•••-••••
Ohio State University Wexner Medical Center ( Site 1032)
ACTIVE_NOT_RECRUITING

Columbus, Ohio, 43210, United States
Onassis Cardiac Surgery Center ( Site 3602)
RECRUITING

Athens, Attica, 176 74, Greece

Contact Phone: •••-•••-••••
Oregon Health & Science University ( Site 1054)
ACTIVE_NOT_RECRUITING

Portland, Oregon, 97239, United States
Ospedale San Giuseppe ( Site 2403)
ACTIVE_NOT_RECRUITING

Milan, Milano, 20123, Italy
Papworth Hospital NHS Foundation Trust ( Site 1208)
ACTIVE_NOT_RECRUITING

Cambridge, Cambridgeshire, CB2 0AY, United Kingdom
Peter Lougheed Centre ( Site 2102)
RECRUITING

Calgary, Alberta, T1Y 6J4, Canada

Contact Phone: •••-•••-••••
Pulmonary Associates, PA ( Site 1008)
ACTIVE_NOT_RECRUITING

Phoenix, Arizona, 85032, United States
Rabin Medical Center ( Site 1703)
ACTIVE_NOT_RECRUITING

Petah Tikva, 4941492, Israel
Radboud University Nijmegen Medical Centre ( Site 2605)
ACTIVE_NOT_RECRUITING

Nijmegen, Gelderland, 6525 GA, Netherlands
Rhode Island Hospital ( Site 1033)
RECRUITING

Providence, Rhode Island, 02903, United States

Contact Phone: •••-•••-••••
Rigshospitalet ( Site 3802)
ACTIVE_NOT_RECRUITING

København Ø, Capital Region, 2100, Denmark
Royal Brompton Hospital ( Site 1206)
ACTIVE_NOT_RECRUITING

London, London, City of, SW3 6NP, United Kingdom
Royal Free Hospital ( Site 1202)
ACTIVE_NOT_RECRUITING

London, London, City of, NW3 2QG, United Kingdom
Royal Hallamshire Hospital ( Site 1207)
ACTIVE_NOT_RECRUITING

Sheffield, S10 2JF, United Kingdom
Royal Hobart Hospital ( Site 1107)
RECRUITING

Hobart, Tasmania, 7000, Australia

Contact Phone: •••-•••-••••
Royal Prince Alfred Hospital ( Site 1106)
RECRUITING

Camperdown, New South Wales, 2050, Australia

Contact Phone: •••-•••-••••
Sahlgrenska Universitetssjukhuset ( Site 3201)
ACTIVE_NOT_RECRUITING

Gothenburg, Västra Götaland County, 41346, Sweden
Samsung Medical Center ( Site 3106)
ACTIVE_NOT_RECRUITING

Seoul, 06351, South Korea
Sanatorio Allende ( Site 1908)
ACTIVE_NOT_RECRUITING

Córdoba, X5021FPQ, Argentina
Sanatorio Parque ( Site 1905)
ACTIVE_NOT_RECRUITING

Rosario, Santa Fe Province, S2000CUB, Argentina
Severance Hospital, Yonsei University Health System ( Site 3101)
ACTIVE_NOT_RECRUITING

Seoul, 03722, South Korea
Sheba Medical Center ( Site 1701)
ACTIVE_NOT_RECRUITING

Ramat Gan, 5265601, Israel
The Carl and Edyth Lindner Center for Research and Education at the Christ Hospital ( Site 1001)
RECRUITING

Cincinnati, Ohio, 45219, United States

Contact Phone: •••-•••-••••
The Prince Charles Hospital ( Site 1104)
RECRUITING

Chermside, New South Wales, 4032, Australia

Contact Phone: •••-•••-••••
Thoraxklinik-Heidelberg gGmbH ( Site 1509)
RECRUITING

Heidelberg, Baden-Wurttemberg, 69126, Germany

Contact Phone: •••-•••-••••
Tufts Medical Center ( Site 1012)
RECRUITING

Boston, Massachusetts, 02111, United States

Contact Phone: •••-•••-••••
UC Irvine Health Medical Center ( Site 1086)
RECRUITING

Orange, California, 92868, United States

Contact Phone: •••-•••-••••
UCSF Helen Diller Medical Center at Parnassus Heights ( Site 1019)
ACTIVE_NOT_RECRUITING

San Francisco, California, 94143, United States
UZ Leuven ( Site 1401)
ACTIVE_NOT_RECRUITING

Leuven, Vlaams-Brabant, 3000, Belgium
Universitaetsklinikum Koeln ( Site 1511)
RECRUITING

Cologne, North Rhine-Westphalia, 50937, Germany

Contact Phone: •••-•••-••••
University Clinical Hospital Center of Serbia ( Site 2901)
RECRUITING

Belgrade, Beograd, 11000, Serbia

Contact Phone: •••-•••-••••
University Of Nebraska Medical Center ( Site 1053)
ACTIVE_NOT_RECRUITING

Omaha, Nebraska, 68198-5990, United States
University of California San Diego Health ( Site 1002)
ACTIVE_NOT_RECRUITING

La Jolla, California, 92039, United States
University of Cincinnati Medical Center ( Site 1035)
RECRUITING

Cincinnati, Ohio, 45219, United States

Contact Phone: •••-•••-••••
University of Colorado Hospital ( Site 1013)
ACTIVE_NOT_RECRUITING

Aurora, Colorado, 80045, United States
University of Kansas Medical Center ( Site 1020)
RECRUITING

Kansas City, Kansas, 66160, United States

Contact Phone: •••-•••-••••
University of Pittsburgh Medical Center - Presbyterian Hosp. ( Site 1059)
RECRUITING

Pittsburgh, Pennsylvania, 15213, United States

Contact Phone: •••-•••-••••
University of Texas Southwestern Medical Center ( Site 1038)
RECRUITING

Dallas, Texas, 75390, United States

Contact Phone: •••-•••-••••
UniversitätsSpital Zürich ( Site 3301)
ACTIVE_NOT_RECRUITING

Zurich, 8091, Switzerland
Universitätsklinikum Halle ( Site 1502)
RECRUITING

Halle, Saxony-Anhalt, 06120, Germany

Contact Phone: •••-•••-••••
Universitätsklinikum Leipzig ( Site 1508)
RECRUITING

Leipzig, Saxony, 04103, Germany

Contact Phone: •••-•••-••••
Université Libre de Bruxelles - Hôpital Erasme ( Site 1402)
ACTIVE_NOT_RECRUITING

Brussels, Bruxelles-Capitale, Region de, 1070, Belgium
Vseobecna fakultni nemocnice v Praze ( Site 2201)
ACTIVE_NOT_RECRUITING

Prague, 128 08, Czechia
Waikato Hospital ( Site 2702)
ACTIVE_NOT_RECRUITING

Hamilton, Waikato Region, 3240, New Zealand
Weill Cornell Medical Center ( Site 1046)
ACTIVE_NOT_RECRUITING

New York, New York, 10021, United States

Conditions

Explore the condition pages connected to this study.

PULMONARY ARTERIAL HYPERTENSION