Gut bacteria capsules could be new weapon against rare lung disease
NCT ID NCT06481852
First seen Jun 25, 2026 · Last updated Jul 31, 2026 · Updated 2 times
Summary
This early-stage trial tests whether transplanting gut bacteria from healthy donors, along with antibiotics and fiber, is safe for people with pulmonary arterial hypertension (PAH). 24 adults with PAH will be randomly assigned to receive either the bacteria capsules or a placebo. Researchers will monitor side effects and check if the donor bacteria take hold in the gut over 24 weeks. This study is too small to prove the treatment works, but it will help design future, larger trials.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- microbiota transplant therapy (freeze-dried gut bacteria from healthy donors) with antibiotic pre-treatment and fiber supplements
- What this could lead to
- If this early trial shows the approach is safe and feasible, it could pave the way for larger studies testing whether changing gut bacteria can help control pulmonary arterial hypertension.
- What could go wrong
- This is a very small, early-phase safety study with only 24 people. It is not designed to prove the treatment works, and the long-term risks of transplanting gut bacteria are not yet known.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
University of Minnesota
RECRUITINGMinneapolis, Minnesota, 55414, United States
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