University Of Minnesota

This study aims to find the ideal length of time for remote blood pressure monitoring after childbirth for mothers who had high blood pressure during pregnancy. Researchers will compare different monitoring durations (from 2 to 6 weeks) to see which leads to the best health outco…

This study compares two surgical approaches for massive, irreparable rotator cuff tears in the shoulder. It tests whether reshaping the shoulder bone (tuberoplasty) or inserting a balloon-like spacer works better to reduce painful bone-on-bone contact and improve function. Resear…

This study is testing whether adding a non-invasive brain stimulation technique (tDCS) and cognitive training exercises helps people who are already taking buprenorphine medication for opioid addiction. Researchers want to see if this combination can improve brain function relate…

This study is testing whether a wearable glucose monitor helps children and young adults in Uganda manage their type 1 diabetes better than standard finger-prick tests. For one year, half the participants will use the continuous monitor while the other half uses standard methods,…

This study is testing whether transplanting healthy gut bacteria from a donor can help regrow hair in people with alopecia areata, an autoimmune condition that causes hair loss. Researchers will enroll 40 adults with moderate to severe hair loss to see if changing the gut microbi…

This study is testing a special soft cast wrap to see if it helps heal foot ulcers in people with diabetes as well as common methods. It will check how well it works, how safe it is, and if patients find it comfortable and easy to use. The goal is to control the wound and prevent…

This study is testing whether combining a gentle, non-invasive brain stimulation technique with specific mental exercises can help people with alcohol use disorder stay sober. Researchers want to see if this 'brain training' improves thinking skills and reduces the chance of rela…

This large international trial is testing if a single infusion of concentrated COVID-19 antibodies can help adults with a recent diagnosis. The goal is to treat people early, before they get sick enough to need the hospital, and prevent the disease from getting worse. Researchers…

This study is testing whether combining a therapy called CBIT with non-invasive brain stimulation (TMS) can help young people with Tourette Syndrome better control their tics. Researchers are recruiting 60 participants aged 12-21 to see if stimulating a specific brain area improv…

This study aims to find the best settings for deep brain stimulators to better control seizures in people with epilepsy that doesn't respond to medication. Researchers will test different stimulation patterns in 20 participants who already have the implant, measuring brain activi…

This study aims to understand how the precise location of deep brain stimulation (DBS) in the brain affects movement difficulties in people with Parkinson's disease. Researchers are studying 24 patients who already have a DBS implant to see if adjusting the stimulation target can…

This study is testing whether a special breathing muscle training device can help lower high blood pressure. Researchers will enroll 144 adults with elevated systolic blood pressure to try different intensities of this training for 6 weeks. The goal is to find the most effective …

This study is testing a mobile app called mGlide-Care, designed to help family caregivers better manage high blood pressure in loved ones with early memory loss or dementia. The app connects caregivers with healthcare providers to share blood pressure readings and coordinate care…

This study is testing whether a drug called fisetin can slow down organ failure in older adults who have developed a serious infection (sepsis). Researchers are enrolling 220 people aged 65 and older who are hospitalized with an infection. The goal is to see if the drug can impro…

This study is testing whether an implanted electrical stimulator on the spinal cord can help people with long-term, severe neck-level spinal injuries. Researchers want to see if the device can safely improve automatic body functions like blood pressure control, bladder and bowel …

This study is testing if a soft, FDA-approved belly wrap can help strengthen the stomach muscles of very premature babies who need breathing support. Researchers will see if using the wrap helps babies develop the muscle strength needed to feed by mouth at an earlier age. The goa…

This study is checking if a specific radiation treatment given right after surgery helps stop Dupuytren's disease from returning and worsening hand function. It will follow 50 people with the condition for two years after they get standard surgery followed by radiation. The main …

This study is testing whether swallowing capsules containing processed, healthy donor stool (a gut bacteria transplant) can help people with active Crohn's disease. Researchers want to see if the new bacteria can successfully take hold in the gut and if this leads to reduced symp…

This study is testing whether delivering a thyroid hormone (T3) directly into the lungs is safe and can help patients with Acute Respiratory Distress Syndrome (ARDS) breathe better. It will involve 68 critically ill adults on breathing machines. Researchers will give the hormone …

This study is testing whether a combination of gentle brain stimulation and thinking exercises can help children and teens with fetal alcohol spectrum disorders. Researchers want to see if this approach improves attention, memory, and problem-solving skills. The study involves 70…

This early-stage study is testing whether transplanting healthy gut bacteria from donors can help control pulmonary arterial hypertension, a serious lung condition. Researchers will give 24 patients either the bacteria transplant capsules with fiber, the transplant alone, or a pl…

This study is testing whether electrical stimulation of the front part of the brain can help people with severe depression that hasn't improved with standard treatments. Fifteen participants will have a small, pacemaker-like device surgically implanted to deliver this stimulation…

This study is testing whether a culturally informed sleep extension program can help African American adults with obesity get more sleep and increase physical activity. Researchers will first gather community input to design the program, then test it with 90 participants who curr…

This study is testing whether a computer-delivered therapy program can help people who have both alcohol use disorder and an anxiety disorder. Researchers want to see if this accessible, online version of a proven therapy works as well as when delivered by a therapist. The goal i…

This large clinical trial aims to find better treatments for cryptococcal meningitis, a severe and often fatal brain infection that primarily affects people living with HIV. It will test multiple new or improved antifungal drug combinations in up to 2000 participants, comparing t…

This study is testing whether empagliflozin, a medication originally for diabetes, can improve heart function in older adults at risk for heart failure. Researchers will give 80 participants either the medication or a placebo pill daily for 9 months to see if it strengthens the h…

This study is testing whether asking teens with obesity to weigh themselves daily helps with weight management. It compares regular clinic care to adding either a simple home scale or a smart scale that shares weight data directly with the clinic. The goal is to see if this daily…

This early-stage study is testing whether magnetic brain stimulation can help people with stimulant addiction. Researchers will use brain scans and EEG to guide magnetic pulses to specific brain areas in 50 adults who are already in treatment and have been sober for at least two …

This study is testing whether adding two procedures—radiofrequency ablation (heat treatment) and bone cement injection—to standard radiation therapy works better than radiation alone for people with cancer that has spread to the spine. The goal is to see if the combined treatment…

This study is testing whether a combination of two existing diabetes medications (pioglitazone and metformin) can shrink or eliminate high-risk white or red patches in the mouth (oral leukoplakia). These patches can sometimes develop into oral cancer. The goal is to see if a 12-w…

This early-stage study is testing whether transplanting healthy gut bacteria from a donor is safe and feasible for patients recovering from colon surgery. The goal is to see if restoring the gut's natural balance of microbes can help control infections and improve recovery. The s…

This study aims to make deep brain stimulation (DBS) therapy for essential tremor work better and be easier to set up. Researchers are testing a computer-guided method to help doctors find the most effective stimulation settings more quickly. The study involves 25 people who alre…

This early-stage study is testing the safety and practicality of giving patients a freeze-dried preparation of healthy gut bacteria (from donor stool) before they have part of their colon removed. It will involve 40 adults scheduled for surgery for conditions like early-stage col…

This study is testing a new, gentler pattern of deep brain stimulation for people with essential tremor, a condition that causes uncontrollable shaking, especially in the hands. Researchers want to see if this new approach, which uses lower currents in a specific pattern, is safe…

This study is testing a new device called CompuFlo CathCheck to see if it works as well as the current standard method (an epidurogram) for checking where an epidural catheter is placed during surgery. Researchers will compare results from both methods in 50 adult patients. The g…

This study is testing a new, non-invasive way to measure pressure inside the skull (intracranial pressure). Researchers will use a special video camera to record the back of the eye (retina) in 90 people who already have a standard pressure monitor surgically placed for medical c…

This study aims to prevent serious behavioral and emotional problems in children by improving how doctors connect parents with help. It tests two things: training for pediatric doctors on how to make better referrals, and an online parenting program delivered by therapists. The g…

This study is testing four different cleaning routines to prevent dangerous staph bacteria from causing infections in surgical wounds. Adult patients having outpatient surgery will try special nose ointments, mouth rinses, and body washes before their operation. Researchers will …

This study is testing three different school-based programs designed to prevent serious conduct problems in high school students who show early warning signs. About 120 students will be randomly assigned to try either a mindfulness program, the same program with a supporting mobi…

This study is testing whether giving probiotic supplements to mothers with diabetes during pregnancy might help their babies' brain development. Researchers will enroll 60 pregnant women with gestational diabetes and give them either probiotics or a placebo. They'll then measure …

This study is testing if a medication called CMVIG can prevent CMV infection in kidney transplant patients who are switching to a different anti-rejection drug called belatacept. Researchers will track how the body processes CMVIG and measure antibody levels over time in 30 adult…

This study is testing a new online training method for mentors in rural communities. The goal is to help mentors learn how to deliver a proven program that prevents depression and anxiety in teenagers. Researchers will compare this new 'just-in-time' training to usual training me…

This study is testing if a nerve block given before major chest surgery can prevent a common and serious complication: irregular heartbeats after the operation. It will involve 48 adults having surgery to remove part or all of a lung or esophagus. Researchers will compare the hea…

This study is testing whether patients can safely skip taking preventive antibiotics after major surgery to remove the bladder for cancer. It compares the rate of urinary tract infections in patients who take a preventive antibiotic for 90 days after surgery versus those who take…

This study is testing if a medication called bupropion can help women who quit smoking during pregnancy stay smoke-free after giving birth. Researchers will enroll 200 new mothers and randomly give them either the real medication or a placebo pill. The main goal is to see if the …

This study is testing whether walking in nature areas is better for stress and health than walking in built-up urban areas for adults with prediabetes. Participants will walk 150 minutes per week for six weeks in each type of environment, with a break in between. Researchers will…

This study is testing which of two pain control methods works better for adults with multiple broken ribs. Researchers will compare freezing the nerves near the ribs (cryoablation) to placing a pain medication catheter in the back. The main goal is to see which method provides be…

This early-stage study is testing a faster form of brain stimulation to help people with long-term chronic pain. Researchers will use a special AI algorithm to find the best spot on each person's brain to target with magnetic pulses. The goal is to see if this personalized approa…

This study is testing two different community-based group programs to see which one better helps people manage chronic back or neck pain. Participants will be randomly assigned to attend one of two 9-week programs: one focuses on mind-body skills like mindfulness, while the other…

This fully remote study is testing two different smartphone-based approaches to help adults with binge eating disorders. Participants will use apps that either teach breathing exercises to improve heart rate patterns or guide them through body-awareness exercises when they feel d…

This study is testing whether adding a second type of nerve block to the standard one provides better pain relief after shoulder replacement surgery. Researchers will compare pain levels and opioid medication use in 110 patients who receive either the real second block or a place…

This study is investigating whether the mind-body practice Qigong can help reduce chronic low back pain by changing how the brain processes body awareness. Researchers will compare Qigong to standard exercise in 60 adults with chronic back pain. The main goal is to see if Qigong …

This study is testing a new approach to spinal cord stimulation, a common treatment for chronic pain. Researchers want to see if they can improve pain relief by using a device that 'listens' to the body's nerve signals in real-time to automatically adjust the stimulation. They ar…

This study aims to find which injection works better for easing shoulder arthritis pain: a common steroid shot into the joint or a nerve-blocking injection that numbs pain signals. Researchers will enroll 40 adults with shoulder arthritis to compare pain relief and shoulder funct…

This study is testing if a one-week breathing exercise called alternate nostril breathing can help reduce nausea and vomiting in people during their first trimester of pregnancy. Researchers will enroll 100 pregnant individuals with mild to moderate symptoms to see if the breathi…

This study is testing whether gentle vibration applied to the neck muscles can help improve head posture in people with cervical dystonia, a condition that causes involuntary neck muscle contractions and abnormal head positions. Researchers will compare different vibration intens…

This pilot study is testing whether a minimally invasive procedure called geniculate artery embolization, when added to standard care (physical therapy and medications), provides better and longer-lasting pain relief for knee osteoarthritis than standard care alone. Researchers w…

This University of Minnesota study is testing whether taking probiotic supplements for 5 weeks can help reduce muscle soreness and improve recovery after exercise. Researchers will measure pain levels, muscle sensitivity, and jumping ability in 24 healthy, active young adults aft…

This study is testing which of two pain control methods works better for adults recovering from hip fracture surgery. It compares freezing specific nerves near the hip (cryoablation) to placing a temporary pain medication catheter. The main goal is to see which method provides be…

This study is testing whether a guided, community-based walking program helps people with peripheral artery disease (PAD) walk farther and feel better after having a procedure to improve blood flow in their legs. Researchers will compare a group that gets coaching and support for…

This study is testing whether the specific words a doctor uses can change how much pain a patient feels during an epidural procedure. Researchers will compare pain levels in pregnant patients who hear either a positive or a negative description right before the epidural is placed…

This study is testing whether spinal cord stimulators can be adjusted remotely to better control chronic back and leg pain. Fifteen adults already scheduled to get a spinal cord stimulator will try different stimulation patterns through a smartphone app over four months, reportin…

This study is testing whether doctors can reliably measure brain wave responses during a specific surgery for trigeminal neuralgia, a severe facial pain condition. Researchers will perform these measurements on 30 adults undergoing the surgery and compare them to healthy voluntee…

This study aims to understand what happens in the brain of people with Visual Snow Syndrome (VSS), a condition where people constantly see tiny flickering dots. Researchers will compare brain scans and vision tests from 100 people, including those with VSS, those with migraines, …

This study aims to understand why Parkinson's disease affects leg muscle control and walking. Researchers will test if a brief, non-invasive stimulation of a nerve in the neck can improve muscle activity and balance in 75 participants. The goal is to gather evidence for future la…

This study aims to understand how the brain's reward system works in people with bulimia nervosa, specifically focusing on the anticipation or planning phase before a binge eating episode. Researchers will use brain scans (fMRI) and daily smartphone surveys to measure brain activ…

This study aims to better understand inflammation and stress in adults with Gaucher disease type 1 by measuring specific markers in their blood. Researchers will collect blood samples from 34 participants over three visits during three months to analyze these markers. The study d…

This study aims to improve genetic counseling for people from all backgrounds. Researchers are testing different counseling approaches to see what creates the best patient experience. The study partners with Somali, Latino/Hispanic, Black/African American, and Hmong communities t…

This study aims to find a brain-based way to measure if a tinnitus treatment is working. Researchers will use a special cap to record brain waves from 24 people with tinnitus before and after they use a stimulation device for six weeks. The goal is to see if changes in brain acti…

This study aims to understand why women who go through menopause early (before age 45) might have higher blood pressure. Researchers will compare the nervous system activity and blood pressure responses of 160 women in different menopause groups. The goal is to gather knowledge a…

This study aims to understand exactly how vagus nerve stimulation (VNS) therapy works for epilepsy. Researchers will use a fine needle to record nerve signals in 60 adults with epilepsy who already have a VNS implant. The goal is to see which specific nerve fibers are activated b…

This study aims to understand how a non-invasive vibration therapy helps people with laryngeal dystonia, a condition that causes involuntary voice spasms. Researchers will give participants a 20-minute vibration treatment and use MRI brain scans before and after to see how brain …

This study is testing whether a computer-based decision support system can help doctors better prevent dangerous blood clots (venous thromboembolism) in patients hospitalized with traumatic brain injury. The research will involve 15,000 adult patients across seven hospitals. The …

This study aims to understand how decision-making works in conditions like schizophrenia. Researchers are giving a single dose of a medication called modafinil to healthy volunteers and measuring changes in their brain activity and performance on computer 'brain games.' The goal …

This study aims to understand how different settings on existing deep brain stimulation devices affect walking, balance, and movement in people with Parkinson's disease. Researchers will use brain scans to create personalized computer models for 60 participants who already have t…

This study aims to find measurable signs, called biomarkers, of ALS and Primary Lateral Sclerosis (PLS) using advanced MRI brain scans. Researchers will compare detailed brain images from 30 people with ALS or PLS to images from healthy people. The goal is to better understand th…

This study is testing a new device that helps doctors position a thin tube (catheter) during heart rhythm procedures in children and young adults. The device is being evaluated for safety and how well it works after the main medical procedure is already finished. The research inv…

This study aims to understand if a mother's stress after a premature birth is linked to changes in her breast milk and her baby's brain development and feeding success. Researchers will follow 120 mothers and their preterm babies, collecting milk and stool samples to look for con…

This study aims to understand how stimulating the vagus nerve affects the body's automatic functions like heart rate, blood pressure, and inflammation. Researchers will measure these effects in 144 adults who already have or will receive a vagus nerve stimulator for drug-resistan…

This study aims to understand chronic jaw pain by looking at how different areas of the brain communicate. Researchers will use MRI brain scans on about 95 women with and without chronic jaw pain to see if specific brain connection patterns are linked to how disabling the pain is…

This study aims to carefully track how rare, inherited disorders called gangliosidoses (like Tay-Sachs and Sandhoff disease) progress over time. Researchers will follow about 52 participants, from infants to adults, using tests and brain scans to measure changes in development, m…

This study aims to understand how DNA repair disorders like Cockayne syndrome, xeroderma pigmentosum, and trichothiodystrophy change over time. Researchers will observe 40 participants to track their movement, balance, and other symptoms. The goal is to gather detailed informatio…

This study aims to understand which specific settings on a deep brain stimulation (DBS) device work best for Parkinson's disease symptoms, especially walking and balance problems. Researchers will compare two different stimulation patterns in 30 people who already have a standard…

This international study aims to better understand how acute infections affect hospitalized adults by observing 1,500 patients across multiple countries. Researchers will collect health data and biological samples to learn about risk factors, disease patterns, and recovery timeli…

This is a small, early study to learn how a rare and aggressive nerve tumor responds to a short course of two oral drugs. The study involves 8 people, aged 12 and older with Neurofibromatosis type 1 (NF1) and a specific type of tumor. Patients take the drugs for 28 days before st…

This study aims to understand why sepsis damages the immune system, leaving survivors vulnerable to serious infections for weeks or months afterward. Researchers will analyze blood samples from 150 ICU patients with sepsis, comparing them to patients without sepsis and healthy vo…

This early pilot study is exploring a new idea: whether swallowing capsules containing healthy gut bacteria from a donor can change a person's gut microbiome and potentially help with the painful skin condition hidradenitis suppurativa (HS). Researchers will enroll 16 adults with…

This study aims to understand how deep brain stimulation (DBS) affects walking, balance, and other movement problems in people with Parkinson's disease. Researchers will use a special, already-implanted DBS device to record brain signals while 36 participants perform daily activi…

This study aims to understand why some patients get infections at their surgical wound after open abdominal surgery. Researchers will collect bacteria samples from the skin and gut of 300 patients during their operation and track them for 30 days afterward. By comparing patients …

This study aims to understand how different brain areas communicate in Parkinson's disease to improve deep brain stimulation (DBS) treatment. Researchers will record brain activity from 25 Parkinson's patients during their scheduled DBS surgery using an additional thin sensor str…

This study is testing whether ultrasound technology can create clear images of brain tumors during surgery. Researchers will compare ultrasound images with standard MRI scans in 15 people already scheduled for brain surgery. The goal is to see if ultrasound could eventually help …

This study aims to better understand how a behavioral therapy called CBIT helps people control their tics. Researchers will closely observe 30 youth (ages 12-21) with chronic tic disorders as they go through 8 therapy sessions. The goal is to identify patterns in how tic control …

This study aims to understand if a gentle, focused ultrasound can safely reach deep parts of the brain and influence thinking skills like attention and problem-solving. Researchers will test this on 100 healthy adults using brain scans and thinking tests. The goal is to gather ba…

This study aims to understand what happens in the body during a long water fast. Researchers will enroll 15 healthy adults to fast and then analyze their blood. They will test if the changes in the blood can affect models of diseases like cancer or diabetes in lab-grown cells.

This study is testing a new way to detect harmful brain wave patterns, called cortical spreading depolarizations, in patients with severe traumatic brain injury (TBI). Researchers will place a special recording wire during a standard medical procedure to monitor brain activity. T…

This study aims to understand how deep brain stimulation (DBS), a treatment for Parkinson's movement symptoms, affects sleep. Researchers will monitor brain activity and sleep patterns in 64 Parkinson's patients who have or will receive a DBS device. The goal is to learn about th…

This study aims to understand how normal aging connects changes in the brain and kidneys with changes in memory and thinking skills. Researchers will use detailed MRI scans and cognitive tests on healthy adults. The goal is to gather knowledge about the aging process, not to test…

This study aims to understand the basic relationship between brain blood flow, brain activity, and balance control in healthy adults as they age. It will involve 102 healthy participants from three age groups (young, middle-aged, and older adults). Researchers will measure brain …

This study is testing if showing a short educational film (a docudrama) to first-time blood donors in Ghana can encourage them to donate again. About 180 new donors will be randomly assigned to either watch the film or receive standard information after donating. Researchers will…

This study aims to test if new brain scanning and stimulation methods can find common markers for thinking problems in people with chronic pain or depression. It will involve 45 people, including healthy volunteers, to see if the research procedures are practical. The goal is to …

This study aims to better understand how different parts of the brain work together in people with Parkinson's disease. Researchers will study brain activity in 30 participants who are already scheduled to receive a deep brain stimulation (DBS) implant as part of their regular ca…

This study aims to understand oxygen levels in the airways during a specific type of lung procedure called rigid bronchoscopy. Researchers are measuring how long it takes for oxygen to drop to a safer level when a special 'laser mode' is used on the breathing machine. The goal is…

This study is testing a new, portable MRI scanner designed just for the head. Researchers want to see if the images it produces are clear enough compared to standard, large MRI machines. They are enrolling 20 healthy adults to try the scanner and compare the picture quality.

This study aims to see if measuring brain signals during a common surgery for trigeminal neuralgia can help doctors personalize the procedure. Researchers will record these signals from the scalp and directly from the nerve during surgery in 30 patients. The goal is to gather inf…

This study aims to understand how Gaucher Disease Type 3 affects the brain in adults. Researchers will use a special brain scan (MRS) to measure chemicals in the brains of up to 5 participants. The goal is to find markers that could one day help measure if treatments are working.

This study aims to understand why some people with Parkinson's disease experience 'freezing of gait,' a sudden and temporary inability to start walking or continue moving. Researchers will measure brain activity in 36 participants who already have a specific deep brain stimulatio…

This study aims to understand how chronic jaw pain influences drinking patterns. Researchers will compare the drinking habits of heavy drinkers with and without this specific pain condition, both in a lab setting and in daily life. The goal is to gather knowledge about why people…