University Of Minnesota

This study tests a method to fine-tune epidural spinal cord stimulation in 100 adults with motor-complete paraplegia from a spinal cord injury between C6 and T10. The goal is to help them regain voluntary leg movement and improve autonomic functions like blood pressure control. P…

This study tests whether a drug called fisetin can prevent sepsis from getting worse in older adults. Sepsis is a life-threatening reaction to an infection that can cause organ failure. The trial will give fisetin to 220 patients aged 65 and older who have a mild infection and ar…

This study tests if a computer-delivered cognitive behavioral therapy can help people who have both an anxiety disorder and alcohol use disorder. The goal is to reduce heavy drinking and delay relapse. If effective, this program could be widely available at low cost. The study en…

This study tests whether a combination of two diabetes drugs, pioglitazone and metformin, can shrink or improve precancerous mouth lesions called oral leukoplakia. About 36 adults with high-risk lesions will take the pills twice daily for 12 weeks. The goal is to see if the treat…

This study tests a new way to fine-tune deep brain stimulation (DBS) settings for people with Parkinson's disease who already have a DBS device. Researchers use each patient's brain scans to create a computer model and then find the best stimulation settings to improve walking an…

This study tests whether pairing a gentle electrical brain stimulation (tDCS) with computer-based cognitive training can help people with alcohol use disorder stay abstinent longer. About 40 participants who are already sober and in a residential program will receive the combined…

This study tests two different deep brain stimulation (DBS) settings in 30 people with Parkinson's disease who already have DBS implants. The goal is to see which setting better improves walking and balance problems. Participants will have their stimulator adjusted and be monitor…

This early-phase trial tests a 28-day course of two oral drugs, mirdametinib and vorinostat, in 8 people aged 12+ with NF1 and a specific type of malignant peripheral nerve sheath tumor (MPNST). The goal is to check safety and see if the drugs shrink the tumor or change its marke…

This early study tests whether taking a capsule of healthy gut bacteria (microbiota transplant) can change the gut microbiome and help treat hidradenitis suppurativa, a chronic skin condition causing painful boils. Sixteen adults with the disease will receive the capsules and be …

This study tests whether a daily pill called empagliflozin, originally used for diabetes, can improve heart function in 80 older adults with high blood pressure and obesity who are at risk for heart failure. Participants take either the drug or a placebo for 9 months, and doctors…

This study tests whether adding weight-loss surgery (vertical sleeve gastrectomy) to lifestyle changes is better than lifestyle changes alone for treating NASH, a serious fatty liver disease. About 48 adults aged 30-70 with NASH and obesity will be randomly assigned to one of two…

This study looks at how long new mothers with high blood pressure should monitor their blood pressure from home after giving birth. Researchers will compare a 2-week program with a 6-week program to see which leads to better blood pressure control at the 6-week checkup. About 400…

This study tests a mobile health program called mGlide-Care that helps caregivers support people with mild memory issues (like early Alzheimer's) in managing high blood pressure. About 75 participants will either use the program or get usual care. The goal is to see if this team …

This study tests whether long-term electrical stimulation of the spinal cord can help people with chronic spinal cord injury regain voluntary movement. Researchers will measure changes in muscle activity with and without stimulation. The study enrolls 50 adults with stable injuri…

This study tests whether an implanted spinal cord stimulator can safely improve blood pressure, heart rate, and overall function in people with chronic cervical spinal cord injury. It involves 36 adults with stable, motor-complete injuries between the C4 and C7 vertebrae. The mai…

This study tests whether a soft, FDA-approved belly band can help strengthen the abdominal muscles of premature babies who need breathing support (CPAP). Researchers will measure muscle thickness with ultrasound and see if babies reach full oral feeding earlier. About 40 infants …

This study tests new drug combinations for cryptococcal meningitis, a brain infection that is always fatal without treatment and still kills many people with HIV. The trial aims to find safer, more effective therapies that are easier to access worldwide. About 2,000 adults with H…

This study looks at whether a non-invasive brain stimulation technique called tDCS, combined with computer-based cognitive training, can help people with opioid use disorder who are already on buprenorphine maintenance. Researchers will measure changes in brain connectivity and t…

This study looks at whether it is safe to skip preventive antibiotics after bladder cancer surgery that creates a new way for urine to leave the body. About 120 adults with muscle-invasive bladder cancer will be randomly assigned to receive either the antibiotic nitrofurantoin or…

This study looks at whether giving probiotics to pregnant women with diabetes can improve their babies' brain development. The researchers will measure brain activity in the babies at 1 and 6 months old. The goal is to see if probiotics change the baby's gut bacteria and help wit…

This study tests whether transplanting healthy gut bacteria (microbiota transplant therapy) can help people with moderate to severe alopecia areata, an autoimmune disease that causes patchy or total hair loss. Researchers will give 40 adults a treatment to change their gut bacter…

This study tests whether a daily breathing exercise called Inspiratory Muscle Strength Training (IMST) can lower blood pressure in adults with high systolic blood pressure. About 144 participants will do one of three breathing intensities for 6 weeks. The goal is to find the best…

This study compares two surgical procedures for people with large, irreparable rotator cuff tears that cause pain. One procedure smooths the bone where the tear is, and the other places a small balloon under the shoulder to reduce friction. Researchers will use special X-rays to …

This study is testing whether transplanting healthy gut bacteria (in capsule form) can take hold in the intestines of people with Crohn's disease and possibly reduce inflammation. Researchers will enroll 120 adults with active Crohn's to see if the donor microbes engraft and if s…

This study is testing whether a continuous glucose monitor (CGM) that shows blood sugar levels in real time can help children and young adults in Uganda with type 1 diabetes keep their blood sugar in a healthy range. Half of the 180 participants will use the CGM for 6 months, whi…

This study is testing a soft, removable cast wrap designed to help foot ulcers heal in people with diabetes. Researchers want to see if the wrap is effective, safe, comfortable, and easy for patients to use. They will follow 100 adults with diabetic foot ulcers for up to 16 weeks…

This study tests whether a special video camera that records the eye can measure pressure inside the brain without needles, anesthesia, or touching the eye. About 90 adults with or without existing brain pressure monitors will participate. If successful, this could lead to a safe…

This study tests whether the medication bupropion can help women who quit smoking during pregnancy stay smoke-free after giving birth. About 200 women will receive either bupropion or a placebo daily for 12 weeks after delivery. Researchers will track smoking abstinence through s…

This study tests whether an antibody treatment called CMVIG can prevent CMV infection in kidney transplant patients. Researchers will measure antibody levels in 30 adults who are switching to a new anti-rejection drug. The goal is to see if CMVIG is safe and effective at blocking…

This study tests three school-based programs to prevent behavior problems in high school students who are at risk. About 120 teens will be randomly assigned to a mindfulness class, a mindfulness class with a mobile app, or a life skills class. Researchers will check how well the …

This study looks at whether testing for and treating Staphylococcus aureus (S. aureus) bacteria before surgery can prevent infections after the operation. About 250 adults having outpatient surgery will be split into four groups, each using different combinations of nasal ointmen…

This study tests a new way to train mentors and their supervisors to deliver a proven depression prevention program to teens in rural communities. The training includes online modules, live supervision, and a buddy system where new mentors learn from experienced ones. About 96 te…

This study looks at whether taking a probiotic supplement for 5 weeks can help reduce muscle soreness after intense exercise in healthy, active young adults. Researchers will measure pain, pressure sensitivity, and jump performance. The goal is to see if probiotics can speed up r…

This study looks at how the mind-body practice of QiGong changes brain activity to help people with chronic low back pain feel better. Researchers will enroll 60 adults with ongoing low back pain and measure changes in pain intensity, body awareness, and mindfulness after QiGong …

This study compares a procedure that uses heat to destroy tumor tissue and strengthen bone (radiofrequency ablation and bone augmentation) plus standard radiation therapy versus radiation alone in people with cancer that has spread to the spine. The goal is to see if the combined…

This study tests a culturally adapted program called ACES for Black immigrant caregivers of people with dementia. The goal is to see if it helps reduce depression and caregiver burden while improving quality of life. About 150 care partners and their loved ones will take part ove…

This study tests whether a one-week alternate nostril breathing (ANB) practice can reduce nausea and vomiting in early pregnancy. Researchers will enroll 100 pregnant individuals in their first trimester with mild to moderate symptoms. Participants will be randomly assigned to do…

This study tests whether a gentle brain stimulation technique (tDCS) combined with computer-based thinking exercises can improve attention, memory, and problem-solving in children aged 8–17 with Fetal Alcohol Spectrum Disorders (FASD). About 70 kids will be randomly assigned to r…

This study compares two common treatments for shoulder pain caused by arthritis: a steroid injection into the joint and a nerve block. Researchers want to see which one provides better pain relief and improves shoulder function. About 40 adults with shoulder arthritis will be ran…

This study is testing whether increasing the heart rate using a pacemaker can improve heart failure symptoms and exercise ability in people with cardiac amyloidosis. Ten adults who already have a pacemaker will take part. Researchers will measure changes in symptoms and heart-rel…

This study tests a telehealth program that coaches parents of children with autism to improve their child's communication and behavior while reducing parental stress. Researchers will train community providers to deliver the coaching remotely, aiming to reach families in rural ar…

This study tests whether adding a pectoserratus nerve block to the standard interscalene block can better control pain and reduce opioid use after total shoulder replacement. About 110 adults aged 18-85 having shoulder replacement will be randomly assigned to receive either the e…

This study tests two mobile app programs designed to help adults with binge eating disorders reduce their symptoms. Participants will use either a heart rate biofeedback app or guided body scan videos over 4 weeks. The goal is to see if improving body awareness can decrease binge…

This study looks at whether weighing yourself every day can help teenagers with obesity manage their weight. About 99 teens aged 12 to 18 will be split into three groups: one gets usual care, another adds a simple scale, and the third uses a smart scale that shares data with thei…

This study tests whether a small, noninvasive device that delivers mild electrical pulses to the ear can help reduce chronic jaw and face pain from temporomandibular disorder (TMD). About 40 adults with TMD will use the device daily at home for several weeks. Researchers will mea…

This study looks at whether spinal manipulation (a chiropractic-style adjustment) can help normalize how the neck moves in people with chronic neck pain. Sixty adults aged 18-39 with neck pain for over 12 weeks will be randomly assigned to receive spinal manipulation, a light mas…

This study tests a way to help people with central vision loss from age-related macular degeneration read more easily. Researchers will move missing text to a different part of the visual field and measure reading speed and errors. About 108 participants will take part, including…

This study tests whether a safe, non-invasive brain stimulation technique called TACS can improve thinking and decision-making in people who have had a mild to moderate traumatic brain injury (TBI). Researchers will enroll 30 adults to see if the approach is practical and well-to…

This study tests if mild electrical stimulation on the brain's surface can help people with severe depression that hasn't improved with other treatments. About 15 participants will have a small device surgically placed under the scalp to deliver targeted pulses. The goal is to se…

This study tests a new type of brain stimulation (called accelerated TMS) for people with long-term chronic pain that hasn't improved with medication. The treatment is personalized using brain scans and a smart algorithm to target the right spot for each person. The goal is to se…

This study tests if freezing a specific nerve group (cryoablation) provides better pain control 30 days after hip fracture surgery compared to the standard method (a catheter that delivers numbing medicine). About 150 adults aged 18-85 having hip fracture repair will take part. T…

This study looks at whether a structured exercise program in a community setting can improve walking ability and heart health in people with peripheral artery disease who have recently had a procedure to restore blood flow in their legs. About 30 participants will take part. The …

This study tests if freezing the nerves between the ribs (cryoablation) provides better pain relief than a standard nerve block (ESP catheter) for people with broken ribs. About 48 adults with more than one broken rib will be enrolled. The main goal is to see which method leads t…

This study tests whether a numbing injection near a nerve cluster in the neck can lower the chance of a common heart rhythm problem after lung or esophagus surgery. About 48 adults having these surgeries will either get the injection plus standard care or standard care alone. The…

This study looks at a new method called 'telefitting' to fine-tune spinal cord stimulators in people with chronic back or leg pain. Fifteen adults who are already scheduled to get a spinal cord stimulator will try different stimulation settings (tonic, burst, and multistim) witho…

This study tests a procedure called geniculate artery embolization for people with mild to moderate knee osteoarthritis. It blocks abnormal blood vessels in the knee to reduce pain and improve function. Twenty adults aged 40–70 will be randomly assigned to get the procedure plus …

This study tests a new way to stimulate the brain called coordinated reset deep brain stimulation (CR-DBS) for people with essential tremor, a condition that causes shaking hands. Researchers want to see if this method is safe and can reduce tremors better than standard stimulati…

This study tests whether gentle vibrations on neck muscles can improve head posture in people with cervical dystonia, a condition causing abnormal head positioning. Fifty adults with the condition will receive different vibration intensities during a single 3-hour lab visit. Rese…

This study tests a new approach for people who still have thinking problems 3 to 12 months after a mild concussion. It combines a gentle, non-invasive brain stimulation technique called tDCS with computer-based cognitive training. Researchers want to see if this combo improves me…

This study follows 40 people with rare DNA repair disorders like Cockayne syndrome, xeroderma pigmentosum, and trichothiodystrophy. Researchers will measure movement, balance, and thinking skills over time to learn how these conditions change. No treatment is given—the goal is to…

This study tests if synchronizing magnetic brain stimulation with a person's own brain waves can improve treatment for stimulant use disorder. Researchers will recruit 50 adults who are currently in treatment and have been abstinent for at least 2 weeks. Participants will receive…

This study looks at what happens to the heart and breathing during a hot flush in women after menopause. Researchers will use a special heating pad to try to trigger hot flushes and measure blood pressure, skin temperature, and heart rate. The goal is to understand if hot flushes…

This study looks at how the exact placement of deep brain stimulation (DBS) electrodes affects movement problems in people with Parkinson's disease. Researchers will study 24 participants who already have DBS implants to see which stimulation spots help or hinder movement. The go…

This study looks at how early menopause affects the body's ability to control blood pressure. Researchers will measure nerve activity and blood pressure in 160 women aged 35-70. The goal is to understand why some women develop high blood pressure after early menopause. No treatme…

This study aims to understand why some people with Parkinson's disease experience freezing of gait—a sudden inability to move their feet. Researchers will use special brain recordings from implanted DBS devices to compare brain activity in people with and without freezing. The go…

This study looks at whether a computer program that helps doctors make decisions can improve how often patients with traumatic brain injury get the right treatment to prevent blood clots. About 15,000 adults across 7 hospitals will take part. The goal is to see if the tool increa…

This study looks at whether giving radiation after a standard procedure to release finger contractures can improve hand function and reduce the chance of the disease returning. Researchers will follow 50 adults with Dupuytren's disease who are already planning treatment. The goal…

This study looks at how gentle vibration on the throat affects brain networks in people with laryngeal dystonia, a condition causing voice spasms. Researchers will use brain scans and voice recordings to understand why some patients get temporary voice relief. The goal is to lear…

This study explores how a mother's stress may change the makeup of her breastmilk and how that affects preterm babies' brain development and feeding. Researchers will follow 120 preterm infants and their mothers from the NICU to 4 months after birth. The goal is to understand the…

This study looks at whether measuring nerve signals during a procedure called rhizotomy can help doctors treat trigeminal neuralgia more precisely. About 30 adults scheduled for the procedure will have their nerve responses recorded before and after treatment. The goal is to see …

This study looks at why young women with PTSD may have higher heart disease risk later in life. Researchers will give beetroot juice to 30 premenopausal women with trauma exposure to see if it improves blood vessel function. The goal is to understand how PTSD affects the body, no…

This study checks if a special ultrasound machine can take pictures of brain tumors during surgery. It compares these images to standard MRI scans to see if ultrasound is a good, cheaper, and faster option. About 15 adults having brain surgery will take part. The goal is to see i…

This study watches 300 adults who have open abdominal surgery to learn why some get surgical site infections. Researchers will collect samples from the skin and gut during surgery and track patients for 30 days. By comparing those who get infections with those who don't, they hop…

This study looks at how different brain circuits are linked to movement and thinking in people with Parkinson's disease who already have a deep brain stimulation (DBS) device. Researchers will measure brain activity patterns during rest and movement, and connect them to standard …

This study looks at how quickly oxygen levels drop in the airway when doctors use a special breathing machine during a lung procedure called rigid bronchoscopy. The goal is to find a safe oxygen level before using heat tools that could cause a fire. About 50 adults having this pr…

This study looks at how the brain controls movement in people with Parkinson's disease. During planned deep brain stimulation (DBS) surgery, researchers will place a thin strip on the brain's surface to record electrical signals. The goal is to learn how different brain areas tal…

This study aims to prevent behavioral health problems in children by improving how doctors refer families to parenting programs and by testing an online program called eGen. Researchers will train primary care doctors to make better referrals and then offer parents of children ag…

This study tests whether computer models can help doctors find the best settings for deep brain stimulation (DBS) in people with essential tremor. About 25 adults who already have a DBS implant will have their stimulation tested and their tremor measured with sensors. The goal is…

This study looks at how the brain's reward system may keep bulimia nervosa going. Researchers will use brain scans and daily surveys to understand what drives binge eating and purging. The goal is to find new ways to treat this condition. About 100 adults with bulimia or healthy …

This study tests whether measuring nerve signals from the face during a routine procedure for severe facial pain (trigeminal neuralgia) is practical. About 30 adults scheduled for a rhizotomy will have small electrical pulses on their skin while brain responses are recorded. The …

This study looks at how and why behavior therapy (CBIT) helps people aged 12–21 with chronic tics. Researchers will track 30 participants over 8 therapy sessions, measuring tic severity, control, and related factors. The goal is to find patterns that predict who improves most, so…

This study looks at how the brain works in 30 people with Parkinson's disease who are scheduled for Deep Brain Stimulation (DBS) surgery. Researchers want to understand brain signals related to movement and thinking to make DBS therapy more effective in the future. Participants w…

This study looks at how the brains of teens aged 15–18 with cannabis use disorder change when they stop using cannabis for 6 weeks. Researchers will use brain scans to measure reward and impulse control, and compare them to teens who never used cannabis. The goal is to better und…

This study aims to understand what causes Visual Snow Syndrome (VSS), a condition where people see constant flickering dots. Researchers will use brain scans and visual tests to find which brain pathways are involved. About 100 adults with VSS, migraine, or healthy vision will pa…

This study involves 20 people with epilepsy who already have a deep brain stimulator implanted. Researchers will test different stimulation settings to see which ones work best to reduce seizures. The goal is to create a personalized approach to improve seizure control.

This study looks at how vagus nerve stimulation (VNS) changes the nervous system, heart, immune system, and metabolism in people who already have a VNS device for epilepsy or depression. It is not a treatment study—it aims to learn how VNS works. About 144 adults aged 18 and olde…

This study looks at whether walking in nature (parks, preserves) or walking in built-up areas (shopping centers, streets) is better for reducing stress and anxiety in adults with prediabetes. About 216 people aged 25-64 will walk 150 minutes each week for six weeks in each type o…

This study looks at how deep brain stimulation (DBS) affects sleep in people with Parkinson's disease. Researchers will monitor brain activity and sleep quality in 64 adults who already have or are getting DBS implants. The goal is to understand which brain circuits are involved …

This study tests whether low-intensity focused ultrasound (LIFU) can improve thinking and memory in healthy adults. Researchers will use brain scans and thinking tests to see if the ultrasound can safely activate deep brain areas. The goal is to understand how ultrasound affects …

This study tests whether transplanting healthy gut bacteria is safe for people who have had part of their colon removed. About 40 adults with diverticulitis or sigmoid colon cancer will receive the transplant through a feeding tube a few days after surgery. Researchers will monit…

This study tests whether giving an educational handout before surgery helps transmasculine people feel more confident about deciding to keep or remove their ovaries during a gender-affirming hysterectomy. About 250 participants will be randomly assigned to receive the handout or …

This study aims to see if it is possible to measure brain activity patterns related to thinking and attention in people with chronic pain or depression, compared to healthy volunteers. Participants will complete computer tasks while their brain activity is recorded. No treatment …

This study looks at how different parts of the brain connect in people with long-term jaw pain (TMD) compared to those without pain. Researchers will use MRI scans to find patterns that may explain why pain becomes chronic. The goal is to better understand the condition, not to t…

This study looks at how the brain changes over time in people with REM sleep behavior disorder (RBD), a condition that often leads to Parkinson's disease or similar disorders. Researchers will use brain scans and other tests to track these changes in 86 adults with RBD and health…

This study looks at why sepsis causes long-term immune system damage, making people more likely to get serious infections again. Researchers will follow 150 ICU patients with sepsis, analyzing their blood over 28 days. The goal is to understand the cellular changes behind this im…

This study will follow 1,500 adults admitted to the hospital with a suspected or confirmed acute infection. Researchers will collect data and samples to understand risk factors, symptoms, and how the disease progresses. The goal is to use this information to design better treatme…

This study looks at why some people with Parkinson's disease suddenly freeze while walking or turning. Researchers will use gentle electrical stimulation and brain wave recordings to understand the brain and balance systems involved. The goal is to find clues that could lead to b…

This study looks at whether the way doctors describe an epidural procedure can change how much pain a person feels. Researchers will compare positive versus negative phrasing in 30 pregnant women getting their first epidural. The goal is to see if positive words can lower pain sc…

This study looks at tiny particles called extracellular vesicles in the blood of people with Gaucher disease, carriers, and healthy volunteers. Researchers want to see if these particles are different in size, amount, and content, which could help explain brain inflammation linke…

This study looks at how deep brain stimulation (DBS) helps with walking problems in people with Parkinson's disease that don't get better with medication. About 36 adults who already have a DBS device will be monitored during daily activities using a smartphone app and the device…

This study is testing whether a special electrode placed deep in the brain can detect harmful electrical waves called cortical spreading depolarizations (CSDs) after a traumatic brain injury (TBI). These waves are linked to worse outcomes, but are hard to spot with standard monit…

This study aims to learn more about the vagus nerve in people with epilepsy. Researchers will use a thin needle to record nerve signals while participants are awake, both with and without a vagus nerve stimulator device. The goal is to understand which nerve fibers are activated …

This study aims to understand how aging changes the brain and kidneys in healthy adults. Researchers will use advanced MRI scans and thinking tests to measure blood flow and brain function. The goal is to learn more about normal aging, not to treat any disease. About 120 healthy …

This early-stage study tests whether a freeze-dried fecal transplant from healthy donors is safe and practical for people having part of their colon removed. About 40 adults aged 18-75 with colon polyps, early-stage colon cancer, or severe diverticulitis will take the oral prepar…

This study looks at how brain blood flow and balance control change from young adulthood to old age. Researchers will measure brain activity and balance reactions in 102 healthy adults aged 21-95. Participants will do a short exercise session and stand on a platform that gently t…

This study looks at what happens in the body during a long fast (no food for several days). Researchers will take blood samples from 15 healthy adults before, during, and after fasting to measure changes in metabolism and cell markers. They will then test how the fasting blood af…

This study aims to create detailed maps of brain areas involved in thinking and effort in adults with epilepsy. Researchers will use mild electrical stimulation on the brain while patients perform tasks during their hospital stay. The goal is to better understand how different br…

This study compares a new device called CompuFlo CathCheck to the standard X-ray method (epidurogram) for confirming that an epidural catheter is in the right spot. About 50 adults getting an epidural for surgery will participate. The goal is to see if the new device works just a…

This study tests whether a short docudrama film can encourage first-time blood donors in Ghana to donate again. About 180 adults who just donated blood for the first time will either watch the film or receive standard information. Researchers will track who returns to donate agai…

This study uses a special brain scan (MRS) to measure brain chemicals in adults with Type 3 Gaucher disease. Researchers want to find markers that show how the disease affects the brain. Only 5 people will join this study at the University of Minnesota.

This study looks at new blood markers for inflammation and oxidative stress in adults with Gaucher disease type I. Researchers want to see if these markers give extra information beyond the usual tests. The goal is to better understand the disease, not to test a new treatment.

This study looks at how chronic jaw pain (TMD) influences the way heavy drinkers consume alcohol, both in a lab setting and in everyday life. Researchers will measure how much and how fast people drink when they feel pain. The goal is to understand the link between pain and alcoh…

This study follows 52 people with Tay-Sachs, Sandhoff, or GM1 gangliosidosis to understand how these rare genetic diseases progress. Researchers measure changes in motor skills, communication, and behavior each year. The goal is to create a clear picture of the diseases so future…

This study looks at how a single dose of modafinil changes decision-making and brain activity in healthy adults. Researchers hope to learn more about psychosis spectrum disorders like schizophrenia. Participants will take one dose of modafinil, play computer brain games, and wear…

This study tests a new tool that helps doctors steer catheters during heart rhythm tests or treatments in children. The tool is used after the main procedure is done, just to see if it works well and doesn't cause problems. About 25 children (up to age 21) will take part. The goa…

This early-stage study tests whether transplanting gut bacteria from healthy donors is safe and possible for people with pulmonary arterial hypertension (PAH). 24 adults with PAH will receive either the bacteria transplant plus fiber, the transplant alone, or a placebo. Researche…

This study tests a new portable, head-only MRI scanner that is smaller and potentially more accessible than traditional machines. Researchers will compare the quality of brain images from this 0.7 Tesla scanner with those from standard MRI scanners. The study involves 20 healthy …

This study aims to find out if brain wave tests (EEG) can objectively measure whether tinnitus (ringing in the ears) improves after using a special device that stimulates hearing and touch. About 24 adults with tinnitus will use the device for six weeks and have their brain waves…

This study aims to find measurable signs, called biomarkers, of amyotrophic lateral sclerosis (ALS) and primary lateral sclerosis (PLS) using powerful MRI scans. Researchers will compare brain scans of people with these diseases to those of healthy volunteers. Finding these bioma…

This study aims to learn if a new measurement technique can help improve spinal cord stimulation devices for chronic pain. Researchers will test 15 people who already have a temporary spinal cord stimulator implant. They will measure electrical signals from the spinal cord during…