Brain games and a wakefulness drug: new study aims to unlock secrets of psychosis

NCT ID NCT07231497

Recruiting now Knowledge-focused Sponsor: University of Minnesota Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is testing whether a single dose of modafinil, a drug that promotes wakefulness, can change how healthy people perform decision-making tasks and alter their brain activity. Researchers will use EEG caps to measure brain waves while participants play computer-based brain games. The goal is to better understand the cognitive problems seen in psychosis, which could help develop better treatments in the future.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Modafinil
What this could lead to: If successful, this could help researchers understand how certain brain processes work in psychosis, potentially guiding future treatments.
What could go wrong: This is an early-phase study in healthy volunteers, not people with psychosis. The results may not directly apply to patients, and modafinil may cause side effects like headache or anxiety.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cognitive disorder Psychotic Disorders

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COGNITION HEALTHY PARTICIPANTS

Contacts and locations

Locations

University of Minnesota
RECRUITING

Minneapolis, Minnesota, 55455, United States

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