HEALTHY PARTICIPANTS

This study tests an experimental vaccine designed to protect against E. coli bacteria. Researchers are giving the vaccine to 310 healthy adults aged 18 to 64 to see if it is safe and tolerable. The main goal is to check for side effects like injection site pain, fever, or fatigue…

This study tests a new vaccine called GBP511, designed to protect against a family of viruses called sarbecoviruses (which includes SARS-CoV-2). Researchers want to see if it is safe and triggers a strong immune response in healthy adults aged 18 and older. The trial involves up …

This early-stage study tests a new drug called TGM-312-SC01 in healthy adults and people with MASH, a type of fatty liver disease. The main goal is to check the drug's safety and how the body processes it. About 99 participants will receive either the drug or a placebo to gather …

This early-stage study tests a new drug called BGB-45035 for safety and how the body processes it. First, healthy volunteers receive single or multiple doses. Then, people with autoimmune skin diseases like atopic dermatitis (eczema) or prurigo nodularis receive the drug to check…

This early-stage study tests a new drug called SR604 in healthy volunteers and people with hemophilia A, B, or factor VII deficiency. The goal is to check safety and how the drug works in the body. About 31 participants will receive the drug as a shot under the skin.

This early-stage study tests a new drug called AZD1043 in healthy adults who are overweight or obese. The main goal is to check if the drug is safe and how the body processes it. About 104 participants, including people of Japanese and Chinese descent, will receive either the dru…

This study is testing whether a portable virtual reality (VR) headset can help diagnose and monitor traumatic brain injury (TBI), like concussions. The device shines colored lights into the eyes and uses a camera to measure how the pupils react. Researchers will compare results f…

This study tests two new imaging drugs that light up tau protein clumps in the brain during a PET scan. Researchers want to see if they are safe and can help diagnose Progressive Supranuclear Palsy (PSP), a rare movement and thinking disorder. About 24 adults—some healthy, some w…

This early-stage study tests a new drug, PF-07832837, in healthy volunteers and people with moderate-to-severe atopic dermatitis (eczema). The main goal is to check safety and how the body processes the drug. Researchers will also look for early signs that it might improve eczema…

This early-phase study tests a new oral drug, NTX-253, in healthy adults and people with stable schizophrenia. The main goal is to check safety and how the body processes the drug. About 73 participants will take single or multiple doses to find the right dose range.

This study looks at whether taking a daily supplement called Alpha-Glycerophosphocholine (α-GPC) can improve thinking, mood, and physical performance in healthy adults aged 25-55. Over 6 weeks, 80 participants will take either α-GPC or a placebo, and complete tests of attention, …

This study tests whether a daily probiotic supplement (Limosilactobacillus reuteri) can reduce symptoms like heartburn and stomach pain in healthy adults who have occasional upper GI discomfort. About 324 participants will take either the supplement or a placebo for 8 weeks and r…

This study looks at how often people with neurological conditions have trouble swallowing their medications. Researchers will test whether using a special gel or semi-solid form of the medicine can make swallowing safer. About 500 adults with swallowing problems and healthy volun…

This study looks at how much of the drug zilucoplan and its breakdown products end up in the breast milk of healthy women who are breastfeeding. About 15 women who are at least 6 weeks postpartum and plan to stop breastfeeding will take daily injections of zilucoplan. Researchers…

This study compares muscle oxygen levels in people with knee osteoarthritis and healthy volunteers. Researchers will measure oxygen in a key thigh muscle at rest, after exercise, and during recovery. The goal is to understand how knee OA affects muscle metabolism and recovery, wh…

This study looks at how food and two other drugs (itraconazole and carbamazepine) affect the levels of an experimental drug called INCB123667 in the body. It involves 51 healthy adults aged 19 to 55. The goal is to gather safety and drug interaction information, not to treat any …

This study looks at how placing tiny needles on the ear (auricular acupuncture) changes communication between two key brain areas involved in emotion and body awareness. Researchers will use brain scans (fMRI) to compare these changes to those caused by a non-invasive nerve stimu…

This study tests a new version of a spinal stimulation device (STEPSS) in 10 healthy adults. The device sends mild electrical pulses to the spine while leg muscle activity is measured. The goal is to see if the new device works as well as or better than the current one. This is n…

This study checks if a new device can prepare blood samples to look for cancer signals. It involves 45 people: 20 healthy volunteers and 25 with advanced breast cancer. Each gives one blood sample. The goal is to see if the tool works well, not to treat or cure any disease.

This study tests how the body handles two different forms of evolocumab, a drug used to lower cholesterol. About 400 healthy adults aged 18 to 60 will receive a single dose and be monitored for drug levels and side effects. The goal is to compare the two versions, not to treat an…

This study looks at how three experimental drugs (AZD6234, AZD9550, and their combination) affect the way birth control pills work in healthy women who are overweight or have obesity. Researchers will measure drug levels in the blood to see if these weight-loss treatments change …

This study looks at whether practicing fine hand movements can affect how the brain processes language. Forty healthy right-handed adults aged 19-24 will be split into two groups: one will do detailed hand exercises, the other a simpler task. Both groups will train online for 20 …

This early-stage study tests a new injection called KLA318-2 in 48 healthy adults aged 18 to 45. The main goal is to check if it is safe and how the body processes it. Participants receive a single dose and are monitored for side effects and drug levels in the blood. This study d…

This study aims to collect body composition data from 40 healthy adults (young and elderly) using special drinks and scans. The information will help researchers develop better ways to measure muscle and water in cancer patients. Participants must be healthy, not pregnant, and fr…

This early-stage study tests a new oral drug called E1018 in 32 healthy adults to see if it is safe and how the body processes it. Participants receive a single dose and are monitored for side effects and drug levels in blood and urine. This study does not aim to treat or prevent…

This study follows 60 people aged 18 to 40 who are having hip surgery for a condition called femoroacetabular impingement. Researchers will measure their strength, movement, and function before surgery and again at 3 and 6 months after. The goal is to learn what factors lead to a…

This study looks at how a commercially available ketone drink, Ketone-IQ, affects sleep and breathing in 20 healthy adults. Participants will take two different doses of the drink before bed at home. They will measure their ketone levels and wear a headband to track sleep pattern…

This study looks at whether text messages or a built-in game can get Black male college students to use a mindfulness app more often. The goal is to see if these features help reduce risky drinking. About 40 participants will use the app for 28 days and complete surveys.

This study is for healthy adults to see how well andexanet reverses the effects of common blood thinners (rivaroxaban or apixaban) and how it interacts with another blood thinner, enoxaparin. Participants will receive andexanet or a placebo, and researchers will measure blood clo…

This early-stage study tests a new drug called ACI-19764 in 78 healthy adults aged 18 to 65. The goal is to check its safety, how the body handles it, and its effects on immune markers. Participants receive either the drug or a placebo, with some taking a single dose and others d…

This study looks at how seeing, smelling, and interacting with food in virtual reality changes food cravings and body responses. Thirty-four healthy adults will have their brain activity, saliva, blood sugar, and temperature measured while exposed to real and virtual food cues. T…

This study is testing a new device called ZenBud that uses ultrasound (sound waves) to stimulate the vagus nerve in 30 healthy adults. The goal is to see how this affects heart rate, brain activity, blood sugar, and mood. It is not a treatment study — it aims to find out if ultra…

This early-phase study tests the safety and how the body handles a new drug called SV003 in 60 healthy adults. Participants receive a single dose of either SV003 or a placebo. The goal is to check for side effects and measure drug levels in the blood, not to treat any disease.

This early-stage study tests a new oral drug, LTG-321, in 236 healthy adults aged 18 to 55 to see if it is safe and how the body processes it. Some participants will also take a cold pressor test to measure pain tolerance. The study does not aim to treat any disease, but to gathe…

This early-stage study is testing a new drug called UCB5285 in healthy adults, including people of Japanese descent. The main goal is to see if the drug is safe and how the body processes it. About 96 participants will receive either the drug or a placebo. This study does not aim…

This early-stage study is testing a new drug called SYH2085 in healthy Chinese adults to see if it is safe and how the body handles it. About 74 participants will receive either the drug or a placebo. The goal is to check for side effects and measure drug levels in the blood, not…

This study looks at a brain protein called neurofilament in the blood of late preterm babies (born at 34-37 weeks). The goal is to find out what normal levels are and how they change after birth. Up to 15 newborns will give small extra blood samples during routine tests. The resu…

This early-stage study tests a single dose of JMT206 injection in healthy adults aged 18 to 60. The goal is to check if it is safe and how the body processes it. No treatment benefit is expected; it is a first step before testing in patients.

This early-stage study tests a new drug called HW201877 in 104 healthy volunteers to see if it is safe and how the body processes it. The study is not meant to treat any disease—it gathers important safety information before testing in patients with inflammatory bowel disease (IB…

This early-stage study tests whether a new drug called AZD4954 is safe and how the body processes it. About 136 healthy volunteers and people with high cholesterol will receive either the drug or a placebo. The main goal is to check for side effects, not to treat the condition.

This early-stage study tests the safety and how the body processes a new drug called JZP047 in 86 healthy adults aged 18 to 55. Participants receive either the drug or a placebo, and some take the drug with or without food to see if meals affect absorption. The goal is to gather …

This study looks at how a person's beliefs about a treatment can influence their mood, motivation, and reactions to rewards. Healthy volunteers aged 15-25 will receive a sham (fake) version of a brain stimulation treatment called accelerated TMS, which delivers no active stimulat…

This study looks at how people learn from rewards and avoid threats, and whether a gentle nerve stimulation (tVNS) can change these processes. It includes healthy volunteers and people with high anxiety or anhedonia (loss of pleasure). Participants will complete online tasks, bra…

This study looks at how blood sugar levels change during exercise in healthy adults and those with type 1 diabetes. Researchers want to see if these changes are similar each time a person exercises. Participants will cycle or rest after a standard breakfast, and their glucose wil…

This study uses a special, non-invasive eye scan called OCTA to look at tiny blood vessels in the back of the eye. Researchers want to see if these blood vessels look different in people with heart disease compared to healthy volunteers. The goal is to find a new, simple way to c…

This study looks at how our beliefs and expectations can change the pain we feel when watching others suffer. Healthy adults will be placed into one of three groups: no treatment, a placebo nasal spray, or a spray with oxytocin. Everyone in the spray groups will be told they are …

This study looks at how the drug vepdegestrant is processed by the body in people with moderate to severe liver problems compared to healthy people. About 24 adults (ages 18-70) will take a single dose and stay at the clinic for 11 days. The goal is to understand how liver functi…

This study looks at how capivasertib changes the way the body processes dextromethorphan, a common cough suppressant. It involves 42 healthy adults who will take both drugs in a fixed order. The goal is to measure drug levels in the blood, not to treat any disease.

This study measures how two experimental drugs (laroprovstat and AZD4954) affect each other's levels in the blood. About 32 healthy adults will receive single doses of both drugs. The goal is to gather safety and dosing information, not to treat any disease.

This study tests whether vimseltinib, an experimental drug, affects the levels of birth control hormones in the blood. About 24 healthy women will take birth control pills with and without vimseltinib over 35 days. The results will help doctors know if extra contraception is need…

This study tests a new type of electrical brain stimulation called temporal interference to see if it can temporarily change how different brain regions communicate. Researchers will recruit 40 healthy adults aged 18-50. Participants will receive stimulation during sleep and wake…

This early-stage study is testing an experimental drug called Debio 1453P in 88 healthy adults aged 18 to 55. The goal is to check if the drug is safe and how the body handles it at different doses. Participants will receive either the drug or a placebo. This study does not aim t…

This study is the first time the experimental drug KT-579 is given to humans. It aims to check the drug's safety and how the body processes it in 96 healthy adults. Participants will receive either the drug or a placebo, and researchers will monitor for side effects and measure d…

This study aims to collect normal walking and movement data from 200 healthy volunteers of all ages using a wearable device called Syde®. Participants will wear the device for three weeks every six months over two years, and all study activities are done remotely by phone or vide…

This study looks at how well the body absorbs omega-3 fatty acids (EPA and DHA) from two different algae sources compared to a fish oil source and a placebo. Healthy adults aged 18-64 will take one of the supplements daily for 6 weeks. The goal is to see which source provides the…

This early-stage study in 64 healthy volunteers aims to understand how different pill versions of AZD5004 are absorbed and processed by the body, and whether taking them with food changes that. Participants will receive single doses of the drug in different forms, and researchers…

This study looks at three ways to help inactive adults (taking fewer than 5,000 steps a day) become more active: supervised group exercise, a mobile app, or video workouts at home. Thirty people aged 18-35 will do aerobic, strength, and flexibility exercises three times a week fo…

This study tests a new device called See.d that processes blood samples to create slides and plasma for liquid biopsy tests. Researchers want to see if the device works reliably and produces high-quality samples. The study involves 200 healthy adults aged 18 and older. Results ma…

This study looks at how drinking A2 milk, regular milk, or oat drink every day for 12 weeks affects bone health, heart health, and the immune system in healthy adults aged 30 to 60. The main focus is on bone density, but researchers also check other health markers. The goal is to…

This early-stage study tests the safety of a new drug called DF5112 in 48 healthy adults aged 18 to 55. Participants receive a single dose of the drug or a placebo and are monitored for about a week in a clinic, with follow-ups for a month. The goal is to check for side effects a…

This study looks at whether muffins made from a special type of oat (Royal Ancient Oats™) affect blood sugar differently than regular oat muffins or white flour muffins. About 38 healthy adults aged 35-65 with slightly high body weight will eat these muffins and have their blood …

This study checks if two different devices (a handheld syringe and a wearable pump) deliver the same amount of trastuzumab into the body. It involves 312 healthy men who get a single injection. The goal is to see if the devices are equivalent, not to treat any disease.

This study looks at how the retina's ability to use oxygen changes as people age. Researchers will measure oxygen extraction in healthy adults aged 18 to 80 using non-invasive eye scans. Participants will also breathe pure oxygen to see short-term effects. The goal is to understa…

This study tests a blood pressure medication called allisartan isoproxil in 54 healthy Chinese adults aged 18 to 65. Participants receive either a single dose of the drug (240, 480, or 720 mg) or a placebo, and researchers measure how the drug moves through the body and any side …

This study looks at how a new medicine called elecoglipron changes the way the body processes two common cholesterol-lowering drugs, atorvastatin and rosuvastatin. About 40 healthy adults will take elecoglipron along with one of the statins to measure drug levels in the blood. Th…

This study looks at how aerobic exercise affects energy use and metabolism in adults who are not very active. 80 participants will run five times a week for 12 weeks. Researchers will measure changes in energy burned, food intake, and physical activity before, right after, and 8 …

This study tests whether low-intensity focused ultrasound (LIFU) can improve thinking and memory in healthy adults. Researchers will use brain scans and thinking tests to see if the ultrasound can safely activate deep brain areas. The goal is to understand how ultrasound affects …

This early-stage study is testing whether an inhaled drug called CPD704 is safe and how it behaves in the body. It involves 90 healthy Chinese adults aged 18–55. The goal is to check for side effects and measure drug levels in the blood, not to treat any disease.

This study looks at whether eating the fast-acting carbs at the beginning or the end of a pre-exercise meal changes how the body uses fat and carbs during exercise and affects cycling performance. Nineteen healthy, trained male athletes will eat a standard meal in two different o…

This study looks at the best way to teach CPR to kids in primary school. About 550 healthy children will either get a 2-hour hands-on session with a nurse and mannequin, or a short video and puzzle activity. The goal is to see which method helps them learn CPR better, so more peo…

This study looks at whether eating pistachios as a snack can help overweight or obese adults burn energy better at rest, during exercise, and after exercise. About 60 healthy but overweight adults aged 25-45 will compare four days of pistachio snacking with four days of their usu…

This early-stage study is testing a new drug called TLC-1180 in healthy people aged 18 to 55. The main goal is to check if it is safe and how the body handles it. About 288 volunteers will take part. This study does not aim to treat any disease.

This study is looking at whether a molecule in the blood called miR-1 can be used as a marker to track how muscle diseases like Duchenne muscular dystrophy and myotonic dystrophy progress. Researchers will compare miR-1 levels in 104 people, including healthy volunteers and patie…

This study tests whether a brief virtual reality (VR) self-help program can increase hope and well-being in healthy young adults aged 18-30. Participants will complete five sessions: one in-person VR experience and four self-guided audio/video sessions. They will fill out questio…

This study looks at how the body turns fructose (a type of sugar) into glucose. Researchers want to see if the small intestine can protect the liver from harm caused by fructose, and if this protection is weaker in people with obesity. The study will involve 40 healthy volunteers…

This study looks at how resistance training (like lifting weights) makes children stronger. It will compare 40 healthy kids who do 12 weeks of training with those who don't. Researchers will use ultrasound and muscle activity tests to see if strength comes from bigger muscles or …

This study looks at how babies' brains develop over time, including healthy infants and those who had a brain injury around birth. Researchers will use online games and parent questionnaires to measure attention, thinking, and language skills. The goal is to learn more about earl…

This study looks at how babies' brains develop after an early injury. Researchers will use fun games and a safe brain-wave test (EEG) to see which babies might have trouble with thinking and memory later. The goal is to find early signs that could help doctors support these child…

This early-phase study looks at how a single dose of AGA2118 moves through and leaves the body in 30 healthy adults of Japanese, Chinese, and Caucasian descent. Participants must be 18-65, have adequate vitamin D levels, and agree to take calcium and vitamin D supplements. The st…

This early-stage study tests a new oral drug, YH35995, in healthy adult men to see if it is safe and how the body processes it. Participants receive either the drug or a placebo, and researchers monitor for side effects and measure drug levels in the blood. The goal is to gather …

This study looks at whether a common dietary fiber called beta-glucan can help the immune system recognize and kill cancer cells. Healthy adults will take beta-glucan or a placebo daily for 4 weeks and do three exercise tests. Researchers will measure changes in immune cells from…

This study looks at how a single dose of modafinil changes decision-making and brain activity in healthy adults. Researchers hope to learn more about psychosis spectrum disorders like schizophrenia. Participants will take one dose of modafinil, play computer brain games, and wear…

This study looks at how a high-fat, high-calorie meal changes the way the body absorbs nalbuphine extended-release tablets. Sixty healthy adults will take the drug once with food and once without, and researchers will compare the levels in their blood. The goal is to understand i…

This early-stage study tests whether the experimental drug AZD3974 is safe and how it moves through the body. It involves 176 healthy adults, including people of Japanese and Chinese descent. Participants receive either the drug or a placebo, and researchers monitor for side effe…

This study looks at how heat pads and massage guns affect the stiffness of a jaw muscle in 40 healthy adults. Researchers will use a special ultrasound to measure muscle tightness before and after each treatment. The goal is to gather information that could lead to better treatme…

This study looks at hearing in people with early-stage Alzheimer's or Parkinson's disease, compared to healthy volunteers. The goal is to find out how common certain hearing issues are, especially trouble understanding speech in noisy places even when standard hearing tests are n…

This early-stage study aims to see how well a new esflurbiprofen pain-relief patch sticks to the skin of healthy adults. Researchers will check how much of the patch stays attached over several days and monitor for any side effects. The study also measures how much medication is …