HEALTHY PARTICIPANTS

This study tests a new vaccine called GBP511, designed to protect against several sarbecoviruses (a group that includes SARS-CoV-2). About 368 healthy adults will receive one or two doses at different strengths, with or without an adjuvant to boost immune response. The goal is to…

Pfizer is testing several experimental vaccines designed to protect against E. coli bacteria. This early-stage study involves 310 healthy adults aged 18 to 64. The main goal is to check if the vaccines are safe and tolerable, not yet whether they work. Participants will receive t…

This early-stage trial tests a new drug called AZD1043 in 104 healthy adults who are overweight or obese. The goal is to check the drug's safety and how the body processes it. Participants receive either the drug or a placebo by injection. The study includes people of Japanese an…

This Phase 1 trial tests the safety and tolerability of enicepatide, a potential weight-loss drug, in 36 generally healthy Chinese adults with a BMI of 23 or higher. Participants will receive either the drug or a placebo by injection, and researchers will monitor side effects and…

This trial is testing whether an experimental drug called NKF-PEG works in the same way as the approved medicine Neulasta. Both are designed to help the body produce more white blood cells, which are important for fighting infection. Healthy adult male volunteers will receive a s…

This early-stage trial tests an inhaled drug called Rev-56 in healthy volunteers and in people with non-cystic fibrosis bronchiectasis who have chronic Pseudomonas aeruginosa lung infections. The study checks whether the drug is safe and how the body processes it, comparing Rev-5…

This early-stage study tests a new drug called SR604 in healthy people and those with hemophilia A, B, or factor VII deficiency. The main goal is to check safety and how the drug moves through the body. About 31 participants will receive single or multiple doses to find the right…

This early-stage study tests a new experimental drug, PF-08103402, for the first time in people. It includes healthy adults and adults with mild-to-moderate asthma to check safety, how the drug moves through the body, and whether food affects its absorption. Participants take the…

This study tests an investigational drug called TGM-312-SC01, given as a shot, for metabolic dysfunction-associated steatohepatitis (MASH), a serious liver condition. It first checks safety and drug levels in healthy adults, then in people with MASH. The trial is currently recrui…

This study is testing a new blood test that looks for DNA from cancer cells. The goal is to see if an artificial intelligence program can accurately detect many different types of cancer at an early stage. The study will include 6,000 adults, some with cancer and some healthy vol…

This study is testing whether a portable virtual reality headset can help diagnose and monitor traumatic brain injury (TBI) by measuring how the pupils react to light. Researchers will compare pupil responses in 150 people: those with mild to moderate TBI, those with other injuri…

This early-stage study tests an experimental drug called PF-07832837 in healthy adults and people with moderate to severe atopic dermatitis (eczema). The main goal is to check safety and how the drug moves through the body. Researchers will also look for early signs that the drug…

This study tests whether text message reminders and a built-in gaming feature can encourage Black college men to use a mindfulness app more often. The goal is to reduce risky drinking and stress. Forty participants will use the app for 28 days and complete surveys.

This study tests whether muffins made from a special type of oat (Royal Ancient Oats™) can help control blood sugar and digestion better than regular oat muffins. About 38 healthy adults aged 35-65 with slightly high body weight will eat different muffins and have their blood sug…

This early-stage study tests an experimental oral drug called NTX-253 in healthy volunteers and people with stable schizophrenia. The main goal is to check safety and how the body processes the drug. 73 adults aged 18–55 will take single or multiple doses to find the right dose r…

This study looks at whether taking a daily supplement called Alpha-Glycerophosphocholine (α-GPC) can improve thinking, memory, and physical performance in healthy adults aged 25 to 55. Over 6 weeks, 80 participants will take either α-GPC or a placebo pill, and complete tests of a…

This trial checks whether a new strength of ammoxetine hydrochloride enteric-coated tablets works the same as the original version in healthy adults. It also looks at how a high-fat meal affects the drug's absorption. Participants take single doses of both formulations, and resea…

This study tests whether a mild, non-invasive electrical stimulation called TI-TES can temporarily change brain activity during sleep, specifically sleep spindles. Up to 24 healthy adults will each have three overnight visits. Researchers will compare brain activity during real s…

This study tests a new type of brain stimulation called temporal interference to see if it can temporarily change how different brain regions communicate. Forty healthy adults aged 18-50 will receive stimulation during sleep and wakefulness, and have their brain activity measured…

This phase 1 trial is testing a single dose of the investigational drug AMG 691 in healthy Chinese and Japanese adults aged 18 to 60. The goal is to understand how the drug moves through the body and to check its safety and tolerability. Participants will receive one subcutaneous…

This observational study looks at how the pupil of the eye reacts to increasing levels of nerve stimulation in healthy adults. Researchers will use a device called AlgometRx to deliver mild electrical stimuli and measure pupil dilation, which may reflect the body's response to pa…

This early-stage trial is testing how well different tablet versions of the experimental drug elecoglipron are absorbed by the body. Healthy volunteers receive a single dose of one formulation, and researchers measure drug levels in the blood over time. The goal is to compare the…

This study follows people with several types of spinocerebellar ataxia (SCA) — rare genetic diseases that cause balance, coordination, and speech problems — to learn how these conditions change over time. Researchers will collect blood samples, perform neurological exams, and use…

This early-stage study tests whether a new drug called AZD3974 is safe and how it moves through the body. About 176 healthy adults, including people of Japanese and Chinese descent, will receive either the drug or a placebo. The goal is to check for side effects and measure drug …

This study in healthy adults aged 18 to 45 examines how different meals (low-fat vs. high-fat) and the stomach-acid drug omeprazole affect the body's absorption of an experimental drug called ABSK-011. In one part, participants take ABSK-011 after different meals to see how food …

This early-phase trial is testing a new drug called Debio 1453P for the first time in humans. The study involves 88 healthy adults aged 18 to 55 who will receive either the drug or a placebo. Researchers are primarily checking if the drug is safe and how the body processes it at …

This study is the first time the experimental drug ARO-033 is being given to humans. Its main goal is to check the safety and tolerability of single and multiple doses in healthy adult volunteers. Researchers will also measure how the drug moves through the body. This is an early…

This study looks at how the brain uses feedback to control speech in 90 adults aged 18-50, including people who stutter, have dyslexia, and those with typical speech. Participants will do speech tasks, have an MRI scan, and receive mild brain stimulation to see how different brai…

This early-stage study in 50 healthy women with overweight or obesity examines whether two experimental weight-loss injections, AZD6234 and AZD9550, change how the body processes a common birth control pill. Participants will receive the drugs alone and together, and researchers …

This study gives 25 depressed individuals aged 15-25 a fake version of accelerated transcranial magnetic stimulation (no real brain stimulation). The goal is to see how their beliefs and expectations about treatment change over time and whether those expectations influence mood, …

This study will measure liver fat, inflammation, and organ sizes in 50 healthy adults in Singapore using MRI. The goal is to establish reference ranges that may differ by ethnicity. Participants must be at least 18 years old and self-reported healthy, with no history of heart dis…

This study is an early-stage trial to check the safety of a new drug called AZD4954. It involves healthy volunteers and people with high cholesterol (dyslipidemia). Researchers will give single and multiple doses to see how the drug moves through the body and if it causes any sid…

This Phase 1 trial studies how the drug ammoxetine hydrochloride is processed in people with moderate kidney impairment compared to those with normal kidney function. Sixteen adults receive the drug daily for six days, and researchers measure drug levels in blood and urine. The g…

This trial investigates how ammoxetine, a drug given as an enteric-coated tablet, is processed by the body in people with mild or moderate liver impairment compared to those with normal liver function. Participants take a 20 mg dose daily for six days, and researchers measure dru…

This early-stage study is testing a new drug, INCA033989, in 72 healthy adults aged 18 to 55. The goal is to see how the drug moves through the body and whether it is safe when given as a shot under the skin or through an IV. No disease is being treated — this is a first step to …

This study aims to better understand how the brain's prefrontal cortex is organized, specifically the part linked to mood and thinking. Researchers will use advanced MRI and TMS-EEG in 34 healthy adults to map connections between brain regions. The goal is to improve targeting of…

This study tests whether combining 40Hz light, sound, and mild nerve stimulation can improve working memory in healthy adults. Thirty participants will try different combinations of these non-invasive stimulations while their brain activity is recorded. The goal is to understand …

This early-stage study tests whether two different tablet forms of the drug navlimetostat are processed the same way in the body. It involves 64 healthy adult women who are not able to become pregnant. Participants will receive both tablet versions at different times to compare d…

This study looks at how a new drug called vimseltinib changes the way the body processes birth control pills. It involves 24 healthy women and lasts about 35 days. The goal is to see if vimseltinib makes birth control less effective, which is important for women who might take th…

This study tests whether low-intensity focused ultrasound can safely target deep brain areas and improve thinking skills like attention and memory. Researchers will enroll 100 healthy adults aged 18 and older. Participants will undergo brain scans and thinking tests to measure an…

This early-stage trial is testing an experimental drug called SYH2072 in 112 healthy adults to see if it is safe and how the body processes it. Participants will receive either the drug or a placebo as single or multiple doses. The study aims to gather basic safety information be…

This study looks at whether replacing table sugar with fresh mango in a high-sugar breakfast can reduce gut inflammation and leakiness. Thirty-five healthy adults will eat two different breakfasts—one sweetened with mango, the other with sugar—and have their blood tested over thr…

This early-phase study is enrolling 24 healthy adults aged 18 to 65 to see how two drugs—oral povorcitinib and topical ruxolitinib cream—move into the skin and bloodstream. Participants will take the drugs and have their skin fluid and blood sampled using a special device. The go…

This early-stage study tests whether a new drug called KLA318-2 is safe and how the body processes it. About 48 healthy adults aged 18-45 will receive a single injection. The goal is to check for side effects and measure drug levels in the blood, not to treat any disease.

This study compares an updated spinal stimulation device (STEPSS) with a current device in 10 healthy adults. Participants lie on their back while small electrodes on the spine send electrical currents, and leg muscle activity is recorded. The goal is to see if the new device wor…

This study is recruiting 200 healthy volunteers of all ages to wear a device called Syde, which looks like a watch, for three-week periods every six months over two years. The device records movement data like walking patterns and arm motion. The goal is to create a reference dat…

This study tests whether doing a therapy exercise in virtual reality feels different from doing it with imagination alone. Thirty healthy students will try both versions and report how they feel. The goal is to see if VR can make therapy more concrete and accessible.

This study follows 60 people aged 18 to 40 who are having hip arthroscopy for femoroacetabular impingement syndrome. Researchers measure strength, mobility, and function before surgery and at 3 and 6 months after. The goal is to find what helps patients recover best and to spot a…

This early-stage trial is testing the safety of a new drug called SPH9788 in 94 healthy Chinese adults aged 18 to 45. Participants will receive either the drug or a placebo, and researchers will monitor for side effects and how the drug moves through the body. The goal is simply …

This study looks at how seeing, hearing, and smelling food in a virtual reality (VR) environment changes food cravings and body responses. Thirty-four healthy adults will have their brain activity, saliva, blood sugar, and temperature measured while exposed to real and virtual fo…

This study tests whether mild electrical stimulation of the vagus nerve (via the ear) can change how people learn from rewards and avoid threats. About 104 participants with high anxiety, high anhedonia, or both will play VR foraging tasks and brain-scan games. The goal is to und…

This early-stage study tests a new drug, JZP047, in 86 healthy adults aged 18 to 55. The goal is to check its safety, how the body handles it, and whether food affects its absorption. Participants receive either a single dose of JZP047 or a placebo. This research does not aim to …

This study tracks how blood metabolites change in healthy people during daily life using simple finger-prick tests. Over four weeks, 35 participants will collect blood samples before and after meals, including a weekly burger, and wear activity monitors. The goal is to understand…

This early-phase trial is testing a new drug called TLC-1180 in 288 healthy adults aged 18 to 55. The main goal is to check if the drug is safe and how the body handles it, not to treat any disease. Participants will receive either the drug or a placebo, and researchers will moni…

This study tests whether practicing a precise manual task—placing colored beads with tweezers after solving math problems—can improve how healthy young adults process language. Forty right-handed participants aged 19-24 will be split into two groups: one doing the context-specifi…

This early-stage trial is testing a new drug called SV003 in 60 healthy volunteers to see if it is safe and how the body processes it. Participants receive a single dose of either SV003 or a placebo. The study is not designed to treat any disease but to gather important safety an…

This study looks at how the body handles a single dose of the drug vepdegestrant in people with moderate to severe liver problems compared to healthy people. About 24 adults (ages 18-70) will take one pill and stay at the clinic for 11 days. The goal is to see if liver function a…

This early-stage study tests a new drug, DF5112, in 48 healthy adults to see if it is safe and how the body handles it. Participants receive a single dose of the drug or a placebo and are monitored for about a week in a clinic, with follow-up visits for a month. The goal is to ga…

This study is testing how much of the drug zilucoplan gets into breast milk after daily injections. Fifteen healthy lactating women who have already decided to stop breastfeeding will provide milk samples over 24 hours. The goal is to estimate how much drug an infant might consum…

This early-stage trial is testing whether eating a high-fat, high-calorie meal changes how the body absorbs nalbuphine extended-release tablets. Sixty healthy volunteers will take the drug once with food and once without, and researchers will compare drug levels in their blood. T…

This early-stage trial is testing a new drug called ACI-19764 in 78 healthy adults to see if it is safe and how the body handles it. The drug targets a protein in the brain linked to inflammation. Participants will receive either the drug or a placebo, and researchers will monito…

This study looks at how the body processes fructose, a type of sugar. Researchers want to see if the small intestine can turn fructose into glucose to protect the liver, and whether this process is weaker in people with obesity. The study will involve 40 healthy volunteers, some …

This study looks at how drinking different types of milk—A2 milk, regular milk, and oat drink—affects bone health, heart health, and immune function in healthy adults aged 30 to 60. Participants will drink 500 ml of one of these beverages daily for 12 weeks. The goal is to see if…

This early-stage study is testing a new oral drug, KT-579, in 96 healthy adults to see if it is safe and how the body handles it. Participants receive either the drug or a placebo. The goal is to gather safety data, not to treat any disease.

This study is looking at whether a molecule in the blood called miR-1 can help doctors understand how muscle diseases like Duchenne muscular dystrophy and myotonic dystrophy are progressing. Researchers will compare miR-1 levels in 104 people, including patients with different mu…

This Phase 1 trial is testing a new drug called SYH2085 in 74 healthy Chinese adults to see if it is safe and how the body processes it. Participants receive either a single dose of SYH2085 or a placebo, and the study also looks at how food affects the drug. This is an early step…

This study is testing whether a single dose of modafinil, a drug that promotes wakefulness, can change how healthy people perform decision-making tasks and alter their brain activity. Researchers will use EEG caps to measure brain waves while participants play computer-based brai…

This study looks at how babies' brains develop after an injury around birth. Researchers will use fun games and brain wave tests (EEG) to see if they can predict which children might have trouble with thinking and memory later. About 100 babies, both healthy and those with brain …

This early-phase trial is testing the safety and tolerability of a single dose of JMT206 in 44 healthy adults aged 18 to 60. Participants receive either the drug or a placebo injection, and researchers monitor for side effects and how the drug moves through the body. The goal is …

This study tests a new device called See.d that processes whole blood into slides and plasma for liquid biopsy. Researchers want to see if the device can standardize sample preparation, making it easier to detect cancer cells or DNA in the blood. The study involves 200 healthy ad…

This research study follows the cognitive development of infants, both healthy and those who had a brain injury around birth. Researchers will use online games and parent questionnaires to measure attention, thinking, and language skills. The goal is to better understand how thes…

This study tests a new device that prepares blood samples to look for cancer cells and DNA. Researchers will collect blood from 20 healthy volunteers and 25 people with advanced breast cancer. The goal is to see if the device works well for liquid biopsy, a less invasive way to d…

This early-stage study is testing an experimental drug called HW201877 in 104 healthy adults to see if it is safe and how the body processes it. The drug is being developed for inflammatory bowel disease (IBD), but this trial does not involve people with IBD. Participants will re…

This study is testing a new medicated patch (TK-254RX) that delivers the pain reliever esflurbiprofen through the skin. Researchers want to see how well the patch stays on over time in 90 healthy adults aged 18 to 64. They will also check for any side effects and measure how much…

This study looks at how our beliefs and expectations influence the pain we feel when watching others suffer. Healthy adults will be placed in one of three groups: no treatment, a placebo nasal spray, or a spray with oxytocin. All participants in the spray groups are told they are…

This study looks at how a 12-week running program affects energy use in 80 sedentary adults. Participants will run five times a week, with researchers measuring changes in calories burned, food intake, and activity levels. The goal is to understand why exercise doesn't always lea…

This study uses a special eye scan called OCTA to measure the density of tiny blood vessels in the retina. Researchers will compare results from 64 people—half with cardiovascular disease and half healthy—to see if the scan can reliably detect vessel changes linked to heart probl…

This study looks at how a commercially available ketone drink (Ketone-IQ) affects sleep and breathing in 20 healthy adults aged 18-50. Participants take two different doses at home on separate nights and measure their ketone levels and sleep quality using a headband device. The g…

This study looks at whether eating pistachios as a snack can improve metabolic flexibility — how well your body switches between burning carbs and fats for energy. Researchers will compare four days of pistachio snacking to four days of normal eating in 60 healthy overweight or o…

This study looks at whether taking a dietary fiber called beta-glucan, along with exercise, can improve how your immune system recognizes and kills cancer cells. Healthy adults will take beta-glucan or a placebo daily for 4 weeks and do three exercise tests. Researchers will meas…

This early-stage study tests whether a new inhaled drug called CPD704 is safe and how the body processes it. It involves 90 healthy Chinese adults aged 18-55. Participants receive single or multiple doses via inhalation and are monitored for side effects and drug levels in the bl…

This study aims to collect body composition data from 40 healthy adults to develop better measurement methods for cancer patients. Participants will undergo tests like sodium bromide and deuterium dilution to measure muscle mass and body water. The study does not involve any trea…

This study tests two methods of teaching CPR to 550 primary school children in Spain. One group gets a 2-hour hands-on session with a nurse and mannequins; the other watches a short video and does a puzzle. Researchers will measure which group learns CPR better, aiming to improve…

This study looks at how resistance training (like lifting weights) helps children get stronger. Forty healthy kids will either do 12 weeks of training or be in a control group. Researchers will use ultrasound and muscle activity tests to see if strength gains come from bigger mus…

This study tests a new device called ZenBud that uses ultrasound waves to stimulate the vagus nerve, a key nerve that controls relaxation and body functions. Researchers want to see if this method can safely change heart rate, brain activity, and mood in 30 healthy adults. The go…

This study looks at levels of a brain protein called neurofilament in the blood of healthy late preterm babies (born at 34-37 weeks). Researchers want to know what normal levels are and how they change in the first weeks of life. Up to 15 newborns will provide extra blood during …

This study is looking at hearing in people with early-stage Alzheimer's or Parkinson's disease, compared to healthy volunteers. Researchers will use detailed hearing tests to find out how common different types of hearing loss are, especially 'hidden hearing loss' where standard …

This study looks at whether using a swallow gel or a semi-solid vehicle can help people with neurological conditions swallow pills more easily and safely. Researchers will observe 500 participants, including patients with swallowing disorders and healthy volunteers, as they swall…

This study looks at how the retina's ability to use oxygen changes as people age. Researchers will measure oxygen extraction in 50 healthy adults aged 18 to 80 using non-invasive eye scans. The goal is to understand normal aging, which may help future studies on eye diseases.

This study tests whether applying heat pads or using a massage gun can reduce stiffness in the jaw muscle (masseter). Researchers will measure muscle stiffness with a special ultrasound in 40 healthy adults. The goal is to gather data that could lead to better treatments for jaw …

This study looks at how blood sugar levels change during exercise in healthy adults and those with type 1 diabetes. Participants will cycle after a standard breakfast, and their glucose will be tracked with a continuous monitor and finger-prick tests. The goal is to see if the bo…

This study is testing an experimental drug called allisartan isoproxil in 54 healthy Chinese adults. Participants will receive a single dose of either the drug or a placebo to see how the body processes it and whether it causes any side effects. The goal is to gather safety and d…