HEALTHY PARTICIPANTS

This study is testing a new vaccine designed to protect against E. coli bacteria. The main goal is to check if the vaccine is safe and well-tolerated in 310 healthy adults. Researchers will give the vaccine as a shot and closely monitor participants for any side effects over a ye…

This study is testing a new vaccine called GBP511, designed to protect against multiple viruses related to COVID-19, including potential future variants. Researchers will give the vaccine to about 368 healthy adults to check if it's safe and if it triggers a strong immune respons…

This early-stage study is testing a new combined vaccine designed to protect older adults against three common viruses that cause respiratory infections: RSV, hMPV, and PIV3. Researchers will give 240 healthy participants aged 60-83 either the experimental vaccine, comparison vac…

This is the first time a new drug called BGB-45035 is being tested in people. The main goal is to check if it is safe and how the body processes it. The study will first give the drug to healthy volunteers at different doses. Later, a small group of adults with itchy skin conditi…

This early-stage study aims to find out if a new injectable medicine called TGM-312-SC01 is safe and how it behaves in the body. It will first test single doses in healthy adults, then test multiple doses in adults diagnosed with MASH, a serious form of fatty liver disease. The m…

This early-stage study is testing a new oral drug called AZD0780 to see if it is safe and can lower 'bad' cholesterol (LDL-C) levels. It will involve about 40 healthy adults who already have higher-than-ideal cholesterol. Participants will take either the drug or a placebo (a dum…

This is the first time a new drug called PF-07832837 is being tested in people. The main goal is to see if it is safe and how the body handles it. The study will involve both healthy volunteers and people with moderate to severe atopic dermatitis (eczema) to check for side effect…

This is the first human study testing a new drug called SR604. Researchers want to see if it's safe and how it behaves in the body. First, healthy volunteers will receive single doses. Then, people with hemophilia A, hemophilia B, or Factor VII deficiency will receive multiple do…

This is the first study in humans to test the safety and how the body processes an experimental oral medication called NTX-253, being developed for schizophrenia. It will involve healthy adults and adults with stable schizophrenia who temporarily stop their regular antipsychotic …

This early study is testing two new imaging drugs to see if they can safely and effectively show tau protein buildup in the brain using PET scans. The study involves 24 adults, including people with Progressive Supranuclear Palsy (PSP) and healthy volunteers. Researchers hope the…

This study is testing whether sending daily text messages and including a game in a mindfulness phone app makes Black male college students more likely to use it. The goal is to see if using the app more often can help reduce risky drinking habits and stress. About 40 eligible st…

This study is testing whether a short, self-guided virtual reality (VR) program can help young adults feel more hopeful and improve their overall well-being. The program involves one in-person VR session followed by four at-home audio/video sessions focused on personal reflection…

This study is testing whether a daily supplement called Alpha-GPC can improve mental performance, mood, and physical power in healthy, active adults. Researchers will compare the effects of taking Alpha-GPC for six weeks against a placebo pill in 80 participants. The goal is to s…

This study aims to find out which type of exercise program works best to get inactive young adults more active and improve their health. Thirty inactive people in Istanbul will be randomly assigned to try either in-person group classes, a mobile app program, or follow-along video…

This study is testing two common at-home treatments—a heat pad and a massage gun—to see which one better relaxes a stiff jaw muscle. Researchers will measure muscle tightness in 40 healthy volunteers using a special ultrasound scan before and after each treatment. The goal is to …

This study is testing whether a daily probiotic supplement can reduce symptoms like heartburn, reflux, and stomach pain in otherwise healthy adults. About 324 participants will take either the supplement or a placebo pill for 8 weeks and report their symptoms. The main goal is to…

This study is testing whether a plant-based supplement called PeptiSleep can improve sleep quality in healthy adults. For 6 weeks, 120 participants will take either the supplement or a placebo pill and wear a sleep tracker to measure their sleep. Researchers will also use questio…

This study is testing a new blood processing device called See.d to help standardize liquid biopsy tests. Liquid biopsies are blood tests that can detect cancer cells or DNA. Researchers will collect blood samples from 200 healthy volunteers to see if the device produces consiste…

This is an early-stage study to understand how the body absorbs, processes, and eliminates a single dose of an investigational drug called AGA2118. It will involve 30 healthy Japanese, Chinese, and Caucasian volunteers who will be followed for about 3 months. The main goal is to …

This study aims to see if new weight loss injections (AZD6234 and AZD9550) change how the body processes birth control pills. It will involve 75 healthy women with overweight or obesity. Researchers will measure drug levels in the blood to check for interactions and monitor safet…

This is the first study testing a new oral medication called LTG-321 in humans. Researchers will give healthy volunteers increasing doses to check for safety, see how the body processes the drug, and measure its effects on pain tolerance using a cold water test. The goal is to ga…

This study aims to understand normal levels of a nerve protein called neurofilament in healthy premature babies. Researchers will measure this protein in small blood samples taken during routine medical care from 15 babies born between 34 and 37 weeks. The goal is to create a ref…

This study aims to understand how often people with neurological conditions have trouble swallowing their medication. Researchers will observe 500 participants, including healthy volunteers, to see if using a special swallowing gel or mixing pills with semi-solid foods makes the …

This study is testing a new, non-invasive eye scan to see if it can reliably measure tiny blood vessels in the retina. Researchers want to compare these measurements between people with heart disease and healthy individuals. The goal is to learn if this scan could one day help do…

This study aims to understand how decision-making works in conditions like schizophrenia. Researchers are giving a single dose of a medication called modafinil to healthy volunteers and measuring changes in their brain activity and performance on computer 'brain games.' The goal …

This early-stage study aims to understand how a new drug called elenestinib might change how the body processes two common medications: a sedative (midazolam) and a birth control pill. Researchers will give these medications to 20 healthy adult women, both with and without elenes…

This is the first time a new drug called AZD3974 is being given to people. The main goal is to check if it is safe and to see how the body absorbs and removes it. The study will involve 176 healthy volunteers, including people of Japanese and Chinese descent. Some participants wi…

This study aims to understand if taking a dietary fiber called beta-glucan, with or without exercise, can improve how the immune system works against cancer. Researchers will compare beta-glucan to a placebo in 60 healthy adults over 4 weeks, measuring immune cell activity in blo…

This is an early-stage study to check the safety of a new injectable drug called KLA318-2 in healthy people. Researchers will give the drug to 48 healthy volunteers and closely monitor them for any side effects. The main goal is to see how the body handles the drug and what dose …

This is a first-in-human study to check the safety and tolerability of a new drug called ACI-19764, which is designed to target the brain. It will involve 78 healthy volunteers to see how the body absorbs and processes the drug at different dose levels. The main goal is to gather…

This study aims to understand hearing problems in people with early-stage Alzheimer's or Parkinson's disease. Researchers will compare detailed hearing test results from 309 participants—some with these conditions and some healthy—to see if specific hearing issues are more common…

This is the first study in humans for a new drug called DF5112. Its main purpose is to check if the drug is safe and how the body handles it. The study will enroll 64 healthy adults who will receive either the drug or a placebo. Researchers will monitor participants closely for s…

This is a very early, first-in-human study to check the safety and how the body processes a new oral drug called Debio 1453P. It will involve 88 healthy adults who will receive either the drug or a placebo. The main goal is to see how well different doses are tolerated and to mea…

This study is testing whether a new laboratory instrument called See.d can properly prepare blood samples for liquid biopsy analysis. Researchers will collect blood from 25 metastatic breast cancer patients and 20 healthy volunteers to see if the device can reliably prepare plasm…

This is the first study to test a new oral drug called E1018 in people. Researchers will give single, increasing doses to 32 healthy adults to check for safety and see how the body absorbs and eliminates the drug. The goal is to gather initial data to see if the drug is safe enou…

This early-stage study aims to test how well a new esflurbiprofen pain-relief patch sticks to the skin of healthy volunteers. Researchers will measure the patch's adhesion area, check for any skin reactions or safety issues, and see how much medication remains in the patch after …

This study is testing a new, non-invasive ultrasound device called ZenBud that gently stimulates a nerve in the ear linked to relaxation. Researchers want to see if using the device causes measurable changes in things like heart rate, brain waves, mood, or thinking in healthy vol…

This study aims to create a reference dataset of precise body composition measurements in healthy adults. Researchers will measure body water and muscle mass using advanced techniques. This data will help develop better tools to study body changes in future cancer patients.

This is the first study in people for a new drug called AG-236. Its main goal is to check if a single injection is safe and well-tolerated in healthy volunteers. Researchers will also measure how the drug moves through and leaves the body. The results will help decide if AG-236 c…

This study aims to collect normal movement data from 200 healthy volunteers of all ages using a wearable device. Participants will wear the device for a few weeks every six months over two years, all from home. The data will help researchers better understand movement patterns in…

This study uses brain scans to see how ear acupuncture changes brain activity in healthy young adults. Researchers want to understand how this type of acupuncture might work, by comparing its effects on the brain to another known therapy. The goal is to build a scientific foundat…

This study is testing if snacking on pistachios changes how the bodies of healthy overweight adults burn fuel (like fat and carbs) when resting, exercising, and recovering. Researchers will compare four days of eating pistachios to four days of normal eating habits in 60 particip…

This early-stage study aims to understand how eating food and taking other common medications affect how the body processes a new drug called INCB123667. It involves 51 healthy adult volunteers who will take the drug under different conditions. The main goal is to gather safety d…

This study aims to compare how well the body absorbs omega-3 fatty acids (EPA and DHA) from two different algae-based supplements versus a standard fish oil supplement and a placebo. Healthy adult participants will take their assigned supplement daily for six weeks. Researchers w…

This is a very early, first-in-human study to check the safety and basic effects of a new drug called TLC-1180. It will involve healthy volunteers to see how their bodies handle the drug and what side effects might occur. The study will test different doses and a tablet form, inc…

This study aims to understand how to spot early signs of future thinking and attention problems in babies who had a brain injury around birth. Researchers will observe 100 infants, some healthy and some with a history of brain injury, by watching them play simple games, measuring…

This early-stage study aims to understand how the body absorbs and processes different pill versions of an experimental drug called AZD5004. It will involve 64 healthy volunteers who will take single doses of different pill formulations. Researchers will measure drug levels in th…

This study aims to understand how the healthy eye's use of oxygen changes as people get older. Researchers will measure eye oxygen levels in 50 healthy adults aged 18 to 80 using special eye scans. The goal is to create a normal reference for future studies on eye diseases linked…

This study aims to find the best way to teach CPR to schoolchildren. Researchers will compare a traditional hands-on training session with a shorter video-based lesson to see which one helps kids learn and remember the life-saving skills more effectively. The goal is to gather ev…

This is a very early, first-in-human study to check if a new drug called AZD4954 is safe and how it behaves in the body. It will test single and multiple doses in healthy volunteers and people with high cholesterol who also have a specific risk factor called elevated Lp(a). The m…

This is an early safety study testing a new inhaled medication called CPD704. Researchers will give single and multiple doses to 90 healthy Chinese adults to check for side effects and measure how the drug moves through the body. The main goal is to understand the drug's safety p…

This study aims to understand if a gentle, focused ultrasound can safely reach deep parts of the brain and influence thinking skills like attention and problem-solving. Researchers will test this on 100 healthy adults using brain scans and thinking tests. The goal is to gather ba…

This is the first study testing a new drug called JMT206 injection in healthy people. Researchers want to see if it's safe, how the body processes it, and what side effects might occur. They will give different doses to small groups of healthy volunteers and compare results to a …

This is the first study to test a new oral drug, called YH35995, in people. The goal is to check its basic safety and how the body processes it in healthy male volunteers. This is an early, necessary step to see if the drug could later help treat the brain-related symptoms of a r…

This study aims to understand if a non-invasive electrical stimulation technique can temporarily change how different areas of the brain communicate with each other. Researchers will test this on 30 healthy adults during both sleep and quiet wakefulness. Participants will undergo…

This study aims to understand how the body absorbs and processes Allisartan Isoproxil, a medication for high blood pressure. It will involve 54 healthy Chinese volunteers who will receive a single dose of the drug or a placebo. Researchers will measure drug levels in the blood an…

This study aims to understand why exercise alone often doesn't lead to the expected weight loss, a phenomenon called 'energy compensation.' Researchers will enroll 80 sedentary but otherwise healthy adults. Participants will complete a 12-week supervised running program while sci…

This study aims to see if two different injection methods for the cancer drug trastuzumab deliver the same amount of medicine into the body. It will involve healthy male volunteers who will receive a single injection. Researchers will measure drug levels and monitor for side effe…

This is an early-stage study to check the safety of a new, unnamed drug called SYH2085. It will involve 74 healthy Chinese adults to see how their bodies react to and process a single dose. The main goal is to find out what side effects might occur and how the drug behaves in the…

This study aims to see if a specific molecule in the blood, called miR-1, can be used as a marker to track the progression of muscle-wasting diseases. Researchers will compare miR-1 levels in people with Duchenne/Becker muscular dystrophy, myotonic dystrophy, and congenital myopa…

This study aims to understand how drinking different types of milk affects bone health, heart health, and immune function in healthy adults. Researchers will compare three drinks over 12 weeks: A2 milk (a special type of cow's milk), regular cow's milk, and an oat-based plant dri…

This study explores how what we believe can change our experience of 'empathic pain'—the discomfort we feel when seeing someone else in pain. Researchers will give 120 healthy adults either a real nasal spray, a fake (placebo) spray, or no spray, but tell everyone they are gettin…

This research study aims to understand how the body processes fructose, a common sugar, and whether this process works differently in people with obesity. Researchers will test if the small intestine's ability to convert fructose into a safer form of sugar helps protect the liver…

This early-stage study aims to understand if eating a high-fat, high-calorie meal changes how the body absorbs a long-acting version of the pain medication nalbuphine. It will involve 60 healthy volunteers who will take the drug once with food and once without, in a random order.…

This early study aims to understand how eating a meal affects the way the body absorbs and processes a new combination pill containing two drugs, zibotentan and dapagliflozin. It involves 26 healthy volunteers who will take the pill once on an empty stomach and once after a high-…

This study aims to understand if taking a ketone supplement before bed affects sleep quality and breathing in healthy adults. Researchers will give 20 volunteers two different doses of the supplement and measure their sleep patterns and ketone levels at home. The goal is to gathe…

This study aims to understand how three different tablet versions of an investigational drug, LY4100511, are absorbed by the body. It will involve 48 healthy volunteers to see if the drug's absorption changes when taken with common stomach acid medication. The goal is to gather d…

This study aims to understand how knee osteoarthritis affects muscle function by measuring oxygen levels in the thigh muscle. Researchers will compare 34 people with knee arthritis to healthy individuals, measuring oxygen before, during, and after a simple squat exercise. The goa…

This study aims to understand how consistently exercise affects blood sugar levels in people with and without Type 1 diabetes. Researchers will monitor 24 participants (12 with diabetes, 12 healthy) while they cycle or rest after breakfast, tracking glucose with continuous monito…

This is the first human study for a new drug called UCB5285. Researchers will give increasing doses to 96 healthy volunteers to check for side effects and see how the drug moves through the body. The main goal is to determine if the drug is safe enough to test in future studies w…

This study is testing whether muffins made from a special type of ancient oat help control blood sugar better than muffins made from regular oats. Researchers will measure blood sugar levels and hunger hormones in 38 healthy but overweight adults after they eat the different muff…

This early-stage study aims to understand how two different versions of the cholesterol-lowering drug evolocumab are absorbed and processed by the body. It will involve 400 healthy adults who will receive a single dose. The main goal is to compare how much of each drug version ge…

This early-stage study aims to determine if a new drug called HW201877 is safe for people. Researchers will give the drug to 104 healthy volunteers to check for side effects and see how the body processes it. The study will test different doses and see if taking the drug with foo…

This study aims to compare an updated spinal stimulation device with the one currently used in research. It involves 10 healthy adult volunteers who will receive electrical stimulation on their lower back while researchers measure muscle activity in their right leg. The goal is t…

This is a very early study to understand how a new drug called INCA033989 moves through the body and to check its safety. It will involve 72 healthy adults who will receive a single dose, either as an injection under the skin or through an IV. The main goals are to measure the dr…

This study aims to understand if practicing fine hand skills in a specific way can change how the brain processes language. Healthy young adults (ages 19-24) will be randomly assigned to either a hand-skill training group or a simpler control task group. Both groups will complete…

This is the very first study giving a new oral medication called KT-579 to people. The main goal is to check if it is safe and how the body processes it. The study will involve about 96 healthy adult volunteers who will take either the drug or a placebo. Researchers will carefull…

This study aims to understand the immediate effects of a single weight training session, with and without added stretching, on heart and blood vessel function. Researchers will measure blood pressure and artery dilation in 27 healthy men after they complete different exercise rou…

This online study aims to understand how thinking skills develop in infants, comparing those who had a brain injury around birth with healthy infants. Researchers will observe 200 children aged 3-24 months through virtual games that measure attention and problem-solving, while pa…

This early-stage study aims to better understand how andexanet, a drug used to reverse the effects of certain blood thinners in emergencies, works and when it's safe to give another blood thinner (enoxaparin) afterward. It involves 186 healthy participants and will measure how th…

This study aims to understand how children's bodies get stronger from weight training. Researchers will compare 40 healthy children, aged 7-12, who do a 12-week strength program to a group that does not train. They will use non-invasive scans and sensors to see if strength gains …

This early-stage study aims to understand how the body processes and eliminates the experimental drug quemliclustat. Eight healthy adult male volunteers will receive a single dose containing a tiny, safe amount of radioactive tracer. Researchers will then measure how much of the …