Scientists test brain zapping during sleep to tweak brain waves

NCT ID NCT07498270

Recruiting now Knowledge-focused Sponsor: University of Wisconsin, Madison Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Aug 11, 2026 · Updated 3 times

Summary

This study tests whether a mild, non-invasive electrical stimulation called TI-TES can temporarily change brain activity during sleep, specifically sleep spindles. Up to 24 healthy adults will each have three overnight visits. Researchers will compare brain activity during real stimulation versus a sham (fake) stimulation.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: temporal interference transcranial electrical stimulation (TI-TES)
What this could lead to: If it works, this could point toward a non-invasive way to influence brain activity during sleep, which may help understand sleep disorders or memory.
What could go wrong: This is a very early, small study in healthy people, so results may not apply to patients. The effects are temporary and may not be noticeable.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEALTHY ADULT PARTICIPANTS HEALTHY PARTICIPANTS

Contacts and locations

Locations

Wisconsin Institute for Sleep and Consciousness
RECRUITING

Madison, Wisconsin, 53719, United States

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