University Of Wisconsin, Madison

This study aims to find the most effective way to help adults with uncontrolled type 2 diabetes manage their condition. Researchers are testing whether extra support from a pharmacist, a community health worker, or both, can help people better manage their medications and daily l…

This study is testing whether a shorter, more intense course of radiation before surgery works as well as the standard longer course for treating soft tissue sarcomas. Researchers will compare 5 treatments over 1-2 weeks versus 25 treatments over 5 weeks in 30 patients. The goal …

This study is testing a new combination treatment for people with metastatic melanoma that has spread to the liver. It combines a liver-targeted chemotherapy (HEPZATO KIT™) with a two-drug immunotherapy (Opdualag™). The main goals are to see if this combination is safe and if it …

This study is testing whether an 8-session nutrition education program is practical and helpful for people with diabetes or prediabetes. The program teaches participants how to eat more fiber-rich foods like fruits, vegetables, and whole grains. Researchers will enroll 48 people …

This study is testing if applying a liquid skin adhesive called Mastisol before putting on clubfoot casts helps the casts stay on better. Researchers want to see if this leads to fewer skin problems, shorter overall treatment time, and less need for repeat procedures in babies wi…

This study is testing if doing moderate exercise right before a therapy session makes the therapy work better for people with depression. Researchers will compare two groups of 100 adults: one group will exercise before their weekly therapy, while the other will rest quietly. The…

This study is testing whether assigning a dedicated, consistent hospital team to patients who are frequently hospitalized improves their care. It will compare 1200 patients with complex medical needs who either get this special team or receive usual hospital care. The main goal i…

This study is testing whether nicotine pouches or mini lozenges can help people who smoke switch away from cigarettes. Researchers will compare how well these products work for 300 adults who smoke at least 5 cigarettes a day but aren't planning to quit right away. Participants w…

This study is testing a new, more precise way to deliver radiation therapy for cancers in the chest area, like lung and esophageal cancer. The goal is to see if using real-time MRI guidance can better protect the heart from radiation damage compared to the standard method. Resear…

This study is testing whether a new DNA vaccine can help the body's immune system fight prostate cancer when given alongside standard hormone-blocking therapy. It is for men with newly diagnosed, high-risk prostate cancer who are scheduled for surgery to remove the prostate. Rese…

This study aims to improve health for people in prison by finding the best ways to expand access to proven opioid addiction medications. Researchers will test two different support strategies across 120 prisons in 12 states to help correctional systems provide these treatments mo…

This early-stage study is testing whether a new DNA vaccine, combined with an immunotherapy drug (nivolumab) and targeted radiation, can eliminate small areas of recurring prostate cancer that have spread. It's for men whose cancer has returned after prostate surgery but is limit…

This study is testing whether a support program helps people connect to regular doctors after leaving prison. It focuses on adults with a history of substance use and chronic health conditions. Researchers will compare if weekly check-in calls from a nurse case manager lead to mo…

This early-stage study is testing the safety and best dose of a special immune cell infusion given after a stem cell transplant. The goal is to help the new immune system fight cancer while reducing a dangerous side effect called graft-versus-host disease. The study will enroll 3…

This study is testing whether a gentle, non-invasive stimulation of a nerve in the forehead can improve the brain's natural cleaning system. Researchers believe this could help clear harmful waste buildup that may contribute to cognitive problems, especially in people who have ha…

This early-stage study aims to see if it's safe to give psilocybin (the active compound in 'magic mushrooms') to people being treated for opioid addiction with standard medication (buprenorphine/naloxone). It will involve 10 adults with opioid addiction who are willing to start a…

This study is testing whether a smartphone app can help people with alcohol-related liver disease stop drinking. About 300 patients from clinics in Michigan and Wisconsin will either use the app along with their usual care or receive usual care alone for six months. The main goal…

This study is testing whether a group therapy program called Cognitive Processing Therapy (CPT) helps reduce PTSD symptoms and behavioral problems in incarcerated men and women. About 900 participants from 6 prison locations will be randomly assigned to either start therapy immed…

This study aims to find the most effective combination of treatments to help people who both smoke cigarettes and vape to quit smoking. Researchers will test different medications (varenicline vs. nicotine patches) and counseling approaches (focusing on quitting both vs. just smo…

This early-stage trial is testing whether injecting a patient's own bone marrow cells into their salivary glands is safe and might help improve severe dry mouth. The study focuses on people whose dry mouth is caused by autoimmune conditions like Sjogren's disease or as a side eff…

This study aims to understand why a standard chemotherapy drug (paclitaxel) works better for some breast cancer patients than others. It will enroll 50 women with breast cancer who are scheduled to receive this drug before surgery. Researchers will measure drug levels in the body…

This early-stage study is testing whether adding a radioactive imaging agent called Y-NM600 can make standard immunotherapy drugs work better for people with metastatic cancer. The main goals are to find a safe dose and see if the combination helps control the cancer. About 60 pa…

This study is testing a very short, 5-session radiation treatment for women with early-stage breast cancer. It aims to see how well the treatment works, how it affects the breast's appearance, and what side effects patients experience. Researchers will follow 50 participants for …

This study aims to see if a special type of PET scan (using Detectnet) can help doctors plan Lutathera radiation therapy more safely for people with neuroendocrine tumors. Researchers want to use the scan to better predict how much radiation reaches tumors versus healthy organs, …

This study is testing the safety of a new type of stem cell transplant for children whose cancers have come back or are very hard to treat. Doctors use a half-matched family donor and a special process to remove certain immune cells from the transplant, aiming to reduce complicat…

This small, early-phase study is testing a new approach for patients whose metastatic breast cancer has become resistant to standard hormone therapy due to a specific gene change (ESR1 mutation). Researchers will use a special imaging scan (FES-PET/CT) to see how well the drug ta…

This early-stage study is testing the safety of a topical version of an HIV medication (lopinavir/ritonavir) applied inside the anus. The goal is to see if it can treat high-grade anal precancer (AIN 2/3) in people living with HIV, which can develop into anal cancer. Researchers …

This study is testing whether community health workers, guided by a mobile app and supervised by remote doctors, can manage high blood pressure as effectively as a physician. It involves 460 adults with high blood pressure in rural Guatemala and will last 12-24 months. The goal i…

This early-stage study aims to find safe weekly doses of two existing drugs, sirolimus and everolimus, that might slow down the fundamental biology of aging. It will enroll 72 healthy adults aged 55-89 who will take one of the drugs once a week for 6 weeks. The main goal is to id…

This study is testing a new tool to help parents of hospitalized children. Parents are randomly assigned to either use a bedside tablet to read their child's medical notes or follow usual care. Researchers want to see if having this information helps parents get more involved and…

This study is testing if a drug called letermovir can prevent cytomegalovirus (CMV) infection from coming back in high-risk kidney or kidney/pancreas transplant patients. It will enroll about 90 adult patients who have already been treated for a CMV infection. The goal is to see …

This study is testing a new, high-precision radiation technique for people with cancer that has spread to the liver. Using real-time MRI scans to guide the radiation, researchers aim to safely deliver the highest possible dose to the tumors while protecting nearby healthy organs.…

This study is testing whether a combined PET/MRI scan can accurately locate the source of chronic pain in people who have had joint surgery. Researchers will compare scans from 128 people with persistent pain to scans from people without pain to see if areas of inflammation light…

This study aims to find babies born with a genetic condition that causes very high cholesterol, called familial hypercholesterolemia (FH). Researchers will work with expecting parents who have FH to test their newborns with cheek swabs and small blood samples. The goal is to iden…

This study is testing a new type of combined PET/MRI scan to help doctors better tell the difference between a brain tumor growing back and harmless changes caused by cancer treatments like radiation or immunotherapy. It involves about 30 adults with brain metastases who have alr…

This study is testing a new type of MRI scan to find swollen, fragile veins in the esophagus and stomach of people with advanced liver disease (cirrhosis). These veins can burst and cause fatal bleeding. The goal is to see if this non-invasive scan can accurately identify high-ri…

This study is testing a new type of imaging scan (called 18F-FFNP PET/MRI) to see if it can predict how well a patient's breast cancer will respond to hormone therapy given before surgery. Researchers want to know if this scan, performed early in treatment, can reliably show whet…

This study is testing a new, automated MRI scanning method designed to measure liver fat and iron much faster than current techniques. Researchers aim to create a reliable, 'single-button' scan that takes less than five minutes in the machine. They are recruiting 200 participants…

This study is testing a new type of imaging scan to see if it can better detect and track prostate cancer that has spread. Researchers want to compare this new scan to the current standard scan to see which is more accurate. About 30 men with prostate cancer will get both types o…

This study is testing a computer tool called pediatric eCART that uses a child's health records to quickly calculate their risk of getting much sicker in the hospital. It will compare outcomes for 30,000 children before and after the tool is introduced to see if it helps doctors …

This study aims to develop a new, more affordable ultrasound method to diagnose bladder and urine flow problems in men. Researchers will compare this new ultrasound technique to the current standard tests (MRI and a catheter-based test) in 80 men with symptoms and healthy volunte…

This study is testing if a special combined PET/MRI scan can better find the cause of ongoing pain in people whose hip pain didn't go away after a previous hip surgery. Researchers will compare scans from people who need a second surgery to those whose pain was resolved. The goal…

This study is testing a new way to take MRI pictures of the abdomen. The goal is to reduce blurring caused by natural body movements like breathing and heartbeat, which can make images unclear. Researchers will first test the method on healthy volunteers, then see how well it wor…

This study is testing a new, candy-like lollipop device designed to make strep throat testing easier and more comfortable for children. Kids aged 5-17 who test positive for strep will try the new 'CandyCollect' lollipop and provide saliva samples. Researchers will compare the lol…

This study is testing whether a culturally tailored nutrition and wellness coaching program can help lower the risk of stroke in members of the Oneida Nation. About 85 participants, aged 7 to 85, will receive health coaching and education for one year. Researchers will track chan…

This study is testing whether a new computer tool in the emergency room can help prevent future falls in older adults. The tool automatically checks if a senior is at high risk for falls and helps doctors refer them to a special fall prevention clinic. Researchers will look at me…

This study aims to adapt and improve a health program called 'Staying Healthy After Childbirth' (STAC) specifically for Black women and birthing persons. Researchers will work closely with community members and a small group of participants to gather feedback on how to best imple…

This study aims to understand older patients' experiences with a new automated screening tool used in emergency rooms. The tool identifies patients at high risk for future falls and allows doctors to refer them to a falls prevention clinic. Researchers are interviewing about 174 …

This study tests whether a virtual early learning program can help babies (ages 0-5) who experienced oxygen deprivation at birth or were born very prematurely. Researchers want to see if online sessions are as effective as in-person therapy at improving children's thinking, movem…

This study is testing whether lifting weights can help treat depression. Researchers will compare a high-intensity weight training program to a low-intensity one over 16 weeks in 200 adults with depression. The goal is to see if exercise reduces symptoms and to understand how it …

This study is testing whether a 6-week mindfulness skills training program can help improve mental health for adults who have recently been released from jail or prison. Researchers want to see if the program reduces symptoms of anxiety, depression, and stress, and if participant…

This study is testing whether a faith-based group therapy program can help reduce depression symptoms in African American adults. The program combines cognitive behavioral therapy techniques with spiritual support and is delivered through church groups. Researchers want to see if…

This study is testing if adding a medication called tranexamic acid (TXA) to standard facial filler injections can reduce common side effects like bruising, swelling, and pain. Participants will get the filler with TXA on one side of their face and the standard filler on the othe…

This study is testing whether a purified CBD medication (Epidiolex) can help reduce urinary incontinence and improve bladder symptoms in adults with recent spinal cord injuries. Twenty participants will take CBD twice daily for 90 days while tracking their symptoms. Researchers w…

This study is testing whether listening to music can help patients feel less anxious during hand surgery performed while they are awake. Researchers are comparing the effect of patients listening to their own choice of music versus a standard set of relaxing music. About 170 adul…

This study is testing whether gently smoothing the skin edges during Mohs surgery for skin cancer leads to less noticeable scars. Researchers will compare two sides of the same scar on 50 patients—one side treated with the smoothing technique and one side left alone. The main goa…

This study is testing whether a combination of celecoxib (a non-opioid anti-inflammatory) and Tylenol can effectively manage pain after parotid gland surgery, potentially reducing the need for opioid painkillers. Researchers will compare this approach to a placebo in 84 adults un…

This study is testing whether a smartphone meditation app called the Healthy Minds Program can help reduce depression symptoms in teenagers. Researchers will enroll 200 teens with elevated depression scores to use the app for 8 weeks, comparing it to a control group using a diffe…

This study is testing a specially adapted self-help workbook to see if it can help reduce symptoms of anxiety and depression for people in prison. About 96 participants will work through the 8-week workbook on their own, with researchers checking in to see if it's helpful and pra…

This study is testing whether a gentle, non-invasive form of electrical brain stimulation, applied while a person naps, can improve the quality of that sleep. Researchers want to see if this can boost specific brain waves linked to deep sleep and help people feel less mentally ti…

This study aims to find the best way to personalize a mental wellness app to help people feel better. It will enroll 1,100 adults with mild depression symptoms to test different app features, like video introductions and reminder messages. The goal is to see which combination of …

This study is testing whether two techniques—gentle electrical brain stimulation delivered during sleep and daily meditation training—can improve mental flexibility and emotional regulation. Researchers want to see if using them alone or together strengthens the brain networks re…

This study aims to understand how the brain regulates its blood supply in healthy older adults. Researchers will use MRI scans to measure blood flow while participants perform breathing exercises and simulated posture changes. The goal is to learn why some people experience faste…

This study aims to understand how the brain processes and controls speech in healthy people. Researchers will measure how participants produce and hear speech sounds, sometimes with altered audio feedback, to learn how we correct errors and learn new sounds. The goal is to gather…

This study aims to understand how chronic lymphocytic leukemia (CLL) cells use nutrients like sugar and glutamine to grow and survive. Researchers will track these nutrients in blood and bone marrow samples from 16 adults with CLL and some healthy volunteers. The goal is to find …

This study aims to understand how bone density changes after knee replacement surgery when different techniques are used. Researchers will follow 100 patients for up to 26 months to compare cemented versus cementless implants and robotic versus manual surgery methods. The goal is…

This study aims to understand why advanced prostate cancer becomes resistant to hormone-blocking treatments. Researchers will use specialized PET/CT scans to track cancer lesions in 25 men who are either starting or already receiving these therapies. By comparing different imagin…

This study aims to see if researchers can successfully find and follow children with PANS or PANDAS for one year. It will not test treatments but will gather information on how many kids get these conditions and how their symptoms change over time. The goal is to learn if this ty…

This study aims to understand how a baby's brain develops and recovers after a stroke that happens around the time of birth. Researchers will observe 65 infants with a confirmed stroke, tracking them from birth up to age 2. They will use safe brain scans and movement assessments …

This study uses a smartphone app to track people's daily activities, locations, and tick encounters to better understand what leads to tick bites. Researchers will enroll up to 1,000 people across the US, focusing on the Midwest and Northeast. The app will also test if sending da…

This study aims to find blood markers that might help predict how skin cancer will progress and respond to treatment. Researchers will collect blood samples from 20 adults with melanoma or other skin cancers who are undergoing regular treatment. The goal is to see if certain subs…

This study is testing a new mail-in kit to see if it can preserve breast milk well enough for genetic research. Researchers want to make it easier for more mothers to participate in studies without having to travel to a lab. They will enroll 50 lactating mothers in Wisconsin to t…

This study is testing a new imaging method called qDSA that measures blood flow during a procedure to block blood supply to liver tumors. The goal is to see if this technique helps doctors better control how much blood flow is reduced to the tumor. Up to 20 patients having this s…

This study aims to gather information on how a common heart condition in premature babies, called a patent ductus arteriosus (PDA), might affect oxygen levels in their kidneys. Researchers will observe 45 very premature infants, using special sensors and heart ultrasounds to meas…

This study aims to find out if practicing specific computer-based thinking tasks can improve skills like memory, attention, and problem-solving. It will enroll 1,600 participants who will be randomly assigned to different training groups. Participants will complete a series of sh…

This study aims to understand why recovery from language loss (aphasia) after a stroke varies so much from person to person. Researchers will use brain scans (MRI) and genetic tests to look for biological markers linked to the brain's ability to rewire itself. The goal is to find…

This study aims to understand how to spot early signs of future thinking and attention problems in babies who had a brain injury around birth. Researchers will observe 100 infants, some healthy and some with a history of brain injury, by watching them play simple games, measuring…

This study aims to understand why blood vessels malfunction in preeclampsia, a dangerous high-blood-pressure condition during pregnancy. Researchers will collect small tissue samples from 166 women during their planned C-sections, comparing those with and without preeclampsia. By…

This study is testing a communication tool called TrialTalk™ to see if it helps doctors and patients talk more clearly about cancer treatment options. It involves 30 participants, including doctors and patients, who will complete surveys about their clinic visits. The goal is to …

This study aims to collect detailed pictures of the eyes from 1000 people, both with and without age-related macular degeneration (AMD). The goal is to create a diverse, high-quality image library that researchers can use to develop and test artificial intelligence (AI) screening…

This study is testing whether a special type of ultrasound can be used to check a baby's lung development before birth. Researchers will scan 16 pregnant women between 32 and 36 weeks of pregnancy to see if the new technique works. The goal is to gather information about normal l…

This study is gathering information to plan a larger future trial comparing local anesthesia to general anesthesia for inguinal hernia repair in Veterans aged 60 and older. About 80 participants will be randomly assigned to receive either local or general anesthesia for their sur…

This research study aims to understand how different types of visual practice or 'training' can improve how people see and process information. It will enroll about 1,140 healthy adults, split between younger (18-30) and older (60-85) age groups, to test which of 12 different com…

This study is testing a new web-based tool designed to help men and boys who have had surgery for hypospadias. Researchers want to see if the tool is easy to use and helpful for tracking physical and emotional health over time. About 20 participants will try the app and give feed…

This study aims to understand how sleep quality affects emotion processing and daily mood in teenagers with Post-Traumatic Stress Disorder (PTSD). Researchers will observe 180 teens, including some with PTSD and some without, to see if using a special headband to improve deep sle…

This study aims to understand if a non-invasive electrical stimulation technique can temporarily change how different areas of the brain communicate with each other. Researchers will test this on 30 healthy adults during both sleep and quiet wakefulness. Participants will undergo…

This study aims to find the best way to help people who lost their Medicaid health insurance due to paperwork problems. Researchers will test if a live phone call from a helper is more effective than a pre-recorded message at getting people re-enrolled. They will track over 400,0…

This study aims to see if changes in a person's speech can serve as an early warning sign for Alzheimer's disease. Researchers will follow 165 adults at risk for Alzheimer's for three years, having them record their speech at home using an iPad. The goal is to develop a simple, h…

This study aims to find the best way to reduce missed dental appointments in clinics that serve low-income and underserved communities. Researchers will test three different approaches at 40 dental clinics: reminder messages, motivational communication, and offering walk-in visit…

This study is testing whether a type of safe, non-invasive brain stimulation can help experienced meditators quickly reach a deep, calm state where they feel less attached to their own thoughts and feelings. Researchers will compare two stimulation techniques on 12 healthy, exper…

This study aims to understand how long-term e-cigarette use affects heart and lung health over three years. Researchers will track 600 people—400 regular e-cigarette users and 200 non-users—using advanced medical tests like ultrasounds, CT scans, and blood work. The goal is to ga…

This study aims to understand how chemotherapy affects memory and thinking skills in women with advanced ovarian cancer. Researchers will follow 18 patients for about 10 months, testing their cognitive function before, during, and after treatment. The goal is to measure changes i…

This study aims to understand why hearing aids often don't work as well in noisy, real-world settings as they do in quiet labs. Researchers will test three different hearing aid settings on 45 experienced adult users with age-related hearing loss. Participants will listen to scen…

This research study aims to understand how healthy young adult brains regulate blood flow during physical challenges. Researchers will use MRI scans to measure blood flow changes while participants breathe different air mixtures and experience simulated posture changes. The goal …

This study aims to learn more about swallowing and oral health problems in adults aged 60 and older who come to the emergency department. Researchers will perform simple tests during the ER visit, like checking tongue strength and collecting saliva samples, to see how common thes…

This study aims to create a database of voice measurements from children with normal voices and those with voice problems. Researchers will test different, child-friendly methods to measure airflow and pressure during speech in one 60-minute session. The goal is to better underst…

This study aims to understand if a gentle ear nerve stimulation can help people better remember and benefit from insights gained during a guided psilocybin experience. Researchers will enroll 108 healthy adults who feel their wellbeing could be better. They will test if the nerve…

This study is testing a new type of CT scan that doesn't require injected dye to see how well blood is flowing through the lungs. Researchers want to see if this new method works as well as the standard scan. They are enrolling 30 adults who are already scheduled for a regular CT…

This study is testing a new type of PET/MRI scan to see if it can better show and measure lung scarring (fibrosis) in people with certain lung diseases. Researchers want to see if this scan can help doctors track how active the scarring process is over time. The study involves up…

This study aims to compare two newer, wide-angle eye cameras to the current standard camera to see if they provide the same quality of information for monitoring inherited retinal diseases. Researchers will take pictures of the back of the eye using all three cameras in about 50 …

This study aims to find biological markers that can predict if a patient's oral cavity cancer will respond to immunotherapy given before surgery. Researchers will take a small tumor sample from each of the 20 participants and grow it in a special lab dish. They will then test if …

This study is creating a list of people interested in CADASIL research. CADASIL is a rare, inherited condition that affects blood vessels in the brain. By joining this registry, participants agree to be contacted about future research opportunities to help scientists learn more a…

This online study aims to understand how thinking skills develop in infants, comparing those who had a brain injury around birth with healthy infants. Researchers will observe 200 children aged 3-24 months through virtual games that measure attention and problem-solving, while pa…

This study aims to understand how psilocybin, the active compound in 'magic mushrooms,' might help the brain adapt and change, and how that relates to feelings of wellbeing. Researchers will test different doses on 60 adults who report feeling slightly down but do not have a diag…

This study aims to learn if a special scan (PET/CT) and a blood test for tumor DNA can help doctors predict, very early on, which patients with advanced melanoma will respond well to immunotherapy and which might experience side effects. It will enroll 24 patients who are startin…

This study aims to understand how CADASIL, a genetic form of vascular dementia, starts and changes over time. Researchers will follow 575 people with a family history of CADASIL for up to 5 years, tracking their brain health, thinking skills, and daily function. The goal is to id…

This study aims to understand if and how severe asthma affects the brain. Researchers will compare brain scans, blood tests, and questionnaires from 100 adults with severe asthma to those from healthy adults. The goal is to see if lung inflammation is linked to brain inflammation…

This study aims to understand why some children become 'carriers' of strep throat bacteria without showing symptoms. Researchers will compare the bacteria from children with active strep infections to those who are carriers. The goal is to learn if carriers need antibiotic treatm…

This study aims to understand why some older adults become confused (delirious) after major surgery. Researchers will measure brain activity, take images, and test blood and spinal fluid from about 468 patients before and after their operations. The goal is to find biological sig…

This study is testing a new training program to help surgeons communicate more clearly with patients about surgery. Researchers want to see if automated training works as well as specialist-led training to improve how surgeons explain surgery risks, benefits, and alternatives. Th…

This study is testing whether a special imaging scan, originally developed for prostate cancer, can detect a specific marker (PSMA) in certain types of advanced breast cancer. Researchers want to see if this marker can help predict which patients might not respond well to a commo…

This study is testing whether gentle brain stimulation can help people who have never meditated before quickly reach a calm, focused state similar to what experienced meditators achieve. Researchers will use a special cap to measure brain activity while participants try a simple …

This study aims to understand if viruses detected in the air inside homes match when family members get sick. Researchers will enroll families with a sick child and place an air sampler in their home while also collecting nasal swabs. The goal is to see if measuring viruses in th…

This study is testing a new system designed to help more older adults get a comprehensive health checkup before major surgery. It involves patients aged 80 and older who are scheduled for surgery, as well as their surgeons and other healthcare providers. The main goal is to see i…

The purpose of this study is to determine 1) if young adults with metabolic syndrome display endothelial dysfunction of the internal carotid artery in a sex-specific fashion and 2) if this endothelial dysfunction can be acutely improved with a single bout of exercise. This will b…

This is an open label, phase II, multi-site trial evaluating the efficacy and safety of the combination of 5-FU, oxaliplatin, nal-IRI, and immunotherapy (plus trastuzumab for HER2-positive tumors) as first-line therapy for participants with advanced Esophageal and Gastric Adenoca…