University Of Wisconsin, Madison

This study tested whether a specific type of COVID-19 booster vaccine (called a recombinant vaccine) could improve and sustain immune protection in people with weakened immune systems. It focused on adults with conditions like Inflammatory Bowel Disease (IBD) or those who have re…

This early-stage study tested a new drug, CLR 131, designed to deliver radiation directly to cancer cells. It was combined with standard external beam radiation for 12 patients whose head and neck cancer had returned. The main goal was to find a safe dose and see how well the dru…

This study tested two different programs to help cancer patients quit smoking. It compared an intensive program (12 weeks of medication plus 7 coaching calls) against a standard program (2 weeks of nicotine patches plus 3 calls). The goal was to see which approach was more effect…

This study tested a specific sequence of four chemotherapy drugs given before surgery (neoadjuvant therapy) for people with triple-negative breast cancer, a type that doesn't respond to hormone therapies. The main goal was to see if this treatment could completely eliminate the i…

This study tested a shorter, more targeted form of radiation therapy for men with early-stage prostate cancer. The goal was to see if delivering higher doses of radiation directly to the tumor over just 5 sessions could effectively control the cancer while causing fewer side effe…

This study tested a new follow-up program called REASSURE for people who have finished treatment for early-stage, low-risk breast cancer. The goal was to see if the program helps survivors feel more prepared and confident in managing their health after cancer, while potentially r…

This study compared two different laser systems used to break up kidney stones during a standard outpatient procedure. Researchers wanted to see which laser was better at completely clearing stones and which was safer and more efficient. 178 patients with kidney stones were rando…

This study tested a new support program designed to help people with HIV, hepatitis C, or substance use disorders get medical care after they are released from prison. Researchers worked with 219 men and women before their release to see if the program was practical and acceptabl…

This study tested a more involved, ongoing support program for quitting smoking against the usual yearly offer of help. It involved 979 primary care patients who smoke and lasted 18 months. The main goal was to see which approach led to more people successfully quitting and if th…

This study tested whether smartphone apps could help people with risky drinking habits and their close family members or partners. Researchers compared two different app approaches—one focused on the person who drinks and one focused on the family—against a basic control app. The…

This study tested four different health system strategies to connect more primary care patients who smoke daily with proven quit-smoking treatments, even if they weren't ready to quit at the start. Over 1,600 adult patients were enrolled for two years to see if methods like finan…

This study tested a new rapid test called SPOTFIRE ST in urgent care clinics. The test checks for multiple causes of sore throat, including bacteria and viruses, in about 25 minutes. Researchers wanted to see how well it worked, if it helped doctors prescribe the right medicines,…

This study tested a new type of combined PET/MRI scan to see if it could accurately measure a specific hormone receptor in breast cancer tumors. Researchers enrolled 21 women with newly diagnosed breast cancer to see if the scan results matched the results from a standard tissue …

This study tested whether a new artificial intelligence (AI) program could accurately identify osteoporosis from standard X-ray images. Researchers used 800 de-identified X-rays from patients who had joint or spine surgery to see if the software could detect signs of low bone den…

This small pilot study tested whether a commercial fitness-to-drive tool (DRIVESC) could detect alcohol impairment in healthy adults. Researchers enrolled 22 participants from a breath alcohol examiner training course, some of whom consumed alcohol up to the legal driving limit. …

This study tested a computer program designed to automatically screen hospitalized patients for substance misuse by reading their electronic health records. The goal was to see if this AI tool could identify more at-risk patients than standard screening methods. Over 64,000 adult…

This study tested a new diagnostic tool called high-resolution manometry (HRM) to see if it could accurately locate blockages in the upper airway of people with sleep apnea. Researchers compared HRM, which uses a thin tube to measure pressure, to the current standard procedure (D…

This study tested a hospital program called MOVIN, designed to help older patients walk more during their stay. The goal was to prevent loss of mobility—a common problem that can lead to nursing home placement—and reduce hospital readmissions. Researchers enrolled about 765 older…

This study tested whether a community health program could prevent strokes in Native Americans at high risk. Researchers trained local health coaches to provide education and intensive lifestyle coaching to 120 tribal members over two years. They measured changes in stroke risk f…

This study tested a new support program for adults who recently experienced sexual assault. Researchers developed a brief video to watch during a medical exam and follow-up text messages for the next month. The goal was to see if this approach could help prevent the development o…

This study tested a new rehabilitation method for people who had a stroke. Researchers wanted to see if using a brain-computer interface (BCI) to control muscle stimulation could help improve arm movement and function. The study involved 84 stroke survivors with arm weakness and …

This study tested a personalized exercise program for women who have survived breast or endometrial cancer. All 323 participants used a Fitbit connected to their electronic health record. Women who struggled to meet activity goals received extra support, like online exercise vide…

This study tested whether a virtual reality video game could help teens in the juvenile justice system learn to manage their emotions. The game used biofeedback, where players see their own heart rate and stress responses in real-time to help them practice calming down. Researche…

This study tested whether doing 30 minutes of moderate exercise right before therapy sessions could make cognitive behavioral therapy (CBT) work better for depression. Researchers compared 40 adults with depression who either exercised or rested quietly before their weekly therap…

This study tested a 12-week digital program designed to help healthcare workers in Mexico manage stress and prevent burnout. Over 2,300 doctors, nurses, and other providers were randomly assigned to either try the program immediately or wait. The program combined video sessions w…

This study tested whether a special communication tool called 'Best Case/Worst Case' helps doctors have better conversations with older patients who have severe, permanent kidney failure. The tool helps doctors and patients talk about future care options, quality of life, and end…

This study tested whether a 6-week group therapy for PTSD, led by people who have also experienced incarceration and trauma, is helpful for those recently released from prison or jail. 59 participants who had PTSD symptoms joined the therapy groups and completed surveys about the…

This study tested whether a 6-month, at-home cycling program delivered via video call could help people with Parkinson's disease. It focused on reaching people in rural or underserved areas who have trouble accessing group exercise. Researchers wanted to see if regular, socially-…

This small pilot study explored whether gentle hands-on osteopathic treatment could safely help reduce shoulder pain and improve arm function in people who have had a stroke. Three adult participants with shoulder pain on their stroke-affected side received either the real treatm…

This study tested whether a 4-week meditation and well-being app called the Healthy Minds Program could help reduce symptoms of depression. Over 1,100 U.S. adults with elevated depression symptoms were randomly assigned to use the app, use a version without meditation, or wait to…

This study tested two simple treatments to help people with Alzheimer's or other dementias swallow more safely. Researchers wanted to see if tongue-strengthening exercises or a saliva-moistening gel could reduce choking risk and prevent pneumonia. The study involved 76 patient-ca…

This study aimed to understand how two types of THC from cannabis affect a person's ability to drive. Researchers gave small doses of THC to a few experienced cannabis users and measured their performance in a driving simulator. The goal was to gather reliable data on impairment …

This study aimed to find biological signs that could predict if a patient's advanced melanoma would respond to immunotherapy drugs. Five patients had scans and tumor biopsies taken before and during their standard treatment. The goal was to learn how to better match patients with…

This study aimed to understand how eating carrots of different colors (red, purple-red, and purple) affects the body's absorption of their natural pigments. Researchers also wanted to see if these pigments might help control blood sugar. Twelve healthy adults drank juices from th…

This study aimed to see if a special swallowing pressure test could predict which patients with swallowing difficulties would benefit from therapy. Researchers followed a small group of patients as they underwent swallowing treatment, measuring their swallowing function at differ…

This study tested a program designed to help African American high school students with developmental disabilities explore technology careers. The program included learning about coding jobs, watching videos of tech professionals, and building workplace social skills. Researchers…

This completed study aimed to understand why Native Americans face higher stroke risks. Researchers worked with 19 Oneida Nation members, aged 55-90, to see if long-term stress and cultural factors affect brain health. They used brain scans, ultrasounds, and memory tests to look …

This study aimed to understand how different prosthetic legs and leg braces affect walking in everyday life. Researchers used wearable sensors to track the movements of 20 participants with lower limb amputation or drop foot over several weeks. The goal was to gather data to help…

This study aimed to understand why children growing up on farms might get fewer or less severe colds and breathing problems. Researchers observed 290 children, ages 4-12, from farm communities and suburban areas, some with and some without asthma. They tracked the kids' cold symp…

This study aimed to understand basic differences in how men and women control blood flow to their brains, both at rest and under stress like low oxygen. Researchers used MRI scans and medicine infusions to test their ideas in 110 healthy young adults aged 18-40. The goal was to b…

This study tested whether a special type of MRI scan, called diffusion tensor imaging, can reveal microscopic damage in injured knee tendons that regular scans might miss. Researchers compared scans from 62 people with and without patellar tendon injuries to see if the advanced i…

This study aimed to understand why parent-led language training works better for some families than others. Researchers observed 156 parent-child pairs, including children with typical development, language delays, and autism. They measured how parents' own language skills and aw…

This study tested a 'Best Case/Worst Case' communication tool to improve how trauma doctors talk with families of severely injured older patients. Researchers trained surgeons at two hospitals to use the tool, which helps outline possible recovery paths. They then surveyed family…

This study aimed to measure how well the body absorbs vitamin A when it's added to bouillon (broth) cubes. Researchers compared absorption from three different fortified broth formulas to a standard oil-based vitamin A supplement. The goal is to find better ways to deliver this e…

This study explored whether gently stimulating the brain with electricity during naps could improve specific sleep patterns linked to emotional health and stress resilience. Healthy adult volunteers who regularly nap wore a special cap to monitor brain activity while napping and …