University Of Wisconsin, Madison

This study planned to test whether a living donor liver transplant could help people with colon cancer that has spread only to their liver and cannot be surgically removed. Participants would first receive standard chemotherapy, then receive part of a liver from a living donor if…

This study is testing whether using anti-EGFR drugs like panitumumab or cetuximab earlier in treatment can better control metastatic colorectal cancer and allow patients to be retreated with these drugs later. It will enroll 71 adults with left-sided, metastatic colon cancer that…

This study is testing whether giving high doses of vitamin C through an IV during and after liver transplant surgery helps patients recover better. Ninety liver transplant patients will receive either vitamin C or a placebo (saltwater) infusion for two days after surgery. Researc…

This study is testing a new way to give standard chemotherapy (R-CHOP) to older adults with an aggressive type of lymphoma called DLBCL. The goal is to split the doses over two weeks instead of giving them all at once, which researchers hope will be easier for older patients to t…

This study is testing a coaching program designed to help urban health clinics better use remote eye screening technology for their diabetic patients. The goal is to increase the number of patients who get their annual diabetic eye exam, which is crucial for catching vision-threa…

This study is testing whether a low dose of a drug called everolimus, taken daily or weekly for 24 weeks, can safely improve signs of aging in older adults who have insulin resistance (a pre-diabetic condition). Researchers will measure changes in metabolism, heart health, brain …

This early-stage study is checking if psilocybin, the active compound in 'magic mushrooms,' is safe and practical to use alongside psychological support for people with methamphetamine addiction. Twelve adults with meth addiction will receive two oral doses of psilocybin under me…

This study is testing whether a specific type of group therapy, called Cognitive Processing Therapy (CPT), can help reduce symptoms of Post-Traumatic Stress Disorder (PTSD) in incarcerated men and women. About 117 participants are randomly assigned to either receive the therapy s…

This study is testing whether a special smartphone app and connection to a support team can help people with HIV who also struggle with substance use. The goal is to help them stay on their medication, keep their virus at undetectable levels, and make it to their doctor appointme…

This study is testing whether adding a second DNA vaccine to an immunotherapy drug helps control advanced prostate cancer better than using one vaccine with the drug. It involves men whose cancer has spread and stopped responding to standard hormone-blocking treatments. The goal …

This study is testing a special fluorescent dye and camera system to help surgeons better see dead tissue in burn wounds. The goal is to give doctors a clearer picture during surgery, which could help them remove only the damaged tissue and improve healing. Up to 100 burn patient…

This study is testing new MRI and ultrasound scanning methods to accurately measure fat in children's livers. It involves 24 children, both with obesity and with a healthy weight, to see if these scans are practical and reliable. The goal is to improve the tools doctors use to de…

This study is testing whether a lung ultrasound scan can help doctors better decide when it's safe to remove a breathing tube from a newborn with respiratory distress. Researchers will scan the lungs of 71 babies before and after the tube is removed to see if the scan score predi…

This study aims to help Salvation Army staff connect people who smoke with free quitline services to reduce tobacco use and prevent related cancers. Researchers will test two approaches: training staff to offer these services and providing small incentives for clients to accept i…

This study is testing whether forgiveness education can improve the mental health and quality of life of college students. Researchers are enrolling 40 first- and second-year students to participate in a psychological welfare program. The study measures changes in forgiveness, se…

This study aims to find out if using the Leva Pelvic Health System for 8 weeks works as well as using it for 16 weeks to help women with fecal incontinence (uncontrolled bowel leakage). Researchers want to see if a shorter treatment time provides similar benefits for symptom impr…

This early-stage study is testing whether injecting a person's own bone marrow stem cells into their salivary glands is safe and might help relieve severe, persistent dry mouth caused by radiation treatment for head and neck cancer. Up to 23 participants who are at least 2 years …

This small, early-stage study is checking if a treatment combining the medicine ketamine with talk therapy is safe and workable for teenagers with severe post-traumatic stress disorder (PTSD). It will involve a few teens aged 15-17 receiving three ketamine sessions with therapy s…

This study is testing whether a 10-week supervised exercise program is practical and helpful for mothers of children with developmental disabilities like autism. It aims to see if the program is easy for busy moms to join and stick with, and if it can improve their strength, stre…

This study is testing whether a special mindfulness-based childbirth and parenting class is better than a standard class at reducing anxiety in pregnant women. It will enroll 60 pregnant women with elevated anxiety and randomly assign them to one of the two class types. The resea…

This study is testing whether a daily mindfulness program delivered through a phone app can help people recover better after hip surgery. Researchers want to see if the 8-week program reduces pain, improves hip function, and boosts quality of life for up to two years after the op…

This study is testing a program called RESTORE that aims to reduce burnout among nurses. Instead of asking nurses to cope better individually, the program lets nursing staff help redesign their own work systems to reduce stress and improve support. About 470 nurses will participa…

This was a small pilot study to see if it's practical to prescribe lorazepam, a medication for anxiety, before an IUD insertion to help reduce pain and anxiety. It planned to enroll 25 adults and have them rate their pain and anxiety before and after the procedure. The main goal …

This study is testing a special communication tool designed to help doctors have clearer conversations with families of seriously injured older adults in the intensive care unit (ICU). It involves about 4,500 patients, 1,500 family members, and 1,600 medical staff across the coun…

This early study aims to understand how two existing constipation medications affect a specific chemical signal in the small intestine. Researchers will compare tissue samples from volunteers who take a single dose of either drug or no drug before a scheduled medical procedure. T…

This study aimed to understand how temperature, visuals, and sounds work together to affect a person's physical comfort and perception. Participants would have watched short videos in two different climate-controlled rooms while their body's responses were measured. The goal was …

This study aims to see how a new ankle brace affects athletic performance and comfort. Researchers will have 30 healthy athletes run and perform cutting drills while wearing different braces and then rate their experience. The goal is to gather information on comfort, stability, …

This study aims to discover how early-life environmental factors like pollutants, viruses, and bacteria contribute to childhood asthma and allergies. Researchers are following 499 children from before birth through early childhood, collecting data and samples to identify root cau…

This study aims to understand if low vitamin A levels are connected to vocal cord leukoplakia, which are white patches that can develop on the vocal cords. Researchers will measure vitamin A levels in 90 people with these patches and compare them to people without the condition. …

This small, early-stage study aims to find clues that can predict how well a patient's high-risk prostate cancer will respond to standard treatment. Researchers will look at special medical scans and a genetic test from 30 men already scheduled to receive radiation and hormone th…

This long-running study is tracking over 1,500 Wisconsin adults to understand how sleep-disordered breathing develops and changes as people age. Researchers are checking in with the same group of people over decades to see how sleep problems might be linked to future heart, brain…

This study is testing two different ways to train surgeons to communicate more clearly with older patients before surgery. It compares traditional coaching by a specialist against a new automated method that reviews transcripts of doctor-patient conversations. The goal is to see …

This study is testing a new 5-year training program designed to teach surgical residents better communication skills, like showing empathy and having difficult conversations with patients. Researchers will enroll about 600 surgical trainees and their instructors to see if the pro…

This study is observing how a specific care plan, called a 'time-limited trial,' is used for very sick patients in the ICU who need a machine to help them breathe. The plan involves setting a period to try treatments, then checking if the patient is improving. Researchers are wat…

This is a small, early-stage study to learn how head and neck cancer tumors respond to a short course of two drugs, imatinib and cetuximab, given in the time between diagnosis and the start of standard treatment like surgery or radiation. Researchers will take small tumor samples…

This study aims to find the most effective ways to help people renew their Medicaid health insurance. It involves over 119,000 Wisconsin residents who need to renew their coverage after special COVID-19 rules ended. Researchers are testing different outreach methods from trained …

This study aims to understand and improve the process of checking older adults' overall health before major abdominal surgery. Researchers will observe clinic visits and interview patients, caregivers, and healthcare staff to create a detailed map of the current system. Then, the…