University Of Wisconsin, Madison

This study tests whether high doses of vitamin C given through an IV can help people recover better after a liver transplant. About 90 adults having their first liver transplant will receive either vitamin C or a placebo for two days. The goal is to see if vitamin C reduces organ…

This phase 2 trial tests whether a low dose of everolimus, a drug used in cancer, can safely improve signs of aging in 106 adults aged 55-80 who have insulin resistance or prediabetes. Participants take the drug daily or weekly for 24 weeks, and researchers measure changes in met…

This phase 2 trial tests whether adding a second DNA vaccine to a standard immunotherapy (pembrolizumab) can improve outcomes for men with castration-resistant metastatic prostate cancer. About 60 participants will receive either one or two DNA vaccines along with pembrolizumab f…

This Phase II trial tests whether giving anti-EGFR drugs (panitumumab or cetuximab) early in treatment can help patients with left-sided metastatic colorectal cancer respond again to these drugs later. About 34 participants will receive alternating cycles of targeted therapy and …

This study tests a mobile app called Connections for people living with HIV who also have substance use disorders. The app provides resources, weekly check-ins, discussion rooms, and private messaging with peer mentors and care teams. Researchers want to see if using the app help…

This phase 2 trial is testing a drug called sacituzumab govitecan in 31 men with metastatic castration-resistant prostate cancer that has worsened despite hormone therapy. The drug works like a smart bomb, delivering chemotherapy directly to cancer cells. Researchers are measurin…

This phase 2 trial tests a DNA vaccine (pTVG-HP) plus the immunotherapy drug nivolumab in 19 men whose prostate cancer has returned after surgery but has not spread. The goal is to see if the combination can safely lower PSA levels to undetectable and delay cancer spread. Partici…

This early-phase trial is testing a new combination of an experimental drug (INCB081776), an immunotherapy (pembrolizumab), and radiation therapy in 10 people with advanced head and neck cancer that has spread or come back. The main goal is to check safety and side effects, while…

This phase 2 trial is testing a shorter course of high-dose radiation (hypofractionated radiotherapy) for soft tissue sarcoma. The goal is to see if this approach can control the tumor for at least two years while reducing damage to nearby healthy tissue. About 48 adults with ino…

This early-phase trial tests whether giving patients a special infusion of donor immune cells (with certain T and B cells removed) after a stem cell transplant is safe and can help prevent their blood cancer from coming back. The study enrolls high-risk patients with hard-to-trea…

This study planned to test whether a living donor liver transplant, after standard chemotherapy, could help people with colorectal cancer that spread to the liver and could not be surgically removed. It aimed to enroll 25 donor-recipient pairs. However, the study was withdrawn be…

This study tests a modified schedule of standard chemotherapy (R-CHOP) for people aged 75 and older with diffuse large B-cell lymphoma, a type of blood cancer. The goal is to see if splitting the doses makes treatment easier to tolerate while still being effective. Twenty-seven p…

This study tests whether using artificial intelligence (AI) to screen for diabetic eye disease during regular primary care visits helps more people get timely eye exams and follow-up care. About 1,700 adults with diabetes who haven't had an eye exam in the past year will take par…

This study tests whether a fluorescent dye called indocyanine green (ICG) can help surgeons see exactly which parts of a burn wound are dead or inflamed. Up to 100 burn patients will receive the dye and have their wounds imaged with a special camera before and during surgery. The…

This study tests a lollipop-shaped device called CandyCollect to see if it can detect strep throat in children ages 5-17. Kids suck on the lollipop for a few minutes, and it captures bacteria in special channels. Researchers compare results to standard throat swabs to see if the …

This study tests a program designed to prevent opioid misuse in people hospitalized for a traumatic injury. Participants complete brief questionnaires about pain and opioid use risk, and receive enhanced care coordination based on their responses. The goal is to see if this adapt…

This study tests whether a short video and a 3-week text messaging program can help people who have recently experienced sexual assault. The goal is to see if these tools can reduce mental health problems like PTSD and prevent misuse of opioids and other substances. About 394 adu…

This study tests whether lightly sanding the skin edges during Mohs surgery (a type of skin cancer removal) can improve how scars look after healing. Thirty adults having facial or neck surgery will have half their scar treated with dermabrasion and the other half left as standar…

This study tests whether a new ankle brace changes how athletes run and cut. Researchers will compare five different bracing conditions. Participants will run on a treadmill, do shuttle runs, and fill out surveys about comfort and stability. The goal is to see if the brace is com…

This study tests a communication tool called Best Case/Worst Case-ICU for older adults (50+) with serious injuries in the ICU. The tool helps doctors, patients, and families discuss possible outcomes and treatment options using simple graphics. Researchers will measure if it impr…

This study tests whether using a mindfulness app for 8 weeks can improve quality of life, reduce anxiety and depression, and help people return to sports after ACL reconstruction surgery. About 47 participants aged 16-40 will use the app and report their progress through question…

This study tests whether an 8-week nutrition education program focused on fiber-rich foods (like fruits, vegetables, and whole grains) is acceptable and helpful for people with diabetes, prediabetes, or obesity. Researchers will track participants' weight and dietary changes over…

This early-phase study tested whether ketamine-assisted psychotherapy is safe and feasible for adolescents aged 15-17 with severe posttraumatic stress disorder (PTSD). Five participants were to receive three intravenous ketamine doses paired with therapy sessions over six weeks. …

This study tests whether a mindfulness-based childbirth and parenting class can lower anxiety in pregnant women. Sixty women with elevated worry will be randomly assigned to either the mindfulness class or a standard childbirth education class. Researchers will track changes in a…

This early-phase study tests whether injecting a person's own bone marrow stem cells into their salivary glands is safe and tolerable for treating dry mouth caused by radiation therapy for head and neck cancer. About 23 participants who finished radiation at least 2 years ago wil…

This study tests a program called RESTORE that helps nurses redesign their work to reduce stress and burnout. About 470 nurses will be interviewed and complete surveys about their job demands, resources, and well-being. The goal is to see if changing how work is organized can imp…

This pilot study aimed to see if giving lorazepam, a sedative, before IUD insertion could reduce pain and anxiety. It planned to enroll 25 adults at a family medicine clinic. However, the study was withdrawn before any participants were enrolled, so no data was collected.

This study looks at whether using the Leva Pelvic Health System for 8 weeks is as good as using it for 16 weeks to help women with fecal incontinence. About 38 women will use the device and fill out surveys. The goal is to find the shortest effective treatment time.

This study looks at whether a special recovery program can help older adults (65+) who experienced confusion (delirium) after emergency surgery. Participants will have virtual visits with a care coordinator and complete physical, cognitive, and psychological assessments over 18 m…

This study looks at how adults at risk for Alzheimer's disease react after learning their amyloid and tau biomarker test results. Researchers will track changes in distress, stigma, quality of life, and future planning over time. The goal is to understand the psychological and be…

This study looks at whether air samplers placed in homes can detect viruses that cause colds and flu, and how that compares to standard nasal swabs. About 422 students and their families will participate. The goal is to better understand how respiratory viruses spread through hou…

This study looks at how brain blood flow and nerve signals work in veterans who served in the Gulf War (1990-1992) and have Gulf War Illness. Researchers will compare them to healthy veterans using breathing tests, ultrasound, and MRI scans. The goal is to learn more about why so…

This pilot study looks at whether special scans (PSMA PET/MRI) and genetic tests can predict how well high-risk prostate cancer responds to hormone therapy and radiation. Thirty participants will be followed for up to 5 years. The goal is to find markers that identify poor respon…

This study looks at blood samples from 20 adults with melanoma or other skin cancers to see if certain markers in the blood can predict how well treatment works or how long someone lives. Researchers will compare these markers to standard measures like tumor response and survival…

This study looks at whether a program called I-SITE can help rural health clinics use teleophthalmology (remote eye exams) to screen more diabetic patients for eye problems. Up to 10 health systems and 10,000 patients will take part. The goal is to see if screening rates improve …

This study looks at how Salvation Army staff can help people who smoke learn about and use free quit-smoking services, like the Wisconsin Tobacco Quit Line. Researchers will train staff to offer a short survey that gives feedback on smoking risks and treatment options. The goal i…

This study trains police officers and first responders to better communicate with people who have aphasia, a condition that affects speech and understanding. 75 participants from the Madison Police Department will take part for up to 6 months. The goal is to see if training impro…

This study uses a special imaging device called optical coherence tomography (OCT) to look at blood vessels in vascular stains (a type of birthmark). Researchers want to see if the size and depth of these vessels relate to the birthmark's genetics. About 73 people with vascular s…

This study compares two methods of training surgeons to have better conversations with patients about surgery risks and goals. About 60 surgeons and 660 patients will take part. One group of surgeons gets training from an education specialist, the other from a computer program. T…

This study is testing whether a new type of MRI can detect changes in the brain that lead to memory and thinking problems in people with multiple sclerosis (MS). Researchers will scan 75 adults with MS and give them thinking and memory tests. The goal is to see if the new MRI mea…

This study looks at how a protein called AXL in head and neck tumors responds to a combination of two drugs, imatinib and cetuximab, given before standard treatment. About 15 adults with head and neck cancer will receive the drugs for a short time between diagnosis and surgery or…

This study looks at different ways to help people keep their dental appointments in clinics that serve low-income and uninsured patients. Researchers will compare reminder messages, walk-in options, and better communication to see which works best. About 48 clinic staff members w…

This study tests a program called I-SITE that helps clinics use teleophthalmology—taking eye photos during regular doctor visits—to increase screening for diabetic retinopathy. Over 12,000 patients with diabetes from urban health systems are included. The goal is to see if this a…

This study looks at how to improve the pre-surgery checkup process for older adults having major abdominal surgery. Researchers will observe clinic visits and interview patients, caregivers, and healthcare providers to find what works well and what could be better. The goal is to…

This study follows 499 children from birth to age 6-7 to understand how early-life factors like allergens, pollution, and microbes may lead to asthma and allergies. Parents with asthma or hay fever are included. No treatments or changes are made—just observation to uncover root c…

This study looks at a care approach called a time-limited trial (TLT) for ICU patients who need a breathing machine. Doctors, patients, and families agree to try treatments for a set time, then check if the patient is recovering. The goal is to see if this approach can reduce ICU…

This study looks at vitamin A levels in 90 adults with vocal fold leukoplakia, a condition that causes white patches on the vocal cords. Researchers want to see if vitamin A status differs between people with and without precancerous changes. Participants provide blood and tissue…

This study tests whether MRI and ultrasound can accurately measure liver fat in children aged 10-14, both those with obesity and those at a healthy weight. Researchers will check if the scans are reliable and easy to perform. The goal is to develop a non-invasive tool to diagnose…

This study follows 1,545 adults over many years to understand how sleep-disordered breathing and other sleep problems develop and affect health. Participants were Wisconsin state employees aged 30-60 when the study began. Researchers use overnight sleep tests, questionnaires, and…

This study aimed to understand how watching videos (like snow or fire scenes) and listening to sounds (like crackling fire or falling snow) affect how people perceive temperature and comfort. It planned to measure heart rate, skin temperature, and blood pressure in healthy adults…

This study looks at a special training program called Fundamentals of Communication in Surgery (FCS) for surgeons and surgery trainees. The goal is to see if the training helps surgeons communicate better with patients and each other. About 600 people will take part, and research…