Could a few days of radiation replace weeks for sarcoma patients?

NCT ID NCT05109494

Terminated Disease control Sponsor: University of Wisconsin, Madison Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 08, 2026 · Updated 3 times

Summary

This study compares a shorter, more intense course of radiation (5 sessions) to the standard longer course (25 sessions) given before surgery for soft tissue sarcoma. The goal is to see if the shorter schedule is safe and effective at killing tumor cells. Thirty adults with sarcoma in their arms, legs, trunk, or head/neck will take part and be followed for up to 5 years.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: radiation therapy (hypofractionated or conventionally fractionated)
What this could lead to: If successful, this could show that a shorter course of radiation before surgery is just as safe and effective as the standard longer course, making treatment more convenient.
What could go wrong: This is a small, early-phase trial with only 30 participants, so results may not apply to everyone. The shorter radiation schedule might not kill as much tumor tissue or could cause different side effects.

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Conditions

The condition(s) this trial relates to.

sarcoma soft tissue sarcoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SOFT TISSUE SARCOMA

Contacts and locations

Locations

University of Wisconsin Hospital and Clinics

Madison, Wisconsin, 53705, United States

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