Can a radioactive antibody light up hidden tumors?

NCT ID NCT06537596

Recruiting now Diagnosis Sponsor: Telix Pharmaceuticals (Innovations) Pty Ltd Source: ClinicalTrials.gov ↗

First seen Aug 14, 2026 · Last updated Aug 14, 2026

Summary

This trial is testing an experimental imaging agent called 89Zr-olaratumab in people with soft tissue sarcoma or other solid tumors that express a protein called PDGFRα. The agent is a radioactive-labeled antibody designed to bind to PDGFRα and show up on PET scans, potentially revealing tumors and helping doctors see who might benefit from future targeted therapies. The study will assess the safety, tolerability, and imaging properties of this agent in about 50 participants.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: A radioactive imaging agent called 89Zr-olaratumab (89Zr-TLX300-CDx), which is an antibody that targets PDGFRα and carries a radioactive label for PET imaging.
What this could lead to: If successful, this could lead to a new imaging method to identify patients with PDGFRα-positive tumors who might benefit from targeted treatments.
What could go wrong: This is an early-phase trial with a small number of participants, so the imaging agent may not work as hoped or may cause unexpected side effects. Results are not yet known.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

sarcoma soft tissue sarcoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PDGFR ALPHA POSITIVE SOLID TUMOURS SOFT TISSUE SARCOMA

Contacts and locations

Locations

GenesisCare Murdoch 100 Murdoch Drive, Murdoch WA
NOT_YET_RECRUITING

Perth, Western Australia, 6150, Australia
Precision Molecular Imaging & Theranostics Pty Ltd
RECRUITING

Melbourne, Victoria, 3051, Australia
Princess Alexandra Hospital 199 Ipswich Road, Woolloongabba
RECRUITING

Brisbane, Queensland, 4102, Australia

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