University Of Wisconsin, Madison

This study tests whether a higher dose of the drug rifampicin can safely shorten tuberculosis treatment for children aged 3 months to 10 years. About 230 children with drug-susceptible TB will receive either the standard or a higher rifampicin dose, with treatment duration adjust…

This trial is testing whether adding a non-invasive ultrasound treatment called histotripsy to the immunotherapy drug durvalumab can strengthen the body's immune response against advanced intrahepatic cholangiocarcinoma, a type of bile duct cancer. Histotripsy uses focused sound …

This trial tests whether an experimental cell therapy called agenT-797 is safe for people receiving a stem cell transplant for blood cancers like leukemia or myelodysplastic syndrome. Participants get an infusion of agenT-797 about a week after their transplant. The main goal is …

This study tests whether combining a gentle nerve stimulation device worn on the ear (taVNS) with intensive arm therapy (CIMT) can help infants and toddlers (8–24 months) with perinatal brain injury improve movement in their weaker arm and hand. The therapy involves placing a mit…

This early-phase study tests a new way to do stem cell transplants for children and young adults with blood diseases. Doctors will take stem cells from a family member or closely matched unrelated donor, filter out certain immune cells using a special machine, and then give them …

This study tests whether combining two drugs—ASTX727 (a pill) and retifanlimab (given through a vein)—can shrink tumors and control advanced Merkel cell cancer in people whose disease has worsened after standard immunotherapy. About 31 adults with stage III or IV Merkel cell canc…

This pilot trial tests whether adding the drug alisertib to usual care can help people with advanced HR+/HER2+ breast cancer whose disease has become resistant to standard treatments. Researchers want to see if alisertib can block communication between hormone receptors and HER2,…

This study tests a text- and web-based tool called FamilyCHESS, designed to help people with moderate to severe opioid use disorder begin and stay on medication. The tool also involves a concerned family member or friend who provides support. Researchers will compare outcomes lik…

This study tests whether giving a special lung medicine (surfactant mixed with budesonide) to extremely premature babies who are still on a breathing machine at 7-14 days old is safe and can help prevent a serious lung condition called bronchopulmonary dysplasia. About 24 babies …

This study tests whether using an AI program to screen for diabetic eye disease during regular primary care visits can get more people to follow up with an eye specialist. It will include 4,000 adults with diabetes who have Medicaid and haven't had an eye exam in the past year. T…

This study investigates whether the drug letermovir can prevent cytomegalovirus (CMV) infection in adults who have received a kidney or liver transplant and have been previously exposed to CMV. Participants take one letermovir tablet daily for 84 days after transplant. The goal i…

This trial investigates whether the Healthy Minds Program, a mobile meditation training app, can reduce symptoms of depression in adults. About 1,500 participants with elevated depressive symptoms will complete a 4-week well-being program using the app. Researchers will measure c…

This study tests whether a 15-week well-being program can improve mood, reduce IBS symptoms, and boost quality of life in 150 adults with Irritable Bowel Syndrome. Participants will attend weekly one-hour sessions and be followed for up to 9 months. The goal is to see if focusing…

This study tests whether an extra virgin olive oil and water mouthwash can remove more leftover asthma medication from the mouth than plain water. The medication residue can cause problems like thrush or sleep apnea. Twenty healthy adults and adults with asthma will rinse with di…

This study tests a non-invasive technique called temporal interference stimulation to boost deep sleep in people with epilepsy. Researchers will compare 4 nights of real stimulation to 4 nights of sham (fake) stimulation in up to 16 patients. The goal is to see if better sleep ca…

This study looks at whether neuromuscular electrical stimulation (NMES) or vibration can help people who have had anterior cruciate ligament (ACL) reconstruction regain strength in their quadriceps (thigh muscle). The researchers want to see if these treatments reduce muscle inhi…

This Phase 2 trial will test whether taking a daily probiotic supplement for six months is safe and practical for people with early Alzheimer's or those at risk. Researchers will enroll 40 participants aged 60 and older. The study does not test whether the probiotic improves memo…

This study investigates whether tirzepatide, a medication used for weight loss, alters the way the body processes alcohol. Five adults aged 21-55 who take tirzepatide will consume a standard amount of alcohol, and researchers will measure blood alcohol levels, elimination rates, …

This study looks at how well the body uses choline from a new dairy ingredient compared to eggs in women aged 51-70 who have gone through menopause. Participants will drink a chocolate-flavored drink with either the dairy ingredient or whole egg powder. The goal is to see if dair…

This study tests whether fun, hands-on activities can help children aged 6 to 12 learn about ticks and how to avoid them. Kids will try activities like checking a mannequin for ticks and examining ticks on a bagel. They answer questions before and after to see if their understand…

This study explores whether a non-invasive technique called transcranial electrical stimulation with temporal interference (TES-TI) can temporarily change brain activity in healthy adults. Using MRI scans to personalize electrode placement, participants will receive different typ…

This study will compare two different devices that measure pressure and flow during swallowing in 25 healthy adults. The goal is to see how differences in the devices affect the measurements, which could help standardize the diagnosis of swallowing disorders (dysphagia). Particip…

This study will use a non-invasive ultrasound test called Transcranial Doppler to measure blood flow in the brains of 125 children in the Pediatric Intensive Care Unit. Researchers want to see how brain blood flow changes during critical illness and whether those patterns relate …

This study tests whether adding a health education and coaching program to Special Olympics activities helps adults with intellectual or developmental disabilities get better healthcare. About 1,040 athletes and their care partners will take part. The goal is to see if this extra…

This early-phase study looks at whether metabolic syndrome reduces brain blood flow more in women than in men. Researchers will use MRI scans and a drug called indomethacin to test this in 72 healthy adults and those with metabolic syndrome. The goal is to understand sex differen…

This study will test whether a special MRI scan (CSE-MRI) can accurately measure active bone marrow in men with metastatic prostate cancer, compared to a standard PET scan using a radioactive tracer (FLT). Fifteen participants will receive both scans at the same time using a comb…

This study will test a new type of CT scanner that may produce clearer images during image-guided procedures like biopsies or injections. Twenty adults scheduled for such procedures will receive one extra scan with the new device. Researchers will compare the image quality to sta…

This study will give 17 healthy adults three different versions of methamphetamine to see how the body processes each one. Meth comes in two mirror-image forms: S-meth, a strong stimulant used for ADHD, and R-meth, a weaker form found in some nasal sprays. Researchers will measur…

This study tests new MRI techniques to measure blood flow and tissue details in the liver. Researchers will scan 110 people, including healthy volunteers and those with chronic liver disease or fibrosis, to see if these scans can reliably detect liver damage. The goal is to devel…

This study compares two types of hamstring training—eccentric exercises like the Romanian deadlift and Nordic hamstring exercise versus sprint-specific drills—in healthy collegiate athletes. Over 10 weeks, researchers measure changes in muscle size, strength, power, and sprint pe…

This study will give psilocybin to 120 healthy adults with low well-being, either while awake or asleep, to see if the psychedelic experience is needed for mood benefits. Participants will also receive a placebo or clonidine for comparison. The goal is to understand how psilocybi…

This study tests new computer software for brain MRI scans that could make them faster, quieter, and produce clearer images. About 131 adults, including healthy volunteers and patients already scheduled for a brain MRI, will have one 60-minute scan. Researchers will compare stand…

This pilot study will test a wearable device called OptiGait that attaches to a shoe to measure walking speed and natural gait. Twenty healthy adults aged 65 and older will walk with and without the device to see if it accurately captures movement. The goal is to refine the devic…