Brain blood flow mystery: does metabolic syndrome hit women harder?

NCT ID NCT07218653

Not yet recruiting Knowledge-focused Sponsor: University of Wisconsin, Madison Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 28, 2026 · Updated 3 times

Summary

This early-phase study looks at whether metabolic syndrome reduces brain blood flow more in women than in men. Researchers will use MRI scans and a drug called indomethacin to test this in 72 healthy adults and those with metabolic syndrome. The goal is to understand sex differences in brain health, not to test a new treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Indomethacin
What this could lead to: If successful, this study could reveal why metabolic syndrome harms brain blood flow more in women, pointing toward sex-specific prevention or treatment strategies.
What could go wrong: This is a very early, small study (72 people) that measures biological signals, not health outcomes. Results may not lead to any direct treatment or apply to broader populations.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

abdominal obesity-metabolic syndrome metabolic syndrome X

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

METABOLIC SYNDROME

Contacts and locations

Locations

University of Wisconsin

Madison, Wisconsin, 53706, United States

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