University Of Wisconsin, Madison

This early-phase trial tests whether an experimental DNA vaccine (pTVG-HP) combined with the immunotherapy drug nivolumab and targeted radiation can help the immune system attack prostate cancer that has returned in a few spots. The study involves 14 men whose cancer has come bac…

This study tests whether combining a liver-directed chemotherapy (HEPZATO KIT) with an immunotherapy drug (Opdualag) is safe and effective for people with metastatic melanoma that has spread to the liver. About 15 participants who have not received prior systemic treatment will r…

This study compares three different quit-smoking programs for Black adults who smoke and want to quit. Participants will receive nicotine patches plus either standard quitline calls, more intensive counseling, or intensive counseling with financial incentives. The goal is to see …

This phase 2 trial is testing a combination of three chemotherapy drugs plus immunotherapy as a first treatment for advanced esophageal and gastric cancer. For patients with HER2-positive tumors, the targeted drug trastuzumab is also added. The study aims to see if this mix is mo…

This study tests a new radiation approach for early breast cancer that uses real-time MRI guidance to deliver just three high-dose sessions over one week, instead of the usual several weeks. The goal is to see if this shorter treatment is safe, preserves the breast's appearance, …

This early-phase trial is testing whether MRI-guided radiation therapy (SBRT) can be given at higher doses safely to people with cancer that has spread to the liver. Up to 32 participants will receive 5 radiation sessions over 1.5 to 2 weeks. The main goal is to find the highest …

This study tests whether the drug letermovir can prevent cytomegalovirus (CMV) from coming back in kidney or kidney/pancreas transplant patients who are at high risk. About 90 adults will take letermovir daily for 84 days and be followed for 6 months. The goal is to see if it red…

This study tests whether a nutrition program rooted in Oneida culture can reduce stroke risk factors and slow cognitive decline. About 85 tribal members aged 7 to 85 will receive health coaching, blood work, and imaging over one year. The goal is to improve blood pressure, BMI, a…

This study tests whether giving extra caffeine to very premature babies (born before 30 weeks) can improve kidney oxygen levels and reduce kidney injury. About 114 babies already receiving standard caffeine will get either an extra dose or a placebo. Researchers will monitor kidn…

This early-phase trial tests a radioactive drug called Y-NM600 in people with metastatic cancer who are already receiving immunotherapy (anti-PD-1 or anti-PD-L1). The goal is to see if adding Y-NM600 is safe and can make the immunotherapy work better. Up to 60 participants will b…

This study looks at whether adding support from a pharmacist or a community health worker helps adults with type 2 diabetes better manage their blood sugar. About 376 people will be placed into one of four groups: usual care, pharmacist help, community health worker help, or both…

This Phase 1 trial tests two drugs, sirolimus and everolimus, given once a week to healthy adults aged 55-89. The goal is to find the safest dose that might slow the aging process. Participants take the drug for 6 weeks and are monitored for side effects and drug levels in the bl…

This early-stage study tests whether a cream made from two HIV drugs (lopinavir/ritonavir) can be safely placed inside the anus to treat high-grade anal growths (AIN 2/3) in people living with HIV. About 21 participants will receive the cream for a few months and be followed for …

This study is testing whether a device that uses mild electrical pulses to stimulate arm muscles and the tongue can help stroke survivors regain arm movement. Researchers will enroll 288 participants, including stroke patients with arm weakness and healthy controls. The main goal…

This study tests whether a smartphone app called Connections can help people with alcohol-related liver disease stop drinking. About 298 participants from two medical centers will use the app along with their usual care, or just receive usual care alone. The goal is to see if the…

This study tests whether a combination of varenicline (a pill) and nicotine patches can help people who both smoke cigarettes and use e-cigarettes quit smoking. About 500 participants will take the medications and be followed for 12 months to see if they stay smoke-free. The goal…

This study tests whether switching from standard tacrolimus to a once-daily version (Envarsus XR) can reduce tremors in people who received a pancreas-kidney transplant. Twenty adults who have had a transplant and developed tremors will take the new drug and be monitored for chan…

This study is testing whether a combination of three drugs—liposomal irinotecan, TAS102, and bevacizumab—can help people with metastatic colorectal cancer that has not responded to prior treatments. About 50 adults with mismatch repair proficient tumors will receive the drugs in …

This study tests whether a virtual version of the Abecedarian Approach, an early childhood education program, can help children ages 0-5 who had a brain injury from lack of oxygen (HIE) or were born very prematurely. Researchers will enroll 225 families and measure parent satisfa…

This study is testing whether adding a DNA vaccine (pTVG-AR) and immune checkpoint blockers (nivolumab or cemiplimab) to standard hormone therapy can improve outcomes for men with newly diagnosed, high-risk prostate cancer. About 60 participants will receive different combination…

This study tests whether community health workers (CHWs) using a mobile app can manage high blood pressure as effectively as doctors. 460 adults with hypertension in rural Guatemala will be randomly assigned to either CHW-led care with app support and remote doctor supervision, o…

This study compares a shorter, more intense course of radiation (5 sessions) to the standard longer course (25 sessions) given before surgery for soft tissue sarcoma. The goal is to see if the shorter schedule is safe and effective at killing tumor cells. Thirty adults with sarco…

This early-phase trial tests a new type of stem cell transplant for children with blood cancers or solid tumors that have relapsed or not responded to standard treatment. Doctors use a half-matched donor's stem cells, specially filtered to remove certain immune cells, and give th…

This study tests a new type of PET/MRI scan to see if it can better tell the difference between a growing brain tumor and changes caused by radiation or immunotherapy. About 30 adults with brain metastases who have had radiation in the last 2 years will get a single 3-hour scan s…

This study tests a new imaging method called FAPI PET/MRI to see if it can find and track prostate cancer that has spread better than current scans. About 30 adults with prostate cancer will get two research scans. The goal is to improve how doctors detect and monitor the disease…

This study tests whether a special PET/MRI scan using a radioactive tracer (18F-FFNP) can detect early signs that hormone therapy is working in breast cancer. About 53 postmenopausal women with a certain type of breast cancer will get the scan before and after taking anastrozole …

This study is testing whether a new type of MRI (4D flow MRI) can detect dangerous veins in the stomach and esophagus of people with cirrhosis, which can cause fatal bleeding. Currently, doctors use a camera down the throat (endoscopy) to check, but that is invasive and often unn…

This study is testing a new automated MRI method to see if it can take clearer pictures of the liver. It will include up to 200 adults (and some children age 7+) who are healthy, have known or suspected liver disease, or have iron overload. Participants will have one MRI scan, an…

This study tests whether a special PET scan (FAPI PET) can better detect active scarring in the lungs of people with fibrotic lung disease. About 50 adults with idiopathic pulmonary fibrosis or fibrotic hypersensitivity pneumonitis will get up to 4 PET/MRI scans. The goal is to i…

This study looks at whether a computer program called pediatric eCART can help doctors quickly identify children in the hospital who are at high risk of serious problems like cardiac arrest or sepsis. Researchers will compare data from before and after the tool was put into use, …

This study tests a new type of MRI scan that tries to reduce blurring caused by breathing, heartbeats, and other movements in the abdomen. Researchers will compare the new method to standard scans in 80 healthy volunteers and patients with liver metastases. The goal is to see if …

This study is testing whether a combined PET and MRI scan, using a radioactive tracer called FDG, can accurately locate the source of chronic pain that persists after joint surgery. Researchers will scan 128 people with and without pain to see if the scan can spot where pain is c…

This study tests whether a smartphone app called the Tick App can help people avoid tick bites and the diseases they carry. Up to 3,500 participants across the U.S. will use the app to log daily activities and receive educational tips on prevention, like doing tick checks and sho…

This study looks at whether a computer program that automatically checks older adults (65+) in the emergency room for fall risk can help prevent future falls. The tool alerts doctors and lets them refer high-risk patients to a special falls clinic. Researchers will compare medica…

This study is testing a smartphone-based system called STAR that uses machine learning to predict when someone with alcohol use disorder might relapse. Participants will complete surveys and use the system to receive personalized recovery support messages. The goal is to see if t…

This early-phase trial tests whether injecting mesenchymal stromal cells (MSCs) into the salivary glands is safe and can ease dry mouth in people with graft-versus-host disease or Sjogren's disease. Up to 36 adults will receive one injection and be monitored for pain and side eff…

This study tests whether nicotine pouches or mini lozenges can help people replace cigarettes. 300 adult smokers who aren't ready to quit will use one of these products or no product for a week, then try to stop smoking for 3 weeks. Researchers will track how many cigarettes they…

This study is testing a very short course of radiation therapy for women with early-stage breast cancer. Instead of weeks of treatment, participants receive whole breast radiation with a targeted boost over just 5 days. Researchers will track how the breast looks and feels, and h…

This study compares four different ureteral stents (small tubes placed in the ureter) to find which one causes the fewest symptoms after laser surgery for kidney stones. About 272 adults who need a stent after stone removal will be randomly assigned to one of four stent types. Re…

This study tests whether special speech strategies, like pointing to letters or using rhythm, can help children with cerebral palsy speak more clearly. About 100 kids ages 7 to 17 will practice these techniques with a speech therapist and then have their speech recorded. The goal…

This pilot study tests whether Tai Chi or exercise can reduce attention problems in college students with ADHD. Researchers will enroll 145 students and measure changes in inattention symptoms. The goal is to see if these non-drug approaches are feasible and worth studying furthe…

This study tests whether an ambient artificial intelligence tool can reduce the time nurses spend on electronic health record documentation. About 250 nurses and nursing assistants in hospital units will use the AI to automatically draft notes, and researchers will measure change…

This study tests whether using a smartphone meditation app (Healthy Minds Program) for 8 weeks can reduce depression symptoms in teens aged 14-19. 200 participants with elevated depression scores will be randomly assigned to either the meditation app or a hydration tracking app. …

This study tests whether a 4-week mindfulness app called the Healthy Minds Program is practical and well-liked by adults who have had suicidal thoughts in the past month. Fifty participants will use the app and complete questionnaires. The goal is to see if the app is easy to use…

This study tests whether using a mindfulness app for 15 minutes a day over two weeks, plus a storytelling workshop, can improve wellbeing in STEM graduate students at the University of Wisconsin-Madison. Researchers will measure changes in depression, anxiety, stress, sleep, and …

This study tests whether adding tranexamic acid (TXA) to standard hyaluronic acid facial filler can reduce bruising, swelling, and pain. Forty adults will receive TXA on one side of their face and a placebo on the other, then report their bruising intensity and duration. The goal…

This study tests whether a nerve block given before surgery (TAP block) works as well as numbing medicine injected into the wound by the surgeon for controlling pain after gynecologic cancer surgery. About 80 women having surgery through a vertical belly cut will take part. The g…

This study is testing whether adding small amounts of human coaching, email reminders, or text messages to a meditation app can help people with depression and anxiety feel better. About 688 adults with elevated symptoms will use the Healthy Minds Program app for four weeks. Rese…

This study is testing a self-help workbook designed to help people in prison manage anxiety and depression. About 96 adults with moderate to severe symptoms will use the workbook for 8 weeks and be followed for 13 weeks total. The goal is to see if the workbook is practical, acce…

This study looks at whether a 16-week resistance exercise program can reduce symptoms of major depression in 200 adults. Participants will do either high or low dose strength training. Researchers will measure changes in mood, thinking, and blood flow in the brain to see if exerc…

This study tests whether listening to your own choice of music during awake hand surgery lowers anxiety more than standardized relaxation music. 170 adults having hand surgery with only local anesthetic will be randomly assigned to one of the two music groups. Researchers will me…

This study tests whether an 8-week mindfulness training program can reduce anxiety and depression in adults returning to the community after incarceration. Sixty participants will be randomly assigned to either the mindfulness program or a waitlist control group. The goal is to s…

This study looks at whether doing moderate aerobic exercise right before a therapy session (CBT) helps people with major depression get more out of their treatment. One hundred adults will be randomly assigned to either exercise or rest quietly before each of 8 weekly therapy ses…

This study tests whether cannabidiol (CBD), a compound from cannabis, can reduce urinary incontinence in people with recent spinal cord injury. Twenty adults with at least two leaks per day will take a purified CBD drug (Epidiolex) twice daily for 90 days. The main goal is to see…

This study tests whether applying Mastisol, a liquid adhesive, during clubfoot casting helps babies with clubfeet get better faster and with fewer problems. Researchers will compare outcomes like how many weeks of casting are needed and how often complications like sores or swell…

This study tests whether Cognitive Processing Therapy (CPT), a talk therapy used in the community, can reduce PTSD symptoms and rule-breaking in incarcerated men and women. About 900 participants from 6 prisons will attend 8–12 therapy sessions over up to 24 weeks. Researchers wi…

This study tests whether gentle electrical stimulation to the brain during a short nap can improve the quality of sleep and reduce mental tiredness. Twenty-five adults with non-restorative sleep will take two naps while wearing a special cap that records brain activity and delive…

This study tests whether personalizing the Healthy Minds Program app can improve well-being in people with mild depression. About 1500 participants will use the app for 4 weeks, with some getting personalized features like tailored module order or supportive text messages. The go…

This study tests whether taking celecoxib (an anti-inflammatory) plus Tylenol can reduce the need for stronger opioid pain pills after a parotidectomy (salivary gland surgery). About 84 adults will receive either celecoxib or a placebo, along with Tylenol, and can take opioids if…

This early-phase study is testing whether adding two doses of psilocybin (the active ingredient in magic mushrooms) to standard buprenorphine/naloxone treatment is safe for adults with opioid use disorder. Ten participants will receive psilocybin along with counseling, while rese…

This study tests a new depression treatment that combines cognitive behavioral therapy with faith-based principles, delivered by therapists and pastors in church settings. It aims to reduce depressive symptoms in African American adults. The trial will enroll 50 participants and …

This study is testing whether a special PET/CT scan that looks for a protein called PSMA can help predict resistance to anti-androgen therapy in people with a specific type of metastatic breast cancer (HER2-negative, AR-positive). About 13 participants will receive an injection o…

This study is testing a special type of ultrasound, called backscatter quantitative ultrasound (bQUS), to see if it can be used to check on a baby's lungs when the mother is 36 weeks pregnant. The study will involve 16 pregnant women who will have a single 30-minute ultrasound. T…

This study tests whether a gentle brain stimulation technique called transcranial electrical stimulation (TES) can help people quickly reach a meditative state—normally achieved only after years of training. 48 healthy adults who have never meditated will wear an EEG cap and rece…

This study gives paclitaxel (Taxol) to 50 women with breast cancer before surgery to see if tumors with high chromosomal instability respond better. Researchers will measure tumor shrinkage and drug levels in the tumor. The goal is to find biomarkers that predict who benefits mos…

This study tests a new CT scan method that measures blood flow in the lungs without using contrast dye. About 30 adults will get a 30-minute chest CT to see if the new method gives as much information as the standard scan. The goal is to find a safer way to check lung health.

This study tests whether a mild, non-invasive electrical stimulation called TI-TES can temporarily change brain activity during sleep, specifically sleep spindles. Up to 24 healthy adults will each have three overnight visits. Researchers will compare brain activity during real s…

This study aims to adapt a program called Staying Healthy After Childbirth (STAC) for Black women and birthing persons. Researchers will work with community organizations and advisory boards to identify barriers and facilitators to implementation. The goal is to make the program …

This study looks at whether a live phone call from a navigator can help people who lost their Medicaid coverage due to paperwork issues get it back. Researchers will compare live calls to pre-recorded messages in 230,000 people in Wisconsin. The goal is to find better ways to red…

This early-stage trial is testing whether bicalutamide, a drug typically used for prostate cancer, can change a protein linked to bladder cancer growth. Researchers will compare men with non-muscle invasive bladder cancer who take the drug to those who don't. The goal is to see i…

This study looks at how starting gender-affirming hormone therapy (GAHT) changes the brain over the first few months. Researchers will measure blood flow, brain structure, and thinking skills like memory and attention in 72 adults before and 4-6 months after starting GAHT. The go…

This study looks at whether airway inflammation from asthma can cause brain inflammation and affect mood. Over six visits, 50 adults with mild asthma will complete questionnaires, computer tasks, allergy tests, breathing tests, blood draws, and brain scans. The goal is to underst…

This study looks at how asthma-related inflammation in the lungs might affect the brain and contribute to depression and anxiety. Researchers will compare brain scans, blood tests, and breathing tests between 100 adults with asthma and healthy volunteers. The goal is to understan…

This study will enroll 1,600 healthy adults (ages 18-30 or 60-85) to see if doing computer-based cognitive tasks—like remembering sequences or spotting patterns—can improve memory, attention, and thinking skills. Participants will complete up to 15 hours of tasks over 4-8 weeks. …

This study is for people with rare, undiagnosed genetic conditions that standard tests couldn't identify. Researchers will use whole genome sequencing of the patient and their parents, plus advanced lab work, to find new disease genes and provide a diagnosis. The goal is to give …

This study explores whether a non-invasive brain stimulation technique can help people quickly achieve a deep meditative state, normally only reached after years of training. About 22 healthy adults who already meditate will wear an EEG cap and receive brain stimulation while per…

This study tests if a new approach called 'Exercise Forecasting' can help people with prolonged-sitting jobs become more active. Twenty participants will wear a smartwatch, answer two questions daily, and receive customized motivational messages. Researchers want to see if these …

This study looks at how common swallowing and mouth health problems are in older adults who come to the emergency department. Researchers will test swallowing, oral health, and breathing, and ask questions to see how these issues connect to other health conditions. The goal is to…

This study looks at whether simple, non-invasive eye tests can help predict brain development in newborns with hypoxic-ischemic encephalopathy (HIE), a type of brain injury caused by lack of oxygen. Researchers will measure eye function using visual evoked potential (VEP) and ele…

This study looks at oxygen levels in the kidneys of premature babies born before 32 weeks who have a heart condition called patent ductus arteriosus (PDA). Researchers want to see how kidney oxygen relates to the severity of the heart condition and whether it can predict kidney i…

This study aims to see if short videos featuring Latinx patients and doctors can encourage more Latinx people with diabetes to get regular eye exams. Researchers will survey about 1,500 people and hold small group discussions to measure changes in eye health knowledge and trust i…

This study aims to create a database of vocal health in people aged 4 to 65 with no voice problems, and compare them to children with voice disorders. Participants will perform simple voice tasks into a device that measures airflow and pressure. The goal is to find the best way t…

This study is testing a new, non-invasive tool called fetal magnetocardiography (fMCG) to better monitor the heart rhythms of babies in the womb. Current methods like ultrasound have limits, and fMCG may provide clearer information. The study will include up to 450 pregnant women…

This study tests whether mild electrical stimulation of a nerve in the forehead can improve blood flow and waste clearance in the brain. Researchers will measure changes in brain fluid flow using MRI and light-based imaging in 55 healthy adults and people with mild traumatic brai…

This study looks at ways to help teenagers and young adults with congenital heart disease (CHD) switch from pediatric to adult doctors. Researchers will compare education led by nurses versus doctors to see which works better. About 450 people with CHD, their supporters, and prov…

This study looks at how neoadjuvant chemotherapy (given before surgery) affects thinking skills like memory and attention in people with advanced ovarian cancer. Researchers will test 18 participants using questionnaires and cognitive tests over about 10 months. The goal is to be…

This study is testing a new AI tool that creates patient-friendly summaries of radiology reports for people with cancer. The goal is to see if these easy-to-read summaries help patients better understand their scan results and reduce the number of questions doctors receive. About…

This study compares two new ultrawide field cameras (Clarus and Optos) to the standard Spectralis camera for taking pictures of the back of the eye in people with inherited retinal diseases. Fifty adults will have their eyes dilated and photographed with all three cameras. The go…

This study tests a new type of brain stimulation called temporal interference to see if it can temporarily change how different brain regions communicate. Forty healthy adults aged 18-50 will receive stimulation during sleep and wakefulness, and have their brain activity measured…

This study aims to see if a custom-made tumor culture system can predict how oral cavity cancer responds to the immunotherapy drug pembrolizumab before surgery. Twenty participants will provide a biopsy, receive pembrolizumab as standard care, and then have their tumor analyzed. …

This study tests a new computer program that reads brain activity to tell if someone is conscious or not. Thirty healthy adults will have their brains scanned while awake and asleep. The goal is to see if a simpler, portable version of the test can accurately detect consciousness…

This pilot study is looking for better ways to see if endocrine therapy is working in people with a type of breast cancer called metastatic invasive lobular carcinoma. Researchers will use a special PET scan and blood tests to measure changes in estrogen signaling after 4 weeks o…

This study enrolls up to 10,000 adults with cancer to see how a special team of experts (a molecular tumor board) uses genetic testing to recommend personalized treatments. Researchers will track whether doctors follow these recommendations and if patients benefit. The goal is to…

This study looks at how the brain processes and controls speech in healthy adults. Researchers want to understand how people notice their own speech mistakes and learn new sounds. About 117 English-speaking adults with normal hearing and no neurological conditions will take part.…

This study tests whether psilocybin, the active ingredient in magic mushrooms, can improve emotional wellbeing by promoting brain plasticity. Sixty adults with mild emotional decline will receive different doses of psilocybin, sometimes combined with a drug that causes temporary …

This study explores whether combining a single dose of psilocybin (the active ingredient in magic mushrooms) with a gentle ear stimulation device can help people remember the insights they gain during the psychedelic experience for longer. Researchers will enroll 108 healthy adul…

This study tests a new imaging method called qDSA that measures blood flow in real time during liver embolization, a procedure that blocks blood supply to tumors. Up to 20 participants will have qDSA and ultrasound images taken before, during, and after the procedure. The goal is…

This study is testing a new web-based tool called the Worldwide Yearly Screening for Hypospadias (WYSH) Application. About 20 males who have had hypospadias repair surgery will use the app to answer questions about possible complications. The goal is to see if the app is easy to …

This study is collecting eye images from 1,000 adults aged 50 and older, with or without age-related macular degeneration (AMD), from up to 25 countries. The goal is to create a high-quality, diverse dataset that researchers can use to train artificial intelligence (AI) to screen…

This study tests a communication tool called TrialTalk™ in cancer clinics. The goal is to see if it helps doctors and patients talk more clearly about treatment options. About 30 patients and their doctors will fill out questionnaires before and after a regular visit. The study f…

This study looks at whether young adults with metabolic syndrome have poorer artery function in the neck, and if a 30-minute bike ride can temporarily improve it. Researchers will compare 48 participants with and without metabolic syndrome. The goal is to understand sex differenc…

This study tests a new process to help older adults (age 80+) get a comprehensive geriatric assessment (CGA) before major surgery. The goal is to see if a special implementation package can increase the number of patients referred and assessed. Researchers will compare results to…

This study looks at how speech changes over time in people at higher risk for Alzheimer's disease. Researchers will have 165 participants complete speech tasks and surveys on an iPad at home for 3 years. The goal is to see if remote speech tracking is a useful and easy way to mon…

This study looks at whether a program with a nurse case manager can help people leaving prison visit a doctor or clinic instead of the emergency room. About 488 adults with a history of substance use and a chronic health condition will take part. Some will get extra support from …

This study tests whether a newer, MRI-guided radiation method (MRgART) is gentler on the heart than standard radiation (LINAC) for people with lung, esophageal, or other chest cancers. About 60 adults will receive radiation and have their heart function checked via MRI and blood …

This study aims to identify different types of familial hypercholesterolemia (FH) in infants and newborns. Expectant parents with FH will provide a cheek swab for genetic testing, and their babies will have 5 blood samples collected over 2 years. The goal is to improve early dete…

This study looks at how brain blood flow changes when healthy adults aged 55-69 breathe differently or shift posture, using MRI scans. Participants will also receive a single dose of prazosin or a placebo to see how it affects blood flow. The goal is to better understand the brai…

This study aims to find out why hearing aids work well in quiet labs but not in noisy real-world settings. About 45 adults with hearing loss who already use hearing aids will listen to different sound scenarios and rate their experience. The goal is to improve hearing aid perform…

This study is for people aged 18-45 who still have hip pain after hip arthroscopy. Researchers will use a special PET/MRI scan to look for problem spots in the hip. The goal is to understand why some people have ongoing pain while others get better. Participants will have one sca…

This study looks at how bone density in the thigh bone changes after knee replacement surgery. Researchers will compare two ways of fixing the new joint: with cement or without. They will also compare surgery done by hand versus with a robot. 100 people aged 55 and older will tak…

This study looks at children ages 5 to 15 who test positive for strep throat to understand why some become carriers—meaning they have the bacteria but no symptoms. Researchers will collect throat samples and analyze gene activity to compare carriers with those who have active inf…

This study uses special PET/CT scans to see how advanced prostate cancer becomes resistant to newer hormone therapies like enzalutamide or abiraterone. Researchers will track changes in cancer lesions over time in 25 participants. The goal is to better understand resistance patte…

This study looks at how babies' brains develop after an injury around birth. Researchers will use fun games and brain wave tests (EEG) to see if they can predict which children might have trouble with thinking and memory later. About 100 babies, both healthy and those with brain …

This study looks at how to get more medications for opioid use disorder (MOUD) to people in prison. Researchers will work with 120 prison sites to see which methods work best for increasing access to these life-saving drugs. The goal is to improve health and reduce harm for incar…

This research study follows the cognitive development of infants, both healthy and those who had a brain injury around birth. Researchers will use online games and parent questionnaires to measure attention, thinking, and language skills. The goal is to better understand how thes…

This study aims to see if it's possible to enroll and keep children with PANS or PANDAS in a year-long observation. Researchers will track symptoms and outcomes to better understand how these conditions develop and change over time. About 30 children aged 3 to 17 will participate…

This study looks at whether having a special hospital team that gets to know frequently hospitalized patients can improve their care. About 1200 adults who have been hospitalized two or more times in the past year will take part. Researchers will compare those assigned to the ded…

This study looks at 24 people with advanced melanoma who are starting immunotherapy. Researchers will do a special PET/CT scan and a blood test for tumor DNA about 3-4 weeks after the first treatment. The goal is to see if these early tests can predict whether the immunotherapy i…

This study collects tissue samples from women with and without preeclampsia during C-sections to examine blood vessel function. Researchers focus on a protein called AT2R, which may play a role in the condition. The goal is to better understand how preeclampsia affects blood vess…

This study follows 660 adults with CADASIL, a genetic condition that causes strokes and dementia, for up to 5 years. Researchers will use brain scans, memory tests, and blood samples to track how the disease progresses from its earliest stages. The goal is to identify factors tha…

This study looks at how sleep and emotion processing are linked in teenagers with post-traumatic stress disorder (PTSD). Researchers will use a special sleep device to try to improve sleep quality and see if it helps with next-day mood. 180 teens aged 15-18 will take part, comple…

This study follows 65 infants who had a stroke around birth, tracking their brain development and motor skills over two years. Researchers use MRI scans, brain stimulation, and movement tests to find markers of recovery. The goal is to understand how the brain heals, which could …

This pilot study is testing whether local anesthesia (with sedation) works as well as general anesthesia for inguinal hernia repair in veterans aged 60 and older. The goal is to gather data to plan a larger, more definitive trial. About 80 participants will be followed for 6 mont…

This study follows 600 adults who vape nicotine regularly to see how it affects their heart and lungs over time. Participants undergo blood tests, lung scans, and heart stress tests at multiple visits. The goal is to understand the long-term health risks of e-cigarette use, which…

This pilot study tests whether a special PET scan (FES-PET/CT) can help doctors find the best dose of tamoxifen for people with metastatic breast cancer that has an ESR1 mutation. These mutations can make standard tamoxifen doses less effective. The study will enroll 12 participa…

This study looks at whether a simple ultrasound can do the same job as an MRI for measuring how well the bladder works in people with lower urinary tract symptoms (like trouble urinating). Researchers will compare results from both scans in 80 adults. If ultrasound works, it coul…

This study looks at how the brain's blood vessels respond when blood flow drops suddenly. Healthy adults aged 20-40 will undergo MRI scans while doing breathing exercises and a simulated postural change. Some will receive a single dose of prazosin, a blood pressure drug, to see h…

This study tests whether giving parents of hospitalized children access to their child's medical notes on a bedside tablet helps them get more involved and spot safety issues. About 630 families will be randomly assigned to either use the Bedside Notes tool or receive usual care.…

This study looks at how brain activity before major surgery might predict delirium afterward. Researchers will monitor 468 older adults (ages 60+) using EEG and blood tests. The goal is to find early warning signs and better understand why some people get confused after surgery.

This research study looks at how practicing certain visual tasks can improve cognitive abilities like attention and reading. Healthy adults aged 18-30 and 60-85 will complete computer-based training over several weeks. The goal is to understand how training changes the way we see…

This study looks at how cancer cells in chronic lymphocytic leukemia (CLL) use nutrients like sugar and glutamine. Researchers will give participants special labeled nutrients and then measure how the cells process them. The goal is to understand cancer cell metabolism better, no…

This study tests a new training program called 'Better Conversations' that helps surgeons explain treatment options more clearly. Researchers will train some surgeons in person and others using an automated system, then compare how well patients understand their choices. The goal…

This study looks at how genes and brain scans can help predict recovery from aphasia, a language disorder that often follows a stroke. Researchers will enroll 90 adults aged 40-90 who have had a stroke and have trouble speaking or understanding language. By understanding these bi…

This study creates a list of people interested in CADASIL research. If you have CADASIL, are at risk, or have a loved one with the condition, you can join. Researchers will then invite you to future studies, making it easier to find volunteers and speed up discoveries about this …