Brain zapping after magic mushrooms may lock in Life-Changing insights

NCT ID NCT05866471

Recruiting now Knowledge-focused Sponsor: University of Wisconsin, Madison Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jul 30, 2026 · Updated 3 times

Summary

This study explores whether combining a single dose of psilocybin (the active ingredient in magic mushrooms) with a gentle ear stimulation device can help people remember the insights they gain during the psychedelic experience for longer. Researchers will enroll 108 healthy adults with mild emotional distress and use brain scans and memory questionnaires to measure effects. The goal is to understand how to enhance the lasting benefits of psychedelic experiences.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: psilocybin
What this could lead to: If it works, this could point toward a way to make insights from psychedelic experiences last longer, potentially improving mental well-being.
What could go wrong: This is an early Phase 1 study in healthy volunteers, so it's not testing a treatment for any disease. The effects may be small or not last, and psilocybin can cause temporary psychological distress.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEALTHY PSYCHEDELIC EXPERIENCES VAGUS NERVE STIMULATION

Contacts and locations

Locations

University of Wisconsin - Madison
RECRUITING

Madison, Wisconsin, 53715, United States

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