Zapping the brain during sleep may tweak rhythms tied to schizophrenia
NCT ID NCT07680114
First seen Jul 02, 2026 · Last updated Jul 02, 2026
Summary
This study tests whether a non-invasive electrical brain stimulation technique called TES-TI can temporarily alter sleep spindles—brain rhythms often reduced in schizophrenia. Researchers will apply the stimulation during sleep in 20 people (half with schizophrenia spectrum disorders, half healthy controls) over two overnight lab visits. The goal is to see if targeting the thalamus can boost spindle activity, which may help understand the brain's role in the condition.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
transcranial electrical stimulation with temporal interference (TES-TI)
What this could lead to
If this works, it could point toward a new way to improve sleep-related brain activity in people with schizophrenia, potentially aiding symptom management.
What could go wrong
This is a very small, early feasibility study with only 20 participants. It tests a temporary effect during one night, so any changes may not last or translate into real-world benefits.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- GABA Function in Psychosis Study (NCT04004416)
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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University of Wisconsin
Madison, Wisconsin, 53719, United States