Can an Anti-Seizure drug quiet the brain and sharpen thinking in schizophrenia?

This trial tests whether levetiracetam, a drug used for seizures, can reduce overactivity in the hippocampus—a brain area linked to memory—and improve cognitive function in people with schizophrenia or schizoaffective disorder. Participants receive either levetiracetam or a placebo, and researchers measure changes in brain activity using fMRI and assess thinking skills with a standard test. The goal is to see if calming this brain region can help with the memory and thinking problems that often accompany schizophrenia.