Va Office Of Research And Development

This study investigates whether oxygen and the drug acetazolamide can help stabilize breathing during sleep in people who take prescription opioids and have sleep apnea. Researchers will measure breathing patterns and sleep quality in 150 veterans. The goal is to find new ways to…

This study tests whether a combination of a special diet, omega-3 and L-carnitine supplements, and resistance exercise can improve muscle quality and reduce fat in veterans with HIV and obesity. The trial will enroll 70 participants and measure changes in muscle density, metaboli…

This study tests whether a virtual weight management program that includes a support person (like a family member or friend) helps Veterans with obesity lose weight. 320 Veterans and their partners will participate in 8 virtual sessions over 14 weeks. The main goal is to see if t…

This study is testing a telemedicine program called Vet-CALD for Veterans with advanced liver disease. The program pairs patients with a nurse care counselor who helps them understand their illness, set personal health goals, and coordinate care between their regular doctors and …

This study explores whether a robotic device that amplifies a person's own walking movements can help improve balance in people who have had a stroke. Participants with chronic stroke (more than 6 months ago) will do two treadmill walking sessions—one in a normal environment and …

This study will compare two widely used blood thinners, apixaban (Eliquis) and rivaroxaban (Xarelto), in about 10,000 veterans with atrial fibrillation (an irregular heartbeat). The goal is to see which drug better prevents strokes and major bleeding. Participants must already be…

This study tests a computer-based training called Approach Avoidance Training (AAT) for veterans with alcohol use disorder. Participants use a joystick to push away alcohol-related images, aiming to retrain their automatic urges. The trial will enroll 176 veterans and measure cha…

This study looks at whether using a positive airway pressure (PAP) machine at night can improve thinking, sleepiness, and quality of life in older veterans (age 60+) who have both COPD and obstructive sleep apnea—a combination called Overlap Syndrome. About 668 participants will …

This study tests a sensory neuroprosthesis—implanted electrodes that send small electrical currents to remaining nerves—to restore sensation of a missing lower limb in people with diabetic peripheral neuropathy and amputation. The 15 participants will also have the option of musc…

This study tests a tailored hand hygiene bundle and non-alcohol hand sanitizer for VA mental health units, where sinks and alcohol rubs are limited for safety. Researchers will observe hand hygiene compliance among 4 VA mental health workers. The goal is to reduce infection trans…

This study looks at how obesity affects recovery from post-COVID conditions in older Veterans. Researchers will test if a weight loss program with diet and exercise can reduce inflammation and improve physical function and quality of life. The study involves 150 Veterans, some wi…

This study tests whether MDMA-assisted therapy can help veterans with both PTSD and alcohol use disorder. Eighty veterans will receive either a full dose of MDMA or a low-dose placebo during three therapy sessions. Researchers will measure changes in PTSD symptoms and drinking ha…

This study looks at whether a 15-week lifestyle program combining weight management and exercise can improve walking and daily function in obese veterans who had a stroke at least six months ago. Researchers will measure changes in walking distance, daily steps, and overall recov…

This study tests whether a dietary fiber supplement called resistant potato starch can improve gut health and quality of life in veterans with Gulf War Illness (GWI). About 52 veterans aged 50-85 with GWI and gut symptoms will take the supplement daily. Researchers will measure c…

This study looks at whether adding a six-session group recovery program and a 90-day home telehealth program can help veterans with substance use disorders drink less and use fewer drugs. About 195 veterans from a VA psychiatric unit will be randomly assigned to one of three grou…

This study tests whether a telehealth pain management program can help veterans who have surgery outside VA hospitals avoid becoming long-term opioid users. About 400 veterans having orthopedic surgery will either receive the program or standard care. The goal is to see if the pr…

This study tests whether colchicine, an inexpensive anti-inflammatory drug used for gout, can prevent heart attacks, strokes, and death in heart disease patients undergoing major surgery. Researchers will give the drug to 700 veterans before and after their operation. The goal is…

This study tests whether a virtual group exercise program combined with health education can lower fall risk and increase physical activity in older veterans who have both obesity and signs of muscle loss (sarcopenia). About 50 veterans aged 55 and older will take part. The goal …

This study is testing whether empagliflozin (Jardiance), a drug used for diabetes and chronic kidney disease, is safe for people who have received a kidney transplant. Researchers will enroll 264 veterans and monitor for side effects like infections and changes in kidney function…

This study tests whether adding a drug that blocks a cancer cell survival process called autophagy can make standard TACE therapy more effective for liver cancer. TACE cuts off the tumor's blood supply, but cancer cells often survive by eating their own parts for energy. The tria…

This study tests whether genetic testing can help veterans at high risk for heart disease start and stick with statin medications. About 410 veterans aged 40-75 with diabetes or heart disease who are not currently taking statins will receive either a genetic report on their stati…

This study for veterans with prostate cancer that has returned in a few spots (oligorecurrence) compares standard systemic therapy alone versus standard therapy plus PET-directed local treatment using surgery or radiation. The goal is to see if adding local therapy delays the can…

This study tests whether a 16-week exercise program can help older adults with chronic kidney disease regain muscle and strength after being in the hospital. Researchers will use ultrasound and strength tests to measure changes. The goal is to find better ways to help patients re…

This study tests whether adding digital coaching to home-based cardiac rehabilitation helps veterans complete more rehab sessions and improve their heart health. 150 veterans with heart disease will be randomly assigned to standard home rehab or home rehab plus a private social m…

This phase 2 trial tests whether adding the targeted drug capivasertib to standard hormone therapy can shrink or destroy high-risk prostate tumors before surgery. The study enrolls 30 men with PTEN-loss prostate cancer, a marker of resistance to standard treatment. Participants r…

This study tests a program called HARPP that combines proven treatments for PTSD and weight management into a single therapy for veterans. The goal is to see if this integrated approach leads to greater weight loss and PTSD symptom reduction compared to standard care. The study w…

This study tests a new combination of two oral drugs, Stenoparib and Temozolomide, in people whose small cell lung cancer has returned after initial treatment. The trial uses a blood test (biomarker) to see who might benefit most from the combo, comparing it to the standard drug …

This study tests whether a program of weekly surveys can help veterans with inflammatory bowel disease (IBD) feel better and avoid flare-ups. About 250 veterans at four VA hospitals will either get the usual care or also complete short weekly check-ins for 12 months. The goal is …

This study tests a surgically implanted device that connects nerves and muscles in an amputated arm to a wireless prosthetic hand. The goal is to let users move the hand intuitively and feel what it touches. The trial will enroll 15 adults with upper-limb amputations to check saf…

This study is for veterans with stage 3 non-small cell lung cancer that cannot be removed by surgery. It combines chemotherapy, immunotherapy, and radiation to see if this approach helps control the cancer longer and is safe. About 25 participants will receive the treatment, and …

This study tests whether a 6-month online stationary cycling program can improve vision, physical function, and thinking skills in veterans aged 65-89 with intermediate age-related macular degeneration (AMD). Researchers will measure contrast sensitivity, night vision, and visual…

This study tests whether a low dose of the thyroid hormone Synthroid can help treat nonalcoholic steatohepatitis (NASH), a serious liver condition common in Veterans. About 128 overweight or obese Veterans with NASH will take either Synthroid or a placebo daily for one year. The …

This study looks at two standard treatments for early-stage lung cancer: surgery and a precise type of radiation called stereotactic radiotherapy. About 670 veterans with stage I non-small cell lung cancer will take part. The goal is to see which treatment leads to longer surviva…

This study tests whether a dietary fiber supplement (soluble corn fiber) can help older men absorb more calcium and improve bone health. Thirty male veterans aged 60 and older will take the fiber supplement and then have their calcium absorption measured. The goal is to see if ch…

This study looks at 136 Veterans recently hospitalized for suicide risk. Half will get a longer psychotherapy, half a shorter one, to see which works better at reducing suicidal thoughts and actions. Researchers will also use MRI brain scans to track changes over a year and see i…

This study tests whether exercising more frequently (5 times a week for one month, then three weeks off) is better than exercising once a week with no breaks for people with moderate Parkinson's disease. The exercise is a partnered dance program based on Argentine tango, adapted …

This study tests a combination of two drugs—tulmimetostat (an EZH2 inhibitor) and pembrolizumab (an immunotherapy)—in 66 veterans with advanced non-small cell lung cancer that has worsened after initial treatment. The goal is to see if the combination can shrink tumors or slow ca…

This study tests whether empagliflozin (Jardiance), a drug used for diabetes, can protect the kidneys and heart in people who have had a heart transplant. About 200 veterans will take either the drug or a placebo daily for 12 months. The goal is to see if it improves kidney funct…

This Phase 1 trial tests a custom virtual-reality game that veterans with traumatic brain injury can play at home to improve their near vision. The study enrolls 45 veterans who have trouble focusing on close objects (convergence insufficiency). The main goals are to see if the g…

This study tests an enhanced version of the Veteran Sponsorship Initiative (VSI+), which pairs high-risk transitioning service members with trained peer sponsors and connects them to mental health care. Researchers will enroll 2,700 veterans from four Army bases to see if this su…

This study tests whether a non-invasive device that sends small electrical pulses to the spine, combined with repetitive hand and arm exercises, can improve movement in people with chronic tetraplegia from a cervical spinal cord injury. Researchers will measure changes in muscle …

This study tests a new type of nerve stimulation to help Veterans with bladder control problems caused by nerve damage. A small wireless sensor is placed in the bladder to detect when it is filling and trigger stimulation to prevent leakage. The goal is to see if this approach wo…

This study compares a once-monthly injectable buprenorphine to the standard daily sublingual tablet (with naloxone) for treating opioid use disorder in 952 veterans. The goal is to see which formulation better keeps people in treatment and helps them stay opioid-free over 48 week…

This phase 3 trial compares two common beta blockers—metoprolol and carvedilol—in about 2,540 hemodialysis patients. The goal is to see if metoprolol, which is removed by dialysis, leads to fewer major heart events like heart attacks, strokes, or heart failure hospitalizations. P…

This study tests a new method to remove excess fluid during dialysis by using a patient's recent blood pressure patterns, instead of standard care. The goal is to lower the risk of dangerously low blood pressure during treatment and improve overall blood pressure control. About 6…

This study tests a program called MINDSET for veterans with chronic conditions like heart disease or diabetes who smoke or drink too much. Participants receive a mailed packet with personalized health information and a brief motivational phone call. The goal is to see if this app…

This phase 2 trial is testing whether a combination of targeted radiation (SBRT) and a radioactive drug called Pluvicto can control metastatic castration-resistant prostate cancer without the need for ongoing hormone therapy. Sixty participants will stop castration and receive th…

This study tests whether a cream containing imipramine (an antidepressant) can improve photodynamic therapy (PDT) for actinic keratosis, a common skin pre-cancer. 48 US veterans with fair skin and many pre-cancerous spots will receive PDT on their face and forearms, with imiprami…

This study compares two treatments for veterans with PTSD who are at high risk for suicide. One group receives Dialectical Behavior Therapy (DBT) plus a special PTSD exposure protocol, while the other gets standard prolonged exposure therapy with suicide risk management. The goal…

This study tests whether briefly inflating a blood pressure cuff on the arm before a heart procedure can protect the kidneys and heart in people with congestive heart failure. About 240 participants will be randomly assigned to receive either the real cuff inflations or a sham ve…

This study is testing whether metformin, a common diabetes medicine, can reduce the risk of death, heart attacks, and strokes in veterans who have pre-diabetes and already have heart or blood vessel disease. About 7,410 participants will receive either metformin or a placebo. The…

This study tests a special therapy program for veterans who have been involved with the criminal justice system. The program, called DBT-J, combines mental health support, substance use help, and case management. Researchers want to see if it lowers the risk of future criminal be…

This study tests whether empagliflozin, a drug used for diabetes, can make arteries less stiff in veterans with obesity. Fifty participants will take either the drug or a placebo daily for 12 weeks. Researchers will measure changes in arterial stiffness using a standard test. The…

This study tests whether a special low-calorie, plant-based diet that mimics fasting can help patients with stage IV non-small cell lung cancer respond better to maintenance immunotherapy. Sixty-six participants will follow the diet for three cycles while continuing their regular…

This phase II trial tests whether adding itraconazole, a common antifungal medication, to standard chemoradiation can improve outcomes for people with resectable esophageal cancer. About 78 participants will receive itraconazole before and after standard treatment, then undergo s…

This study looks at whether treating obstructive sleep apnea (OSA) early with a positive airway pressure (PAP) device can improve outcomes for veterans with both PTSD and substance use disorder. About 194 veterans in a residential treatment program will either receive PAP therapy…

This phase 2 trial is testing whether a butyrate supplement (Cal-Mag Butyrate) can improve physical function in 120 veterans with Gulf War Illness. The study also looks at effects on fatigue, memory, gut health, and inflammation. Participants take the supplement or a placebo for …

This study tests whether adding a smartphone app to standard medication helps Veterans with alcohol use disorder drink less heavily. About 330 Veterans will either get medication alone or medication plus the app. The goal is to see if the app makes treatment more effective and ea…

This study tests whether people with chronic kidney disease can safely adjust their own blood pressure medications at home, guided by a pharmacist. 160 veterans with uncontrolled high blood pressure and stage 2-4 kidney disease will either self-manage their meds or just monitor t…

This study is testing a surgically implanted device that uses small electrical currents to stimulate nerves and muscles in the trunk and hips. The goal is to help people with spinal cord injury improve their seated posture, balance, breathing, reaching, and ability to push a whee…

This study tests a program called Transition to Cardiac Rehabilitation (T2CR) for Veterans with heart disease who also have other health problems or frailty. The program starts in the hospital and continues at home, helping patients build skills and motivation to do cardiac rehab…

This study looks at 100 people with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) who are already taking a BTKi pill (like ibrutinib). Half will keep taking the BTKi alone, while the other half will add a second pill called venetoclax for one year. After …

This study tests whether breathing a low-oxygen gas mixture (mild intermittent hypoxia) can help prevent blood pressure problems in people with spinal cord injuries. The 24 participants will have motor-incomplete injuries above the 12th thoracic vertebra and signs of autonomic dy…

This study tests whether oxygen, acetazolamide, or finasteride can help treat sleep apnea in people aged 60 and older. Researchers will measure how these treatments affect breathing stability during sleep. The goal is to find better, more personalized options for elderly veterans…

This study is testing whether a dietary supplement called MitoQ, combined with exercise rehabilitation, can improve blood vessel function in older adults (50+) suffering from long-COVID. The trial will enroll 300 participants, including both long-COVID patients and those who have…

This early-phase trial is testing whether dronabinol, a synthetic form of THC, can reduce the severity of obstructive sleep apnea. 120 adults with moderate to severe sleep apnea will take the drug for two weeks. Sleep studies before and after treatment will measure changes in bre…

This study tests a smart mat that checks foot temperature at home to catch early signs of damage in high-risk diabetes patients. 800 Veterans with a history of foot ulcers or amputation will use the mat for up to 24 months. The goal is to see if this technology can prevent new ul…

This early-stage trial tests a new drug called PPM, which are tiny particles loaded with the chemotherapy drug paclitaxel and coated with a molecule (PLZ4) that helps them target bladder cancer cells. The drug is given directly into the bladder through a catheter once a week for …

This study is testing whether adding a special PET scan (using F18-Piflufolastat) to standard imaging can better diagnose and stage liver cancer. Researchers will enroll 90 veterans with suspected or confirmed hepatocellular carcinoma. The goal is to see if the scan helps clarify…

This study is testing whether a smartphone app can detect early knee osteoarthritis by measuring how the knee moves during simple activities like walking. Researchers will compare the app's results to standard motion-capture equipment and patient symptoms. If it works, this could…

Lung cancer is the top cancer killer of Veterans, often found too late to cure. This trial tests whether giving doctors personalized prediction tools and dashboards can increase lung cancer screening rates among 23,520 high-risk Veterans. The goal is to catch cancer earlier and r…

This study tests if a faster MRI scan, combined with a blood test, can find liver cancer earlier than the standard ultrasound in people with cirrhosis. The goal is to catch cancer at an early, more treatable stage and reduce deaths from liver cancer. About 4,700 veterans with cir…

This study tests whether a brief, two-session alcohol counseling program can help Veterans reduce their drinking and prevent intimate partner violence. Researchers will compare this program to alcohol education or standard check-in calls. 300 Veterans who are already in a partner…

This study tests a decision support tool called CAPP-FIT to help prevent pressure injuries in people with spinal cord injury. About 808 veterans from 7 VA clinics will use a survey to identify risks, and providers get a report with recommended actions. The goal is to see if the t…

This study tests whether yoga-based exercises can help veterans with schizophrenia, schizoaffective disorder, or bipolar 1 disorder improve their ability to function in daily life—like socializing, working, and managing leisure activities. About 112 veterans will be randomly assi…

This study tests a program called CONNECTED, designed to help veterans who feel socially isolated. The program involves peer support, counseling, and help finding social resources, all delivered by video over 8 weeks. Researchers will compare it to weekly friendly check-ins to se…

This study tests whether sitting in front of a bright lightbox for 60 minutes each morning can improve sleep and overall well-being in veterans who have traumatic brain injury, post-traumatic stress disorder, and chronic pain together—known as the polytrauma clinical triad. The t…

This study tests a 4-week telehealth program called I-SLEPT for Veterans leaving a rehabilitation facility. The program combines sleep education and tips for staying active in meaningful activities. Researchers want to see if it is acceptable and feasible for Veterans, and whethe…

This study is testing a short, values-based therapy for Veterans who have recently started medication for opioid use disorder (like buprenorphine). The therapy focuses on helping them clarify their personal values, set goals, and improve social connections. The study has three ph…

This study tests whether a program of water-based exercise followed by memory training can help Veterans with long COVID symptoms like brain fog and fatigue. About 50 people will take part over 8 months. The goal is to see if the program is safe, doable, and helpful.

This study tests whether a type of talk therapy called Exposure and Response Prevention (ERP) can improve daily functioning and quality of life in veterans with obsessive-compulsive disorder (OCD). About half of the 160 participants also have post-traumatic stress disorder (PTSD)…

This study tests a short, 3-session program called MERA (Manage Emotions to Reduce Aggression) for veterans with PTSD who struggle with impulsive aggression. The program teaches skills to manage emotions better, with the goal of reducing aggressive outbursts and preparing veteran…

This study compares two support programs for family and friends caring for Veterans with dementia after a hospital stay. One program, Hospital GamePlan4Care, offers a handbook, online training, and phone coaching tailored to the caregiver. The other provides general education and…

This study tests a small, FDA-cleared device that gently stimulates nerves in the ear to reduce pain and improve daily function in 240 veterans with fibromyalgia. Half will get the real device, half a sham, and researchers will track pain levels and brain activity over 24 weeks. …

This study is testing a mobile app called MyHealtheBladder to help women veterans manage urinary incontinence. Researchers will compare two ways of introducing the app at 20 VA clinics to see which works better. The main goal is to see how many women use the app and how engaged t…

This study tests whether a high-protein nutrition plan combined with resistance exercises, started weeks before surgery and continued for 24 weeks after, can help older adults with cancer preserve their physical function. The trial enrolls Veterans aged 55 and older with certain …

This study tests whether tadalafil, a drug often used for erectile dysfunction, can reduce shortness of breath in 126 veterans who have both COPD and high blood pressure in the lungs. Participants will be randomly assigned to take either tadalafil or a placebo for six months, and…

This study looks at whether daily growth hormone shots for 6 months can improve quality of life in veterans who have both mild traumatic brain injury and adult growth hormone deficiency. About 172 veterans aged 21-55 will receive either the hormone or a placebo. The main goal is …

This study tests four different approaches—behavioral therapy, physical therapy, medication changes, and buprenorphine rotation—to help cancer survivors reduce their opioid use while keeping pain under control. It involves 294 veterans who have finished cancer treatment but still…

This study looks at how to best offer group physical therapy to veterans with knee osteoarthritis. About 20 VA clinics will take part to see if this approach helps more patients start and stick with therapy. The goal is to make it easier for veterans to manage knee pain and stay …

This study looks at how to best offer cognitive behavioral therapy for chronic insomnia to older veterans at 20 VA clinics. About 20 veterans will take part to see if the therapy helps them sleep better and feel better. The goal is to find the best way to bring this effective tre…

This study is testing a web-based program called Calm Moms for pregnant veterans who have experienced trauma and are feeling anxious, stressed, or down. The program uses proven techniques to help manage these symptoms and is tailored to the unique concerns of pregnancy. About 36 …

This study tests whether Written Exposure Therapy (WET), a brief talk therapy for PTSD, works for veterans who also have serious mental illness like bipolar disorder or schizophrenia. Researchers will enroll 48 veterans to see if the therapy is feasible and acceptable. The goal i…

This study tests a cognitive training program called GOALS for veterans who have had a mild traumatic brain injury (mTBI) and still have trouble with attention and daily tasks. The program teaches mindfulness and goal-management skills through real-life activities. Researchers wi…

This study tests a coaching program called OPTIONS that helps veterans with chronic pain learn non-medication strategies. Around 296 veterans with musculoskeletal pain will work with a coach to align pain management with their personal values and goals. The main goal is to see if…

This study tests whether a drug called pimavanserin can improve sleep in veterans with post-traumatic stress disorder (PTSD) who also have insomnia. About 60 veterans will receive either the drug or a placebo for 8 weeks. The goal is to see if it reduces insomnia severity and imp…

This study tests whether giving oxytocin nasal spray before couples therapy can help veterans with PTSD feel better and improve their relationships. About 240 veterans and their partners will take part. Half get oxytocin, half get a placebo, and all receive eight sessions of brie…

This study aims to find the most effective non-surgical treatments for chronic low back pain in Veterans. Over 2,500 participants will first try either continued care, an online pain self-management program, or enhanced physical therapy. Those who don't improve can then choose fr…

This study tests two home-based walking programs for veterans with peripheral artery disease (PAD), a condition that causes leg pain when walking. Participants will either use a website, have telehealth coaching, or get usual care. The goal is to see if these programs help them w…

This study looks at whether adding morning bright light therapy to cognitive training can improve thinking, daily function, and sleep in 144 veterans who have both mild traumatic brain injury and PTSD. Participants will receive either the light therapy or a placebo light device. …

This study is testing whether a weighted blanket can help veterans with chronic pain and sleep problems. 160 veterans will use either a light (3-pound) or heavy (15-pound) blanket at home for 6 weeks. Researchers will track changes in pain, sleep quality, and medication use to se…

This study tests whether practicing driving skills in a simulator can improve real driving performance in veteran stroke survivors. One hundred participants will complete both active training (focusing on speed, lane position, collision avoidance, and attention) and a control ses…

This study tests a suicide prevention program called VA BIC for Veterans who recently received mental health care outside the VA system. The program includes a one-hour education session and follow-up support. Researchers will measure whether it reduces suicidal thoughts in 120 V…

This study looks at whether interval exercise (short bursts of activity with rest) can improve daily steps, daytime sleepiness, and heart health in veterans who have both COPD and obstructive sleep apnea (called Overlap Syndrome). About 28 veterans will take part for 12 weeks. Th…

This study tests two treatments for insomnia in veterans who also have PTSD. One is a brief behavioral therapy focused on sleep habits, and the other is a relaxation technique. Researchers want to see which one improves sleep and daily life more, and if benefits last over time. A…

This study tests whether a non-invasive brain stimulation technique called rTMS can safely improve mild thinking problems in veterans with Parkinson's disease. Researchers will give real or fake rTMS sessions to 56 veterans and measure changes in executive function (like planning…

This study tests a treatment called repetitive transcranial magnetic stimulation (rTMS) for people who have had a stroke more than six months ago and still feel very tired. Fatigue is a common problem after a stroke that can make daily activities hard. The researchers will give r…

This study tests whether a natural hormone called pregnenolone can improve daily functioning in veterans with anxiety and depression. 84 veterans will take either pregnenolone or a placebo for 8 weeks. The goal is to see if it helps with mood, sleep, and pain, with minimal side e…

This study tests whether a wearable robotic arm device called MyoPro, combined with motor learning therapy, can improve arm function in people who had a stroke at least six months ago and have severe arm weakness. The device reads muscle signals to help move the arm. Sixty partic…

This study looks at whether giving L-Citrulline, tetrahydrobiopterin (BH4), and atorvastatin can improve blood vessel function and physical ability in veterans with a type of heart failure called HFpEF. About 90 participants will take these medications and be tested on how well t…

This study compares a new adjustable prosthetic socket to a standard rigid socket in 40 veterans with leg amputations. Participants will walk on a treadmill at different speeds while researchers measure how evenly they walk and how comfortable the socket feels. The goal is to fin…

This study tests whether a special type of sleep therapy, adapted for trauma, can help women veterans with both insomnia and PTSD feel more ready to engage in PTSD treatment. About 100 women veterans will be randomly assigned to either the sleep therapy or a general education pro…

This study tests a home-based exercise program called Smart MOVE! for Veterans with peripheral artery disease (PAD), a condition that limits walking ability. Participants will use a wearable activity monitor and receive behavioral coaching via the MOVE! program. The goal is to se…

This study tests whether metformin, a standard diabetes drug, can improve walking ability in people with peripheral artery disease (PAD) who experience leg pain during activity. Researchers will give 200 Veterans either metformin or a placebo for several months and measure change…

This pilot study tests a handheld device that gently stimulates the vagus nerve in the neck to see if it can improve walking and balance in veterans with Parkinson's disease. Forty participants will use the device at home while researchers measure changes in stride length and oth…

This study tests whether hearing aids can improve daily hearing for veterans who have normal hearing tests but still struggle to understand speech in noisy places. About 142 veterans will either get hearing aids or standard communication advice. The goal is to see if the devices …

This study tests a new multi-speed ergonomic wheelchair designed to reduce shoulder overuse injuries common in manual wheelchair users. Thirty adults who use a manual wheelchair daily will try different gear ratios on various surfaces. The goal is to see if the design improves pr…

This study tests whether methylphenidate (Ritalin), a drug used for ADHD, can improve attention and memory in adults with epilepsy. 226 participants will be randomly assigned to take either the drug or a placebo for 8 weeks, then all can take the drug for another 8 weeks. The goa…

This study compares a 3-session couples program (Brief Relationship Checkup) to standard individual care for 360 veterans and their partners who have relationship and mental health concerns. The goal is to see which approach better reduces suicide risk factors by improving relati…

This study tests a magnetic brain stimulation technique called iTBS in 55 veterans aged 22-65 who have had a mild traumatic brain injury and struggle with impulsivity or suicidal thoughts. The treatment involves applying magnetic pulses to the front of the head over several sessi…

Many blast-exposed veterans struggle to hear in noisy places even though their standard hearing tests are normal. This study tests whether a new fitting method called speech-based audiometry (SBA) makes low-gain hearing aids more effective than the usual approach. Eighty veterans…

This study tests whether using mild electrical pulses in the rectum can help people with spinal cord injury empty their bowels more quickly. Many with spinal cord injury have slow bowel movements and rely on a finger to stretch the rectum. The trial compares the usual method with…

This study tests two walking training programs to help veterans with leg amputation walk more evenly. The goal is to reduce pain, improve mobility, and protect the skin of the remaining limb. About 54 veterans who lost a leg due to diabetes or artery disease will take part.

This study tests whether a single dose of intravenous ketamine can quickly improve depression in veterans with Parkinson's disease. Researchers will also look at how ketamine affects brain flexibility and inflammation. The trial involves 80 veterans and compares ketamine to a mil…

This study looks at whether walking on an incline is better than walking faster on flat ground for people with COPD. The goal is to find ways to improve exercise programs so patients feel less short of breath. About 54 veterans with COPD will take part, and researchers will measu…

This study tests whether a group exercise program done over video calls is practical and helpful for Veterans with knee or hip arthritis. Fifty participants will exercise together online for 3 months, then get either text reminders or extra group sessions for 6 more months. Resea…

This study is testing whether backward walking training can help stroke survivors improve their gait and balance. About 48 veterans who had a stroke 2-4 months ago will receive either 18 or 27 sessions of backward walking on a treadmill and over ground. Researchers will also use …

This study tests whether a gentle brain stimulation technique called tDCS, combined with cognitive training, can help veterans with obesity reduce impulsive behavior and lose weight. About 124 veterans will be randomly assigned to receive either real or fake stimulation during tr…

This study tests a new prosthetic foot system for women veterans with below-knee amputations. The device uses 3D-printed feet that can be swapped to fit different shoes, giving users more footwear options. Researchers want to see if this improves body image and social participati…

This early-stage trial tests whether stem cells taken from a patient's own bone marrow can reduce pain caused by chronic pancreatitis and possibly improve pancreas function. Forty adults with long-term painful pancreatitis will receive either the stem cells or a placebo. The stud…

This study tests whether goal-oriented cognitive training delivered via video calls can help veterans with mild to moderate traumatic brain injury (TBI) improve attention, planning, and daily functioning. 80 veterans with lasting cognitive difficulties will participate remotely. …

This study looks at whether adding a Whole Health Coach to standard pain management teams helps veterans with chronic pain feel better and use opioids more safely. About 432 veterans will work with a coach to set personal health goals and learn self-management strategies. The mai…

This study tests whether daily treatments with slightly elevated carbon dioxide (hypercapnia) can improve breathing and reduce sleep apnea in Veterans with spinal cord injury. About 30 adults with chronic spinal cord injury or able-bodied people with sleep apnea will receive the …

This study tests a new clinical decision support tool that helps physical therapists tailor rehabilitation for veterans after total knee replacement. Instead of a one-size-fits-all approach, the tool uses each patient's recovery data to personalize therapy. The goal is to improve…

This study tests whether a non-invasive device that gently stimulates the vagus nerve can reduce withdrawal symptoms, anxiety, and cravings in 80 veterans with moderate-to-severe alcohol use disorder. Participants will receive the stimulation and complete questionnaires and a bra…

This study tests whether pairing non-invasive brain and spinal cord stimulation with hand exercises can improve hand strength and dexterity in veterans with ALS. Thirty-two participants will first undergo a personalized optimization period, then receive two weeks of the combined …

This study tests a brief, two-session program for family members of Veterans with PTSD. The goal is to see if this family support helps Veterans stay in their regular PTSD therapy longer and have fewer symptoms. About 200 Veterans and their family members will take part. If it wo…

This study tests whether a combination of flywheel resistance and aerobic exercise can reduce fatigue and improve muscle function in veterans with chronic kidney disease who are not yet on dialysis. Researchers will measure changes in leg muscle endurance, perceived exhaustion, a…

This study tests a new talk therapy called Continuous Identity Cognitive Therapy (CI-CT) for veterans who have recently had a suicidal episode. The goal is to help them feel more hopeful, build a positive sense of self, and improve their quality of life. About 57 veterans will ta…

This study looks at whether a supervised exercise program can improve balance and mobility in older adults who have moderate narrowing of the carotid artery (50-69% blockage) but no stroke symptoms. About 50 participants will do aerobic and balance exercises to see if their walki…

This pilot study tests a 12-week workshop called STEP-Home-SP for veterans who recently left military service. The workshop teaches emotional regulation and problem-solving skills to help with reintegration and reduce suicide risk. Researchers will enroll 120 veterans to see if t…

This study tests whether a small device that gently stimulates a nerve in the neck can reduce PTSD symptoms in veterans. 80 veterans will use the device at home twice a day for three months. Researchers will measure changes in brain activity, heart function, and PTSD symptoms com…

This study explores whether a virtual reality version of a mindfulness program called VA CALM can help veterans with spinal cord injuries manage chronic pain. Ten veterans will try the program, and researchers will see if it's practical and acceptable. The goal is to make mindful…

This phase 2 trial is testing whether cannabis-based medicines—THC, CBD, or a combination—can safely reduce chronic nerve pain in Veterans. 320 participants will receive one of these treatments or a placebo for six weeks. The goal is to see if these options offer better pain reli…

This study is testing a wearable robotic exoskeleton that stretches the legs of people with spasticity caused by spinal cord injury. The device aims to mimic the stretching done by nurses or caregivers. Ten veterans will try the device during leg stretching, treadmill walking, an…

This study tests a strength training program using blood flow restriction (BFR) in people with advanced multiple sclerosis (MS) who need help walking or use a wheelchair. BFR uses a device that partially blocks blood flow to the exercising limb, allowing low-intensity exercise to…

This study tests a home-based program for veterans aged 60+ with multiple chronic conditions and poor physical function. The program combines high-intensity exercise, education, and motivational coaching delivered via video calls. Researchers want to see if it improves strength a…

This study tests whether a short writing therapy called Written Exposure Therapy (WET) can help veterans who have both posttraumatic stress disorder (PTSD) and a substance use disorder. About 170 veterans will complete five writing sessions about their trauma. The goal is to see …

This study tests a new way to help veterans with PTSD stop smoking. It combines counseling, nicotine gum, and a noninvasive brain stimulation called TMS. Researchers want to see if this approach is practical and helps veterans stay smoke-free for at least 3 months. About 50 veter…

This study tests a short behavioral therapy called T-SIB designed to help veterans reduce nonsuicidal self-injury (like cutting or burning) and improve how they function day-to-day. Researchers will enroll 40 veterans who have self-injured at least twice in the past month. Half w…

This study compares a new type of below-knee amputation (Ewing amputation) to the standard surgery in 120 veterans with peripheral artery disease. The goal is to see if the new method improves walking, balance, and pain. Participants are randomly assigned to one of the two surger…

This study compares a single therapy (Transdiagnostic Behavior Therapy) to separate treatments for social anxiety and PTSD in 264 veterans. The goal is to see if one therapy can effectively reduce symptoms and improve daily life. Participants will be assessed before, during, and …

This study tests a smartphone tool called the Virtual Hope Box Enhanced Facilitation (VHB-EF) to see if it lowers suicide risk in veterans after they leave a psychiatric hospital. About 928 veterans who recently had a suicidal crisis will use the tool, which provides coping resou…

This study tests whether cognitive behavioral therapy (CBT) can help veterans with serious mental illness (like schizophrenia or bipolar disorder) who also have chronic low back pain. Researchers will measure changes in pain interference, quality of life, and pain severity after …

This study is testing whether a brief, therapist-guided expressive writing program can reduce symptoms of depression and anxiety in sexual minority veterans. Participants will complete three writing sessions focused on minority stress. The goal is to see if this approach is feasi…

This study tests a therapy called Targeted Cognitive Training (TCT) for veterans with serious mental illnesses like schizophrenia, bipolar disorder, or PTSD. The goal is to improve thinking skills and daily functioning by using EEG brain scans to identify who will benefit most. A…

This study tests a home-based telerehabilitation program for veterans who have completed treatment for early-stage lung cancer. The program lets participants choose from exercises to reduce shortness of breath, fatigue, or anxiety. Researchers hope to improve quality of life and …

This study tests a drug called CORT108297, which blocks the stress hormone cortisol, as a short-term treatment for PTSD in veterans. Forty veterans with PTSD will take either the drug or a placebo daily for one week. The goal is to see if it reduces PTSD symptoms and to check its…

This study tests a remote program that combines walking with Tai Chi for veterans who have both COPD and long-term muscle or joint pain. The goal is to see if it helps them move better and feel less limited by their conditions. Researchers will track daily steps, pain levels, and…

This study is for Veterans who smoke and want to quit. Each Veteran picks a friend or family member to support them during the quitting process. Researchers will track whether this support helps Veterans use proven treatments like medication or counseling. The goal is to find bet…

This study looks at whether a smartphone app called PE Coach can help veterans with PTSD do better in a proven type of talk therapy called prolonged exposure. About 124 veterans will be randomly assigned to receive therapy with or without the app. The goal is to see if the app im…

This study is for people with spinal cord injury who also have depression. It tests a new method to dose a brain stimulation treatment called rTMS, which is already approved for depression but usually requires a thumb movement to set the dose. Since many with spinal cord injury h…

This study tests whether adding a noninvasive brain stimulation technique called rTMS to a brief writing therapy (WET) can better reduce PTSD symptoms in veterans. About 98 veterans with PTSD will receive either real or fake rTMS before their writing sessions. Researchers will me…

This study tests a new type of supervised exercise for people with peripheral artery disease (PAD), which causes leg pain when walking due to blocked arteries. Researchers want to see if using muscle oxygen levels to guide exercise is better than standard therapy. The study invol…

This study tests whether wearing bright light therapy glasses can reduce daytime sleepiness and depressive symptoms in people with obstructive sleep apnea who still feel tired despite using their CPAP machine. Sixty participants will wear the glasses for four weeks of active trea…

This study looks at whether adding aerobic exercise (like walking or cycling) to standard physical therapy can help stroke survivors recover better. The goal is to improve arm movement, thinking, and mood. About 40 people who had a stroke at least 6 months ago will take part. Res…

This study tests whether a type of talk therapy called Behavioral Activation, delivered via home-based telehealth, can improve social functioning and mood in veterans recently discharged from the hospital for a heart condition. About 132 veterans with depression will receive eith…

This study tests whether the stimulant medication methylphenidate (Ritalin) can improve PTSD symptoms and thinking problems like poor memory and concentration in 70 Veterans. Each participant will switch between the drug and a placebo every 4-5 weeks over 20 weeks, without knowin…

This study tests two approaches to help people with knee osteoarthritis stay active after physical therapy: a game-like reward system with social support, and health coaching. About 254 veterans will use a Fitbit and smartphone app to track their progress. The goal is to see if t…

This study tests a non-invasive method called sensory augmentation for people who have had a stroke at least 6 months ago and still have balance problems. Small vibrations are applied to the skin to enhance the body's natural sense of position, aiming to make standing steadier an…

This study tests a smart exercise bike that adjusts its resistance based on how well a person performs, aiming to improve movement and thinking in people with Parkinson's disease. The bike is used at home and monitored remotely, so patients don't need to travel to a clinic. Resea…

This study tests a new training program for veterans who have both mild traumatic brain injury (mTBI) and PTSD. The training combines exercises to recognize emotions in faces and voices with attention training, since paying attention is key to understanding emotions in daily life…

This study tests a 40-minute web-based program designed to teach veterans coping skills for suicidal thoughts. Researchers will compare veterans who use the program to those receiving standard care, measuring changes in suicidal thoughts and behaviors over one month. The goal is …

This pilot study is testing whether ketamine infusions, combined with a brief counseling session, can help veterans who have both chronic low back pain and depression. About 44 veterans will receive four ketamine infusions over two weeks, and some will also get a short behavioral…

This study tests a simple, non-surgical program for older veterans with lumbar spinal stenosis, a common cause of back and leg pain when walking or standing. The program includes using a modified rolling walker and changing sleep positions to relieve symptoms. Researchers will tr…

This pilot study tests whether a neurofeedback device can reduce light sensitivity in 36 Veterans who have had a mild traumatic brain injury at least 6 months ago. The device uses low-intensity electrical pulses to train brain activity. Researchers will also use MRI scans to see …

This study looks at whether high intensity interval training (HIIT) can reduce frailty and improve resilience in older veterans. Researchers will enroll 200 veterans aged 65 and older who are not severely frail. Participants will do supervised and home-based HIIT exercises. The g…

This study tests whether taking oral glutamine, a dietary supplement, three times a day for 12 weeks can reduce chronic stomach pain, bloating, and diarrhea in veterans with Gulf War Illness. Researchers will also check if it helps repair the gut lining. The trial involves 80 vet…

This study tests whether brief, mild low-oxygen breathing sessions can improve blood vessel function, lower blood pressure, and reduce tiredness in people with obstructive sleep apnea. Researchers will enroll 60 adults aged 30-60 who are newly diagnosed and not yet using CPAP. Th…

This study is testing whether a lightweight leg exoskeleton called Keeogo is safe and helpful for improving walking and preventing falls in people with Parkinson's disease. Thirty veterans with mild to advanced Parkinson's will wear the device during supervised walking sessions t…

This study tests two remote brain-training programs for Veterans who have had a traumatic brain injury (TBI) and struggle with focus, memory, or staying on track. About 120 Veterans will use either BrainStrong-GSR or BrainStrong-OPT via tele-rehabilitation and digital apps. The g…

This study tests whether a home-based, supervised group exercise program can help high-risk Veterans recover their fitness after COVID-19. 80 Veterans with conditions like high blood pressure or diabetes will do guided workouts from home. The goal is to improve heart and lung fun…

This pilot study is testing a new approach called MI-CBTech that combines in-person counseling with a mobile phone app to help homeless veterans who have serious mental illnesses like schizophrenia. The goal is to help them set and achieve personal goals for community integration…

This study tests a mobile app that guides veterans through mental exercises to reduce phantom limb pain—pain felt where a leg used to be. About 36 veterans with a below-knee amputation will use the app at home with telehealth support. The goal is to see if the app is easy to use …

This study tests a non-invasive device that stimulates the vagus nerve (a key nerve in the body) to see if it can improve memory and reduce PTSD symptoms in veterans with mild traumatic brain injury. One hundred veterans will receive either active stimulation or a sham (fake) tre…

This study aims to develop and test a 12-week exercise program designed specifically for women veterans who have experienced sexual violence. The program is tailored to their needs and delivered virtually. Researchers will check if the program is feasible and acceptable, and expl…

This study looks at whether giving Veterans who have trouble hearing a small personal amplifier in the emergency room can help them understand their discharge instructions better and lower their chances of coming back to the ER within 3 or 30 days. About 1,050 Veterans from six V…

This study compares two ways of delivering a combined attention and strategy training program to veterans with mild traumatic brain injury and PTSD. One group receives the training in person, the other via telehealth. The goal is to see if remote delivery works just as well for i…

This study tests a mobile app designed to help veterans with PTSD who struggle with anger. 150 veterans will be randomly assigned to use either the anger-reduction app or a health education app. The goal is to see if the anger app helps more veterans get their anger under control…

This pilot study tests a mobile app called MIST designed to reduce suicidal thoughts in veterans. The app uses techniques to change unhelpful beliefs linked to suicide. Fifty veterans with recent suicidal thoughts will try the app alongside their usual care, and researchers will …

This study tests whether adding memory-support strategies to standard cognitive processing therapy (CPT) helps older veterans with PTSD learn and remember therapy content better. Thirty veterans over age 59 will receive either standard CPT or CPT with extra memory aids. The goal …

This study is testing a new social skills training program for Veterans with serious mental illness (like schizophrenia, bipolar disorder, or PTSD) who are looking for work. The program teaches skills to better understand social cues and handle workplace relationships. Researcher…

This study tests a program called Contingency Management that gives Veterans rewards for quitting smoking, verified by breath tests. Researchers will first gather feedback from Veterans and staff, then run a small pilot with 20 Veterans over 5 weeks. If successful, a larger trial…

This study tests three group-based psychological treatments—Cognitive-Behavioral Therapy, Emotional Awareness and Expression Therapy, and Mindfulness Meditation—delivered over video to older veterans (ages 60-95) with chronic musculoskeletal pain. The goal is to see which therapy…

This study looks at a type of tinnitus called somatosensory tinnitus, where ringing in the ears changes with head, neck, or jaw movements. Researchers are testing whether physical therapy, sound-based therapy, or a combination of both can help. The study involves 72 veterans with…

This study tests whether combining a gentle brain stimulation technique (tDCS) with repetitive arm and hand exercises can help people who have neglect after a stroke. Neglect means they have trouble paying attention to one side of their body or space. The study also aims to combi…

This study tests a prescription wrist device called NightWare that detects when a veteran with PTSD is having a nightmare and gently disrupts it without waking them. Researchers want to see if better sleep from fewer nightmares can also improve blood vessel and heart health. 125 …

This pilot study tests a new flexible bandage called exciflex that delivers mild electrical stimulation to chronic wounds that won't heal normally. The study includes 16 veterans with diabetes or spinal cord injury who have lower leg wounds. The bandage is designed to work for up…

This study compares a powered prosthetic knee (Ossur Power Knee) to a standard microprocessor knee in 20 people with above-knee amputations. Participants will use each knee for a month, then researchers measure walking speed, energy use, and sit-to-stand movements. The goal is to…

This study tests a short behavioral program called PST-Concussion for Veterans who have had a mild traumatic brain injury (concussion) and still feel distressed or have trouble thinking clearly. The program teaches problem-solving skills, goal-setting, and coping strategies in a …

This study tests whether a computer-based working memory training program can help veterans with PTSD improve their ability to unlearn fear responses. 120 veterans will be randomly assigned to either the training or a sham version. The goal is to see if the training changes brain…

This study tests a low-burden screening tool to help doctors identify and manage functional impairment and frailty in veterans aged 60 and older. The goal is to improve quality of life and independence by catching problems early. Researchers will measure how well clinics adopt th…

This study tests whether a new referral program helps more Veterans with heart conditions get into cardiac rehabilitation. Researchers will compare referral and attendance rates before and after the program starts at three VA hospitals, involving 816 participants over 12 months. …

This study investigates whether a clinical test using lorazepam (Ativan) and brain imaging can identify veterans with PTSD who might benefit from medications that boost GABA signaling. Researchers aim to validate a computational method to distinguish subgroups of PTSD patients ba…

This study looks at how spinal cord stimulation (SCS) affects brain activity in veterans with long-term nerve pain. Researchers will use non-invasive brain scans (fNIRS and EEG) to compare brain connectivity in SCS users and those being evaluated for SCS. The goal is to understan…

This study uses a robotic arm and brain stimulation to learn how different brain areas control reaching movements in people who have had a stroke and those who haven't. Researchers will measure movement paths, speeds, and accuracy. The goal is to understand brain changes after st…

This study looks at how different amounts and types of exercise can improve thinking and memory in Veterans aged 65 and older. Researchers will measure changes in cognitive skills and blood markers related to brain health. The goal is to understand which exercise habits work best…

This study tests whether small electric currents applied to nerves can give upper limb amputees a sense of where their missing hand is in space. Researchers will try different stimulation placements to see which ones create these sensations. The goal is to use this feedback to he…

This study looks at older veterans who have both sleep apnea and COPD, a combination called 'overlap syndrome.' Researchers want to see if having both conditions worsens thinking and memory more than having just one. They will also test whether using a breathing machine (CPAP) pl…

This study looks at how endurance exercise (like walking or cycling) and resistance exercise (like lifting weights) affect bone health in older veterans aged 60 and over. Researchers want to see if either type of exercise causes bone breakdown and how the body adapts over time. T…

This study looks at whether older adults (75+) who had precancerous polyps removed in the past still benefit from repeat colonoscopies. Researchers will analyze health records from 130,000 Veterans and interview patients and doctors. The goal is to create clear guidelines on who …

This study is recruiting 136 veterans to understand why Long-COVID causes walking and balance issues. Researchers will test thinking, vision, muscle strength, and movement under different conditions. The goal is to create better ways to diagnose and treat these problems, helping …

This study tests whether smartphone location data can give early warning of mood episodes (mania or depression) and drops in social activity for 200 veterans with bipolar disorder. Participants use an app that tracks their phone's GPS, and researchers will build computer algorith…

This study tests whether a mild electrical current applied to the ear can help the brain learn and control hand movements. Researchers want to understand how this stimulation affects brain chemicals that support learning. The study involves 110 adults, including some who have had…

This study looks at how a moderate traumatic brain injury (TBI) from early or middle adulthood might speed up physical and mental decline in older age. Researchers will test balance and thinking in 70 Veterans aged 50-75 who had a TBI at least 15 years ago, even if they feel fine…

This study is using a special X-ray technique (dynamic stereo X-ray) to see exactly how the bone and skin of a residual limb move inside a prosthetic socket. Researchers will compare two suspension methods—suction and elevated vacuum—in 21 people with below-knee amputations. The …

This study looks at why veterans with a common type of heart failure (HFpEF) have trouble exercising due to poor blood flow in their leg muscles. Researchers will compare 35 veterans with HFpEF to healthy volunteers, then have the veterans do 8 weeks of knee exercises to see if i…

This study looks at whether a brain scan can identify which stroke survivors with spatial neglect—a condition that makes it hard to notice or act on the left side—will benefit most from prism adaptation therapy. About 244 Veterans who had a right-brain stroke will be tested. The …

This study tests whether a helper (like a family member) can use a simple digital scanner to capture the shape of a veteran's leg for a new prosthetic socket. The goal is to see if this remote method works as well as the traditional in-person casting by a prosthetist. 25 veterans…

This study looks at how different blood pressure treatment goals affect artery stiffness in veterans over 60 with high blood pressure. Researchers will measure stiffness caused by blood pressure itself and by changes in the artery wall, and explore genetic factors. The goal is to…

This study aims to find out if wearable devices can reliably measure how stable a person is while walking after losing a lower limb. Researchers will test 20 veterans with one leg amputated below the knee, using both simple wearable sensors and advanced motion capture. The goal i…

This study aims to help Veterans and their primary care doctors decide whether an in-person, phone, or video visit is best for each situation. Researchers will survey 600 Veterans and their doctors to understand what they value in each type of visit. Then, they will test a new te…

This study looks at whether a 3-month online nutrition program, including food delivery and cooking demonstrations, can improve diet and reduce loneliness in older veterans who have trouble walking. About 180 veterans aged 65 and older with slow walking speed or who use a walker …

This study looks at why some veterans experience ongoing brain fog and other mental health issues after COVID-19. Researchers will track 200 veterans over time, using memory tests and blood samples to find clues. The goal is to better understand these symptoms and identify target…

This study is looking for biological clues to explain why some stroke survivors improve their walking with high-intensity interval training (HIIT) while others do not. Researchers will measure blood lactate, brain chemicals, and blood flow in 55 veterans with chronic stroke. The …

This study is testing a new group program called Qnnections, designed to help LGBTQ+ veterans feel more connected to others and reduce suicidal thoughts. The program was created with input from veterans themselves. Researchers will work with 66 veterans to see if the program is p…

This study looks at why central sleep apnea happens and how to treat it better. Researchers will test a combination of a drug (acetazolamide), extra oxygen, and a breathing machine (PAP therapy) in 200 veterans with this condition. The goal is to understand the body's breathing c…

This study aims to create and test a telehealth program to help veterans with psychogenic nonepileptic seizures (PNES) improve their thinking skills and daily functioning. About 47 veterans with PNES who report cognitive difficulties will give feedback to design a cognitive treat…

This study is developing and testing a behavioral activation program for older veterans at risk of losing the ability to do daily tasks on their own. The program, delivered via video telehealth, helps veterans engage in activities that matter to them. The study will first adapt t…

This study reviews medical records from up to 400,000 U.S. Veterans to see how COVID-19 treatments like Paxlovid and remdesivir are used and how well they work. It also looks at RSV and flu patterns. The goal is to improve treatment strategies for respiratory viruses in the VA he…

This study looks at whether a direct-to-patient teledermatology app, combined with artificial intelligence, can make it easier for veterans to get skin care. Researchers will track wait times, travel distance, and satisfaction for over 63,000 new patients at three VA hospitals. T…

This study looks at how sleep issues and sleep apnea might affect thinking, memory, and daily life in people who had COVID-19. Researchers will follow 200 veterans for up to a year, testing their brain function, sleep quality, and exercise ability. The goal is to find out if trea…

This study aims to understand what causes substance use and cravings in veterans, especially when combined with issues like anxiety, depression, or PTSD. Researchers will create a personal model for each participant showing their unique triggers, then give them feedback on how to…

This study tests a program that pairs soon-to-be-discharged service members with a volunteer sponsor in their hometown. The sponsor helps them with reintegration tasks like finding work, school, or healthcare. Researchers will track 630 veterans in Texas to see if the program red…

This study looks at whether a genetic test can better identify which men ages 55-69 are at risk for serious prostate cancer and which are not. Current screening methods often lead to unnecessary biopsies. The goal is to see if using genetic information can help high-risk men get …

This early-phase study looks at how a single dose of intranasal testosterone affects nerve and autonomic function in 15 male veterans with spinal cord injury who have low testosterone. Researchers will measure muscle responses and heart rate changes before and after the dose. The…

This study looks at how deep brain stimulation (DBS) affects the ability to align and focus both eyes on objects at different depths in people with Parkinson's disease. Researchers will use eye-tracking and brain models to find the best stimulation settings. The goal is to improv…

This study tests a training program for VA doctors to improve how they care for Veterans with Long-COVID. The training focuses on listening to patients, building a shared understanding of the condition, and creating a personalized care plan. About 348 Veterans and their doctors w…

This study is testing two different ways to slowly reduce the dose of the steroid prednisone in people with rheumatoid arthritis. One group will taper over 15 days, the other over 150 days. Researchers want to see who develops symptoms or flare-ups during the taper, and why. The …

This study tests a new care pathway for non-alcoholic fatty liver disease (NAFLD) in VA primary care. The pathway automatically identifies at-risk patients and educates providers. Researchers will compare this approach to usual care in 32 primary care teams to see if it increases…

This study aims to understand why people with Parkinson's disease have balance problems and falls. Researchers will use wearable sensors and brain recordings from deep brain stimulation electrodes in 100 Veterans. The goal is to find brain pathways linked to balance issues so new…

This study looks at how mood, brain inflammation, and exercise are linked to pain in 60 veterans with fibromyalgia. Participants will do a 6-week supervised walking program and complete pain, mood, and blood tests. The goal is to understand these connections and design a better e…

This study aims to create brain-based tools to identify which veterans with chronic psychosis are most likely to benefit from cognitive rehabilitation. Researchers will use EEG recordings to measure brain activity and see if these signals can predict improvements in thinking skil…

This study is creating a program called START-VET to help veterans with mental illness or substance use disorders who have recently left prison. Researchers will work with 20 veterans to develop transition materials and tools. The goal is to improve quality of life and reduce cri…

This study is looking at 800 veterans to see if mild traumatic brain injury (concussion) increases the risk of dementia later in life. Researchers will test memory, brain waves, brain scans, and proteins in blood and spinal fluid. The goal is to find early warning signs of diseas…

This study compares different training methods for therapists who treat PTSD. It aims to find the most effective way to train therapists so they stick to the proven treatment plan. 240 therapists will be assigned to various training components, like online courses or feedback ses…