Could fasting boost immunotherapy? new trial tests diet combo for lung cancer

NCT ID NCT06671613

Recruiting now Disease control Sponsor: VA Office of Research and Development Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a special low-calorie, plant-based diet that mimics fasting can help patients with stage IV non-small cell lung cancer respond better to maintenance immunotherapy. Sixty-six participants will follow the diet for three cycles while continuing their regular treatment. The main goal is to see if patients can safely complete the diet, with secondary goals of measuring tumor response and side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Fasting-mimicking diet (Xentigen plant-based diet program)
What this could lead to: If it works, this could point toward a simple dietary strategy to boost the effectiveness of immunotherapy for advanced lung cancer.
What could go wrong: This is a small, early feasibility study (66 people) with no control group. It only tests if patients can stick to the diet, not yet if it improves outcomes. The diet may cause side effects or be hard to follow.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Fasting non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

FASTING MIMICKING DIET IMMUNOTHERAPY NSCLC STAGE IV NSCLC

Contacts and locations

Locations

Jesse Brown VA Medical Center, Chicago, IL
RECRUITING

Chicago, Illinois, 60612, United States
Richard L. Roudebush VA Medical Center, Indianapolis, IN
RECRUITING

Indianapolis, Indiana, 46202-2884, United States
St. Louis VA Medical Center John Cochran Division, St. Louis, MO
RECRUITING

St Louis, Missouri, 63106-1621, United States
VA Long Beach Healthcare System, Long Beach, CA
RECRUITING

Long Beach, California, 90822, United States

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