Can a Two-Target antibody shrink Hard-to-Treat cancers?

NCT ID NCT03526835

Recruiting now Disease control Sponsor: Merus B.V. Source: ClinicalTrials.gov ↗

First seen Jul 29, 2026 · Last updated Jul 30, 2026 · Updated 1 time

Summary

This trial is testing an experimental drug called petosemtamab (MCLA-158) in people with advanced solid tumors, including colorectal, head and neck, and lung cancers. The drug is a bispecific antibody designed to block two cancer-related proteins, EGFR and LGR5. Researchers want to see if it is safe and effective when used alone or combined with other cancer treatments.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: petosemtamab (MCLA-158), a bispecific antibody targeting EGFR and LGR5, given alone or with pembrolizumab, FOLFIRI, or FOLFOX
What this could lead to: If successful, this could offer a new treatment option for people with advanced solid tumors that have stopped responding to standard therapies.
What could go wrong: This is an early-phase trial, so the drug may not prove effective or may cause significant side effects. Results may not apply to all tumor types.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

carcinoma of esophagus colorectal cancer colorectal neoplasm esophageal cancer Esophageal Neoplasms gastric cancer gastric neoplasm gastroesophageal cancer gastroesophageal junction adenocarcinoma head and neck squamous cell carcinoma metastatic malignant neoplasm non-small cell lung carcinoma pancreatic adenocarcinoma Squamous Cell Carcinoma of Head and Neck

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED/METASTATIC SOLID TUMORS COLORECTAL CANCER ESOPHAGEAL CANCER GASTRIC CANCER GASTROESOPHAGEAL JUNCTION CANCER HEAD AND NECK SQUAMOUS CELL CARCINOMA HNSCC NSCLC

Contacts and locations

Locations

ASST Grande Ospedale Metropolitano Niguarda
RECRUITING

Milan, 20162, Italy
Cambridge University Hospitals NHS Foundation Trust
COMPLETED

Cambridge, United Kingdom
Cancer Care Northwest
RECRUITING

Spokane, Washington, 99202, United States
Cayuga Medical Center
RECRUITING

Ithaca, New York, 14850, United States
Centre Antoine Lacassagne
RECRUITING

Nice, France
Centre Henri Becquerel
RECRUITING

Rouen, France
Centre Leon Berard
RECRUITING

Lyon, France
Chu Ucl Namur Site De Sainte-Elisabeth
RECRUITING

Namur, Belgium
Cleveland Clinic
RECRUITING

Cleveland, Ohio, 44195, United States
Clinica Universidad de Navarra
RECRUITING

Pamplona, Spain
Cliniques universitaires Saint-Luc
RECRUITING

Brussels, Belgium
Emory University
RECRUITING

Atlanta, Georgia, 30322, United States
Florida Cancer Specialists
ACTIVE_NOT_RECRUITING

Fort Myers, Florida, 33901, United States
Georgetown University Medical Center
RECRUITING

Georgetown, Washington, 20007, United States
Hematology-Oncology Associates of Central New York
RECRUITING

Syracuse, New York, 13057, United States
Hopital La Timone
RECRUITING

Marseille, France
Hopital Saint Andre, CHU Bordeaux
RECRUITING

Bordeaux, France
Hospital 12 de Octubre
RECRUITING

Madrid, Spain
Hospital Universitario de Navarra
RECRUITING

Pamplona, Spain
Institut Curie
RECRUITING

Paris, France
Institut Gustave Roussy
RECRUITING

Paris, France
Institut Jules Bordet
COMPLETED

Brussels, Belgium
Institut Régional du Cancer de Montpellier
RECRUITING

Montpellier, France
Instituto Valenciano de Oncologia
RECRUITING

Valencia, Spain
Karmanos Cancer Institute
COMPLETED

Detroit, Michigan, 48201, United States
Massachusetts General Hospital - Dana Farber
RECRUITING

Boston, Massachusetts, 02114, United States
Memorial Sloan Kettering Cancer Center
RECRUITING

New York, New York, 10065, United States
Mt. Sinai
RECRUITING

New York, New York, 10029, United States
NKI - Antoni van Leeuwenhoek
RECRUITING

Amsterdam, Netherlands
Ohio State University
RECRUITING

Columbus, Ohio, 43221, United States
Oncology & Hematology Associates of Southwest Virginia
RECRUITING

Roanoke, Virginia, 24014, United States
Oncology Consultants
RECRUITING

Houston, Texas, 77030, United States
Rocky Mountain Cancer Centers
RECRUITING

Lone Tree, Colorado, 80124, United States
SSM Health Saint Louis University Hospital
COMPLETED

St Louis, Missouri, 63110, United States
SSM OKC Hightower Clinical
RECRUITING

Oklahoma City, Oklahoma, 73102, United States
Sarah Cannon Research Institute
COMPLETED

Nashville, Tennessee, 37203, United States
Sarah Cannon Research Institute
RECRUITING

London, United Kingdom
Sarah Cannon Research Institute (Lake Nona)
RECRUITING

Orlando, Florida, 32827, United States
Sharp Healthcare
RECRUITING

San Diego, California, 92123, United States
Taylor Cancer Research Center
RECRUITING

Maumee, Ohio, 43537, United States
Texas Oncology
RECRUITING

Dallas, Texas, 75246, United States
Texas Oncology
RECRUITING

Tyler, Texas, 75702, United States
The University Of Tennessee Health Science Center
RECRUITING

Memphis, Tennessee, 38103, United States
UCSD
RECRUITING

La Jolla, California, 92093, United States
UMC Radboud
RECRUITING

Nijmegen, Netherlands
UMC Utrecht
RECRUITING

Utrecht, Netherlands
USC Norris Comprehensive Cancer Center
ACTIVE_NOT_RECRUITING

Los Angeles, California, 90033, United States
UZ Gent
RECRUITING

Ghent, Belgium
University of Florida
RECRUITING

Gainesville, Florida, 32610, United States
University of Pennsylvania
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
University of Utah Health Huntsman Cancer Hospital
RECRUITING

Salt Lake City, Utah, 84112, United States
Utah Cancer Specialists
RECRUITING

Salt Lake City, Utah, 84106, United States
Vall d'Hebron
RECRUITING

Barcelona, Spain
Washington University School of Medicine at St Louis
RECRUITING

St Louis, Missouri, 63110, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.