ESOPHAGEAL CANCER

This study is testing a personalized treatment plan for people with advanced, inoperable esophageal cancer. It first uses a combination of immunotherapy and chemotherapy to see how the cancer responds. Based on that response, patients then receive a tailored follow-up treatment t…

This is a first-in-human safety study testing a new two-part treatment for people with advanced HER2-positive solid tumors that have stopped responding to standard therapies. First, a specially designed virus is injected directly into one tumor to help alert the immune system. A …

This is an early-stage study to test the safety and initial effectiveness of a new drug called RO7502175 for people with advanced solid tumors that have spread or cannot be cured. The drug will be tested both by itself and combined with other approved cancer drugs. The main goals…

This large study aims to find the best pre-surgery treatment combination for patients with esophageal cancer, which has a low survival rate. Researchers will compare different approaches, including chemotherapy, radiation, immunotherapy, and targeted drugs, given before surgery. …

This early-stage study is testing a new drug called BL-M17D1 in adults with advanced gastrointestinal cancers and other solid tumors that have a specific marker called HER2. The main goal is to find the safest dose and see how the body processes the drug. Researchers will also ch…

This is an early-stage study testing a new drug called MT-4561 in people with various advanced solid tumors who have run out of standard treatment options. The main goals are to find a safe dose, see how the body processes the drug, and check for any early signs that it might hel…

This early-stage study is testing the safety and effects of an experimental cancer drug called PF-08046876 in adults with advanced solid tumors. The drug is an antibody drug conjugate designed to target and kill cancer cells. Researchers will give the drug through an IV to about …

This study is testing a combination of four treatments for a specific type of advanced esophageal cancer. It aims to see if using a new antibody drug (bemosubaiabimab) together with a cancer growth blocker (anlotinib), radiation, and chemotherapy is safe and effective. The trial …

This study is testing whether a new combination of airway devices can prevent dangerous drops in blood oxygen levels in morbidly obese patients during sedated gastrointestinal endoscopy. Researchers will compare the new approach, which uses a special airway tube plus high-flow ox…

This study is testing new drug combinations for people with advanced stomach or esophageal cancer that cannot be removed by surgery. Researchers will give 160 participants experimental drugs along with standard chemotherapy and immunotherapy to see if they are safe and effective.…

This study is testing two different orders of intensive pre-surgery treatments for people with a type of esophageal cancer that has spread to nearby lymph nodes. The goal is to see if combining two established chemotherapy and radiation regimens before surgery can better control …

This program provides access to an investigational drug called ulixertinib for patients with advanced cancers that have specific genetic changes (MAPK pathway mutations). It is for people who have run out of other treatment options. The drug aims to control the cancer's growth, e…

This study aims to see if a combination of chemotherapy and radiation can be as effective as major surgery for controlling a specific type of esophageal cancer. It is for patients whose tumors shrink significantly after initial drug treatment. The goal is to determine if this les…

This is a first-in-human study to test the safety and early signs of effectiveness of a new drug called STRO-004 in adults with advanced solid tumors that have come back or stopped responding to other treatments. The trial will test STRO-004 alone and in combination with an exist…

This study is testing whether giving a combination of an immunotherapy drug (camrelizumab) and chemotherapy before surgery can shrink tumors enough to preserve the esophagus in patients with a type of esophageal cancer. The goal is to see if this approach can control the cancer e…

This study is testing if adding a precise, high-dose internal radiation treatment can help control cancer better for people with a specific type of advanced esophageal cancer. Participants have already received standard chemotherapy, external radiation, and an immunotherapy drug.…

This study is testing a combination treatment for advanced esophageal cancer that cannot be removed by surgery. Patients receive immunotherapy and chemotherapy first, followed by radiation with chemotherapy. Researchers will use regular blood tests to track tiny cancer DNA fragme…

This study is testing a new oral medication called NEO212 for adults with specific aggressive brain tumors (like glioblastoma) or brain metastases from other cancers. The main goals are to find a safe and effective dose, see how the body processes the drug, and check if it can he…

This early-stage study is testing a new oral drug called VMD-928, both by itself and combined with an existing immunotherapy (pembrolizumab). It is for adults with advanced solid tumors or lymphoma that have progressed despite available treatments. The main goals are to find safe…

This large Phase 3 study is testing whether adding new targeted drugs to standard chemotherapy works better for people with advanced stomach, esophageal, or gastroesophageal junction cancers. The trial is specifically for patients whose cancers test positive for a protein called …

This study is testing whether adding new targeted drugs to standard chemotherapy works better for people with advanced stomach or esophageal cancer that has worsened after initial treatment. It will enroll 210 participants to compare different drug combinations, focusing on safet…

This study is testing if combining immunotherapy drugs (called PD-1/PD-L1 inhibitors) with targeted radiation is more effective for controlling several advanced cancers, including lung and head/neck cancers. It aims to help patients live longer and also tries to find patterns in …

This is the first-ever study in people of an experimental cancer drug called TJ101. The main goal is to find a safe dose and see how the body handles it. The study will also look for early signs that the drug can shrink tumors in adults with advanced cancers who have run out of s…

This study is testing if adding two types of radiation therapy to standard first-line treatment helps people with advanced esophageal cancer that has spread. About 100 adults who haven't had prior cancer treatment will be randomly assigned to receive either the standard immunothe…

This study is testing whether a personalized approach to palliative care (comfort-focused treatment) helps people with advanced esophageal cancer live longer and feel better compared to standard palliative care. Researchers will enroll 624 adults who are receiving immunotherapy a…

This study is testing an experimental drug called zanidatamab for people with advanced cancers that have a specific marker called HER2 and have stopped responding to prior treatments. It will enroll about 200 adults with various cancers including breast, lung, stomach, and ovaria…

This is an early safety study testing an experimental drug called SH009 injection in adults with advanced solid tumors who have run out of standard treatment options. The study aims to find a safe dose, see how the body processes the drug, and check for early signs that it might …

This study is testing an experimental drug called HLX43 for people with advanced esophageal cancer that has returned or spread after standard treatment failed. The trial aims to find a safe and effective dose and see if the drug can help control the cancer. About 72 participants …

This early-stage study is testing a new type of treatment called CAR-T cell therapy for people with advanced cancers that have a specific marker (CEA) and have stopped responding to standard treatments like chemotherapy. The main goals are to find a safe dose and see if the treat…

This study is testing a new type of treatment called EBNK-001, which uses donated immune cells (Natural Killer cells) to fight cancer. It is for adults with advanced solid tumors that have grown or returned after standard treatments. The main goals are to find a safe dose and see…

This study is testing if giving a standard cancer drug (paclitaxel) over a longer time to patients with low muscle mass results in drug levels similar to those seen in patients with normal muscle mass. The goal is to see if this personalized timing approach could make the treatme…

This is the first study in people to test a new drug called BL-B01D1. It aims to find a safe dose and see if it can help control advanced cancers that have spread or cannot be removed by surgery. The trial will enroll about 470 adults with various solid tumors, including lung, br…

This is a first-in-human study to test the safety and find the right dose of a new investigational drug called LY4052031 for people with advanced or metastatic solid tumors. The drug is designed to target a specific protein found on many cancer cells, delivering its medicine dire…

This study is testing a new medical device designed to help obese patients breathe better and maintain safe oxygen levels while they are sedated for stomach and colon exams. The device combines several functions like oxygen support and airway management into one tool. Researchers…

This study is testing whether adding naturopathic doctor-guided care—including personalized diet, supplements, and lifestyle advice—to standard cancer surgery helps patients recover better. It aims to reduce complications, improve quality of life, and potentially help patients li…

This study is testing whether adding a new immunotherapy drug called Iparomlimab helps control cancer better for older patients (70+) with inoperable esophageal cancer. After patients finish standard chemotherapy and radiation, they will receive the immunotherapy drug for one yea…

This study is testing a three-part treatment for advanced esophageal cancer that cannot be removed by surgery right away. It combines a modified virus designed to attack cancer cells with standard chemotherapy and an immunotherapy drug. The main goals are to see if this combinati…

This first-in-human study is testing an experimental cancer treatment called IDOV-Immune, which uses a modified virus designed to infect and destroy cancer cells while boosting the immune system. The trial aims to find the safest dose and check for early signs that the treatment …

This is the first human study of an experimental cancer drug called LY4101174. Researchers want to find a safe dose and see if it can help control advanced cancers that have spread or returned after other treatments. The study will enroll about 490 people with various solid tumor…

This early-stage study is testing a new drug called BL-M07D1 for people with advanced cancers that have a specific marker called HER2. The trial aims to find the safest dose and see if the drug helps control cancer growth in patients who have already tried standard treatments. Re…

This study is testing an experimental drug called patritumab deruxtecan (HER3-DXd) in people with advanced solid tumors that have spread or cannot be removed by surgery. The goal is to see if the drug can shrink tumors and control the disease in people who have already tried at l…

This clinical trial is testing an experimental drug called TQB6411 injection for people with advanced esophageal cancer that has returned or spread. The study aims to find the safest dose and see if the drug can help control the cancer in patients whose previous treatments with i…

This study is testing three different treatment approaches for people with advanced cancers of the esophagus, stomach, colon, and other digestive organs. Researchers want to see if new drug combinations can shrink tumors and control the disease better than current options. The tr…

This early-stage trial is testing a new drug called CA-4948 in combination with standard chemotherapy and immunotherapy for people with advanced stomach or esophageal cancer that cannot be surgically removed. The study aims to find the safest dose of this combination and see if i…

This study aims to see how well the drug T-DXd works in real-world settings for patients with advanced HER2-positive cancers who have already tried other treatments and have no good options left. It will follow about 100 patients with various solid tumors (excluding breast, lung,…

This study is testing whether adding two newer drugs (pembrolizumab and trastuzumab) to standard chemotherapy before surgery can better control HER2-positive stomach and esophageal cancers. The goal is to shrink tumors before surgery and prevent cancer from returning. About 49 pa…

This study is testing a new type of targeted radiation therapy for people with advanced solid tumors that have stopped responding to standard treatments. The therapy uses a radioactive drug designed to seek out and deliver a powerful dose of radiation directly to cancer cells. Th…

This study is testing a new imaging system designed to help surgeons better see cancer cells during operations for gastrointestinal cancers. Patients scheduled for surgery for colorectal, pancreatic, or esophageal cancer receive an intravenous imaging agent before their procedure…

This study is a survey to understand what people value most in a test for stomach or esophageal cancer. Researchers want to know which test features patients and the general public prefer, and if these preferences differ by location. Participants will complete a 20-25 minute onli…

This study is testing a special fluorescent dye called CYTALUX that is given before surgery. The dye attaches to cancer cells and glows under a special camera, helping surgeons see and remove more cancerous tissue during the operation. The goal is to see if this method helps find…

This study is testing whether a special fluorescent dye called CYTALUX can help surgeons see gastrointestinal cancer cells more clearly during surgery. The dye is injected before the operation and glows under special near-infrared light, potentially revealing cancer that might ot…

This study aims to create a simple scoring system that helps doctors predict which patients might have leftover food or liquid in their stomach during sedated gastroscopy procedures. Researchers will follow 5,000 patients undergoing these common stomach exams to identify risk fac…

This study is testing whether chemical markers found in a person's breath and blood can be used to detect early-stage stomach and esophageal cancer. Researchers will compare samples from 1,000 people, including those with cancer, those with a pre-cancerous condition called Barret…

This study is testing a new type of PET/CT scan called [¹⁸F]FAPI-74 to see if it can better detect when stomach or esophageal cancer has spread to other parts of the body. The trial will involve 200 adults with these cancers who are being evaluated for treatment. Researchers will…

This study is testing a simple, swallowable sponge capsule called EsophaCap to collect cell samples from the esophagus and stomach. Researchers aim to find biological markers that can identify early signs of Barrett's esophagus, esophageal cancer, and stomach cancer. The goal is …

This study is testing a new blood test designed to detect many types of cancer early, before symptoms appear. It will involve 7,000 people, both with and without cancer, to see if the test can accurately spot cancer signals and identify where in the body the cancer started. The t…

This study is testing a new type of PET scan designed to find cancers in the stomach, pancreas, bile ducts, and esophagus. It uses a special tracer that attaches to a protein called CLDN18.2, which is often found on these cancer cells. The goal is to see if this scan can accurate…

This study is testing whether a special high-flow nasal oxygen device can prevent dangerous drops in oxygen levels during sedated endoscopy procedures. The research focuses on 600 patients who are at high risk for obstructive sleep apnea and are scheduled for gastrointestinal exa…

This study is testing if a special vacuum sponge can prevent a dangerous complication called an anastomotic leak after surgery for esophageal cancer. The sponge is placed inside the patient where the stomach and esophagus are reconnected and applies gentle suction. Researchers wi…

This study is testing whether a pre-surgery program of exercise and nutrition supplements is practical and helpful for adults with esophageal cancer. Researchers want to see if this 'prehabilitation' improves patients' strength and well-being before and after their major surgery.…

This study asks cancer patients which way they prefer to receive their immunotherapy drugs: as a quick injection under the skin or through a longer IV infusion. Researchers will enroll 480 people with various advanced cancers to compare comfort, convenience, and quality of life b…

This small pilot study is testing whether an exercise program before surgery is practical and acceptable for people with esophageal cancer. Researchers want to see if patients can complete the exercise program and if it might help with recovery after surgery. The study involves 2…

This study is testing if adding two chemotherapy drugs to a short course of radiation therapy works better than radiation alone to relieve severe swallowing problems in people with advanced, inoperable esophageal cancer. It will involve about 50 patients and focuses on improving …

This study is testing an artificial intelligence (AI) tool designed to predict how patients with esophageal cancer will respond to treatment and their likely survival. The AI analyzes various types of patient data, including medical scans and tissue samples, to find patterns. The…

This study examines past medical records of 4,000 people who had surgery for esophageal cancer. Researchers want to understand how different surgical approaches and treatment timing affect long-term survival. The goal is to learn from historical data to improve future cancer care…

This study aims to discover new biological markers that could help detect gastrointestinal cancers earlier. Researchers are collecting tissue, blood, urine, and stool samples from 5,000 people undergoing colonoscopy, endoscopy, or surgery. The goal is to identify substances that …

This large international study is collecting information on a new, more precise type of radiation therapy that uses real-time MRI scans to guide treatment. It aims to see if this advanced technology helps people with many types of cancer live longer, better control their tumors, …

This study looks back at past patient records to see if hospitals that perform a higher number of esophageal cancer surgeries each year have better patient outcomes than hospitals that perform fewer. It will also examine how treatments given before or after surgery affect results…

This study is testing a blood test that looks for tiny pieces of tumor DNA to see if it can detect cancer recurrence earlier than standard scans. It aims to enroll 100 adults, including people with various solid tumors and healthy volunteers. The goal is to gather information tha…

This study aims to better understand how often esophageal cancer spreads to a specific set of lymph nodes near the windpipe, and what factors make that spread more likely. It will observe 1100 patients with esophageal cancer who are scheduled for surgery. The goal is to gather ev…

This study aims to understand long-term survival and outcomes for people who have had surgery for esophageal cancer. It will follow over 2,100 patients who had their esophagus removed at participating hospitals. The main goal is to collect information on how patients fare after t…

This study aims to see if changes in specific DNA markers in the blood can tell doctors how well treatment is working for esophageal cancer. Researchers will enroll 300 patients and compare these new blood test results to standard methods like CT/MRI scans and other blood markers…

This early-stage study is testing a new type of PET scan (called 18F-FAraG PET) to see if it can better detect tumors in people with esophageal cancer. The main goal is to learn if this scan can predict whether a patient's cancer will completely disappear after receiving standard…

This study aims to learn if finding cancer cells or cancer DNA in a person's blood, urine, or bone marrow can help doctors better understand how cancer spreads. Researchers will collect samples from 100 people with cancer and 200 people at high risk for lung cancer to see if thes…

This study is building a large, long-term database of health information and biological samples from people with cancer, people at risk for cancer, and healthy volunteers. The goal is to collect this data to help researchers better understand what causes cancer and how to prevent…

This study aims to understand if the molecular markers used to guide treatment in stomach and esophageal cancers change when the cancer spreads to the brain. Researchers will analyze stored tissue samples from 30 patients to compare the original tumor with its brain metastasis. T…

This study aims to better understand how often esophageal cancer spreads to a specific set of lymph nodes near the windpipe. Researchers will observe 1,852 patients undergoing surgery to see how common this spread is and identify which patients are most at risk. The goal is to ga…

This study aims to understand how radiation treatment for esophageal cancer affects patients' ability to respond to pneumonia vaccines. Researchers will compare vaccine responses in 80 cancer patients and healthy individuals to see if radiation weakens immune protection. The goal…

This study aims to identify biological markers (biomarkers) in tissue and sputum samples that could signal the development of lung, head, neck, or esophageal cancers. Researchers are enrolling 700 participants who either have precancerous cell changes, a history of these cancers,…

This study aims to understand if a specific gene variation (ALDH2) is linked to how long patients survive after an esophageal cancer diagnosis. Researchers will analyze genetic information from 700 patients who have already been diagnosed with esophageal cancer. The goal is to se…

This study aims to understand how genes and proteins contribute to the development of stomach and esophageal cancers. Researchers will analyze tissue samples from biopsies and blood samples from 100 participants who either have these cancers or are at high inherited risk. The goa…