Promising cocktail for tough cancer? early trial combines immunotherapy, targeted pill, and radiation
NCT ID NCT07455019
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase 2 trial is testing whether a combination of the immunotherapy drug bemosubaiabimab, the targeted pill anlotinib, plus radiation and chemotherapy can help people with oligometastatic esophageal cancer—cancer that has spread to a few spots. About 28 participants will receive up to 6 cycles of the combo, then continue on the two drugs alone. The main goal is to see how many patients' tumors shrink significantly.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- bemosubaiabimab (a drug given by IV) plus anlotinib hydrochloride (a pill taken by mouth), along with radiation and chemotherapy
- What this could lead to
- If it works, this could point toward a new combination treatment that shrinks tumors and delays progression in people with limited-spread esophageal cancer.
- What could go wrong
- This is a small, early-phase trial with only 28 people and no comparison group, so results may not apply broadly. The combination also carries risks from chemotherapy, radiation, and immune-related side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Jiangsu Provincial People's Hospital
RECRUITINGNanjing, Jiangsu, China
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