The First Affiliated Hospital With Nanjing Medical University

This study tests two different drug combinations in people newly diagnosed with marginal zone lymphoma (MZL), a slow-growing blood cancer. One group gets a new targeted therapy (orelabrutinib) plus two other drugs, while the other gets standard chemo-immunotherapy. The goal is to…

This study tests a combination of the experimental drug linperlisib plus three standard chemotherapy drugs (cyclophosphamide, prednisone, and thalidomide) in 180 adults with non-Hodgkin lymphoma that has come back or stopped responding to treatment. The goal is to see how well th…

This early-phase study tests a new type of cell therapy that uses a virus to deliver two cancer-fighting targets (CD19 and CD20) directly into the body. It is for adults with B-cell blood cancers that have relapsed or not responded to standard treatments. The main goals are to ch…

This study tests a combination of four drugs (zanubrutinib, rituximab, lenalidomide, and tislelizumab) in 33 adults with follicular lymphoma that has returned or not responded to at least two prior treatments. The goal is to see how well the combo shrinks or eliminates tumors aft…

This study looks at whether adding the immunotherapy drug sintilimab to standard chemotherapy (SOX) can help prevent stomach cancer from returning after surgery. It involves 460 adults with a specific type of advanced stomach cancer (PD-L1 positive, stage N3) who have had their t…

This study looks at whether using a tiny camera (endoscope) during mastectomy and immediate breast reconstruction is safe and works well for breast cancer patients. The goal is to see if this newer method helps prevent cancer from coming back in the same area. About 800 women wit…

This study tests whether giving two drugs (thiotepa and trastuzumab) directly into the spinal fluid can shrink or control breast cancer that has spread to the lining of the brain. It involves 26 adults with HER2-positive breast cancer who already have a special port (Ommaya reser…

This study tests a combination of two drugs, tislelizumab and anlotinib, in 20 people with thymoma or thymic carcinoma whose cancer worsened after initial chemotherapy (with or without immunotherapy). The goal is to see if this second-line treatment can shrink or control tumors. …

This study tests a new treatment using stem cells from amniotic membrane for people with calciphylaxis, a rare and painful condition where blood vessels harden and cause severe skin wounds. The treatment is given to 9 adults with chronic kidney disease to see if it helps wounds h…

This study is testing whether a combination of three treatments—an immunotherapy drug (bemosubaiabimab), a targeted therapy (anlotinib), and standard chemoradiation—can shrink tumors in people with esophageal cancer that has spread to a limited number of other sites (oligometasta…

This study tests a 7-day treatment for H. pylori, a stomach bacteria that can cause ulcers. About 316 adults with H. pylori will get either the new 7-day combo (vonoprazan, amoxicillin, and bismuth) or the standard 14-day therapy. The goal is to see if the shorter treatment works…

This study is for people with HER2-negative breast cancer that has spread to the brain. It tests whether combining radiation therapy with two drugs (anlotinib and a tubulin inhibitor) can help control the cancer in the brain. The goal is to see if this approach can delay the canc…

This study tests whether giving a mix of immunotherapy (PD-1 blocker and IL-2) plus chemotherapy before surgery can shrink tumors more effectively in people with locally advanced rectal cancer. About 130 adults with a specific type of rectal cancer (MSS/pMMR) will take part. The …

This early-stage study tests whether a person's own natural killer (NK) cells, grown in a lab and infused back, are safe and can help control lung nodules. About 24 adults aged 18-70 with high-risk nodules will receive increasing doses. The main goal is to check for side effects …

This study is for people with a certain type of stage III stomach cancer (HER2-positive) who have had surgery to remove the tumor. It tests whether adding the targeted drug disitamab vedotin to standard chemotherapy (SOX) can help keep the cancer from returning. About 124 partici…

This study tests a combination of four drugs (PD-1 inhibitor, rituximab, methotrexate, and orelabrutinib) in 50 adults with newly diagnosed or relapsed central nervous system lymphoma. The goal is to see if this treatment can stop the cancer from growing for at least one year. Pa…

This study tests whether using focused ultrasound (HIFU) to destroy tumors, with or without an immune-boosting drug (PD-1 inhibitor), before standard chemotherapy can improve outcomes for people with early-stage triple-negative breast cancer. About 40 participants will receive on…

This study tests a new treatment using specially engineered immune cells (CAR-T cells) to target and destroy faulty B cells in people with severe autoimmune diseases like lupus, rheumatoid arthritis, and scleroderma. About 72 adults aged 18-70 will receive a single infusion of th…

This study tests a combination of three drugs (orelabrutinib, rituximab, and possibly lenalidomide) in people with untreated marginal zone lymphoma, a type of blood cancer. The goal is to see how well the treatment shrinks tumors and to check for side effects. About 50 adults wit…

This study looks at whether a type of diabetes medicine called GLP-1RA (like semaglutide) can improve nerve damage in the heart caused by type 2 diabetes. About 60 adults will receive either standard care or standard care plus a weekly injection for 6 months. Researchers will che…

This study tests a new drug, romiplostim N01, against the current standard treatment (interleukin-11) for cancer patients whose platelet counts drop due to chemotherapy or other cancer therapies. About 88 adults with various cancers and low platelets will be randomly assigned to …

This study tests whether adding a drug called thymosin alpha 1 to standard chemo-radiation and immunotherapy can improve outcomes for people with stage III gastroesophageal junction cancer. About 48 adults who have not yet been treated will be randomly assigned to receive either …

This study looks at whether the drug durvalumab can safely help control limited-stage small cell lung cancer in patients who have already had chemotherapy and radiation therapy. Researchers will track side effects and how long the cancer stays under control in 25 participants. Th…

This study tests a new treatment plan for people with locally advanced rectal cancer. Participants first get a short course of radiation along with an immune-boosting drug (IL-2). Then they receive chemotherapy (CAPOX) plus two immunotherapy drugs (a PD-1 antibody and IL-2). The …

This study looks at how safe robotic surgery is for removing gastrointestinal stromal tumors (GISTs) that are in tricky spots in the stomach. About 182 people with small to medium-sized tumors (2 to 5 cm) will have the surgery and be watched for 3 years to see if the tumors come …

This study tests whether adding venetoclax to standard BTK inhibitor therapy can help people with chronic lymphocytic leukemia (CLL) achieve deep remission and then stop all treatment. About 79 adults who have been on a BTK inhibitor for at least 6 months will receive the combina…

This study tests a combination of two drugs (disitamab vedotin and bevacizumab) in people with HER2-low breast cancer that has spread and worsened after prior treatment with T-DXd. The goal is to see if the combination can shrink tumors or slow the disease. About 37 adults will t…

This study tests a combination of three drugs (glofitamab, a PD-1 inhibitor, and lenalidomide) in 24 people with a type of large B-cell lymphoma that has returned or not responded to treatment and has a specific gene change (TP53). The goal is to see if this combination can shrin…

This early study tests a single injection of SC101 into the fat around the kidneys for people with resistant hypertension and moderate to severe chronic kidney disease. The main goal is to check safety, with a secondary look at whether it helps lower blood pressure over six month…

This study tests whether adding a targeted drug (HRS-4642) to standard chemotherapy can shrink locally advanced pancreatic tumors enough to allow surgery. About 30 adults with a specific gene mutation (KRAS G12D) will receive the combination. The main goal is to see how many pati…

This early-stage study is testing a new cell therapy called LVIVO-TaVec200 for patients with multiple myeloma that has returned or stopped responding to at least three prior treatments. The main goals are to find a safe dose, see how the body handles the treatment, and check for …

This study aims to see if a new type of MRI using a contrast agent called ferumoxytol can better detect calcium buildup in heart arteries compared to standard CT scans. Researchers will enroll 100 adults with known coronary calcification and compare the MRI results to the gold-st…

This study tests an artificial intelligence (AI) system that analyzes routine contrast-enhanced CT scans to detect gastric cancer and determine its stage (how far it has spread). The goal is to help doctors plan the best treatment, such as surgery or chemotherapy. The study will …

This study tests a personalized sound therapy for people with chronic tinnitus (ringing in the ears lasting over 6 months). Researchers will create custom sound clips based on each person's hearing and tinnitus, aiming to retrain the brain to reduce the perception of the ringing.…

This study tests if using ultrasound to deliver a medicine mix (tranexamic acid and glutathione) can safely treat melasma, a skin condition causing dark patches on the face. About 35 adults aged 20-55 will join. Each person's face is split in half to compare the treated side with…

This study aims to improve how doctors measure disease activity in people with axial spondyloarthritis (axSpA), a type of inflammatory arthritis affecting the spine and joints. Researchers will use whole-body MRI scans and machine learning to create a new assessment system. About…

This study is looking for 1,000 pregnant women to help researchers understand what causes gestational diabetes and how to predict it. The goal is to create a tool that can identify women at risk early. Then, a special health program will be tested to see if it can improve blood s…