The First Affiliated Hospital With Nanjing Medical University

This study tests a special balloon that uses sound waves to break up hard calcium deposits in heart arteries. It involves 200 adults with severe blockages. The goal is to see if this approach safely improves blood flow and lowers the risk of heart attacks or death.

This early-stage study tests whether transplanting lab-made retinal cells into the eye is safe and can help people with late-stage age-related macular degeneration (AMD). Nine adults aged 50–80 with advanced AMD will receive the cell transplant under the retina. The main goal is …

This study tests whether adding nimotuzumab to standard chemotherapy (nab-paclitaxel and gemcitabine) before and after surgery can help prevent pancreatic cancer from returning. About 156 adults with high-risk or borderline resectable pancreatic cancer will take part. The goal is…

This early-phase study tests a new treatment called RN1701 for people with B-cell lymphoma that has returned or not improved after standard therapy. RN1701 uses specially engineered immune cells (CAR-T cells) from a donor to find and attack cancer cells. The main goal is to check…

This study tests whether adding brentuximab vedotin to standard chemotherapy (R-CHP) works better for people newly diagnosed with a rare, aggressive lymphoma linked to the Epstein-Barr virus. About 25 adults will receive the combination and be followed for 2 years to see if the c…

This study tests whether giving a PD-L1 antibody (a type of immunotherapy) together with chemotherapy and radiation can shrink advanced bile duct cancer enough to allow patients to receive a liver transplant. The trial will enroll 25 adults aged 18-70 with locally advanced perihi…

This study tests whether adding the drugs SHR-1701 and apatinib to standard chemotherapy before surgery can improve outcomes for people with advanced stomach or gastroesophageal junction cancer. About 80 adults with resectable tumors will be randomly assigned to one of two treatm…

This study tests a combination of two immunotherapy drugs (iparomlimab and tuvonralimab) plus chemotherapy and a targeted therapy (lenvatinib) in 20 people with a specific type of advanced stomach cancer (MSI-H/dMMR). The goal is to see if this treatment can shrink tumors enough …

This study tests a combination of drugs (anlotinib, bempegaldesleukin) plus standard chemoradiotherapy for people with advanced soft tissue sarcoma that cannot be removed by surgery. The goal is to see if this treatment can shrink tumors and control the disease. About 46 adults a…

This study tests whether adding an experimental immunotherapy drug (QL1706) to standard chemotherapy before surgery can completely eliminate stomach cancer in patients with a specific type of advanced stomach cancer. About 74 adults aged 18-75 with resectable, HER2-negative diffu…

This study compares two types of minimally invasive surgery for people with a certain stage of stomach cancer (cT4a). Participants will be randomly assigned to have their tumor removed by either a robot-assisted or a standard laparoscopic procedure. The main goal is to see if the…

This study tests two different chemotherapy combinations in 70 adults whose diffuse large B-cell lymphoma has come back more than 12 months after initial treatment. Participants will receive either the modified R-MINE regimen or the R-GemOx regimen for four 21-day cycles. The goa…

This study tests the drug SHR2554 as a maintenance therapy for people with peripheral T-cell lymphoma (PTCL) who have responded to their first treatment. The goal is to see if taking this drug can help keep the cancer from coming back longer. About 30 adults whose cancer is in re…

This early-phase study tests an injection called LV009 in 19 adults whose CD19-positive blood cancer has returned or not responded to standard treatment. The main goal is to check safety and side effects. Participants receive one infusion and are monitored for up to 24 months to …

This study is testing a new combination of two immunotherapy drugs (iparomlimab and tuvonralimab, together called QL1706) with a modified chemotherapy regimen (TFOX) for people with advanced stomach or gastroesophageal junction cancer that is HER2-negative. The goal is to see if …

This study is testing a new single-port robotic surgery system for removing excess breast tissue in men with gynecomastia (male breast enlargement). Researchers will enroll 20 adult men to evaluate how safe and effective this robotic procedure is compared to traditional surgery. …

This study compares two surgical methods for early-stage breast cancer: conventional and endoscopic nipple-sparing mastectomy with immediate reconstruction. The goal is to see which approach better preserves breast skin sensation after surgery. About 170 women will be randomly as…

This study compares two types of keyhole spine surgery for middle-aged and older adults (50-75 years) with lumbar spinal stenosis, a condition that causes leg pain and trouble walking. One surgery just takes pressure off the nerves, while the other also fuses the bones together. …

This study tests whether adding megestrol acetate (a drug that boosts appetite) to standard chemoimmunotherapy can prevent weight loss in 48 patients with stage III stomach cancer who are losing weight before surgery. Participants will either get the drug or not, and researchers …

This study tests whether a combination of two sedative drugs, esketamine and dexmedetomidine, can safely and effectively reduce the time ICU patients spend in a state of severe confusion and agitation (hyperactive delirium) while they are on non-invasive breathing support. About …

This study looks at whether a drug called remimazolam can lower the chance of confusion (delirium) after stomach cancer surgery in people aged 65 and older. About 170 participants will get either remimazolam or standard anesthesia. The goal is to see if remimazolam leads to clear…

This study looks at 32 adults with liver cirrhosis to see if their blood proteins and gut bacteria differ between those who develop hepatic encephalopathy (brain fog) and those who don't. By identifying unique patterns, researchers hope to better understand the condition and guid…

This study looks back at medical records of 201 people with triple-negative breast cancer who received chemotherapy or immunotherapy before surgery. The goal is to see which treatment leads to a complete disappearance of cancer in the breast and lymph nodes, and what factors affe…