The First Affiliated Hospital With Nanjing Medical University

This phase 1 trial is testing an experimental therapy called CD19/CD20 dual-target in vivo CAR-T for people with relapsed or refractory B-cell malignancies—blood cancers that have not responded to standard treatments. The approach uses a lentiviral product to engineer a patient's…

This phase 2 trial is testing whether a combination of five drugs—chidamide, azacitidine, prednisone, cyclophosphamide, and thalidomide—can help people with peripheral T-cell lymphoma (PTCL) who are unable to tolerate standard chemotherapy. The study will enroll 58 adults with PT…

This phase II trial tests whether adding an immunotherapy drug (retlirafusp alfa) and possibly a third drug (pertuzumab) to the targeted therapy trastuzumab rezetecan can completely eliminate tumors before surgery in people with locally advanced HER2-positive stomach or gastroeso…

This phase 3 trial tests whether giving clot-busting drugs directly into the blocked brain artery (intra-arterial thrombolysis) helps people recover better from a medium-vessel stroke. About 306 adults aged 18-80 with acute stroke will be randomly assigned to receive either the d…

This phase 2 trial tests a combination of three drugs—sintilimab, ramucirumab, and paclitaxel—in 30 adults with HER2-negative stomach cancer that came back during or within 6 months of finishing adjuvant therapy. The main goal is to see how many patients' tumors shrink significan…

This early-phase trial tests a new cell therapy called RN9101 in 19 adults with relapsed or refractory multiple myeloma, a blood cancer that has not responded to at least two prior treatments. RN9101 is a type of CAR-T cell therapy given as a single intravenous infusion. The main…

This study tests a new combination of drugs for adults with diffuse large B-cell lymphoma (DLBCL) that has come back or not responded to previous treatment. About 46 participants will receive an experimental drug (EZH2 inhibitor) along with two other drugs (glofitamab and chemoth…

This early-stage study tests a new treatment called LVIVO-TaVec122 in 48 adults with B-cell blood cancers that have come back or not responded to standard therapy. The main goals are to check safety, find the right dose, and measure how long the treatment lasts in the body. It is…

This early-phase trial is testing a combination of two drugs—trastuzumab rezetecan and retlirafusp alfa—in 12 people with HER2-positive stomach or gastroesophageal junction cancer. The treatment is given before surgery to see if it can safely shrink tumors. The main focus is on s…

This study tests whether adding 4 cycles of the targeted drug trastuzumab rezetecan (T-DXh) can eliminate residual cancer in HER2-positive breast cancer patients who still have disease after standard chemotherapy. About 59 adults will receive the drug before surgery. The main goa…

This early-stage study tests a new treatment called RN1701 for people with B-cell lymphoma that has come back or not responded to other treatments. RN1701 is a type of immune cell therapy made from donor cells, designed to target two markers on cancer cells. The study will enroll…

This phase II trial tests whether combining an immunotherapy drug (PD-L1 inhibitor) with chemotherapy and radiation can shrink advanced bile duct tumors enough to allow a liver transplant. The study will enroll 25 adults with locally advanced perihilar cholangiocarcinoma that can…

This study tests a special balloon that uses shockwaves to break up hardened calcium deposits in heart arteries. About 200 people with severe blockages will receive this treatment to see if it safely improves blood flow and reduces the risk of heart attack or death. The goal is t…

This early-stage trial tests whether transplanting lab-grown retinal cells (made from stem cells) into the eye is safe for people with late-stage age-related macular degeneration. Nine participants will receive the cell transplant and be monitored for side effects and any improve…

This Phase II trial tests a new combination of two immunotherapy drugs (iparomlimab and tuvonralimab, together called QL1706) plus chemotherapy for people with advanced HER2-negative stomach or gastroesophageal junction cancer. The study will enroll 64 participants who have not h…

This phase II trial will test two different drug combinations in 70 people whose diffuse large B-cell lymphoma has returned more than a year after initial treatment. One group gets a modified R-MINE regimen (rituximab, ifosfamide, mitoxantrone liposome, etoposide), the other gets…

This study tests a drug called SHR2554 as a maintenance therapy for people with peripheral T-cell lymphoma who have responded to initial treatment. The goal is to see if taking this pill can help keep the cancer from progressing for longer. About 30 adults who have achieved compl…

This study tests if robot-assisted surgery helps people with a certain type of stomach cancer live longer without the cancer coming back, compared to standard laparoscopy. About 335 adults aged 18-80 with stage cT4a stomach cancer will be randomly assigned to one of the two surgi…

This early-phase trial will test the safety of an experimental cell therapy called LV009 injection in 19 adults with relapsed or refractory CD19-positive blood cancers. Participants receive a single infusion, then are monitored for side effects and tumor response for up to 24 mon…

This Phase II trial tests whether adding a new immunotherapy drug (QL1706) to standard chemotherapy (SOX) before surgery can completely eliminate stomach cancer in patients with a specific, aggressive type. About 74 adults with stage III diffuse-type gastric cancer will be random…

This phase 2 trial tests whether adding nimotuzumab, a targeted antibody, to standard chemotherapy can help people with high-risk pancreatic cancer that can still be surgically removed. About 156 participants will receive either the drug combo or a placebo before and after surger…

This study tests whether adding brentuximab vedotin to standard chemotherapy (R-CHP) works better for people newly diagnosed with a rare, aggressive lymphoma linked to the Epstein-Barr virus. About 25 adults will receive the combination and be followed for 2 years to see if the c…

This phase 2 trial tests whether combining two drugs (anlotinib and bempegaldesleukin) with standard radiation and chemotherapy can shrink or control advanced soft tissue sarcoma that cannot be surgically removed. About 46 adults aged 18 to 80 will receive the treatment in two ph…

This phase 2 trial tests a combination of two immunotherapy drugs (iparomlimab and tuvonralimab), a targeted therapy (lenvatinib), and chemotherapy (SOX) in 20 people with a specific type of advanced stomach or gastroesophageal junction cancer (MSI-H/dMMR). The goal is to see if …

This study investigates whether offering regular breast ultrasound screening to women aged 65 to 80 can increase the rate of early-stage breast cancer detection compared to routine health check-ups. Over 82,000 women from communities in China will be assigned to either receive st…

This study tests a new blood test that looks for DNA fragments in the blood (called cfDNA) to detect multiple myeloma and its early forms (MGUS and smoldering myeloma) in people over 40. The test uses machine learning to tell the difference between healthy individuals and those w…

This study tests whether a combination of two sedatives, esketamine and dexmedetomidine, can better control agitation and shorten delirium in intensive care unit (ICU) patients who are on non-invasive breathing support. The trial will enroll 388 adults with hyperactive delirium a…

This study tests whether a small device that gently stimulates a nerve in the ear can help reduce depression in people with Parkinson's disease. Participants use the device at home twice a day for 14 days. The trial measures changes in mood and brain activity to see if this simpl…

This study compares two types of keyhole spine surgery for middle-aged and older adults with lumbar spinal stenosis, a condition that causes leg pain and trouble walking. One surgery just removes the tissue pressing on nerves, while the other also fuses the bones together. The go…

This study tests whether a drug called megestrol acetate can help prevent weight loss in people with stage III stomach cancer who are about to have surgery. About 48 participants will receive either standard treatment (chemoimmunotherapy) or standard treatment plus megestrol acet…

This study will compare two surgical techniques for nipple-sparing mastectomy in 170 women with early breast cancer: the traditional open surgery and a newer endoscopic method using small hidden cuts. The main goal is to see which approach leads to better recovery of breast skin …

This study tests whether remimazolam, a newer anesthetic, can reduce the risk of postoperative delirium (sudden confusion) in elderly patients undergoing laparoscopic stomach cancer surgery. Researchers will compare remimazolam to standard anesthesia in 170 patients aged 65 and o…

This study tests a new robotic surgery to remove excess breast gland tissue in men with gynecomastia (enlarged breasts). Twenty men aged 18-75 who have had breast enlargement for over a year and haven't responded to medication will undergo single-port robotic-assisted surgery. Th…

This study looks at hepatic encephalopathy, a brain complication from liver cirrhosis that can cause memory loss and confusion. Researchers will follow over 700 liver cirrhosis patients and 120 healthy volunteers in China for up to 3 years. Participants use a simple phone app to …

This study is testing whether a blood test can locate where colorectal cancer has returned or spread after surgery. Researchers are analyzing genetic markers in the blood to build a model that predicts whether a recurrence is local or distant. The goal is to improve early detecti…

This study looks at whether breast-conserving surgery (removing only the tumor, not the whole breast) is safe for women diagnosed with multifocal or multicentric breast cancer—meaning they have two or more tumors in one breast. Researchers will follow 100 adult women for at least…

This study follows 100 women whose breast cancer has come back after a mastectomy. Researchers will track their health for at least three years to understand what factors affect survival and how different standard treatments work. No experimental drugs are given; the goal is to l…

This study looks back at data from 201 people with triple-negative breast cancer who received chemotherapy or immunotherapy before surgery. The goal is to compare how often the cancer completely disappears after treatment and find out what factors influence success. This is an ob…

This study looks at differences in proteins and gut bacteria between liver cirrhosis patients with and without hepatic encephalopathy (a brain complication). Researchers will analyze blood and stool samples from 32 adults to find unique patterns that could help diagnose and under…