Drug cocktail aims to shrink stomach tumors before surgery in small trial
NCT ID NCT07151209
First seen Jun 26, 2026 · Last updated Jun 26, 2026 · Updated 1 time
Summary
This phase 2 trial tests a combination of two immunotherapy drugs (iparomlimab and tuvonralimab), a targeted therapy (lenvatinib), and chemotherapy (SOX) in 20 people with a specific type of advanced stomach or gastroesophageal junction cancer (MSI-H/dMMR). The goal is to see if this treatment can completely eliminate the tumor before surgery, potentially improving outcomes. The study is not yet recruiting.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- iparomlimab, tuvonralimab, lenvatinib, and SOX chemotherapy (oxaliplatin and S-1)
- What this could lead to
- If successful, this combination could shrink advanced gastric tumors enough to allow surgical removal, potentially improving long-term survival.
- What could go wrong
- This is a small, early-phase trial with only 20 participants, so results may not apply broadly. The drug combination also carries risks of serious side effects like immune reactions and organ damage.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
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