Can a Five-Drug combo tame a tough lymphoma without standard chemo?
NCT ID NCT07746245
First seen Aug 05, 2026 · Last updated Aug 06, 2026 · Updated 1 time
Summary
This phase 2 trial is testing whether a combination of five drugs—chidamide, azacitidine, prednisone, cyclophosphamide, and thalidomide—can help people with peripheral T-cell lymphoma (PTCL) who are unable to tolerate standard chemotherapy. The study will enroll 58 adults with PTCL, including those who are newly diagnosed or have relapsed/refractory disease. Participants will receive the drug combo in 21-day cycles for up to 6 cycles, followed by a maintenance phase. The main goal is to see how many patients achieve a complete or partial response to the treatment.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- A combination of chidamide, azacitidine, prednisone, cyclophosphamide, and thalidomide
- What this could lead to
- If successful, this could offer a new treatment option for people with peripheral T-cell lymphoma who cannot tolerate standard chemotherapy, potentially helping to control the disease.
- What could go wrong
- This is an early-phase, single-arm study without a comparison group, so results may not be definitive. The drug combination may cause side effects, and it's unclear if it will be more effective than existing options.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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The First Affiliated Hospital of Nanjing Medical University
Nanjing, Jiangsu, China
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