New pill aims to shrink Hard-to-Treat cancers

NCT ID NCT04104776

Recruiting now Disease control Sponsor: Novartis Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 17, 2026 · Updated 1 time

Summary

This study tests an experimental drug called Tulmimetostat (DZR123) in people with advanced solid tumors or lymphomas that have not improved with standard treatments. The drug is taken as a daily pill, either alone or combined with another drug (enzalutamide) for certain prostate cancers. The goal is to find a safe dose and see if the drug can shrink tumors or slow cancer growth.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Tulmimetostat (also known as DZR123 or CPI-0209)
What this could lead to: If successful, this could provide a new treatment option for people with advanced solid tumors or lymphomas that have not responded to other therapies.
What could go wrong: This is an early-phase trial, so the drug may not prove effective or may cause significant side effects. Results may not apply to all cancer types.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

B-cell neoplasm castration-resistant prostate carcinoma diffuse large B-cell lymphoma endometrial cancer endometrial carcinoma endometrium neoplasm immune system disorder immunoproliferative disorder lymphatic system disorder lymphoma lymphoproliferative syndrome malignant mesothelioma mature T-cell and NK-cell non-Hodgkin lymphoma Mesothelioma, Malignant neoplasm Neoplasms by Histologic Type Neoplasms by Site non-Hodgkin lymphoma ovarian clear cell cancer Prostatic Neoplasms, Castration-Resistant T-cell non-Hodgkin lymphoma urothelial carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED SOLID TUMOR DIFFUSE LARGE B-CELL LYMPHOMA ENDOMETRIAL CANCER LYMPHOMA, T-CELL MESOTHELIOMA, MALIGNANT METASTATIC CASTRATION-RESISTANT PROSTATE CANCER OVARIAN CLEAR CELL CARCINOMA PROSTATIC NEOPLASMS, CASTRATION-RESISTANT

Contacts and locations

Locations

Abramson Cancer Center of the University of Pennsylvania
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
Asan Medical Center
RECRUITING

Seoul, 05505, South Korea
Azienda Ospedaliero Universitaria di Bologna - Policlinico S. Orsola-Malpighi
COMPLETED

Bologna, 40138, Italy
CHU Bordeaux Hopital Saint Andre
WITHDRAWN

Bordeaux, 33000, France
CHU Nantes Hopital Hotel Dieu
RECRUITING

Nantes, 44093, France
CHU Nantes Hopital Hotel Dieu
RECRUITING

Nantes, 44093, France
CHU Nantes Hopital Nord Laennec
RECRUITING

Saint-Herblain, 44800, France
CLCC Institut Bergonie
RECRUITING

Bordeaux, 33076, France
CLCC Institut Gustave Roussy
RECRUITING

Villejuif, 94800, France
Catalan Institute of Oncology
WITHDRAWN

Barcelona, 08908, Spain
Centre Leon Berard
RECRUITING

Lyon, 69008, France
Centre Oscar Lambret
RECRUITING

Lille, 59000, France
Centrum Medyczne Pratia - Poznan
COMPLETED

Poznan, 60-192, Poland
Churchill Hospital
WITHDRAWN

Oxford, OX3 7LE, United Kingdom
Clinica Universidad de Navarra
RECRUITING

Pamplona, 31008, Spain
Clinica Universidad de Navarra
RECRUITING

Pamplona, 31008, Spain
Dana Farber Cancer Institute (HARVARD)
COMPLETED

Boston, Massachusetts, 02215, United States
Emory University School of Medicine
RECRUITING

Atlanta, Georgia, 30322, United States
European Institute of Oncology (IEO), IRCCS
COMPLETED

Milan, 20141, Italy
European Institute of Oncology (IEO), IRCCS ( Department of Urogenital and Head-and-Neck Medical Oncology)
RECRUITING

Milan, 20141, Italy
Fondazione IRCCS Istituto Nazionale Dei Tumori
WITHDRAWN

Milan, 20133, Italy
Fred Hutchinson Cancer Center
RECRUITING

Seattle, Washington, 98109, United States
Gachon University Gil Medical Center
RECRUITING

Incheon, 21565, South Korea
Gangnam Severance Hospital
RECRUITING

Seoul, 06273, South Korea
H. Lee Moffitt Cancer Center and Research Institute
WITHDRAWN

Tampa, Florida, 33612, United States
Hackensack University Medical Center
COMPLETED

Hackensack, New Jersey, 07601, United States
Hematology Department - Hospital Universitario de Salamanca, IBSAL, CIBERONC
COMPLETED

Salamanca, 37007, Spain
Hospital Clinic of Barcelona
RECRUITING

Barcelona, 08036, Spain
Hospital Universitari de Girona Doctor Josep Trueta
RECRUITING

Girona, 17007, Spain
Hospital Universitario 12 de Octubre
COMPLETED

Madrid, 28041, Spain
Hospital Universitario Quirónsalud Madrid
RECRUITING

Pozuelo de Alarcón, 28223, Spain
Hospital Universitario Son Espases
RECRUITING

Palma, 07120, Spain
Hospital Vall d Hebron
RECRUITING

Barcelona, 08035, Spain
Hospital Virgen del Rocio
RECRUITING

Seville, 41013, Spain
Humanitas San Pio X
RECRUITING

Milan, 20159, Italy
IRCCS Istituto Clinico Humanitas - Research Hospital
RECRUITING

Rozzano, 20089, Italy
IRCCS Policlinico Universitario Fondazione Agostino Gemelli
RECRUITING

Roma, 00168, Italy
Imperial College Healthcare NHS Trust
WITHDRAWN

London, W2 1NY, United Kingdom
Institut Cancerologie de Strasbourg
RECRUITING

Strasbourg, 67200, France
Institute of Polish Mother Health Centre - ICZMP
WITHDRAWN

Lodz, 93-338, Poland
Instituto Valenciano de Oncologia
RECRUITING

Valencia, 46009, Spain
La Fe University and Polytechnic Hospital
RECRUITING

Valencia, 46026, Spain
Leicester General Hospital
RECRUITING

Leicester, LE5 4PW, United Kingdom
Loyola University Medical Center
WITHDRAWN

Maywood, Illinois, 60153, United States
Massachusetts General Hospital (MGH)
RECRUITING

Boston, Massachusetts, 02114, United States
Memorial Sloan Kettering Cancer Center
WITHDRAWN

New York, New York, 10065, United States
Montefiore Einstein Center for Cancer Care (MECCC)
WITHDRAWN

The Bronx, New York, 10467-2490, United States
Musgrove Park Hospital
COMPLETED

Taunton, TA1 5DA, United Kingdom
NYU Langone Medical Center
COMPLETED

New York, New York, 10016, United States
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy
COMPLETED

Gliwice, 44-102, Poland
National Cancer Center
COMPLETED

Goyang-si Gyeonggi-do, 10408, South Korea
National Cancer Institute, IRCCS
RECRUITING

Milan, 20133, Italy
Novartis Investigative Site
WITHDRAWN

Daegu, 42602, South Korea
Parc Taulí Hospital Universitari
RECRUITING

Sabadell, 08208, Spain
Pratia MCM
WITHDRAWN

Krakow, 30-727, Poland
Puerta de Hierro Majadahonda University Hospital
RECRUITING

Majadahonda, 28222, Spain
Roswell Park Cancer Institute
WITHDRAWN

Buffalo, New York, 14203, United States
Royal United Hospital Bath NHS Trust
WITHDRAWN

Bath, BA1 3NG, United Kingdom
Santiago Clinic Hospital CHUS
RECRUITING

Santiago de Compostela, 15706, Spain
Seoul National University Hospital
RECRUITING

Seoul, 03080, South Korea
South Texas Accelerated Research Therapeutics (START) - Midwest Location
ACTIVE_NOT_RECRUITING

San Antonio, Texas, 78922, United States
South Texas Accelerated Research Therapeutics (START) - San Antonio
COMPLETED

San Antonio, Texas, 78229, United States
Southampton General Hospital
WITHDRAWN

Southampton, SO16 6YD, United Kingdom
Swedish Cancer Institute
RECRUITING

Seattle, Washington, 98104, United States
The Catholic University of Korea, Yeouido St. Mary's Hospital
WITHDRAWN

Seoul, 07345, South Korea
The Christie NHS Foundation Trust
COMPLETED

Manchester, M20 2BX, United Kingdom
The Royal Marsden NHS Foundation Trust - Royal Marsden Hospital (RMH)
COMPLETED

Sutton, SM2 5PT, United Kingdom
The Royal Marsden NHS Foundation Trust - Royal Marsden Hospital (RMH)
WITHDRAWN

Sutton, SM2 5PT, United Kingdom
University Hospital Clinical San Carlos, Department of Medical Oncology
RECRUITING

Madrid, 28040, Spain
University Hospital Foundation Jimenez Diaz
RECRUITING

Madrid, 28040, Spain
University Hospital Ramon y Cajal
RECRUITING

Madrid, 28034, Spain
University Teaching Hospital
RECRUITING

Poznan, 60-569, Poland
University of Chicago
RECRUITING

Chicago, Illinois, 60637, United States
University of Cincinnati Cancer Institute
WITHDRAWN

Cincinnati, Ohio, 45219, United States
University of Maryland Medical Ctr
WITHDRAWN

Baltimore, Maryland, 21201, United States
University of Michigan Rogel Cancer Center
WITHDRAWN

Ann Arbor, Michigan, 48109, United States
University of Rochester Medical Center
WITHDRAWN

Rochester, New York, 14642, United States
University of Virginia Health System (UVAHS)
RECRUITING

Charlottesville, Virginia, 22908, United States
Uniwersyteckie Centrum Kliniczne GUMed
RECRUITING

Gdansk, 80-952, Poland
Weill Medical College of Cornell University
WITHDRAWN

New York, New York, 10021, United States
Yonsei Univ Health System YUCM
RECRUITING

Seoul, 03722, South Korea

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