Can an immune booster outsmart brain lymphoma?

NCT ID NCT07764601

Not yet recruiting Disease control Sponsor: WEI XU Source: ClinicalTrials.gov ↗

First seen Aug 14, 2026 · Last updated Aug 14, 2026

Summary

This trial is testing whether adding an immunotherapy drug called penpulimab to a standard chemotherapy regimen can help people with primary central nervous system lymphoma, a rare type of brain cancer. Participants, who have not yet received treatment, are randomly assigned to receive either the standard chemo alone or the chemo plus penpulimab. The study aims to see if the combination improves the chance of staying free of disease for two years.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: penpulimab (an anti-PD-1 immunotherapy) added to a standard chemotherapy regimen (rituximab, methotrexate, cytarabine)
What this could lead to: If adding penpulimab works, it could improve how long people with this rare brain lymphoma stay free of disease, potentially offering a new standard of care.
What could go wrong: This is a relatively small, early-stage trial, and the added drug may increase side effects without improving outcomes. Results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

diffuse large B-cell lymphoma primary central nervous system lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DIFFUSE LARGE B-CELL LYMPHOMA PRIMARY CENTRAL NERVOUS SYSTEM LYMPHOMA

Contacts and locations

Locations

The First Affiliated Hospital of Nanjing Medical University

Nanjing, Jiangsu, China
The First People's Hospital of Changzhou

Changzhou, Jiangsu, China
The First People's Hospital of Huai'an

Huai'an, Jiangsu, China
Wuxi People's Hospital

Wuxi, Jiangsu, China
Yixing People's Hospital

Yixing, Jiangsu, China

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