ENDOMETRIAL CANCER

This study tests a new drug called EIK1005, alone or with another drug (pembrolizumab), in people with advanced solid tumors that have not responded to other treatments. The goal is to find a safe dose and see if the combination can shrink tumors. About 160 adults with certain ca…

This study tests a new drug called BNT323 (also known as DB-1303) against standard chemotherapy in 480 adults whose endometrial cancer has come back after previous treatment. The cancer must have a certain protein (HER2) on its surface. The main goals are to see if BNT323 slows c…

This study tests whether two drugs, abemaciclib and letrozole, can help keep advanced or recurrent endometrial cancer from progressing. The trial enrolls 32 people with a specific type of cancer (ER-positive, mismatch repair proficient, TP53 wildtype). Participants take the drugs…

This early-stage study tests an experimental drug called MOMA-341, taken as a pill, for people with advanced solid tumors that have specific genetic features (MSI-H or dMMR). The study includes up to 132 adults whose cancer has not responded to prior treatments. The main goal is …

This study tests personalized treatments for young women with endometrial cancer who want to preserve their fertility. By analyzing the genetic makeup of each tumor, doctors will assign the most effective therapy—such as hormone therapy or immunotherapy—to improve the chance of c…

This early-phase study tests a new drug called IPH5301 in people with advanced solid tumors that have spread. The drug works by blocking a protein (CD73) that tumors use to hide from the immune system. The study first finds the safest dose of IPH5301 alone, then tests it combined…

This early-phase trial tests an experimental drug called ALTA2618 in about 110 adults whose advanced solid tumors (including breast and endometrial cancers) have a specific AKT1 E17K gene mutation. The main goals are to check the drug's safety and find the right dose. Participant…

This study tests a new drug called TER-2013 in people with advanced solid tumors (like breast, endometrial, ovarian, lung, head and neck, esophageal, or cervical cancer) that have specific changes in the AKT/PI3K/PTEN pathway. The goal is to see if the drug is safe and shrinks tu…

This study tests whether combining two drugs—avelumab (an immunotherapy) and M1774 (a targeted pill)—can shrink or slow the growth of recurrent endometrial cancer in people whose tumors have a specific genetic change (ARID1A mutation). About 25 participants will receive the combi…

This study tests a treatment called lifileucel, made from a patient's own immune cells (tumor-infiltrating lymphocytes), for advanced endometrial cancer that has been treated before. About 60 participants will receive this cell therapy to see if it can shrink tumors. The goal is …

This study looks at how well the drug T-DXd works in adults with advanced HER2-positive solid tumors that have spread and are not responding to other treatments. About 100 people will be followed to see if their tumors shrink and how long that lasts. The goal is to provide a trea…

This early-phase study tests a new drug called BL-B01D1 in people with advanced lung cancer or other solid tumors that have spread or cannot be removed. The main goals are to check the drug's safety and find the best dose. About 470 adults will take part to see if the drug can he…

This early-stage study tests a new drug, PF-08046054/SGN-PDL1V, in people with advanced solid tumors that have spread or can't be removed. The drug is given alone or with pembrolizumab to see if it's safe and what side effects occur. About 714 participants with cancers like lung,…

This study tests a personalized vaccine plus two approved drugs and an immune booster in people with advanced HER2-positive endometrial cancer. The vaccine is made from each participant's own blood cells and aims to help the immune system attack cancer. The goal is to see if this…

This early-phase study tests whether giving radiation over just one week (instead of the usual five) alongside standard chemotherapy is practical for people with stage III endometrial cancer. About 28 participants who have already had surgery will receive the combined treatment. …

This early-stage study tests a new drug called PHST001, alone or with chemotherapy, in adults with advanced solid tumors that have stopped responding to standard treatments. The main goals are to check safety and find the best dose. The study includes people with ovarian, endomet…

This study tests a new drug called Rina-S in people with advanced solid tumors that have spread or can't be removed by surgery. The goal is to see if Rina-S is safe and how well it works against cancers like ovarian, lung, and breast cancer. About 764 participants will receive th…

This study is for women with a specific type of endometrial cancer (MMR-D/MSI-H) who have had surgery. It tests whether adding radiation and an immunotherapy drug called Dostarlimab can help keep the cancer from returning. About 62 participants will receive the combination treatm…

This study tests a new drug, puxitatug samrotecan, against standard chemotherapy for people with advanced or metastatic endometrial cancer that has worsened after platinum-based chemo and immunotherapy. About 700 participants will be randomly assigned to receive either the new dr…

This early-phase study tests a new drug called SLV-154 in about 70 people whose solid tumors (like head and neck, lung, breast, or ovarian cancer) have spread. The main goal is to find a safe dose and watch for side effects. Participants must have a confirmed diagnosis and be in …

This early-phase study tests a new drug called CTX-10726 in people with advanced cancers (stomach, liver, uterine, or kidney) that have not responded to standard treatments. The main goal is to check the drug's safety and find the best dose. About 70 adults will take part, and th…

This early-stage study tests a new drug called STRO-004 in about 200 adults with advanced solid tumors (like lung, colon, or pancreatic cancer) that have not responded to standard treatments. The study has three parts: finding a safe dose of STRO-004 alone, testing that dose in m…

This study tests a combination of two drugs, cabozantinib and dostarlimab, in 37 women whose gynecologic carcinosarcoma has returned after at least one prior chemotherapy. The goal is to see if the combination can keep the cancer from growing for at least 6 months. Participants w…

This study tests a drug called ivonescimab in 50 people with advanced endometrial or cervical cancer that has worsened after standard chemotherapy. The drug targets two proteins (PD1 and VEGF) to help the immune system fight the cancer. The main goal is to see if the drug shrinks…

This early-phase study tests a new drug called HWK-016 in people with advanced ovarian or endometrial cancers that have not responded to standard treatments. The drug is designed to target and attack cancer cells while sparing healthy ones. The main goals are to find the safest d…

This early-stage study tests a new drug called HWK-007 in people with advanced solid tumors, such as certain ovarian, endometrial, and lung cancers. The drug is designed to target and attack cancer cells that have a specific marker (PTK7). The main goals are to find the safest do…

This study tests whether adding sacituzumab tirumotecan (Sac-TMT) to standard pembrolizumab helps people with advanced or recurrent endometrial cancer live longer without the cancer growing. About 1,100 participants with a specific type of cancer (pMMR) will receive either the co…

This study compares a new drug, Rina-S, to standard chemotherapy (paclitaxel or doxorubicin) in people with endometrial cancer that has returned or worsened after prior treatment. About 660 participants will be randomly assigned to receive either Rina-S or standard chemo. The goa…

This study tests a new drug called PC14586 (rezatapopt) in people with advanced or spreading solid tumors that have a specific change in the TP53 gene (Y220C mutation). The goal is to see if the drug is safe and works against these cancers. About 300 adults (and some teens after …

This study is collecting real-world data from 150 women in Germany with advanced or recurrent endometrial cancer. Participants receive standard chemotherapy plus durvalumab, followed by maintenance therapy with durvalumab alone or with olaparib. The goal is to see how well this t…

This study tests a new drug called TCC1727 combined with other cancer treatments (benmelstobart, olaparib, or topotecan) for people with advanced solid tumors that have stopped responding to standard therapy. The goal is to find the safest dose and see if the combination can shri…

This study tests an experimental drug, REGN5668, alone or with other immune-boosting medicines in people with ovarian, fallopian tube, peritoneal, or endometrial cancers. The goal is to find the safest dose and see if the combination shrinks tumors. About 612 adults whose cancer …

This early-phase study tests an experimental oral drug, RGT-490, in adults with advanced solid tumors (including breast, ovarian, and endometrial cancers) that have a specific genetic change called PIK3CA. The main goals are to check the drug's safety, find the right dose, and se…

This early-stage study tests a new drug called XmAb541 in people with advanced ovarian, endometrial, or germ cell tumors that have not responded to prior treatments. The main goals are to check if the drug is safe and to find the best dose. About 282 participants will receive the…

This study tests a drug called elacestrant, alone or with another drug (abemaciclib), for people with advanced or recurrent ER+ endometrial cancer. The goal is to see if these treatments can shrink tumors or slow the disease. Participants must have already tried platinum chemothe…

This study tests a 24-week digital wellness program combined with online support from healthcare professionals to help endometrial cancer survivors reduce waist size and improve overall health. About 148 participants who have completed cancer treatment will use a smartphone app a…

This early-phase study tests a new drug called IDE161, alone or with another drug (pembrolizumab), in people with advanced solid tumors (like breast, ovarian, prostate, or lung cancer) that have not responded to other treatments. The main goals are to check safety, find the right…

This early-stage study tests a modified virus (KD01) designed to infect and kill cancer cells in women with cervical or endometrial cancer. Phase I includes patients who have exhausted other treatments; Phase II focuses on younger women who wish to preserve fertility. The goal is…

This study is testing a shorter course of pelvic radiation for women with endometrial or cervical cancer. The goal is to see if giving slightly higher daily doses over fewer days is safe and tolerable. About 100 women who have already had surgery will participate. The study will …

This study looks at whether a less invasive weight-loss procedure called endoscopic suture gastroplasty (ESG) is safe and works well for obese women who have finished treatment for endometrial cancer. About 74 women will be enrolled to see if the procedure helps them lose weight …

This early-phase study tests an investigational drug called BL0175 in postmenopausal women with advanced breast, ovarian, or endometrial cancer that is hormone receptor-positive. The main goals are to check the drug's safety, find the best dose, and see if it helps shrink or cont…

This study tests whether the drug belzutifan can shrink or control certain gynecologic cancers (like ovarian, endometrial, cervical, vaginal, or vulvar) that have come back or not gone away. About 32 adults with clear cell carcinoma will receive belzutifan pills. The main goal is…

This study looks at whether a blood test that detects tumor DNA (ctDNA) can guide decisions to stop maintenance immune therapy after one year in people with advanced or recurrent endometrial cancer. About 30 participants will receive standard chemotherapy plus immune checkpoint i…

This early-phase trial tests an experimental drug called MOv18 IgE in people with advanced ovarian, endometrial, or triple-negative breast cancers that have high levels of a protein called folate receptor alpha. The study has two parts: first, finding a safe dose, and then checki…

This study tests a new oral drug, AVZO-021, in people with advanced solid tumors that have not responded to other treatments. The drug targets a protein called CDK2 to slow or stop cancer growth. The trial has two phases: first to find the safest dose, then to see if it shrinks t…

This study tests whether combining targeted drugs with the immunotherapy atezolizumab can shrink tumors or slow cancer growth in people with recurrent or persistent endometrial cancer. About 148 participants whose cancer has returned after at least one prior treatment will receiv…

This study tests an experimental drug called ART0380 in people with advanced or metastatic solid tumors (cancers that have spread). The goal is to find a safe dose and see if it works alone or with other chemotherapy drugs like gemcitabine or irinotecan. About 442 participants wi…

This early-phase study tests a new drug called 177Lu-RAD204, which is a radioactive antibody that seeks out and attaches to a protein (PD-L1) on cancer cells. The goal is to see if it is safe and tolerable for people with advanced solid tumors like lung, breast, or skin cancer th…

This early-phase trial tests whether combining chemotherapy, radiation, and the drug dostarlimab is safe and can help control stage IIIC endometrial cancer that has spread to lymph nodes. About 21 participants will receive chemoradiation followed by chemotherapy plus dostarlimab.…

This study tests an experimental drug called patritumab deruxtecan in people with advanced solid tumors that have spread or cannot be removed. The trial includes 740 participants with 13 different cancer types, such as lung, breast, and prostate cancer. The goal is to see if the …

This early-phase study tests a new drug called BG-68501 in people with advanced solid tumors (like breast, lung, or ovarian cancer) that have not responded to standard treatments. The goal is to find a safe dose and see if the drug shrinks tumors, either alone or combined with ot…

This study tests a new combination of drugs (sapanisertib and serabelisib, called PIKTOR) plus chemotherapy (paclitaxel) in people with advanced or recurrent endometrial cancer that has not been cured by prior treatments. About 40 participants will receive the drug combo, and a s…

This study tests whether taking selinexor pills after standard chemotherapy can delay cancer growth in people with a specific type of advanced or recurrent endometrial cancer (p53 wild-type). About 276 adults whose cancer shrank or disappeared after at least 12 weeks of platinum-…

This study tests whether taking a daily pill called olaparib for one year after standard treatment can help prevent endometrial cancer from coming back. It is for people with a specific type of aggressive endometrial cancer (p53abn). About 554 participants will be randomly assign…

This study tests a new drug called datopotamab deruxtecan (Dato-DXd) alone or with other cancer drugs in people with advanced solid tumors that have spread. The goal is to see if the drug can shrink tumors or slow cancer growth. About 454 adults with cancers like endometrial, gas…

This study tests whether adding a collagen injection into the uterus to standard hormone therapy can help women with early endometrial cancer or atypical hyperplasia achieve remission while preserving fertility. About 30 participants will receive either hormone pills alone or hor…

This study tests a new drug called AZD8205, alone or with other cancer drugs, in people with advanced solid tumors (like breast, ovarian, or lung cancer) that have spread or come back. The main goals are to check safety and find the right dose. About 460 adults whose cancer has n…

This early-stage study tests a new drug called TORL-1-23 in people with advanced solid tumors, including ovarian, endometrial, and lung cancers. The main goals are to check safety, find the best dose, and see if the drug can shrink tumors. About 90 participants will take part.

This study tests an experimental drug called MT-4561 in people with advanced solid tumors (like lung, breast, or pancreatic cancer) who have run out of standard options. The goal is to find a safe dose and see if the drug can shrink tumors. About 27 adults will take part in this …

This study tests a new drug called KIVU-107 in people with advanced solid tumors that have stopped responding to standard treatments. The drug is designed to target and kill cancer cells while limiting harm to healthy cells. The main goals are to find the safest dose and check fo…

This early-stage trial tests a new drug called GV20-0251 in people with advanced solid tumors that no longer respond to standard treatments. The main goal is to check the drug's safety. About 10 adults with cancers like liver, lung, or skin cancer will take part. This is not a cu…

This study tests whether people with certain genetic types of early-stage endometrial cancer can safely receive less intense treatment after surgery. About 393 participants will be assigned to one of two groups based on their tumor's molecular profile. The goal is to see if this …

This early-phase study tests a new drug called CTIM-76 in people with ovarian, testicular, or endometrial cancer that has come back or stopped responding to standard treatments. The drug works by helping the immune system attack cancer cells that have a specific marker called CLD…

This early-stage study tests a new oral drug, NKT5097, in 205 adults with advanced solid tumors that have not responded to other treatments. The main goals are to find the safest dose and understand side effects. The study focuses on breast cancer and other tumors with specific g…

This study tests a combination of two or three drugs (BL-B01D1, pembrolizumab, and possibly bevacizumab) in people whose cervical or endometrial cancer has come back or spread. The goal is to see if the treatment shrinks tumors or slows the disease. About 96 adults aged 18-75 wit…

This study tests whether a new drug combination (trastuzumab deruxtecan plus immunotherapy) works better than standard chemotherapy for people with advanced or returning endometrial cancer that has a specific protein (HER2) and is mismatch repair proficient. About 600 adults will…

This early-phase study tests a new drug called ADU-1805, alone or with another cancer drug (pembrolizumab), in adults with advanced solid tumors that have not responded to standard treatments. The main goals are to check safety and how the drug moves through the body. About 130 p…

This study is testing a new robotic surgery system (Medtronic Hugo™) to see if it is safe and works well for hysterectomy. About 70 adult women with conditions like fibroids, endometriosis, or certain cancers will take part. The main goal is to see if the surgery can be completed…

This early-phase study tests a new drug called XMT-1660 in people with advanced solid tumors, including triple-negative breast, ovarian, and endometrial cancers. The main goals are to find the safest dose and check for side effects. About 319 participants will receive the drug to…

This study tests an experimental drug called ubamatamab, given alone or with another drug (cemiplimab), for people with ovarian, fallopian tube, peritoneal, or endometrial cancer that has come back. The main goals are to check safety, find the best dose, and see if the drugs can …

This study is testing an experimental drug called MGC026 in about 250 adults with advanced solid tumors that have not responded to other treatments. The main goals are to check the drug's safety and find the right dose. Participants receive the drug by IV and are closely monitore…

This study tests a combination of two drugs, nab-sirolimus and letrozole, in people with advanced or recurrent endometrioid endometrial cancer. The goal is to see if the combination can shrink or control tumors. About 29 participants will receive the treatment, and researchers wi…

This study tests an experimental drug called lorigerlimab in about 60 people with advanced ovarian or other gynecologic cancers that no longer respond to standard chemotherapy. Participants receive the drug by IV every 3 weeks. The goal is to see if the drug can shrink tumors and…

This early-phase study tests a new drug called NRM-823, alone or with an immunotherapy, in 150 adults with advanced solid tumors that have not responded to standard treatments. The main goals are to check safety and find the right dose. The study includes several cancer types lik…

This early-phase study tests a new treatment called 177LuBetaBart for people with advanced solid tumors that have stopped responding to standard therapies. The treatment combines a targeting antibody with a radioactive particle to deliver radiation directly to cancer cells. The s…

This study tests a new drug called ETX-19477 in people with advanced solid tumors (like breast, ovarian, or prostate cancer) that have stopped responding to standard treatments. The goal is to find the safest dose and see if the drug can shrink tumors or slow their growth. About …

This early-phase study tests an experimental drug called BL-M07D1 in 280 adults with advanced solid tumors that have the HER2 protein. The goal is to see if the drug is safe and can shrink tumors in cancers like breast, lung, stomach, and ovarian cancer. Participants must have tr…

This study tests a new drug, zanzalintinib, combined with standard chemotherapy (paclitaxel) in people with recurrent high-grade uterine cancer. The goal is to find the safest and most effective dose and see if the combination can shrink tumors. About 36 participants will be enro…

This study tests a drug called relacorilant combined with other treatments for people with ovarian, fallopian tube, peritoneal, or endometrial cancers. About 270 participants will join to see if the combination helps slow cancer growth. The goal is to control the disease, not cur…

This early-phase study tests a new drug called LNCB74 in people with advanced solid tumors (ovarian, breast, endometrial, bile duct, or lung cancer) that have not responded to standard treatments. LNCB74 is an antibody-drug conjugate designed to deliver a cancer-killing agent dir…

This early-phase study tests a new drug called DR-0202 in people with advanced solid tumors (like breast, lung, or pancreatic cancer) that have stopped responding to standard treatments. The main goal is to check the drug's safety and find the right dose. About 96 participants wi…

This program provides the experimental drug selinexor to people with multiple myeloma, lymphoma, sarcoma, or other cancers who have run out of standard treatments and cannot join a clinical trial. The goal is to offer a potential treatment option when nothing else is left. Patien…

This study looks at how safe and effective durvalumab (with or without olaparib) is for people with endometrial cancer in everyday medical practice in Korea. About 50 patients will be followed for up to a year. The goal is to see how well the treatment works outside of a strict r…

This study tests an experimental drug called AZD5335, alone or with other cancer treatments, in people with advanced ovarian, lung, or endometrial cancers that have not responded to standard therapy. The main goals are to check safety and find the right dose. About 506 participan…

This early-stage study tests the safety of combining two drugs, atezolizumab and ONC201, for women with advanced or recurrent endometrial cancer. The trial includes both obese and non-obese participants to see how body weight affects treatment. Researchers aim to find the best do…

This study tests whether tirzepatide, a drug used for weight loss and diabetes, can slow tumor growth in obese patients with endometrial cancer. About 20 participants will take the drug before their scheduled hysterectomy. Researchers will compare tumor samples taken before and a…

This study tests a drug called zanidatamab in people with advanced solid tumors that have high levels of HER2 protein. Participants must have already tried at least one other cancer treatment. The goal is to see if the drug can shrink tumors or stop them from growing. This is not…

This phase 3 trial tests whether the targeted drug trastuzumab deruxtecan (T-DXd) works better than standard chemotherapy (with or without radiation) to prevent endometrial cancer from coming back after surgery. The study enrolls 710 adults with HER2-expressing endometrial cancer…

This is an early-stage study testing a new type of personalized cell therapy for adults with advanced solid tumors that have a specific genetic change called KRAS G12D. Doctors will collect a patient's own immune cells, genetically modify them in a lab to recognize and attack can…

This study explores whether a tampon can collect samples to detect endometrial (uterine) and ovarian cancer early. Researchers will analyze DNA and proteins from tampons used by 1,500 women before surgery. The goal is to develop a simple, non-invasive screening tool that could ca…

This study collects vaginal fluid samples from 4,200 people to help develop a test for endometrial cancer and related conditions. Participants include those with abnormal uterine bleeding or a new diagnosis of endometrial cancer. The goal is to use these samples to create better …

This early-stage study tests an investigational drug called CYTALUX (pafolacianine) that makes cancer cells glow under a special camera during surgery. The goal is to see if it helps surgeons find and remove all endometrial cancer tissue. About 10 adults with endometrial cancer w…

This study is testing a new type of PET scan that uses a special tracer to find a protein called Trop2 on cancer cells. The goal is to see if this scan can detect and monitor many types of solid tumors more accurately than current methods. About 400 adults with or suspected of ha…

This study aims to create a test that can find endometrial, ovarian, and cervical cancers by looking for specific DNA markers in vaginal fluid or blood. Researchers at Mayo Clinic will collect samples from over 3,000 women to see how well the test works. The goal is to make cance…

This study looks at whether people with Lynch syndrome can collect their own vaginal samples at home to check for early signs of uterine cancer. About 30 participants will use a self-collection kit and answer health surveys. The goal is to see if this method is easy, acceptable, …

This study is testing whether DNA changes in urine and vaginal samples can accurately detect endometrial cancer. Researchers will compare samples from 120 women—half with diagnosed cancer and half healthy—to see if this simple, patient-friendly method works. If successful, it cou…

This study is testing a blood test that looks for DNA signals from 20 different cancers, including breast, lung, and colon cancer. Researchers want to see if the test can find cancer early, detect any cancer left after treatment, and catch a relapse before symptoms appear. About …

This study looks at whether a menstrual cup can collect enough tissue from the uterus to screen for cancer, as an alternative to a standard biopsy. It involves 25 women with Lynch syndrome, who are at higher risk for uterine cancer. Participants will use a menstrual cup at home a…

This study looks at whether the things people buy at stores—like painkillers or indigestion remedies—could be early warning signs of cancer. Many cancers cause vague symptoms that people treat with over-the-counter products before seeing a doctor. Researchers will compare the sho…

This study aims to find a non-invasive method to predict endometrial (uterine) cancer risk in people with abnormal uterine bleeding. Researchers will collect health questionnaires and vaginal samples from 1,000 participants who are already scheduled for a biopsy. A smaller group …

This study compares two methods to find cancer cells in lymph nodes removed during surgery for endometrial cancer. About 1,922 women with early-stage cancer will be randomly assigned to have their lymph nodes checked either by the standard ultrastaging method or by a newer techni…

This study is creating an educational tool to help women and their doctors decide if a hormone-releasing IUD (LNG-IUS) is right for preventing endometrial cancer. The tool will be tested with 270 women, including those at risk and those who have had the cancer. The goal is to mak…

This study tests whether Reiki, a gentle hands-on therapy, can reduce anxiety and pain in people receiving brachytherapy (internal radiation) for gynecologic cancers like endometrial, cervical, vaginal, or vulvar cancer. About 70 participants will be randomly assigned to receive …

This study looks at whether fasting every other day can reduce the harsh side effects of chemotherapy and improve quality of life for women with ovarian, endometrial, or uterine cancer. About 30 women who have had surgery and are about to start chemotherapy will either follow an …

This study looks at two standard radiation treatments for early stage endometrial cancer to see how they affect sexual function. About 258 women who have had surgery for early stage endometrial cancer will receive either 3 or 6 sessions of vaginal brachytherapy. The goal is to fi…

This study tests whether a 16-week home-based exercise program (aerobic and strength training) is practical and helpful for women with advanced ovarian or endometrial cancer who are starting chemotherapy after surgery. Researchers want to see if it improves leg function and reduc…

This study tests whether tirzepatide and semaglutide (weight loss drugs) are practical and safe for endometrial cancer patients who are overweight, obese, or have diabetes and are receiving chemotherapy. About 36 adults will take weekly doses for 24 weeks. Researchers will track …

This study tests a precise type of proton radiation given after surgery for cervical, uterine, or endometrial cancer. The goal is to see if it causes fewer bowel side effects than standard radiation. About 25 adults who need pelvic radiation after surgery will take part.

This study looks at whether a program of exercise, nutrition advice, and mental support before surgery (called prehabilitation) can help people with ovarian or endometrial cancer recover faster and feel better. About 64 patients will be randomly assigned to either standard care o…

This study looks at whether using the Headspace mindfulness app before surgery or chemoradiation can help people with endometrial or cervical cancer use fewer opioid painkillers. About 120 participants will be randomly assigned to use the app or not. The goal is to see if mindful…

This study is testing a new computer model called ENDORISK that helps doctors predict whether early-stage endometrial cancer has spread to lymph nodes. About 735 patients will use the tool to guide treatment decisions, and researchers will compare results to standard care. The go…

This study looks at what women know and think about endometrial cancer and ways to lower their risk. Researchers will talk to women with and without the disease to understand their views. The goal is to create a tool that helps women make informed choices about prevention.

This study looks at whether changes in a blood marker called CRP can help predict how well immunotherapy works in women with advanced gynecological cancers (cervical, endometrial, ovarian, or vulvar). Researchers will follow 120 women receiving immunotherapy plus chemotherapy and…

This study looks at whether using a uterine manipulator during minimally invasive surgery for early stage endometrial cancer causes cancer cells to appear in the abdominal fluid. About 278 women will be randomly assigned to have surgery with or without the manipulator. The goal i…

This study is testing whether tumor tissue from endometrial cancer patients can be collected during surgery at other hospitals, shipped to a central lab, and successfully grown into organoids (tiny lab-grown tumor models). About 20 adults with endometrial cancer will take part. T…

This study looks at how the amount and storage of a green dye (indocyanine green) affect its ability to find the first lymph nodes where cancer might spread in people with cervical, endometrial, or vulvar cancer. Researchers will test different doses and storage methods to see wh…

This study looks at whether showing educational videos about genetic testing helps more people with ovarian or endometrial cancer get tested. About 30 participants will watch a short video and may fill out a satisfaction survey. Researchers will compare testing rates before and a…

This study looks at two different surgical methods for checking lymph nodes in women with endometrial cancer. The goal is to see which approach helps keep cancer from coming back. About 625 women will take part to help doctors learn the best way to do this surgery.

This study tests whether 3D-printed custom applicators can deliver radiation more precisely than standard cylinder applicators for gynecologic cancers like endometrial, vaginal, and vulvar cancers. Ten participants will receive brachytherapy using a personalized 3D-printed mold d…

This study is testing whether an artificial intelligence (AI) tool can help match people with advanced cancer to the right clinical trials. Researchers will enroll up to 50,000 participants to see if the AI improves trial enrollment rates and patient outcomes. The goal is to make…

This study is checking how often women with cervical or endometrial cancer have long-term side effects in their bowels or bladder after receiving a modern type of radiation called IMRT. Researchers will look back at the records of 300 women treated at Tata Memorial Hospital betwe…

This study collects live tumor tissue from 2,000 people with various cancers to understand why some respond to immunotherapy and others don't. Participants give a biopsy as part of their normal care, and researchers analyze the samples in the lab. The goal is to develop better wa…

This study collects tissue samples, medical data, and family history from 1,120 adults undergoing routine screening for colorectal or endometrial cancer. Researchers aim to discover new genes and immune system clues that could lead to better prevention and targeted treatments for…

This study is observing how well a single-port robotic system (da Vinci SP) performs staging surgery for endometrial cancer. About 564 patients will be enrolled to track how often the surgery is completed successfully, as well as any complications during or after the procedure. T…

This study looks at how chemotherapy given before surgery affects frailty in adults over 55 with advanced ovarian or endometrial cancer. Researchers will track changes in an electronic frailty score and check for thinking problems. The goal is to see if chemo helps patients becom…

This study is a large registry that will follow about 2,000 people in Germany with advanced ovarian or endometrial cancer. Researchers will collect information on the treatments patients actually receive, how their disease progresses, and their quality of life. The goal is to bet…

This early-phase study is testing a new substance called RAD301 in 9 healthy volunteers and people with certain cancers (pancreatic, lung, esophageal, cervical, endometrial, or ovarian). The goal is to see how the body absorbs and handles the radiation from RAD301, and whether it…

This study aims to collect and analyze genetic information from 25,000 adults who either have cancer or are at risk of developing it. Researchers will look at tumor DNA and other health records to better understand what drives different cancers. The goal is to find new ways to de…

This study tests whether a special ultrasound (mpUS) can measure how vaginal tissue changes after internal radiation therapy (IVRT) for endometrial cancer. Ten participants will get scans before and after treatment to see if the imaging can detect side effects like dryness, narro…

This study follows 1715 people with early-stage endometrial cancer to see how often the cancer comes back after standard treatment and how often lymphedema (swelling) occurs. Participants are checked every 6 months for 3 years. The goal is to better understand outcomes and improv…

This study is looking at 500 women in Russia with advanced or aggressive endometrial cancer. Researchers will test their tumor tissue for specific genetic changes and see which first treatments doctors choose. The goal is to learn more about the disease, not to test a new treatme…

This study looks at the best times to send messages that encourage physical activity to older adults (65+) who have survived certain cancers and still have chronic pain. Researchers will track activity with a wearable device and ask participants to rate their pain four times a da…

This study is creating a large database of medical information and biological samples from adults with or at risk for many types of cancer, as well as healthy volunteers. The goal is to help researchers better understand what causes cancer, how it progresses, and how to improve p…