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New targeted drug LNCB74 enters human trials for Hard-to-Treat cancers

NCT ID NCT06774963

Recruiting now Disease control Sponsor: NextCure, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-phase study tests a new drug, LNCB74, in people with advanced solid tumors (ovarian, breast, endometrial, bile duct, or lung cancer) that have not responded to standard treatments. The drug is designed to deliver a cancer-killing agent directly to tumor cells. The main goals are to find the safest dose and to see if it can shrink tumors. About 145 adults will take part.

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Conditions

The condition(s) this trial relates to.

biliary tract cancer Biliary Tract Neoplasms breast cancer breast neoplasm endometrial cancer endometrium neoplasm metastatic malignant neoplasm neoplasm non-small cell lung carcinoma ovarian cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED OR METASTATIC SOLID TUMORS BILIARY TRACT CANCER BREAST CANCER ENDOMETRIAL CANCER NON-SMALL CELL LUNG CANCER OVARIAN CANCER

Contacts and locations

Locations

  • Cleveland Clinic Taussig Cancer Institute

    RECRUITING

    Cleveland, Ohio, 44195, United States

    Contact Email: •••••@•••••

  • Dana Farber Cancer Institute

    RECRUITING

    Boston, Massachusetts, 02215, United States

  • Hoag Family Cancer Institute

    RECRUITING

    Newport Beach, California, 92663, United States

  • Inova Schar Cancer Institute

    RECRUITING

    Falls Church, Virginia, 22031, United States

  • Intermountain/LDS Hospital Ph 1 Research Program

    RECRUITING

    Salt Lake City, Utah, 84143, United States

  • John Theurer Cancer Ctr at Hackensack Univ. Med Ctr.

    NOT_YET_RECRUITING

    Hackensack, New Jersey, 07601, United States

  • MD Anderson

    RECRUITING

    Houston, Texas, 77030, United States

  • NEXT Oncology

    COMPLETED

    San Antonio, Texas, 78229, United States

  • Roswell Park Comprehensive Cancer Center

    RECRUITING

    Buffalo, New York, 14203, United States

  • Sidney Kimmel Comprehensive Center at Jefferson

    RECRUITING

    Philadelphia, Pennsylvania, 19107, United States

  • St. Elizabeth Healthcare

    RECRUITING

    Edgewood, Kentucky, 41017, United States

  • UPMC

    RECRUITING

    Pittsburgh, Pennsylvania, 15213, United States

  • UT Health San Antonio - MD Anderson Cancer Center

    RECRUITING

    San Antonio, Texas, 78229, United States

  • Washington University, Siteman Cancer Center

    RECRUITING

    St Louis, Missouri, 63108, United States

    Contact Email: •••••@•••••

More trials for these conditions

Other studies related to the condition(s) this trial covers.