ENDOMETRIAL CANCER

This early-phase study tests a new drug called BL-M07D1 in people with advanced solid tumors that have a protein called HER2. The goal is to see if the drug is safe and can shrink tumors. About 280 adults with cancers like breast, lung, or stomach cancer who have tried at least t…

This study tests whether 3D-printed custom applicators can deliver radiation more precisely to gynecologic cancers (endometrial, vaginal, vulvar) compared to standard cylinder applicators. Ten participants will receive brachytherapy with a personalized 3D-printed mold. The goal i…

This early-phase trial tests the safety of combining two drugs, atezolizumab and ONC201, in 58 women with advanced or recurrent endometrial cancer. The study compares how obese and non-obese patients respond to the treatment. The goal is to find the best dose and see if the combi…

This early-phase study tests a new drug called ADU-1805, alone or with another drug (pembrolizumab), in adults with advanced solid tumors that have stopped responding to standard treatments. The main goals are to check safety and how the drug moves through the body. About 130 par…

This early-phase trial tests a new drug called MOv18 IgE in people with advanced ovarian, endometrial, or triple-negative breast cancers that have a specific marker (folate receptor alpha). The study has two parts: first, finding a safe dose, and then checking how well the drug w…

This early-phase study tests a new drug called DR-0202 in people with advanced solid tumors (like breast, lung, or pancreatic cancer) that have not responded to at least two prior treatments. The main goals are to check the drug's safety and find the best dose. About 96 participa…

This early-stage study tests a new drug called XMT-1660 in people with advanced solid tumors, including triple-negative breast, ovarian, and endometrial cancers. The main goals are to find the safest dose and check for side effects. About 319 participants will receive the drug to…

This study tests a new drug called Rina-S against standard chemotherapy (paclitaxel or doxorubicin) in people with endometrial cancer that has come back or worsened after prior treatment. About 544 participants will be randomly assigned to receive either Rina-S or standard chemo.…

This early-stage study tests a new drug, PF-08046054/SGN-PDL1V, alone or with pembrolizumab in people with advanced solid tumors (like lung, head and neck, or breast cancer) that have spread or can't be removed. The main goals are to find a safe dose and check for side effects. A…

This early-phase study tests a new drug called 177Lu-RAD204, which combines a radioactive particle with an antibody that seeks out a protein (PD-L1) on cancer cells. The goal is to see if it is safe and how it spreads in the body. About 30 adults with advanced lung, breast, skin,…

This study is testing a new drug called AZD8205, alone or with other cancer drugs, for people with advanced solid tumors like breast, ovarian, and lung cancer. The goal is to see if it is safe and helps control the disease. About 460 adults whose cancer has spread or returned aft…

This study tests an experimental drug called TER-2013 in people with advanced solid tumors (like breast, endometrial, ovarian, lung, head and neck, esophageal, or cervical cancer) that have specific genetic changes in the AKT/PI3K/PTEN pathway. The trial has two phases: first, fi…

This study tests whether combining cabozantinib (a drug that blocks blood vessel growth) with dostarlimab (an immunotherapy) can help control recurrent gynecologic carcinosarcoma, a rare and aggressive cancer. About 37 women whose cancer returned after at least one prior chemothe…

This study aims to create a test that can find endometrial, ovarian, and cervical cancers using special DNA markers in vaginal fluid or blood. Researchers at Mayo Clinic will collect samples from over 3,000 women to see how well the test works. The goal is to make cancer detectio…

This study is testing a new blood test that looks for DNA signals from 20 different cancers, including lung, breast, and colon cancer. Researchers will enroll 7,000 people to see if the test can find cancer early, detect any cancer left after treatment, and spot a relapse before …

This study is testing a shorter course of pelvic radiation for women with endometrial cancer. The goal is to see if giving slightly higher daily doses over fewer days is safe and causes fewer bowel and bladder side effects. About 100 women who have had surgery for non-spreading c…

This study is creating a large database of medical information and biological samples from adults with or at risk for many types of cancer, as well as healthy volunteers. The goal is to help researchers better understand what causes cancer, how it progresses, and how to improve p…

This study looks at whether showing short educational videos to people with ovarian or endometrial cancer can increase the number who get genetic testing. About 30 participants will watch a video about genetic testing and then fill out a survey. Researchers will compare testing r…

This early-stage study tests a new substance called RAD301 in 9 people—some healthy, some with pancreatic, lung, esophageal, cervical, endometrial, or ovarian cancer. The goal is to see how RAD301 moves through the body and how much radiation reaches organs and tumors, and to che…

This study looks at whether using a uterine manipulator during minimally invasive surgery for early-stage endometrial cancer causes cancer cells to appear in the abdominal fluid. About 278 adults with suspected early-stage cancer will be randomly assigned to have surgery with or …

This study tests whether a special ultrasound (mpUS) can measure changes in vaginal tissue caused by internal radiation therapy (IVRT) for endometrial cancer. Ten participants will have ultrasound scans before and after treatment to see if the method can detect side effects like …

This study is testing whether an artificial intelligence (AI) tool can help connect cancer patients with the right clinical trials. Researchers will enroll up to 50,000 people with various cancers and use the AI to suggest trials based on their tumor's genetic markers. The goal i…