ENDOMETRIAL CANCER

This early-phase trial tests whether combining chemotherapy with radiation, followed by a maintenance drug called dostarlimab, is safe and can help control stage IIIC endometrial cancer that has spread to lymph nodes. About 21 participants will receive the treatment and be monito…

This study tests an experimental drug called REGN5668, alone or with other cancer drugs, in people with ovarian, fallopian tube, peritoneal, or endometrial cancers. The goal is to find the safest dose and see if the combination can shrink tumors. About 612 adults will take part i…

This study compares a new drug called Rina-S to standard chemotherapy (paclitaxel or doxorubicin) in people with endometrial cancer that has returned or worsened after platinum-based chemo and immunotherapy. About 660 participants will be randomly assigned to receive either Rina-…

This study tests a combination of an immune-boosting drug (TQB2450) and a high-dose hormone (progestin) to treat young women (ages 18-45) with a specific type of early-stage endometrial cancer (MMRd). The goal is to eliminate the cancer while preserving the uterus so patients can…

This study tests a less invasive weight-loss procedure called endoscopic suture gastroplasty (ESG) in 74 obese women who have completed curative treatment for endometrial cancer. The goal is to see if the procedure is safe and feasible, helping women lose weight and reduce obesit…

This study tests an experimental drug called patritumab deruxtecan (HER3-DXd) in people with advanced solid tumors that have not responded to standard treatments. The drug targets a protein called HER3 found on many cancer cells. About 740 participants with various cancers (inclu…

This study tests a personalized vaccine plus three other drugs in 60 adults with advanced HER2-positive endometrial cancer that returned after treatment. The vaccine is made from each patient's own blood cells and targets the HER2 protein. The goal is to see if this combination c…

This early-stage trial tests a new drug called MDX2001 in about 285 people with advanced solid tumors that have spread. The main goals are to check the drug's safety and see if it can shrink tumors. This is a first-in-human study, so researchers are also finding the best dose to …

This study tests a combination of two drugs, nab-sirolimus and letrozole, in 29 people with advanced or recurrent endometrioid endometrial cancer that cannot be removed by surgery. The goal is to see if the combination can shrink or control the tumor. Participants will receive th…

This early-phase study tests an experimental oral drug, CSCJC3456, in 102 adults with advanced solid tumors that have not responded to standard treatments. The main goals are to check safety, find the right dose, and see if the drug can shrink tumors. Participants must be 18-75, …

This study tests a new drug called BNT323 (DB-1303) against standard chemotherapy in 480 women with recurrent endometrial cancer that expresses a protein called HER2. The goal is to see if BNT323 can slow cancer growth or shrink tumors better than chemo. Participants are divided …

This study is for people with endometrial cancer that has come back or persists after prior treatment. It tests combinations of targeted drugs and an immunotherapy drug called atezolizumab. The goal is to see if these treatments can shrink tumors or stop the cancer from growing f…

This early-phase study tests the safety of combining two drugs, atezolizumab and ONC201, in women with advanced or recurrent endometrial cancer. The trial includes both obese and non-obese participants to see how body weight affects treatment. Up to 58 women will take part, and t…

This early-phase study tests an experimental drug called CGT6297 in about 90 adults whose advanced solid tumors (including certain breast and endometrial cancers) have a specific genetic change called PIK3CA. The main goals are to find a safe dose and see if the drug can shrink o…

This early-phase study tests a new drug called SLV-154 in about 70 people with advanced solid tumors (like head and neck, lung, breast, or ovarian cancer) that have spread. The main goal is to find a safe dose and check for side effects. Researchers will also watch for any signs …

This study tests a new drug called MORAb-202 for people with ovarian, endometrial, lung, or triple-negative breast cancer. The drug is designed to find and attack cancer cells that have a specific marker (FRα). The goal is to find the safest and most effective dose, and to see if…

This study tests a new drug called AZD8205, alone or with other cancer treatments, for people with advanced solid tumors like breast, ovarian, or lung cancer. About 460 adults whose cancer has spread or returned after standard therapy will participate. The goal is to find safe do…

This early-phase study tests an experimental drug called MGC026 in 250 adults with advanced solid tumors that have not responded to other treatments. The main goals are to check safety, find the right dose, and see if the drug can shrink tumors. Participants receive the drug by I…

This study aims to improve fertility-sparing treatment for young women with endometrial cancer by using the tumor's genetic profile to choose the best therapy. About 260 participants will receive treatments matched to their cancer subtype, such as hormone therapy or immunotherapy…

This study tests a 24-week digital wellness program combined with online support from health professionals to help endometrial cancer survivors reduce waist size and improve overall health. About 148 participants who have completed cancer treatment will be enrolled. The goal is t…

This study tests a new drug called TER-2013 in people with advanced solid tumors (like breast, endometrial, ovarian, lung, head and neck, esophageal, or cervical cancer) that have specific changes in the AKT/PI3K/PTEN pathway. The goal is to see if the drug is safe and can shrink…

This phase 2 study tests two immunotherapy drugs, durvalumab and tremelimumab, alone or together, in 60 people with colorectal or endometrial cancer. It focuses on tumors that are either unstable (MSI) or stable (MSS) to see if the drugs can shrink or control the cancer. The goal…

This study tests a new treatment called KD01, a modified virus designed to infect and kill cancer cells while also boosting the immune system. It involves 97 women with cervical or endometrial cancer, including those who have not responded to other treatments. The goal is to see …

This early-phase study tests a new drug called CTIM-76 in people with ovarian, testicular, or endometrial cancers that have come back or are hard to treat. The drug is designed to help the body's immune cells attack cancer cells that have a specific marker (CLDN6). The main goals…

This study tests an experimental drug called AZD5335, alone or with other cancer treatments, in people with advanced ovarian, lung, or endometrial cancers. The goal is to see if it is safe and shrinks tumors. About 506 adults will take part, and the drug is given by IV.

This early-stage study tests a new oral drug, MOMA-341, alone or with other treatments, in people with advanced solid tumors that have specific genetic changes (MSI-H or dMMR). The main goal is to check safety and find the best dose. About 132 adults whose cancer has not responde…

This study tracks 150 women with advanced or returning endometrial cancer to see how well a first treatment of chemotherapy plus durvalumab works, followed by maintenance durvalumab (with or without olaparib). It collects real-world data from German hospitals to measure how long …

This early-phase study tests a new drug called GV20-0251 in people with advanced solid tumors (like liver, lung, or skin cancer) that have stopped responding to standard therapies. The main goal is to check the drug's safety in a small group of 10 patients. It is not a cure, but …

This study tests a drug called zanidatamab in about 200 adults with several types of advanced solid tumors (like breast, lung, or stomach cancer) that have high levels of HER2 protein and have worsened after at least one prior treatment. The goal is to see if zanidatamab can shri…

This study tests a new targeted therapy, puxitatug samrotecan, against standard chemotherapy for people with advanced or metastatic endometrial cancer that has worsened after platinum-based chemo and immunotherapy. About 800 participants will be randomly assigned to receive eithe…

This early-phase study tests a new drug called zanzalintinib combined with standard chemotherapy (paclitaxel) in people with recurrent high-grade uterine or endometrial cancer. The main goal is to find the safest and most effective dose of the combination. About 36 participants w…

This study tests new treatments for endometrial cancer based on the genetic makeup of each person's tumor. About 1,615 participants will be assigned to one of four trials depending on their cancer's molecular profile. The goal is to see if these tailored therapies can prevent the…

This study tests a drug called relacorilant combined with other treatments for people with certain gynecological cancers, including ovarian, fallopian tube, peritoneal, and endometrial cancers. About 270 adults whose cancer has returned or is resistant to standard treatments will…

This early-stage study tests a new drug called ADU-1805, alone or with another cancer drug (pembrolizumab), in adults with advanced solid tumors that have stopped responding to standard treatments. The main goals are to check safety and how the drug moves through the body. About …

This program provides early access to the investigational drug selinexor for people with multiple myeloma, lymphoma, sarcoma, or other cancers who have run out of standard treatments and cannot join a clinical trial. Patients must get approval from their doctor and local regulato…

This study tests a treatment called lifileucel, which uses a patient's own immune cells (tumor-infiltrating lymphocytes) to fight advanced endometrial cancer. About 60 people who have already tried other treatments will receive this cell therapy. The main goal is to see if the tr…

This early-phase study tests whether a short course of radiation (1 week instead of the usual 5) combined with chemotherapy is practical for people with stage III endometrial cancer. About 28 participants who have had surgery will receive the treatment. The main goal is to see if…

This study tests if the drug elacestrant, alone or with abemaciclib, can shrink or control advanced or recurrent ER+ endometrial cancer. About 75 adults who have already had chemotherapy and immunotherapy will take part. The goal is to see how well the treatment works and if it i…

This study tests a new drug called TCC1727 combined with other cancer treatments (benmelstobart, olaparib, or topotecan) in people with advanced solid tumors, including lung, stomach, endometrial cancers, and melanoma. The goal is to find the safest dose and see if the combinatio…

This study is testing a new experimental drug called ETX-19477 in people with advanced solid tumors, including breast, ovarian, prostate, and other cancers that have not responded to standard treatments. The main goals are to find the safest dose and to see if the drug can shrink…

This study tests a new drug called INV-6452 in people with advanced breast cancer or other solid tumors that have stopped responding to standard treatments. The goal is to find a safe dose and see if the drug can shrink tumors. About 201 adults will take part in this early-phase …

This study tests a new drug called ivonescimab in 50 people with advanced endometrial or cervical cancer that has worsened after standard chemotherapy. The drug targets two proteins (PD1 and VEGF) to help the immune system fight cancer and block tumor blood supply. Researchers wi…

This study tests a new combination of drugs (sapanisertib and serabelisib, together called PIKTOR) plus standard chemotherapy (paclitaxel) in people with advanced or recurrent endometrial cancer that has not been cured by prior treatments. The goal is to see if this combo can shr…

This study tests a new oral drug, AVZO-021, in people with advanced solid tumors that have not responded to other treatments. The goal is to find safe doses and see if the drug can shrink tumors or slow cancer growth. The trial includes patients with certain breast, ovarian, and …

This early-phase study tests a new drug called HWK-016 in people with advanced ovarian or endometrial cancers that have not responded to other treatments. The drug is designed to deliver a toxic payload directly to cancer cells that carry a specific marker (MUC16). The main goals…

This early-phase study tests an experimental oral drug, RGT-490, in adults with advanced solid tumors (including breast, ovarian, and endometrial cancers) that have a specific genetic change called PIK3CA. The main goals are to check safety, find the right dose, and see if the dr…

This early-stage study tests a new drug, PF-08046054/SGN-PDL1V, in people with advanced solid tumors that have spread or can't be removed. The goal is to find a safe dose and check for side effects, both when the drug is given alone and with another cancer drug called pembrolizum…

This early-stage study tests the safety and best dose of a new drug called BL0175 in postmenopausal women with advanced breast, ovarian, or endometrial cancer that is hormone receptor-positive. The trial enrolls 9 participants and aims to find out if the drug is safe and how it a…

This study looks at whether a simple blood test (ctDNA) can help doctors decide if it's safe to stop maintenance immunotherapy after one year in people with advanced or recurrent endometrial cancer. About 30 participants will receive standard treatment, and if their ctDNA test is…

This early-phase study tests a new drug called PHST001, alone or with chemotherapy, in adults with advanced solid tumors that have stopped responding to standard treatments. The main goals are to check safety and find the best dose. About 272 people with cancers like ovarian, end…

This study tests an experimental drug called ART0380 in people with advanced or metastatic solid tumors (cancers that have spread). The goal is to find a safe dose and see if it works alone or with chemotherapy drugs gemcitabine or irinotecan. About 442 participants will take par…

This study is for women with a specific type of endometrial cancer (called MMR-D/MSI-H) who have already had surgery. It tests whether adding radiation to the immunotherapy drug Dostarlimab can prevent the cancer from returning. About 62 participants will be enrolled to check saf…

This early-stage study tests a new treatment using a patient's own immune cells, modified in a lab to recognize and attack cancer cells with a specific KRAS mutation. It is for adults with advanced solid tumors (like lung, colon, or pancreatic cancer) that have not responded to s…

This study tests a new drug called lorigerlimab in about 80 people with advanced ovarian or other gynecologic cancers that no longer respond to standard chemotherapy. Participants receive the drug through an IV every 3 weeks. The goal is to see if the drug can shrink tumors and t…

This early-phase study tests a new drug called BL-M07D1 in adults with advanced solid tumors that have the HER2 protein. The goal is to check safety, find the right dose, and see if it shrinks tumors. About 280 people with cancers like breast, lung, stomach, or ovarian cancer tha…

This study tests whether combining two drugs—cabozantinib and dostarlimab—can help women with a rare and aggressive gynecologic cancer called carcinosarcoma that has come back after initial treatment. About 37 participants will receive the combination therapy. The main goal is to…

This study tests a new combination of drugs (BL-B01D1, pembrolizumab, and possibly bevacizumab) in people with cervical or endometrial cancer that has come back or spread. The goal is to see if the treatment can shrink tumors and control the disease. About 96 adults aged 18-75 wi…

This study tests a new drug called TORL-1-23 in about 90 adults with advanced solid tumors, including ovarian, endometrial, and lung cancers. The main goals are to check safety, find the best dose, and see if the drug can shrink tumors. Participants must have measurable disease a…

This study tests an experimental drug called STRO-004 in adults with advanced solid tumors that have not responded to other treatments. The trial has three parts: finding a safe dose of STRO-004 alone, testing that dose in more people, and combining STRO-004 with another drug (pe…

This early-phase study tests a new oral drug, NKT5097, in adults with advanced solid tumors, especially breast cancer and tumors with a specific genetic change (CCNE1 amplification). The main goals are to check safety, find the best dose, and see if the drug can shrink tumors. Ab…

This early-phase study tests a new drug called IPH5301 in people with advanced solid tumors that have spread. The goal is to find a safe dose and see if it works alone or with chemotherapy and another drug. About 27 adults with certain cancers like breast, lung, or stomach cancer…

This study tests a drug called belzutifan in people with a rare, hard-to-treat type of gynecologic cancer called clear cell carcinoma. The goal is to see if the drug can shrink tumors or stop them from growing. About 32 participants will receive the drug, and researchers will mon…

This study tests a tailored, less intense treatment plan for people with early-stage endometrial cancer whose tumors have certain genetic markers (POLE-mutated or p53wt/NSMP). About 393 participants will receive treatment adjusted to their tumor type, with the goal of reducing si…

This early-stage study tests a new drug, NRM-823, alone or with an immunotherapy, in people with advanced solid tumors that have not responded to other treatments. The main goals are to check safety and find the right dose. About 150 adults with cancers like lung, ovarian, or tri…

This phase 3 trial tests whether a targeted drug called trastuzumab deruxtecan (T-DXd) works better than standard chemotherapy (with or without radiation) to prevent endometrial cancer from coming back after surgery. The study enrolls 710 adults with HER2-expressing endometrial c…

This study tests a new drug, Rina-S, in people with advanced solid tumors that have spread or can't be removed by surgery. The goal is to see if Rina-S is safe and how well it works against cancers like ovarian, lung, and breast cancer. About 884 participants will receive the dru…

This early-phase study tests a new drug called XMT-1660 in people with advanced solid tumors, including triple-negative breast, ovarian, and endometrial cancers. The main goals are to find a safe dose and check for side effects. About 319 participants will receive the drug, and r…

This study tests whether two drugs, abemaciclib and letrozole, can help keep advanced or recurrent endometrial cancer from getting worse. About 32 people with a specific type of estrogen-sensitive cancer will take these pills daily after initial treatment. The goal is to see if t…

This study tests whether injecting a lab-made collagen into the uterus, along with daily high-dose hormone pills, can help shrink or eliminate early-stage endometrial cancer or precancerous growths. The goal is to preserve fertility in women aged 45 or younger. Participants recei…

This study tests an experimental drug called MT-4561 in people with advanced solid tumors (like lung, breast, or pancreatic cancer) who have already tried at least one other treatment. The main goals are to find a safe dose and see if the drug can shrink tumors. About 27 adults w…

This early-phase study tests a new drug called DR-0202 in people with advanced solid tumors (like breast, lung, or prostate cancer) that have not responded to at least two prior treatments. The main goal is to check the drug's safety and find the right dose. About 96 participants…

This study tests whether combining two drugs, avelumab and M1774, can help people with a certain type of endometrial cancer that has come back after prior immunotherapy. The cancer must have a specific gene change called ARID1A. About 25 participants will receive the drug combina…

This early-phase trial tests a new drug called MOv18 IgE in people with advanced ovarian, endometrial, or triple-negative breast cancers that have a specific marker (folate receptor alpha). The study aims to find a safe dose and see if the drug can shrink tumors. About 45 partici…

This study tests a new drug called EIK1005, alone or with another drug (pembrolizumab), in people with advanced solid tumors that have not responded to other treatments. The main goals are to find a safe dose and see if the drug shrinks tumors. About 160 adults with certain cance…

This early-stage study tests a new drug called 177Lu-RAD204, which is a radioactive antibody designed to seek out and attack cancer cells. About 30 adults with advanced solid tumors (like lung, breast, or skin cancer) that have not responded to other treatments will receive the d…

This study tests a new drug called Dato-DXd, given alone or with other cancer drugs, in people with advanced solid tumors that have spread. The goal is to see if it can shrink tumors or slow cancer growth. About 454 adults with cancers like endometrial, gastric, prostate, ovarian…

This study tests whether taking a daily targeted therapy pill (olaparib) for one year after standard chemoradiation can help prevent endometrial cancer from coming back in people with a specific genetic subtype (p53abn). About 554 participants will be randomly assigned to receive…

This early-stage study tests a new drug called CTX-10726 in about 70 people with advanced cancers of the stomach, liver, uterus, or kidney that have not responded to standard treatments. The main goal is to check the drug's safety and find the best dose. Participants will receive…

This study looks at how safe and effective durvalumab (with or without olaparib) is for people with endometrial cancer in everyday medical practice in Korea. About 50 patients will be followed for up to a year. The goal is to see how well the treatment works and what side effects…

This study tests whether a new drug combination (trastuzumab deruxtecan plus rilvegostomig or pembrolizumab) works better than standard chemotherapy plus pembrolizumab for people with advanced or recurrent endometrial cancer that has a specific protein (HER2). About 600 adults wi…

This study tests an experimental drug called ubamatamab, alone or with another drug (cemiplimab), in people whose ovarian or uterine cancer has come back. The main goals are to check safety, find the best dose, and see if the treatment can shrink tumors. About 890 participants wi…

This study looks at how well the drug T-DXd works for adults with advanced HER2-positive solid tumors who have already tried other treatments and have no good alternatives. About 100 people will take T-DXd as part of their regular care, and researchers will track tumor shrinkage …

This early-phase study tests a new drug called BL-B01D1 in people with advanced lung cancer or other solid tumors that have spread or cannot be removed. The main goals are to check safety, find the right dose, and see if the drug shrinks tumors. About 470 adults will take part.

This early-stage study tests a new drug called XmAb541 in people with advanced ovarian, endometrial, or germ cell tumors that have not responded to other treatments. The main goal is to see if the drug is safe and find the best dose. About 282 adults will take part, and researche…

This early-phase study tests a new drug called HWK-007 in people with advanced solid tumors, including certain ovarian, endometrial, and lung cancers. The drug is designed to seek out and attack cancer cells that have a specific marker (PTK7). The main goal is to find the safest …

This study tests a new drug called PC14586 (rezatapopt) in people with advanced solid tumors that have a specific change in the TP53 gene (Y220C mutation). The goal is to see if the drug is safe and shrinks tumors. About 300 adults whose cancer has worsened after prior treatment …

This study tests whether adding sacituzumab tirumotecan (Sac-TMT) to pembrolizumab helps people with advanced or recurrent endometrial cancer live longer without their cancer worsening. About 1,100 participants with a specific type of endometrial cancer (pMMR) will receive either…

This early-phase study tests an experimental drug called LNCB74 in people with advanced solid tumors (cancers that have spread and are hard to treat), including ovarian, breast, endometrial, bile duct, and lung cancers. The main goals are to find a safe dose and see if the drug s…

This study tests whether tirzepatide, a drug used for weight loss and diabetes, can slow tumor growth in people with obesity-driven endometrial cancer. About 20 participants will take the drug before their scheduled hysterectomy. Researchers will compare cancer cell activity in t…

This early-phase study tests a new drug called 177LuBetaBart in people with advanced solid tumors that have stopped responding to standard treatments. The drug is a radioactive antibody designed to seek out and destroy cancer cells. The study will check for safety and side effect…

This study compares two methods for finding cancer in sentinel lymph nodes of people with early-stage endometrial cancer. About 1,900 participants will be randomly assigned to receive either the standard ultrastaging method or the newer OSNA test. The goal is to see which method …

This study collects vaginal fluid samples from 4,200 people to help researchers develop a test for endometrial cancer and related conditions. Participants include those with abnormal uterine bleeding or a new diagnosis of endometrial cancer. The goal is to use these samples to cr…

This study is testing a new, patient-friendly way to detect endometrial cancer using DNA markers in urine and vaginal samples collected by the patient herself. Researchers will compare samples from 120 women—half with endometrial cancer and half healthy—to see if the test can acc…

This study tests if a menstrual cup can collect enough uterine tissue to screen for endometrial cancer in women with Lynch syndrome, who have a higher risk. Participants will use a cup at home and also get a standard biopsy, then compare results. If it works, it could offer a pai…

This study is testing a new type of PET scan that targets a protein called Trop2, found on many solid tumors. The goal is to see if this scan can find and stage cancers like lung, bladder, ovarian, and others more accurately than current methods. About 400 adults with confirmed o…

This early-stage study tests whether a dye called CYTALUX (pafolacianine) can make endometrial cancer cells glow under a special camera during surgery. The goal is to help surgeons find and remove all cancer. Ten adults with endometrial cancer who are already scheduled for surger…

This study aims to find a gentler way to detect uterine cancer early in people with abnormal bleeding. Instead of relying only on a biopsy, researchers will use a health questionnaire and a self-collected vaginal swab to look for cancer-related genetic changes and microbiome patt…

This study is testing a new blood test that looks for DNA signals from 20 different cancers, including lung, breast, and colon cancer. Researchers will enroll 7,000 people to see if the test can find cancer early, detect any cancer left after treatment, and spot a relapse before …

This study explores whether a tampon can be used to collect samples for detecting endometrial (uterine) and ovarian cancer. Researchers will analyze DNA and proteins from tampons and compare them to tissue samples from 1,500 women undergoing surgery. The goal is to develop a simp…

This study looks at whether people with Lynch syndrome can use a self-collected vaginal swab at home to find early signs of uterine cancer. Researchers want to see if participants are willing and able to do the test and find it acceptable. The study involves 30 adults with Lynch …

This study aims to create a test that can find endometrial, ovarian, and cervical cancers by looking at specific DNA markers in vaginal fluid or blood. Researchers will collect samples from about 3,110 women to see how accurate the test is. The goal is to make cancer detection ea…

This study is testing a new imaging agent called 18F-T2, which is used in a PET/CT scan to find tumors that have high levels of a protein called CAIX. The goal is to see if this scan is better than standard scans at detecting and staging several types of cancer, including kidney,…

This study looks at whether the things people buy at stores—like pain relievers or digestive aids—could be early warning signs of cancer. Researchers will compare the shopping habits of 2900 people, some diagnosed with cancer and some not, to see if certain purchases happen more …

This study is creating an educational tool to help women and their doctors talk about using a levonorgestrel-releasing IUD to prevent endometrial cancer. The tool will be tested with 270 women, including those at risk and those who have had the cancer. The goal is to make it easi…

This early-phase study tests whether tirzepatide or semaglutide (weight loss and diabetes drugs) are practical and safe for endometrial cancer patients who are overweight, obese, or have diabetes while they undergo chemotherapy. About 36 participants will take weekly doses for 24…

This study looks at whether women having robotic hysterectomy for non-cancerous conditions or endometrial cancer can safely go home the same day instead of staying overnight. About 300 women at three hospitals will be randomly assigned to either day-care or overnight stay. The ma…

This study compares robot-assisted keyhole surgery to standard keyhole surgery for removing the uterus in people with early-stage endometrial cancer. The goal is to see which approach offers better value for money and quality of life after recovery. About 1,680 participants will …

This study compares two standard radiation treatments (vaginal brachytherapy) for early-stage endometrial cancer to see which causes less sexual dysfunction. About 258 women who have had surgery will receive either 3 or 6 radiation sessions. The main goal is to measure sexual fun…

This study tests whether a 16-week virtual exercise program (aerobic and resistance training) can help patients with ovarian or endometrial cancer maintain leg function and reduce numbness or tingling in hands and feet caused by chemotherapy. About 30 adults who have had surgery …

This study is testing a precise type of radiation (proton beam) given to the pelvis after surgery for cervical, uterine, or endometrial cancer. The goal is to see if it causes fewer bowel side effects than standard radiation. About 25 adults who need pelvic radiation after surger…

This study compares a new barbed stitch (SYMMCORA®) to a standard one for closing the vaginal cuff during laparoscopic hysterectomy. The goal is to see if the new stitch can close the area faster without causing more complications. About 132 women having elective hysterectomy wil…

This study is for women with endometrial or cervical cancer who have had surgery. It tests a shorter course of pelvic radiation (hypofractionation) to see if it is safe and causes fewer bowel and bladder side effects. About 100 participants will receive slightly higher daily radi…

This study tests whether a shorter course of pelvic radiation after surgery is as safe and effective as the standard longer schedule for people with cervical or endometrial cancer. About 120 participants will be randomly assigned to one of the two radiation plans. The goal is to …

This study tests whether a program of physical activity, nutritional advice, and psychological support before surgery can improve recovery and quality of life in people with ovarian or endometrial cancer. 64 participants will be randomly assigned to either standard care or the pr…

This study looks at whether using the Headspace mindfulness app before surgery or chemoradiation can help people with endometrial or cervical cancer use fewer opioid painkillers. About 120 participants will be randomly assigned to use the app or not. The goal is to see if mindful…

This study looks at whether alternate day fasting (eating very little every other day) before chemotherapy can help reduce side effects and improve quality of life for women with ovarian, endometrial, or uterine cancer. About 30 women who have had surgery and are about to start c…

This study tests whether Reiki, a gentle touch therapy, can reduce anxiety and pain in people receiving brachytherapy for gynecologic cancers like endometrial or cervical cancer. About 70 participants will be randomly assigned to receive either Reiki or usual care during their tr…

This study tests a personalized physical activity program for women over 60 with gynecologic cancers who are receiving chemotherapy or other systemic treatments. The program includes a wearable activity tracker and a smartphone app, plus optional features like an exercise partner…

This study looks at whether using a uterine manipulator during minimally invasive surgery for early-stage endometrial cancer causes cancer cells to appear in the abdominal fluid. About 278 women will be randomly assigned to have surgery with or without the manipulator. The goal i…

This study looks at whether short educational videos can increase the number of people with ovarian or endometrial cancer who get genetic testing. About 30 participants will watch a video about genetic testing and fill out a satisfaction survey. Researchers will compare testing r…

This study looks at whether giving chemotherapy before surgery helps older adults (over 55) with advanced ovarian or endometrial cancer become fitter for their operation. Researchers will measure changes in frailty using a special score from medical records. The goal is to see if…

This study looks at the genetic makeup of advanced endometrial cancer in 500 women in Russia. Researchers will test tumor samples for specific gene changes to see how common they are and what treatments patients receive. The goal is to gather information, not to test a new treatm…

This early-stage study is testing a new imaging agent called RAD301 in 9 people: healthy volunteers and patients with certain cancers like pancreatic, lung, or ovarian cancer. The goal is to see how the body handles the radiation from RAD301 and whether it is safe. No treatment i…

This study will analyze the genes of 25,000 adults who have cancer or are at risk for it. Researchers will use advanced testing to find genetic changes linked to cancer and track health records over time. The goal is to learn more about cancer biology and discover new ways to per…

This study looks at the best times to send messages that encourage physical activity in older adults (65+) who have survived certain cancers and live with chronic pain. Researchers will track activity levels and pain episodes after each message. The goal is to learn how to time a…

This study collects tissue samples, medical data, and family histories from 1,120 adults undergoing routine screening for colorectal or endometrial cancer. Researchers aim to discover new genes and immune system clues that could lead to better prevention and targeted treatments. …

This study is creating a large, long-term database of medical information and biological samples from people with many types of cancer, those at high risk, and healthy volunteers. Researchers will use this resource to study what causes cancer, how it progresses, and how to better…

This study looks at whether it is safe for women with endometrial cancer to fast overnight before their surgery. Many women with this cancer have high blood sugar and inflammation, which can make treatment harder. The study will check if fasting is doable and liked by patients, a…

This study looks at how the amount and storage conditions of a dye called indocyanine green affect its ability to find sentinel lymph nodes in people with cervical, endometrial, or vulvar cancer. Researchers want to see if changing these factors can make the procedure more succes…

This study tests whether 3D-printed custom applicators can safely and effectively deliver radiation therapy for gynecologic cancers like endometrial, vaginal, and vulvar cancers. Ten participants will receive brachytherapy using a personalized 3D-printed mold instead of standard …

This study is a registry that collects information from about 1,975 people with advanced ovarian or endometrial cancer in Germany. Researchers will track treatments, test results, and how patients feel over time. The goal is to understand real-world care and outcomes, not to test…

This study talks to women with and without endometrial cancer to learn what they know about risk factors and prevention options. Researchers hope to create a tool that helps women make informed decisions. About 45 women will take part at MD Anderson Cancer Center.

This study looks at women who had radiation therapy for cervical or endometrial cancer to see how often they experience long-term side effects in the bowel or bladder. Researchers will review medical records of 300 patients treated at Tata Memorial Hospital. The goal is to unders…

This study is testing whether an artificial intelligence (AI) tool can help match cancer patients with the right clinical trials. Researchers will enroll up to 50,000 people with various cancers to see if the AI improves trial enrollment rates and patient outcomes. The goal is to…

This study collects live tumor tissue from 2,000 people with various cancers to learn how tumors respond to immunotherapy. Participants undergo a biopsy as part of their normal care, and researchers analyze the samples to find clues about treatment response. The goal is to improv…

This observational study looks at 350 women with early-stage endometrial cancer to see if current risk assessments accurately predict who needs lymph node staging. Participants receive standard care and are followed for 3 years. The goal is to identify a group of patients who can…

This study is testing a computer model called ENDORISK that helps doctors predict whether endometrial cancer has spread to lymph nodes. About 735 patients with early-stage endometrial cancer will use the model to guide decisions about lymph node surgery. The goal is to see if the…

This study is testing whether tumor tissue from endometrial cancer patients can be successfully turned into organoids (tiny lab-grown models) after being transported from other hospitals. About 20 adults with endometrial cancer will provide a sample during their standard surgery.…

This study is observing how well a new robotic surgery system (da Vinci SP) works for staging endometrial cancer. About 564 patients will be followed to see if the surgery meets guideline standards and to track complications and survival. The goal is to gather information, not to…

This study follows about 1,715 people with early-stage endometrial cancer to see how often the cancer comes back after standard treatment and how often it causes a condition called lymphedema (swelling). Participants get routine check-ups every 6 months for 3 years. The goal is t…

This study looks at 625 women with endometrial cancer to compare two surgical methods for checking lymph nodes: selective staging versus removing all nodes. The goal is to see which approach leads to better cancer-free survival. Participants will be followed over time to track re…

This study tests whether a special ultrasound can measure changes in vaginal tissue caused by radiation therapy for endometrial cancer. Ten participants will have ultrasound scans before and after treatment to see if the method works. The goal is to better understand and monitor …

This study is a survey of about 264 Italian hospitals that treat endometrial cancer. Researchers want to find out how often hospitals use a test called POLE testing, which can identify patients with a very low risk of cancer returning. The goal is to see if this test is being use…

This study looks at whether changes in a blood marker called CRP can help predict how well immunotherapy works in women with advanced gynecologic cancers (cervical, endometrial, ovarian, or vulvar). Researchers will track CRP levels in 120 women receiving immunotherapy plus chemo…