New drug HWK-007 targets Hard-to-Treat cancers in early trial

NCT ID NCT07444814

Recruiting now Disease control Sponsor: Whitehawk Therapeutics, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 06, 2026 · Updated 2 times

Summary

This early-stage study tests a new drug called HWK-007 in people with advanced solid tumors, including certain ovarian, endometrial, and lung cancers. The drug is designed to target a protein (PTK7) found on cancer cells and deliver a chemotherapy-like payload directly to them. The main goals are to find the safest dose and check for side effects. About 226 adults will take part, and the study is currently recruiting.

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Conditions

The condition(s) this trial relates to.

endometrial cancer endometrial carcinoma endometrium neoplasm lung neoplasm non-small cell lung carcinoma ovarian cancer ovarian carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ENDOMETRIAL CANCER NON-SQUAMOUS EGFR WT NSCLC OVARIAN CANCER OVARIAN CANCER METASTATIC OVARIAN CANCER METASTATIC RECURRENT PLATINUM-RESISTANT OVARIAN CANCER PROC

Contacts and locations

Locations

Fred Hutchinson Cancer Center
NOT_YET_RECRUITING

Seattle, Washington, 98109, United States
Hackensack University Medical Center - John Theurer Cancer Center
RECRUITING

Hackensack, New Jersey, 07601, United States
NEXT - Oncology - Houston
RECRUITING

Houston, Texas, 77054, United States
NEXT Oncology - Austin
RECRUITING

Austin, Texas, 78758, United States
NEXT Oncology - Virginia Cancer Specialists
RECRUITING

Fairfax, Virginia, 22031, United States
Roswell Park Comprehensive Care Center
RECRUITING

Buffalo, New York, 14263, United States
START - Midwest
RECRUITING

Grand Rapids, Michigan, 49546, United States
START - San Antonio
RECRUITING

San Antonio, Texas, 78229, United States
St. Francis Medical Center (OSF Healthcare)
RECRUITING

Peoria, Illinois, 61637, United States
UCLA - Hematology/Oncology Clinical Research Unit
NOT_YET_RECRUITING

Los Angeles, California, 90095, United States
University Hospital - Cleveland Medical Center
RECRUITING

Cleveland, Ohio, 44106, United States
University of Arkansas
RECRUITING

Little Rock, Arkansas, 72205-7199, United States

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