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New hope for advanced cancers: experimental drug EIK1005 enters human trials

NCT ID NCT07262619

Recruiting now Disease control Sponsor: Eikon Therapeutics Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a new drug called EIK1005, alone or with another drug (pembrolizumab), in people with advanced solid tumors that have not responded to other treatments. The goal is to find a safe dose and see if the drug shrinks tumors. About 160 adults with certain cancer types (including MSI-H or dMMR tumors) will take part.

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Conditions

The condition(s) this trial relates to.

colorectal cancer endometrial cancer endometrium neoplasm gastric cancer gastroesophageal junction adenocarcinoma mismatch repair cancer syndrome 1 neoplasm Neoplasm Metastasis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED SOLID TUMORS ENDOMETRIAL CANCER MISMATCH REPAIR DEFICIENT OR MSI-HIGH SOLID TUMORS MSI-H OR DMMR ADVANCED SOLID TUMORS MSI-H/DMMR COLORECTAL CANCER MSI-H/DMMR GASTRIC CANCER MSI-H/DMMR GASTROESOPHAGEAL-JUNCTION CANCER

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Email: •••••@•••••

Locations

  • Calvary Mater Newcastle Hospital

    RECRUITING

    Waratah, New South Wales, Australia

  • Chris O'Brien Lifehouse (Sydney Cancer Centre)

    RECRUITING

    Camperdown, Victoria, Australia

  • GenesisCare North Shore (Oncology)

    NOT_YET_RECRUITING

    Saint Leonards, New South Wales, Australia

  • Grampians Health

    RECRUITING

    Ballarat, Victoria, Australia

  • Health New Zealand

    RECRUITING

    Wellington, New Zealand

  • Memorial Sloan Kettering Cancer Center (MSKCC)

    NOT_YET_RECRUITING

    New York, New York, 10022, United States

  • Morristown Medical Center

    NOT_YET_RECRUITING

    Morristown, New Jersey, 07960, United States

  • Oncology Clinics Victoria (OCV) - Cabrini Brighton Hospital

    NOT_YET_RECRUITING

    Frankston, Victoria, 3199, Australia

  • Peninsula and Southeast Oncology (PASO) Medical

    RECRUITING

    Frankston, Victoria, Australia

  • University of Texas MD Anderson Cancer Center

    RECRUITING

    Houston, Texas, 77030, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.