New hope for recurrent endometrial cancer: Rina-S faces off against standard chemo

NCT ID NCT07166094

Recruiting now Disease control Sponsor: Genmab Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 05, 2026 · Updated 4 times

Summary

This study compares a new drug called Rina-S to standard chemotherapy (paclitaxel or doxorubicin) in people with endometrial cancer that has returned or worsened after platinum-based chemo and immunotherapy. About 660 participants will be randomly assigned to receive either Rina-S or standard chemo. The goal is to see which treatment better delays cancer growth and extends survival.

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Conditions

The condition(s) this trial relates to.

endometrial cancer endometrial carcinoma endometrium neoplasm Recurrence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ENDOMETRIAL CANCER RECURRENT OR PROGRESSIVE ENDOMETRIAL CANCER

Contacts and locations

Locations

Aalborg University Hospital
RECRUITING

Aalborg, 9000, Denmark
Alexandra General Hospital
RECRUITING

Athens, 11528, Greece
Antwerp University Hospital
RECRUITING

Edegem, Antwerp, 2650, Belgium
Aretaieio Hospital
RECRUITING

Athens, 115 28, Greece
Arthur J E Child Cancer Comp
RECRUITING

Calgary, Alberta, T2N 5G2, Canada
Asklepios Hospital Barmbek
RECRUITING

Hamburg, 22453, Germany
Atlantic Health - Overlook MC
RECRUITING

Summit, New Jersey, 07901, United States
Austin Health
RECRUITING

Heidelberg, 3084, Australia
BC Cancer - Vancouver
RECRUITING

Vancouver, British Columbia, V5Z 4E6, Canada
Białystok Onc. Ctr. (MSC), GO
RECRUITING

Bialystok, Podlaskie Voivodeship, 15-027, Poland
CGFL Dijon
RECRUITING

Dijon, Bourgogne-Franche-Comté, 21079, France
CH de la Côte Basque
RECRUITING

Bayonne, Pyrénées-Atlantiques, 64109, France
CHU A Coruña
RECRUITING

A Coruña, La Coruña, 15006, Spain
CHU Brest - Cavale Blanche
RECRUITING

Brest, Brittany Region, 29609, France
CHU Orléans - Pharmacie
RECRUITING

Orléans, Loiret, 45067, France
CHU UCL Namur/Ste Elisabeth
RECRUITING

Namur, Wallonia, 5000, Belgium
CUN Madrid
RECRUITING

Madrid, 28027, Spain
CUN Pamplona
RECRUITING

Pamplona, Navarre, 31008, Spain
Calvary Mater Newcastle
RECRUITING

Waratah, New South Wales, 2298, Australia
Cancer Institute Hospital of JFCR
RECRUITING

Tokyo, 135-8550, Japan
Cancer Institute Jean Godinot
RECRUITING

Reims, Marne, 51092, France
Centre Jean Perrin
RECRUITING

Clermont-Ferrand, Auvergne-Rhône-Alpes, 63011, France
Chiba University Hospital- Center for Outpatient
RECRUITING

Chiba, Chiba, 260-8677, Japan
Chris O'Brien Lifehouse
RECRUITING

Camperdown, New South Wales, 2050, Australia
Clinique Tivoli Ducos
RECRUITING

Bordeaux, Gironde, 33000, France
Corewell Health
RECRUITING

Grand Rapids, Michigan, 49503, United States
Curie Oncology (Farrer)
RECRUITING

Singapore, 217562, Singapore
Dept., VUH Santaros Clinics
RECRUITING

Vilnius, LT-08406, Lithuania
Duke Cancer Institute
RECRUITING

Durham, North Carolina, 27710, United States
Emory Winship Cancer Inst.
RECRUITING

Atlanta, Georgia, 30308, United States
Emory Winship Cancer Inst.
RECRUITING

Atlanta, Georgia, 30322, United States
Emory Winship Cancer Inst./Emory Decatur Hospital
RECRUITING

Decatur, Georgia, 30033, United States
European Institute of Oncology
RECRUITING

Milan, MI, 20141, Italy
Fukushima Medical University Hospital
RECRUITING

Fukushima, 960-1247, Japan
GHM Grenoble
RECRUITING

Grenoble, Auvergne-Rhône-Alpes, 38028, France
Galilee Medical Center
RECRUITING

Nahariya, 2210001, Israel
GenesisCare Campbelltown
RECRUITING

Campbelltown, New South Wales, 2560, Australia
Grand Hôpital de Charleroi
RECRUITING

Gilly, Hainaut, 6060, Belgium
Gunma Prefectural Cancer Center
RECRUITING

Ōta, Gunma, 373-8550, Japan
H.R.U. Málaga - Materno-Inf.
RECRUITING

Málaga, 7120, Spain
HM Sanchinarro
RECRUITING

Madrid, 28050, Spain
HU Miguel Servet
RECRUITING

Zaragoza, 50009, Spain
HU Virgen de Valme
RECRUITING

Seville, 41014, Spain
HU Virgen de la Victoria
RECRUITING

Málaga, 29010, Spain
HU Virgen del Rocío
RECRUITING

Seville, 41013, Spain
HUS Strasbourg
RECRUITING

Strasbourg, Bas-Rhin, 67200, France
Haukeland University Hospital
RECRUITING

Bergen, Vestland, NO-5021, Norway
Holy Name Medical Center
RECRUITING

Teaneck, New Jersey, 07666, United States
HonorHealth Research Inst
RECRUITING

Phoenix, Arizona, 85016, United States
Hosp. Univ. Son Espases
RECRUITING

Palma de Mallorca, Balearic Islands, 07120, Spain
Hospital Clínic BCN
RECRUITING

Barcelona, Catalonia, 08036, Spain
Hospital La Paz
RECRUITING

Madrid, 28046, Spain
Hospital Universitari de Girona Doctor Josep Trueta
RECRUITING

Girona, GI, 17007, Spain
Humanitas San Pio X
RECRUITING

Milan, MI, 20159, Italy
Hus Ccc/Ctu
RECRUITING

Helsinki, 00250, Finland
Hyogo Cancer Center
RECRUITING

Hyōgo, 673-0021, Japan
Hôpital Foch
RECRUITING

Suresnes, Île-de-France Region, 92150, France
ICM Montpellier
RECRUITING

Montpellier, Occitanie, 34298, France
ICO Angers
RECRUITING

Angers, Pays de la Loire Region, 49055, France
ICZMP
RECRUITING

Lodz, 93-338, Poland
IVO Valencia
RECRUITING

Valencia, Valenciana, Comunidad, 46009, Spain
Irst Meldola
RECRUITING

Meldola, FC, 47014, Italy
Iwate Medical University Hosp
RECRUITING

Shiwa-gun, Iwate, 028-3695, Japan
Kaiser Permanente SoCal
RECRUITING

Irvine, California, 92618, United States
Kanagawa Cancer Center
RECRUITING

Yokohama, Kanagawa, 241-8515, Japan
Keio University Hospital
RECRUITING

Tokyo, Tokyo, 160-8582, Japan
Kitasato University Hospital
RECRUITING

Sagamihara-shi, Kanagawa, 252-0373, Japan
Klinikum Lippe GmbH Pharmacy
RECRUITING

Lemgo, North Rhine-Westphalia, 32657, Germany
Kuopio Univ. Hospital, PSHVA
RECRUITING

Kuopio, Northern Savonia, 70210, Finland
L'Hôpital Privé Nancy Lorraine
RECRUITING

Nancy, Meurthe-Et-Moselle, 54000, France
LSMU Hospital Kauno klinikos
RECRUITING

Kaunas, Central Lithuania, LT-45434, Lithuania
MUHC - Glen Site
RECRUITING

Montreal, Quebec, H4A 3J1, Canada
MedStar Washington Hospital
RECRUITING

Washington D.C., District of Columbia, 20010, United States
Mie University Hospital
RECRUITING

Tsu, Kansai, 514-8507, Japan
Morristown Medical Center
RECRUITING

Morristown, New Jersey, 07960, United States
NEXT San Antonio
RECRUITING

San Antonio, Texas, 78240, United States
NUC Tohoku Univ. Hospital
RECRUITING

Sendai, Miyagi, 980-8574, Japan
NUH Singapore
RECRUITING

Singapore, 119082, Singapore
NW Cancer Specs. P.C.
RECRUITING

Happy Valley, Oregon, 97015, United States
NYU Laura and Isaac Perlmutter Cancer Center - 34th Street
RECRUITING

New York, New York, 10016, United States
National Cancer Center Hospital East
RECRUITING

Chiba, 277-8577, Japan
National Hospital Organization Kyushu Cancer Center
RECRUITING

Fukuoka, 811-1347, Japan
Niigata Cancer Center Hospital
RECRUITING

Niigata, Japan
Northside Hospital Atlanta
RECRUITING

Atlanta, Georgia, 30342, United States
Norwalk Hospital
RECRUITING

Danbury, Connecticut, 06810, United States
Norwalk Hospital
RECRUITING

Norwalk, Connecticut, 06856, United States
OUH Radium Hospital
RECRUITING

Oslo, Oslofjord, 0379, Norway
Osaka International Cancer Institute - Osaka - Otemae Acti
RECRUITING

Osaka, Osaka, 541-8567, Japan
Osaka Medical and Pharmaceutical University Hospital
RECRUITING

Takatsuki, 569-8686, Japan
Ospedale S Stefano
RECRUITING

Prato, PO, 59100, Italy
Oulu University Hospital
RECRUITING

Oulu, North Ostrobothnia, 90220, Finland
PR Cancer Specialists
RECRUITING

San Juan, 00917, Puerto Rico
Perlmutter CC NYU Langone LI
RECRUITING

New York, New York, 11501, United States
SMH - Sarasota - Main Campus
RECRUITING

Sarasota, Florida, 34239, United States
Saint-Luc University Clinics
RECRUITING

Brussels, Brussels Capital, 1200, Belgium
Saitama Medical University - International Medical Center
RECRUITING

Saitama, 350-1298, Japan
Sapporo Medical University Hospital
RECRUITING

Sapporo, 060-8543, Japan
Shaare Zedek Medical Center
RECRUITING

Jerusalem, 9103102, Israel
Shizuoka Cancer Center
RECRUITING

Nagaizumi-cho, Shizuoka, 411-8777, Japan
Siedleckie Centrum Onkologii
RECRUITING

Siedlce, Masovian Voivodeship, 08-110, Poland
Sinai Hospital
RECRUITING

Baltimore, Maryland, 21215, United States
TX Onc - Arlington North
RECRUITING

Arlington, Texas, 76012, United States
TX Onc - Bedford
RECRUITING

Bedford, Texas, 76022, United States
TX Onc - Methodist Charlton
RECRUITING

Dallas, Texas, 75237, United States
TX Onc - Methodist Dallas
RECRUITING

Dallas, Texas, 75203, United States
TX Onc - Presbyterian Dallas
RECRUITING

Dallas, Texas, 75231, United States
TX Onc - Sammons
RECRUITING

Dallas, Texas, 75246, United States
Tampere University Hospital
RECRUITING

Tampere, 33520, Finland
Trials365, LLC
RECRUITING

Shreveport, Louisiana, 71103, United States
UCH No. 2, PMU Szczecin
RECRUITING

Szczecin, West Pomeranian Voivodeship, 70-111, Poland
UGH Patras
RECRUITING

Pátrai, RIO, 265 04, Greece
UMass Memorial Medical Ctr
RECRUITING

Worcester, Massachusetts, 01605, United States
USAH Mitchell Cancer Inst
RECRUITING

Mobile, Alabama, 36604, United States
USOR - Minnesota Oncology
RECRUITING

Minneapolis, Minnesota, 55404, United States
USOR - Minnesota Oncology - Edina Clinic
RECRUITING

Edina, Minnesota, 55435, United States
USOR - Minnesota Oncology-Coon Rapids Clinic
RECRUITING

Coon Rapids, Minnesota, 55433, United States
USOR - Minnesota Oncology-Maplewood Clinic
RECRUITING

Maplewood, Minnesota, 55109, United States
USOR - Minnesota Oncology/ Coon Rapids Clinic
RECRUITING

Coon Rapids, Minnesota, 55433, United States
USOR - Minnesota Oncology/ Maple Grove Clinic
RECRUITING

Maple Grove, Minnesota, 55369, United States
USOR - Minnesota Oncology/ Maplewood Clinic
RECRUITING

Maplewood, Minnesota, 55109, United States
USOR - Minnesota Oncology/ Minneapolis Clinic
RECRUITING

Minneapolis, Minnesota, 55404, United States
USOR - Minnesota Oncology/ Woodbury Clinic
RECRUITING

Woodbury, Minnesota, 55125, United States
USOR - Minnesota Oncology/Edina Clinic
RECRUITING

Edina, Minnesota, 55435, United States
USOR - NW Cancer Specs P.C.
RECRUITING

Portland, Oregon, 97227, United States
USOR - NW Cancer Specs P.C.
RECRUITING

Vancouver, Washington, 98684, United States
USOR - NW Cancer Specs. P.C.
RECRUITING

Tigard, Oregon, 97223, United States
USOR - TX Oncology - SA NE
RECRUITING

San Antonio, Texas, 78217, United States
USOR - Texas Oncology
RECRUITING

Austin, Texas, 78731, United States
USOR - Texas Oncology
RECRUITING

Austin, Texas, 78745, United States
USOR - Texas Oncology
RECRUITING

Harlingen, Texas, 78550, United States
USOR - Texas Oncology
RECRUITING

McAllen, Texas, 78503, United States
USOR - Texas Oncology
RECRUITING

Weslaco, Texas, 78596, United States
USOR - Texas Oncology - Dallas Fort Worth (DFW)
RECRUITING

Fort Worth, Texas, 76104, United States
USOR - Texas Oncology- Austin North
RECRUITING

Austin, Texas, 78758, United States
USOR - Texas Oncology- Horizon Circle
RECRUITING

Waco, Texas, 76712, United States
USOR - Texas Oncology- Waco
RECRUITING

Waco, Texas, 76712, United States
Universitair Ziekenhuis Leuven
RECRUITING

Leuven, Flanders, 3000, Belgium
University of Cincinnati Medical Center
RECRUITING

Cincinnati, Ohio, 45219, United States
University of Virginia
RECRUITING

Charlottesville, Virginia, 22908, United States
VITAZ
RECRUITING

Sint-Niklaas, 9100, Belgium
Washington University School of Medicine
RECRUITING

St Louis, Missouri, 63110, United States
Willamette Valley Cancer Institute and Research Center - Eugene
RECRUITING

Eugene, Oregon, 97401, United States
William Kahlert Reg. Can. Ctr
RECRUITING

Westminster, Maryland, 21157, United States
Women's Care - 9th Ave
RECRUITING

St. Petersburg, Florida, 33713, United States
Women's Care - Armenia Ave
RECRUITING

Tampa, Florida, 33603, United States
Yamagata University Hospital
RECRUITING

Yamagata, 990-9585, Japan
ŚCO SPZOZ Kielce
RECRUITING

Kielce, 25-734, Poland

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