New drug BL-B01D1 targets Hard-to-Treat cancers in early trial

NCT ID NCT05983432

Recruiting now Disease control Sponsor: SystImmune Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-phase study tests a new drug called BL-B01D1 in people with advanced lung cancer or other solid tumors that have spread or cannot be removed. The main goals are to check the drug's safety, find the best dose, and see if it helps shrink tumors. About 470 adults will take part.

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Conditions

The condition(s) this trial relates to.

breast cancer breast neoplasm cervical cancer endometrial cancer endometrium neoplasm esophageal cancer Esophageal Neoplasms head and neck squamous cell carcinoma Her2-receptor negative breast cancer hormone receptor-positive breast cancer lung cancer lung neoplasm nasopharyngeal carcinoma, susceptibility to, 1 nasopharyngeal neoplasm non-small cell lung carcinoma ovarian cancer prostate adenocarcinoma small cell lung carcinoma Squamous Cell Carcinoma of Head and Neck triple-negative breast carcinoma Uterine Cervical Neoplasms

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BREAST CANCER CERVICAL CANCER ENDOMETRIAL CANCER ESOPHAGEAL CANCER HEAD AND NECK SQUAMOUS CELL CARCINOMA LUNG CANCER NASOPHARYNGEAL CANCER NON-SMALL CELL LUNG CANCER OVARIAN CANCER PROSTATE ADENOCARCINOMA SMALL CELL LUNG CANCER TRIPLE NEGATIVE BREAST CANCER

Contacts and locations

Locations

Beverly Hills Cancer Center
RECRUITING

Beverly Hills, California, 90211, United States
Centre Léon Bérard
RECRUITING

Lyon, 69373, France
Chao Family Comprehensive Cancer Care and Ambulatory Care
NOT_YET_RECRUITING

Irvine, California, 92612, United States
Chao Family Comprehensive Cancer Center and Ambulatory Care
NOT_YET_RECRUITING

Irvine, California, 92612, United States
City of Hope Cancer Center
RECRUITING

Duarte, California, 91010, United States
Dana-Farber Cancer Institute
RECRUITING

Boston, Massachusetts, 02215, United States
Fondazione del Piemonte per l'Oncologia IRCC Candiolo
RECRUITING

Candiolo, 10060, Italy
Georgetown University Medical Center
RECRUITING

Washington D.C., District of Columbia, 20007, United States
Groupe Hospitalier Pitie-Salpetriere
RECRUITING

Paris, 75013, France
Hematology - Oncology Associates of the Treasure Coast
RECRUITING

Port Saint Lucie, Florida, 34952, United States
Hospital Beata María Ana
RECRUITING

Madrid, 28007, Spain
Hospital Universitari Vall d'Hebron
RECRUITING

Barcelona, 08035, Spain
Hospital Universitario 12 De Octubre
RECRUITING

Madrid, 28041, Spain
Hospital Universitario Virgen Macarena
RECRUITING

Seville, 41009, Spain
Hospital de la Santa Creu I Sant Pau
RECRUITING

Barcelona, 8041, Spain
IRCCS Istituto Clinico Humanitas, Cancer Center
RECRUITING

Rozzano, 20089, Italy
Institut Gustave Roussy
RECRUITING

Villejuif, 94800, France
Institut de Cancerologie de Ouest (ICO) - Saint-Herblain
RECRUITING

Saint-Herblain, 44805, France
Massachusetts General Hospital
RECRUITING

Boston, Massachusetts, 02114, United States
Memorial Sloan Kettering Cancer Center Head Neck Services
RECRUITING

New York, New York, 10065, United States
National Cancer Center Hospital
RECRUITING

Chūōku, 104-0045, Japan
Northwestern University Feinberg School of Medicine
RECRUITING

Chicago, Illinois, 60611, United States
Norton Cancer Institute
RECRUITING

Louisville, Kentucky, 40202, United States
Oncology Consultants, P.A.
RECRUITING

Houston, Texas, 77030, United States
PRISMA Health/ITOR
RECRUITING

Greenville, South Carolina, 29605, United States
START Madrid / Centro Integral Oncologico Clara Campal
RECRUITING

Madrid, 28050, Spain
START Madrid / Hospital Universitario Fundacion Jimenez Diaz
RECRUITING

Madrid, 28040, Spain
START Rioja
NOT_YET_RECRUITING

Piqueras, 26006, Spain
Sara Cannon Research Institute Lake Nona
RECRUITING

Orlando, Florida, 32827, United States
Sarah Cannon - Tennessee Oncology
RECRUITING

Nashville, Tennessee, 37203, United States
Sylvester Comprehensive Cancer Center
RECRUITING

Miami, Florida, 33125, United States
UCLA Santa Monica
RECRUITING

Santa Monica, California, 90404, United States
University of California Irvine Medical Center
RECRUITING

Orange, California, 92868, United States
University of Colorado Cancer Center
RECRUITING

Aurora, Colorado, 80045, United States
University of Iowa Hospital and Clinics
RECRUITING

Iowa City, Iowa, 52242, United States
University of Texas M.D. Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States
University of Washington Fred Hutchinson
RECRUITING

Seattle, Washington, 98109, United States
Virginia Cancer Specialists
RECRUITING

Fairfax, Virginia, 22031, United States
Yale University, Yale Cancer Center
RECRUITING

New Haven, Connecticut, 06520, United States

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