LUNG CANCER

This early-phase study tests a new treatment called GC203 TIL for people with advanced solid tumors (cancers in organs like the breast, lung, or gut) that have not responded to standard therapies. The treatment uses a patient's own immune cells, which are modified in a lab to bet…

This study tests a new oral drug, TNG456, in people with advanced solid tumors that have lost a gene called MTAP. The drug works by blocking a protein (PRMT5) that these tumors need to grow. The study has two parts: first, finding the safest dose of TNG456 alone or with abemacicl…

This study tests the drug atezolizumab in about 200 adults with different incurable solid tumors. Researchers use each person's tumor DNA and RNA to see if their cancer might respond to the drug. Participants receive the same dose every 3 weeks, and the study checks if the geneti…

This study tests whether adding valemetostat to the standard immunotherapy pembrolizumab helps people with advanced non-small cell lung cancer that has high PD-L1 levels. About 137 adults who have not had prior treatment for advanced disease will take part. The goal is to see if …

This study tests whether adding the targeted drug sotorasib to standard chemotherapy before surgery can shrink tumors more effectively in people with a specific genetic lung cancer (KRAS G12C mutation). About 27 adults with stage IIA to IIIB non-squamous non-small cell lung cance…

This study is testing whether adding Chinese herbal medicine to standard chemotherapy and immunotherapy can prevent lung cancer from returning after surgery. About 367 adults with a certain type of lung cancer (non-small cell, stage Ib to IIIb, without driver gene mutations) will…

This study tests whether adding a vitamin A-like drug (ATRA) to a platelet-boosting medication (romiplostim N01) works better than the platelet drug alone for cancer survivors whose platelet counts stay low after chemotherapy. About 220 adults with gynecologic, breast, or lung ca…

This early-stage study tests a new treatment called CD70-targeted CAR-T cells in people with advanced solid tumors, including kidney, lung, and ovarian cancers. The therapy uses a patient's own immune cells, modified to recognize and attack cancer cells that have a specific marke…

This study is testing whether a precise type of radiation called stereotactic radiosurgery (SRS) can help people with small cell lung cancer that has spread to the brain. About 62 adults with up to 20 brain tumors will receive SRS, and researchers will track how many are alive af…

This early-phase study tests a new drug called BL-B01D1 in people with advanced lung cancer or other solid tumors that have spread or cannot be removed. The main goals are to check the drug's safety and find the best dose. About 470 adults will take part to see if the drug can he…

This study tests whether giving low-dose radiation and immunotherapy before standard chemotherapy can help shrink tumors in people with stage II to III non-small cell lung cancer. The goal is to make surgery more effective and improve long-term outcomes. About 30 adults who have …

This study tests a new drug called CNSI-Fe(II), which is injected directly into tumors. It uses iron to trigger a type of cell death called ferroptosis, aiming to control or shrink advanced solid tumors like lung, pancreas, and colorectal cancers. The study involves 54 adults who…

This study tests an experimental treatment called OBX-115 for people with advanced melanoma or non-small cell lung cancer that has spread or come back. The treatment uses a patient's own immune cells (tumor-infiltrating lymphocytes) that are modified to produce a protein (IL15) t…

This early-phase study tests a new drug, CLSP-1025, in adults with advanced solid tumors (like lung, colon, or pancreatic cancer) that have a specific genetic change called p53 R175H and a certain immune type (HLA-A*02:01). The goal is to find a safe dose and see if the drug can …

This trial tests a personalized cancer vaccine made from tumor cells grown in a lab. The cells are modified to boost the immune system, then killed and injected into the patient. The goal is to help people with metastatic melanoma, breast, ovarian, colorectal, gastric, lung, or k…

This study tests a minimally invasive treatment called cryoablation, which uses extreme cold to freeze and destroy early-stage lung nodules. It is designed for 90 patients who cannot have surgery due to age, other health issues, or multiple nodules. The goal is to see how well th…

This early-phase study tests a new treatment for advanced lung cancer that uses a person's own immune cells, modified to better recognize and attack cancer cells. The treatment, called iC9-GD2.CAR.IL-15 T cells, combines antibodies and T cells to target a protein (GD2) found on s…

This study tests a new drug called TNG462, given with other cancer medicines, for people with pancreatic or lung cancer that has a specific genetic change (MTAP loss). The goal is to find safe doses and see if the combination shrinks tumors. About 183 adults with advanced cancer …

This early-phase study tests whether adding carotuximab to the standard drug osimertinib is safe and tolerable for people with advanced EGFR-mutated non-small cell lung cancer. About 60 participants whose cancer has worsened on previous treatments will receive the combination. Th…

This early-stage study tests a new treatment using a patient's own immune cells, engineered to target a protein called CEA found on certain cancer cells. It is for adults with advanced lung, stomach, colon, rectal, esophageal, or pancreatic cancer who have not responded to standa…

This study tests whether adding a special gut bacteria therapy (RMT) to standard immunotherapy and chemotherapy can help control advanced lung cancer better than placebo. About 82 people with untreated, advanced non-small cell lung cancer will take RMT or placebo pills along with…

This study tests a new drug called FH-006, given alongside other cancer treatments, for people with advanced non-small cell lung cancer. The goal is to find the best dose and see if the combination is safe and helps shrink tumors. About 200 adults aged 18 to 75 who cannot have su…

This small study tests a new technique to mark suspicious lung nodules before surgery. Using a special imaging system, doctors place a tiny marker near the nodule through a breathing tube, avoiding a needle through the chest. The goal is to make it easier for surgeons to find and…

This study tests a new drug called PC14586 (rezatapopt) in people with advanced or spreading solid tumors that have a specific change in the TP53 gene (Y220C mutation). The goal is to see if the drug is safe and works against these cancers. About 300 adults (and some teens after …

This early-phase study tests a new drug called RSC-1255, alone or with hydroxychloroquine, in people with advanced solid tumors (like lung, colon, pancreatic cancer, or glioblastoma) that have stopped responding to standard treatments. The goal is to find a safe dose and see if t…

This study tests a new drug called HRS-4508 combined with other cancer treatments for people with advanced non-small cell lung cancer that has stopped responding to standard therapy. About 100 adults aged 18 to 75 will participate. The goal is to find the best dose and see if the…

This study is for adults with advanced solid tumors that have a specific genetic change called STK11 mutation. The goal is to test a new drug, TNG260, given alone or with an immunotherapy drug (pembrolizumab). Researchers want to find the best dose, check safety, and see if the c…

This study tests a new type of CAR T cell therapy for adults with advanced solid tumors (like colorectal, lung, or pancreatic cancer) that have lost a specific marker on their cells. The treatment uses the patient's own immune cells, modified to target cancer cells while protecti…

This study tests a new device called FlexAblate that uses microwaves to destroy lung cancer nodules. It is for adults over 18 with small lung tumors who cannot have surgery or choose not to. The goal is to see if the device safely and completely treats the tumor, with follow-up s…

This study tests a new treatment for people with a specific type of advanced small cell lung cancer (SLFN-11 positive). The treatment combines low-dose radiation, chemotherapy, and two drugs (sugemalimab and olaparib). The goal is to see if this combination is safe and helps cont…

This study tests a new treatment called LK101, given together with standard immunotherapy drugs, for people with advanced lung cancer that has not responded to previous treatments. The goal is to see if the combination is safe and can shrink tumors. About 60 adults with non-small…

This study is testing whether doctors can deliver very focused, high-dose radiation to tumors in the abdomen or chest while limiting damage to nearby organs. The approach uses a special MRI machine combined with a linear accelerator (MR-Linac) to guide the treatment. About 60 peo…

This study tests a drug called osimertinib, given before and after radiation, for people with stage III lung cancer that has a specific gene mutation (EGFR). Participants are those who cannot or choose not to have chemotherapy. The goal is to see if this approach helps control th…

This early-phase study tests a new treatment called IDOV-Immune, a virus designed to infect and kill cancer cells while boosting the immune system. It is for adults with advanced solid tumors (like colorectal, pancreatic, or lung cancer) that have not responded to standard treatm…

This study tests whether adding focused radiation to a standard drug combination (durvalumab plus chemotherapy) can help people with extensive-stage small cell lung cancer live longer without the cancer getting worse. About 49 adults who have not yet been treated for this advance…

This study tests an experimental drug called VMD-928, taken as a pill, either alone or with pembrolizumab (an immunotherapy), in adults with advanced solid tumors or lymphoma that have stopped responding to standard treatments. The goal is to find safe doses and see if the drug c…

This study tests a special radiation method called lattice radiation therapy (LRT) combined with immunotherapy for people with advanced solid tumors that have not responded to standard treatments. The radiation creates high-dose spots inside the tumor to kill cancer cells while s…

This study tests an experimental drug called patritumab deruxtecan in people with advanced solid tumors that have spread or cannot be removed. The trial includes 740 participants with 13 different cancer types, such as lung, breast, and prostate cancer. The goal is to see if the …

This study tests new combinations of drugs in people with non-small-cell lung cancer. It includes three groups: those with newly diagnosed advanced cancer, those whose cancer has returned after treatment, and those with early-stage cancer that can be surgically removed. The goal …

This study tests whether adding certolizumab (an anti-inflammatory drug) to standard chemotherapy before surgery can shrink stage II-III lung cancers more than chemo alone. About 60 adults with operable lung cancer will receive the combination, then have surgery to remove any rem…

This study tests a short, intensive rehab program for people who smoke and have a new lung nodule that may be cancer. Participants will do pulmonary rehab and get help quitting smoking before their cancer treatment. The goal is to see if this approach is practical and helps impro…

This phase 2 trial tests whether adding the investigational drug NKTR-255 to the standard immunotherapy durvalumab can help restore immune cells and improve survival in people with locally advanced non-small cell lung cancer after chemoradiation. About 39 adults will receive the …

This study tests a new treatment called A2B395 for adults with advanced solid tumors (like colorectal, lung, breast, and kidney cancers) that have not responded to standard therapy. The treatment uses specially engineered immune cells designed to kill cancer cells while protectin…

This study tests if axelopran, a drug typically used for opioid-induced constipation, can help slow tumor growth in people with advanced breast, lung, pancreas, or prostate cancer. About 34 adults whose cancer has worsened after standard treatment will take axelopran capsules dai…

This study looks at whether people with lung cancer that has spread to the brain can safely delay radiation therapy if they take the targeted drug alectinib. It involves 56 adults with specific genetic changes. The goal is to see if alectinib alone controls brain tumors as well a…

This early-stage trial tests a new device that delivers a special type of radiation directly into lung tumors that have come back. The goal is to see if the procedure is safe and possible to do. About 10 adults with recurrent lung cancer will take part.

This study looks at people with lung, colorectal, or prostate cancer that has spread to up to 10 spots in the body. It compares starting treatment right away versus waiting 6 months to see which approach helps people live longer and maintain quality of life. About 800 participant…

This study tests a flexible microwave probe that can be guided through the airways to destroy small lung cancer nodules (up to 3 cm). Ten people with stage I or II lung cancer will receive this treatment during a bronchoscopy. The goal is to see if the procedure works as planned …

This study tests the safety of dapagliflozin, a drug approved for diabetes and heart failure, when given before surgery to people with early-stage lung adenocarcinoma. The drug targets a protein found at high levels in these cancer cells. About 48 participants will receive the dr…

This early-phase study tests an experimental oral drug called CID-078 in 220 adults with advanced solid tumors that have stopped responding to standard treatments. The goal is to see if the drug is safe and can shrink tumors. It is a first-in-human trial, so the main focus is on …

This early-phase study tests a radioactive drug called Lutetium-177 BL-ARC001 in people with advanced lung, breast, head and neck, or other solid tumors that have not responded to standard treatments. The main goals are to find a safe dose and check for side effects. About 22 par…

This study tests whether the drug osimertinib can stop small, hazy spots (called GGNs) in the lungs from growing after surgery for a type of lung cancer. About 43 adults with stage I lung cancer and an EGFR gene mutation will take the pill daily. The goal is to see if the spots s…

This study tests a new radiation technique called SMART, which uses MRI to guide and adapt radiation beams in real time. It aims to improve tumor control and reduce side effects for people with cancers of the pancreas, lung, kidney, prostate, liver, and others. About 400 particip…

This study is testing a device that uses short electric pulses to destroy lung tumors before they are surgically removed. About 25 adults with suspected or confirmed lung cancer will receive this treatment. The goal is to see if the device is safe and can successfully reach and t…

This early-stage study is testing the safety of combining the drug talazoparib with low-dose chest radiation in people with extensive-stage small cell lung cancer. Up to 24 participants who have finished initial chemotherapy without their cancer getting worse will take talazopari…

This early-phase study tests an experimental drug called BL-M07D1 in 280 adults with advanced solid tumors that have the HER2 protein. The goal is to see if the drug is safe and can shrink tumors in cancers like breast, lung, stomach, and ovarian cancer. Participants must have tr…

This study tests whether a new drug, PF-08634404, combined with chemotherapy works better than the current standard treatment (pembrolizumab plus chemo) for adults with advanced non-small cell lung cancer. About 1,410 participants will be randomly assigned to receive either the n…

This study tests a new drug called 3H-10000 in people with advanced lung or stomach cancer that cannot be removed by surgery or has spread. The drug is designed to target and kill cancer cells while limiting harm to healthy cells. The trial will check for side effects, find the b…

This study tests a combination of three drugs (datopotamab deruxtecan, carboplatin, and pembrolizumab) in people with non-small cell lung cancer that has spread to the brain and has not been treated yet. The goal is to see if the treatment shrinks brain tumors. About 46 adults wi…

This study tests a new drug combination (BMS-986507) in about 416 adults with advanced solid tumors, specifically lung and breast cancers. The goal is to find safe doses and see if the treatment can shrink tumors. Participants must have measurable tumors and be in fairly good hea…

This study tests a new medical device that uses microwave energy to heat and destroy lung cancer tumors. The goal is to see if it is safe and works well. Up to 18 people who are already scheduled for lung surgery will receive this extra procedure first. If successful, this approa…

This early-stage trial tests a personalized, accelerated radiation method (called HART) combined with chemotherapy for people with locally advanced lung cancer. The goal is to see if a shorter, more targeted radiation schedule can control the tumor while reducing lung and throat …

This early-stage study tests a new drug, QXL138AM, for safety in about 100 people with advanced solid tumors (like ovarian, pancreatic, lung, or breast cancer) or multiple myeloma. Participants must have tried other treatments without success. The study will find the right dose a…

This study tests whether adding chemotherapy to standard immunotherapy (pembrolizumab) can improve outcomes for people with advanced lung cancer. Researchers will use a blood test that detects cancer DNA (ctDNA) to decide when to add chemo. About 230 participants will be enrolled…

This early-stage study tests an experimental drug called VSV-02 in 6 adults with advanced solid tumors (like melanoma, breast, or lung cancer) who have run out of standard options. The drug is given both into a vein and directly into the tumor to see if it can shrink or control t…

This early-phase study tests a new oral drug, DO-2, in adults with advanced solid tumors (like lung cancer) that have a specific MET gene change and no standard treatment options left. The main goal is to check the drug's safety and find the right dose. About 55 participants will…

This study tests whether adding trilaciclib to the standard drug lurbinectedin can lower the risk of dangerous low white blood cell counts (neutropenia) in people with advanced small cell lung cancer that has stopped responding to initial treatment. About 30 adults will receive t…

This early-stage trial is testing the safety of a new two-part treatment for people with advanced HER2-positive solid tumors, such as breast, lung, or gastric cancer. First, a specially designed virus is injected directly into one tumor to help alert the immune system. A few days…

This study is testing a new, non-invasive way to screen for early lung cancer using breath, blood, and CT scans. The goal is to reduce false alarms from CT scans and more accurately tell the difference between harmless nodules and cancer. Researchers will enroll 1,800 people, inc…

This study is observing how well the Ion endoluminal system, a robotic tool, can diagnose lung nodules and cancer in real-world use. About 1,200 adults across Europe who need a lung biopsy will take part. The main goal is to see how accurate the system is at getting a clear diagn…

This study looks at whether using telehealth (phone or video visits) can make lung cancer screening easier for people at high risk. Researchers will identify eligible adults aged 50-80 with a heavy smoking history, then offer them low-dose CT scans at a nearby center. The goal is…

This study compares standard bronchoscopy (a lung scope procedure) with and without a special laser imaging tool called nCLE. The goal is to see if nCLE helps doctors place the biopsy needle more accurately, leading to a clear diagnosis more often. About 208 adults with suspiciou…

This study aims to improve how doctors tell if a small lung nodule is cancerous. Researchers will collect fluid from a routine lung exam and analyze DNA in it for cancer signals. The goal is to make the test more sensitive, especially for tiny nodules, so fewer patients need inva…

This study is testing a new radioactive tracer that targets a protein called LRRC15, found on many cancers like pancreatic, breast, lung, and brain tumors. The tracer is used with PET scans to see if it can better detect and stage these cancers compared to standard scans. The stu…

This study is testing a new blood test that looks for DNA from lung cancer cells in the blood. It is for healthy Asian and Latinx adults aged 50 to 80 who do not smoke but are at risk for a type of lung cancer linked to the EGFR gene. The goal is to see if the test can find lung …

This study is testing whether a blood test can be used as a first step to see who really needs a low-dose CT scan for lung cancer. The goal is to avoid unnecessary scans, radiation, and costs for people at high risk, including smokers and those with a family history of lung cance…

This study aims to see if synthetic PET images, created from standard CT scans using artificial intelligence, can accurately diagnose and guide treatment for lung cancer. Researchers will enroll 10,000 people with non-small cell lung cancer to compare the synthetic images with re…

This study is testing a new type of PET scan that uses a special tracer to find a protein called Trop2 on cancer cells. The goal is to see if this scan can detect and monitor many types of solid tumors more accurately than current methods. About 400 adults with or suspected of ha…

This study is testing a new breath test to see if it can find lung cancer early in people at high risk. The test looks for specific markers in exhaled breath and will be compared to standard low-dose CT scans. If successful, it could offer a cheaper, easier way to screen for lung…

This early-phase study is testing a new radioactive tracer called [18F]-αvβ6-BP for PET/CT scans in people with non-small cell lung cancer that has spread to the brain. The goal is to see if this scan can find tumors more accurately than current methods. About 20 adults with this…

This study tests whether giving people a direct referral for lung cancer screening from the emergency room, plus text message reminders, helps more high-risk smokers get screened. About 300 people aged 50-80 who smoke or quit recently will be split into two groups: one gets basic…

This study offers free mobile low-dose CT scans to people aged 40-54 who have smoked heavily (30 pack-years or more). The goal is to catch lung cancer earlier than current guidelines allow, potentially saving more lives. Participants will be screened up to three times over a few …

This study is testing a blood test that looks for DNA signals from 20 different cancers, including breast, lung, and colon cancer. Researchers want to see if the test can find cancer early, detect any cancer left after treatment, and catch a relapse before symptoms appear. About …

This study tests a combined approach for people with ground-glass lung nodules (a type of early lung cancer). Doctors will use microwave ablation to destroy the nodule and take a tissue sample at the same time to confirm the diagnosis. The goal is to see if this one-step method c…

This study tests a special PET scan probe called [68Ga]CBP8 to see if it can detect early signs of radiation damage in lung and pancreatic cancer patients. About 72 adults who are getting radiation therapy will have scans before and 3-6 months after treatment. The goal is to find…

This study is testing a new blood test that uses laser technology and artificial intelligence to find early signs of breast, colon, pancreatic, ovarian, and lung cancers. Researchers will collect blood samples from 1,400 people aged 45 and older who have or are suspected to have …

This study tests a special dye that makes cancer cells glow during lung cancer surgery. About 132 adults having lung cancer surgery will receive the dye, and surgeons will use a special camera to see the glow. The goal is to help surgeons find cancer that is hard to see with the …

This study looks at whether biomarkers (substances in the body) can help find lung cancer early. It will enroll about 3,600 people who are at high or low risk for lung cancer, or who have suspicious lung nodules. Participants will be followed with CT scans and pathology tests eac…

This study is testing whether a breath test can help doctors tell the difference between harmless and cancerous lung nodules. About 3,000 adults with lung nodules will provide a breath sample, which will be analyzed for specific chemical markers (VOCs) using artificial intelligen…

This study compares two ways to check if lung cancer has spread to lymph nodes in the chest: a standard CT/PET scan versus a minimally invasive scope test called EBUS-TBNA. The goal is to see which method is more accurate for patients with early-stage non-small cell lung cancer w…

This study aims to see if artificial intelligence (AI) can help detect lung cancer early in non-smokers who have a parent, sibling, or child with lung cancer. About 3,000 people aged 50-75 who have never smoked will get a low-dose CT scan and blood test. The AI will help doctors …

This early-phase study is testing a new imaging agent called [68Ga]CBP8 to see if it can safely detect collagen buildup (scarring) in the lungs of people with pulmonary fibrosis and lung cancer. Researchers will compare scans from healthy volunteers and patients to see if the age…

This study tests whether an AI tool that analyzes routine chest X-rays can help doctors identify patients at high risk for lung cancer and encourage them to get a screening CT scan. About 1,500 current or former smokers aged 50-77 will take part. The goal is to see if the AI aler…

This study is looking at whether a blood test (liquid biopsy) can help find lung cancer by measuring certain markers called miRNA and DNA methylation. Researchers will compare results from people with and without lung nodules. The goal is to see if this test can be a useful tool …

This study is testing a lung cancer screening program for current and former smokers aged 45 to 74. Participants will get low-dose CT scans to find suspicious lung nodules. The goal is to see how well the program works in a public health setting and to improve early detection.

This study is testing whether low-dose CT scans can find lung cancer early in over 6,600 people in Taiwan who are at high risk. Participants include heavy smokers who quit, people with a family history of lung cancer, and those exposed to pollution or cooking fumes. The goal is t…

This study aims to see how well a robotic system works for finding and taking samples from suspicious spots in the lungs. It will observe 3,000 adults who are already scheduled to have this procedure as part of their regular care. The main goal is to measure how often the biopsy …

This study looks at whether smokers are more likely to get a lung cancer screening CT scan when their regular doctor suggests it. About 500 adults aged 50-74 who smoke or recently quit will be invited to get a low-dose CT scan. The goal is to see how many people actually complete…

This study is testing whether a Central Screening Unit (CSU) can help more people in the Bronx get screened for lung cancer. The CSU handles tasks like checking eligibility and scheduling scans, so busy doctors don't have to. Researchers will see if this approach leads to more ea…

This study tests a special program designed to improve quality of life for people living in rural areas who have had lung cancer. The program includes support to reduce stigma and help survivors stay active in their own care. About 300 participants will be randomly assigned to ei…

This study tests a program called MyCarePulse and ASCENT that helps cancer patients overcome food-related challenges. About 100 adults recently diagnosed with certain cancers will either get the program or standard care. Researchers will check if the program improves food securit…

This early-phase study tests whether fecal microbiota transplantation (FMT) can safely reduce severe diarrhea or colon inflammation caused by immune-checkpoint inhibitors in people with genitourinary and other cancers. About 40 participants will receive FMT and be monitored for s…

This study tests whether the drug riluzole can prevent memory and thinking problems (often called 'chemo brain') in people receiving chemotherapy for various cancers. About 24 adults with breast, lung, or other cancers will receive either riluzole or a placebo during their chemo.…

This pilot study tests if brodalumab, a drug approved for autoimmune diseases, can safely reduce severe side effects caused by cancer immunotherapy. About 11 adults with various solid tumors who have immune-related side effects will receive brodalumab. The goal is to see if it lo…

This study looks at whether having a conversation about care goals in the emergency department can improve quality of life for people with advanced lung or gastrointestinal cancer. It involves 200 adults who are at least 18, have advanced cancer, and have certain severe symptoms.…

This study tests whether injecting a small amount of the patient's own blood into the lung lining can prevent air leaks after thermal ablation for lung cancer. About 106 adults scheduled for lung ablation will be randomly assigned to receive either standard care or the extra bloo…

This study tests a new, technology-supported care plan for people aged 70 and older who have cancer (breast, lung, colorectal, or prostate) along with other health problems. The goal is to see if this approach improves their quality of life after 6 months. About 720 participants …

This study looks at whether an 8-week pulmonary rehabilitation program can help people with advanced non-small cell lung cancer who have trouble breathing and feel tired. Half of the 85 participants will do the rehab program, while the other half will get their usual care. Resear…

This study tests whether using a SPECT scan to guide radiation therapy can reduce lung damage in people with advanced lung cancer. About 90 patients receiving chemo-radiation will be randomly assigned to standard or SPECT-guided planning. The goal is to see if avoiding highly fun…

This study tests whether special breathing exercises can help people who have had lung cancer surgery improve their oxygen use, balance, and physical activity. Researchers will measure how well the lungs and muscles work during exercise and at rest. The goal is to see if this tra…

This study tests whether a special dietary supplement can reduce severe side effects from standard cancer treatments in people with head and neck, lung, or rectal cancer. About 52 participants will take the supplement during their treatment, and their results will be compared to …

This study compares two ways to block pain during lung cancer surgery. One method uses a combination of two nerve blocks, and the other uses a single block. Sixty adults having lung cancer surgery will be randomly assigned to one of the two approaches, and their pain levels will …

This study compares a long-acting painkiller (liposomal bupivacaine) to a standard one (bupivacaine hydrochloride) for pain relief after lung surgery. About 210 adults having chest surgery will be randomly assigned to one of three groups. The goal is to see if the long-acting ver…

This study compares two types of nerve blocks (costotransverse foramen block and thoracic paravertebral block) to control pain after lung cancer surgery. The goal is to see which method reduces the need for morphine and provides longer pain relief. About 70 adults undergoing thor…

This study explores whether a couple-based meditation program can improve physical, emotional, and spiritual well-being for people with metastatic lung cancer and their romantic partners. Researchers will enroll 300 couples to see if the program is practical and helpful. The goal…

This study tests a stress management program for people with lung cancer who are waiting for routine scan results. The program includes coaching calls and online modules to help reduce stress. About 60 adults with lung cancer will participate to see if the program is helpful and …

This study tests a short supportive program called Pathways to see if it can improve mental health and quality of life for people being treated for advanced lung cancer. About 234 adults with stage 3 or 4 lung cancer who are 3-12 weeks into treatment will take part. Participants …

This study tests a non-invasive treatment called Transcutaneous Acupoint Electrical Stimulation (TAES) to see if it can reduce coughing in people who have had lung cancer surgery. About 84 adults who have had a dry cough for at least two weeks after their operation will receive t…

This study tests whether a nurse-led program that includes symptom tracking, exercise, and help navigating the healthcare system can improve survival and quality of life for vulnerable lung cancer patients. About 250 adults with lung cancer who face extra challenges will be rando…

This study tests a personalized program of diet, exercise, supplements, and stress management for people undergoing surgery for lung, stomach, or esophageal cancer. The goal is to see if this approach improves quality of life, reduces complications, and helps patients feel better…

This study looks at whether using a high flow nasal cannula (a special oxygen device) during a lung cancer procedure called EBUS bronchoscopy can reduce breathing problems and procedure interruptions. About 198 adults having this procedure will be randomly assigned to receive eit…

This study looks at whether a 12-week exercise program at different intensity levels is possible and helpful for people with advanced lung cancer who are already receiving immunotherapy. Researchers will track how many participants complete the exercise sessions and measure immun…

This study compares two types of minimally invasive surgery—robotic-assisted and video-assisted—for people with early-stage non-small cell lung cancer. The goal is to see which approach leads to better quality of life and recovery. About 512 adults across Europe will take part, a…

This study compares two types of nerve blocks (RIB and ESPB) to see which one controls pain better after lung cancer surgery. Sixty adults having a thoracotomy will receive one of the blocks, and researchers will measure how much morphine they need in the first 24 hours. The goal…

This study tests whether adding acupuncture to standard anti-nausea medicine can better control nausea caused by chemotherapy. About 90 adults with various cancers who still feel sick despite medication will either receive acupuncture plus medicine or medicine alone. Researchers …

This study tests whether two drugs—N-acetyl cysteine and a short course of dexamethasone—can reduce severe shortness of breath after lung radiation in people with both lung cancer and interstitial lung disease. About 98 participants will receive either the drugs or placebos. The …

This study looks at whether spiritual care sessions can improve spiritual wellbeing and reduce anxiety and depression in people with stage IV lung or gastrointestinal cancer. About 36 adults will be randomly assigned to receive either spiritual care or informational support over …

This study tests whether using an incentive spirometer—a device that encourages deep breathing—can lower the risk of lung inflammation (pneumonitis) in people with advanced lung cancer receiving chemotherapy and radiation. About 100 participants will use the device 10 times every…

This study tests a home-based rehab program for 40 veterans who finished lung cancer treatment in the past 1-6 months. The program uses video calls and a fitness tracker to help reduce shortness of breath, fatigue, and fear of cancer returning. The goal is to improve quality of l…

This study tests whether adding intravenous vitamin C to standard chemotherapy can improve quality of life for people with incurable non-small cell lung cancer. About 90 adults with stage IIIB or IV lung cancer will receive either vitamin C or a placebo alongside their usual trea…

This study looks at whether adding endurance training (like cycling) to standard physical therapy helps people recover better after minimally invasive lung cancer surgery. About 184 adults having lung surgery will be randomly assigned to standard rehab or standard rehab plus extr…

This study looks at whether artificial intelligence (AI) can help doctors write more accurate and efficient treatment reports for patients with common cancers like lung, breast, and colon cancer. The researchers will have 40 junior doctors use either an AI tool or traditional met…

This study compares two ways of taking tissue samples from lung tumors to see which one gives better material for genetic testing. About 250 adults with suspected lung cancer will be randomly assigned to get either a standard needle biopsy or a newer freezing technique. The goal …

This study looks at whether a health campaign called Pink & Pearl can encourage more women who are at risk for lung cancer to get screened. About 279 women aged 50-80 who smoke or used to smoke will be invited to screening during their regular mammogram visit. Researchers will tr…

This study aims to collect information from 180 lung cancer patients to better understand their nutritional and metabolic needs. Researchers will look at factors like genetics, gut bacteria, and tumor characteristics to build a model that can suggest personalized diets. The goal …

This study looks at why Hispanic current and former smokers may not get screened for lung cancer. Researchers will give 2000 participants an educational video and then ask them questions. The goal is to find better ways to help more people get this important screening.

This study enrolls 7,000 people with various cancers who have had or will have treatment aimed at curing their disease. Researchers collect blood, tissue, urine, and saliva samples over time to look for tiny bits of cancer DNA that might remain after treatment. The goal is to lea…

This study observes 110 adults with head/neck, lung, or rectal cancer to track changes in their nutrition and body composition during standard cancer treatments. Researchers measure daily food intake, muscle mass, and strength over time. The goal is to gather information that wil…

This study screens up to 7,000 adults with cancers like melanoma, lung, or colorectal cancer to see if they qualify for experimental treatments developed by the National Cancer Institute's Surgery Branch. These treatments involve taking a patient's own immune cells, growing them …

This study is for people with lung or chest cancers that have come back or are new, and who have already had radiation before. Researchers want to see how safe and effective a second round of high-dose radiation is by tracking side effects and survival in 500 participants. The go…

This study tests whether teaching oncology care providers empathic communication skills can reduce the stigma lung cancer patients often feel during medical visits. Over 1,200 doctors, nurse practitioners, and physician assistants across the U.S. will receive training and be eval…

This study is testing an artificial intelligence (AI) tool that estimates a person's chance of developing lung cancer in the next 3 years. Researchers want to see how learning this risk score affects patients' feelings, health beliefs, and whether they follow up with lung cancer …

This study is creating a questionnaire to measure how closely lung cancer patients follow their respiratory rehabilitation program. About 281 Mexican adults with lung cancer will fill out the 56-question scale. The goal is to make sure the tool is accurate and reliable, so doctor…

This study tests a new way to predict how well your lungs will work after lung cancer surgery. Doctors use a 3D CT scan to create a virtual model of your lungs and simulate the surgery beforehand. The goal is to improve safety and help plan recovery. About 60 adults with non-smal…

This study is testing whether low-dose CT scans and blood tests can help find lung cancer early in people at risk, including smokers and non-smokers. About 1,000 adults aged 50-80 in Singapore will take part. The goal is to see if this screening approach is practical and accurate…

This study looks at whether combining PET scan images with genetic testing can better predict how well lung cancer treatments will work and how long patients may survive. Researchers will study 120 adults with non-small cell lung cancer. The goal is to create a more accurate tool…

This study looks at whether tissue samples taken during a routine lung biopsy (called EBUS-TBNA) can be used to analyze gene changes in lung cancer. The goal is to see if these gene changes can help predict which treatments—like surgery, chemo, or radiation—will work best for eac…

This study looks at whether DNA from blood, sputum, and breath can help track non-small cell lung cancer before and after surgery. About 210 adults having surgery to remove their cancer will provide samples over 24 months. The goal is to see if these tests are practical and safe …

This study is collecting information from 200 people with advanced lung cancer to build computer models that can predict how well a treatment will work or if resistance will develop. Researchers will gather medical, imaging, and lifestyle data to create these models. The goal is …

This study is testing whether tiny particles in the blood, called extracellular vesicles, can predict nerve damage caused by chemotherapy. Researchers will follow 120 adults with various cancers who are receiving specific chemotherapy drugs. Participants will give blood samples a…

This study looks at 400 people with non-small cell lung cancer who had pre-treatment (like chemo or immunotherapy) and then needed a specific type of lung surgery called sleeve lobectomy. Researchers want to see if a less invasive surgery (using small cuts and a camera) works as …

This study collects blood and other samples from adults with cancer to learn how certain immune cells change before and after chemotherapy. It does not provide any treatment. Up to 1,750 participants will give blood samples, and some may also provide tissue, urine, or stool. The …

This study looks at ways to encourage people to test their homes for radon, a radioactive gas that can cause lung cancer. Researchers will test an online tool and reminder messages to see if they help more people request and use free radon test kits. The study involves 172 adults…

This study tests whether a special MRI scan using inhaled xenon gas can help doctors see and predict lung damage caused by radiation therapy for lung cancer. Researchers will compare scans from 70 participants, including healthy volunteers and lung cancer patients receiving radia…

This study watches how standard lung cancer treatments work in people aged 70 and older. It aims to learn about treatment effectiveness, side effects, and quality of life in this age group. Participants receive their usual care and provide blood samples and answer questionnaires.…

This study aims to develop a new 4D-MRI imaging method to track how tumors move when you breathe, which could make radiation therapy more accurate for lung and liver cancer. Researchers will test this technique in 100 healthy volunteers and cancer patients. The goal is to improve…

This study follows up with people who previously took part in cancer vaccine studies using gene therapy. It does not give any new treatment. Instead, it checks their health once a year for 15 years to watch for any long-term side effects. Up to 750 participants with various cance…

This study is testing whether yearly low-dose CT scans can help find lung cancer early in 1,000 high-risk adults in Mexico. Participants are 50 or older and are heavy smokers, former smokers, or have been exposed to wood smoke. The goal is to see if this screening method can catc…

This study looks at whether a special care program helps younger adults (under 50) with lung cancer feel more satisfied with their care. Researchers will also ask about the needs of patients and their families, and see if joining peer support groups makes a difference. About 75 p…

This study aims to collect information from cancer patients (breast, lung, ovarian, multiple myeloma, or AML) using weekly online surveys about their symptoms. The goal is to build a database that helps doctors better understand and manage side effects during treatment. Participa…

This study aims to find genetic and immune changes that lead to lung cancer. Researchers will collect tissue samples from 6,000 people with lung cancer or suspicious lung growths. The goal is to understand how the disease starts and progresses, which could lead to better risk pre…

This study is creating a large collection of blood and other biological samples from 3,000 people with lung nodules or lung cancer. Researchers will use these samples to identify new biomarkers that could improve how we diagnose, predict outcomes, and choose treatments for lung c…

This study looks at CT scans from 2,000 people to see if computer models can better predict lung cancer biopsy results and treatment success. Participants are adults diagnosed with early-stage lung cancer. The goal is to improve how doctors interpret scans, not to test a new trea…

This study aims to see if low-dose CT scans are a good way to screen for lung cancer in Black individuals aged 50-80 who have smoked. Researchers will enroll 900 participants to check how many people agree to join and how well the scans find cancer. The goal is to improve early d…

This study tests a program called CARES that provides advocacy, resources, education, and support to rural cancer patients. The goal is to see if it helps them start treatment sooner after diagnosis and finish it faster. The study will include 320 adults with solid tumors like lu…

This study creates a registry of 1500 lung cancer patients to track their health over 10 years. Researchers will collect information on survival, how the disease changes, and how well treatments work in real life. The goal is to learn from patient experiences to improve future ca…

This study aims to create a program that helps older adults with lung cancer address concerns related to aging, such as managing symptoms and connecting with specialists. In the first phase, patients, caregivers, and providers give feedback on the program. In the second phase, ol…

This study looks at different types of immune cells called neutrophils in the blood of people with lung cancer. Researchers want to see if certain neutrophil types are linked to how the cancer grows or resists treatment. About 100 patients and healthy volunteers will give blood s…

This study looks at whether a special campaign called Pink & Pearl can help more women who are at risk for lung cancer get screened. About 5,500 women ages 50 to 80 who come for mammograms at Christian Hospital will be included. Researchers will track how many get referred and co…

This study is collecting information and biological samples from 730 adults newly diagnosed with lung cancer. Researchers want to see how patients respond to treatments in everyday medical practice, not just in strict clinical trials. The goal is to better understand the disease …

This study is testing a web-based tool called CARE that gives cancer patients information about treatment costs, health insurance, and financial help. About 430 adults with gynecologic, prostate, lung, or colorectal cancer will use the tool to see if it reduces financial stress a…

This study will look at how doctors currently diagnose lung and breast cancer by examining tissue samples. Researchers will also test new computer programs that use artificial intelligence to help read the samples faster and more accurately. The goal is to see if AI can improve t…

This observational study tracks 2,400 lung cancer patients treated with immune checkpoint inhibitors to understand how often blood clots (in veins or arteries) occur and what raises that risk. Researchers will compare patients who develop clots with those who don't, looking for b…

This study collects blood or cheek swab samples from people with cancer who are already in treatment at the National Cancer Institute. Researchers will analyze the DNA to find genetic differences that may affect how the body processes cancer drugs and whether side effects occur. …

This study looks at how modern, minimally invasive lung cancer surgery affects the heart's electrical signals and stress levels. Researchers will monitor 100 adult patients before, during, and after surgery to see if any heart changes occur and if they are temporary. The goal is …

This study tests a new imaging method called full-field optical coherence tomography (FFOCT) to see if it can quickly analyze small lung biopsy samples as accurately as standard lab tests. About 20 adults having a bronchoscopy for diagnosis or staging will participate. The goal i…

This study is building a large database of blood, tissue, and imaging samples from 4,000 people with lung cancer. Researchers will follow participants for up to 10 years to better understand the disease. The goal is to gather information, not to test a new treatment.

This study follows 600 people with early-stage lung cancer who have a type of surgery called segmentectomy. Participants fill out questionnaires before surgery, a few weeks after, and 6 months later. The main goal is to see how many people are alive and cancer-free 3 and 5 years …

This study looks at whether bacteria in the lungs and gut can help predict how well immunotherapy works for people with advanced lung cancer. Researchers will collect airway, stool, and blood samples from 48 patients before and after 8 weeks of treatment. The goal is to find patt…

This study is collecting information from 8,000 cancer patients treated with a special machine called the MR-Linac, which combines an MRI scanner with a radiation therapy device. The goal is to see how well this technology works for different cancers, including breast, prostate, …

This study collects fluid from around the lungs (pleural fluid) from people with lung cancer, breast cancer, or lung infections. The goal is to build a registry of samples and health information for future research. No treatments or new procedures are involved—samples are taken d…

This study collects blood and leftover tissue samples from 9,600 adults with different types of cancer, such as breast, lung, and pancreatic cancer. Researchers will use these samples to improve tests that look for tiny bits of cancer DNA in the blood, which may help detect if ca…

This study tests whether a patient navigation program helps more Black adults who are at high risk for lung cancer complete their lung cancer screening. Researchers will enroll 675 people and track how many get a low-dose CT scan. The goal is to see if having a guide through the …

This study compares using a virtual agent (like a smart assistant) versus a real person over the phone to teach lung cancer patients how to use home monitoring devices. These devices measure weight, blood pressure, heart rate, temperature, and oxygen levels. About 36 adults with …

This study is adapting and testing a decision aid (a simple guide) to help people decide whether to get screened for lung cancer. It involves 360 current or former smokers aged 50-80 who are part of a safety-net healthcare system. The goal is to see if the guide is safe and helpf…

This study aims to develop a simple, non-invasive test for lung diseases like cancer by analyzing cough samples. Researchers will collect coughs, mouthwash, and lung fluid from 2,000 adults to see if genetic material from the lungs can be detected in breath. The goal is to create…

This study looks at sputum and tissue samples from 700 people with or without precancerous changes in the airways. The goal is to find biomarkers—biological clues—that may help detect lung, head and neck, or esophageal cancer earlier. Participants provide samples during routine p…

This study looks at how many breast and lung cancer patients have a strong, ongoing fear that their cancer will return. Researchers will survey 200 patients and interview 40 of them to understand their feelings, thoughts, and whether they feel they get enough support. The goal is…

This study enrolls 50 adults with lung cancer whose disease has worsened while on immunotherapy. Researchers will take a new tumor sample (rebiopsy) to study why the treatment stopped working. The goal is to learn more about resistance mechanisms, not to provide a new treatment. …

This study is creating a large database of 10,000 lung cancer patients who received radiotherapy. Researchers will collect information on tumor control, side effects, and quality of life to build models that predict outcomes. The goal is to use these models to select the best tre…

This study aims to understand how lung tumors burn sugar for fuel using a special MRI scan and a natural sugar solution. About 200 adults with suspected lung cancer who need surgery will take part. The goal is to develop a method to see tumor metabolism, not to treat the disease.

This study looks at whether a new, step-by-step method for examining lung tissue after surgery can find more lymph nodes than the usual approach. Finding more lymph nodes helps doctors stage lung cancer more accurately and decide if extra treatment like chemotherapy is needed. Ab…

This study aims to collect and analyze genetic information from 25,000 adults who either have cancer or are at risk of developing it. Researchers will look at tumor DNA and other health records to better understand what drives different cancers. The goal is to find new ways to de…

This study collects blood, tumor, and other tissue samples from up to 1,250 people with head and neck, lung, or gastrointestinal cancers. Researchers will analyze these samples to learn how different cancer treatments affect the immune system, identify who might develop side effe…

This research study collects and analyzes lung tumor samples from 4,000 people with early-stage non-small cell lung cancer who are having surgery. The goal is to find unique patterns in RNA and proteins (molecular fingerprints) that may help predict cancer recurrence and survival…

This study looks at how a person's muscle mass (fat-free mass) relates to side effects from standard chemotherapy (carboplatin/paclitaxel) in advanced non-small cell lung cancer. Researchers will track 132 participants to see if adjusting the chemo dose based on body composition …

This study looks at whether certain genetic markers in blood and tumor samples can predict how well immunotherapy works before surgery for non-small cell lung cancer. Researchers will collect samples from 100 people with stage II-IIIB lung cancer who are scheduled to receive immu…

This study aims to collect blood samples (liquid biopsies) from 2,500 people with cancer or at high risk for cancer, along with their medical information. The samples will be stored and used by researchers to develop better ways to detect, monitor, and understand cancer over time…

This study collects blood, urine, sputum, and lung tissue from 4,000 adults at high risk for lung cancer. Researchers will analyze these samples to find DNA changes and other molecular markers that could predict cancer behavior. The goal is to learn how lung cancer develops and t…

This study compares different outreach methods to encourage lung cancer screening in people at high risk. About 27,000 participants aged 50-77 who smoke or recently quit will use a digital tool called mPATH-Lung. The goal is to see which approach works best, especially for racial…

This study collects tissue samples from 7,000 adults with lung cancer, COPD, lung transplants, or other chest diseases. The samples are stored in a repository to help researchers better understand how these diseases start, how to diagnose them early, and how to improve treatment.…

This study tests whether the emergency department can be used to identify people at high risk for lung cancer and help them get screened. Researchers will screen patients for social needs and offer a tailored program to encourage lung cancer screening. The goal is to see if this …

This study is for people aged 50-80 who have never smoked but have a close family member with lung cancer. Researchers will use questionnaires, blood tests, and CT scans to create a model that better predicts lung cancer risk in this group. The goal is to improve early detection …

This study is developing and testing two new kits that help predict if early-stage lung cancer will come back after surgery. One kit uses a tissue sample, and the other uses a blood test. Researchers will follow 236 patients to see how accurate these tests are at identifying thos…

This study is testing whether a blood test that looks for tumor DNA (ctDNA) can find cancer returning sooner than standard scans. Researchers will follow 100 people with various solid tumors to see if early detection leads to better treatment options. The goal is to improve how w…

This study is creating a detailed atlas of pre-cancerous spots in the lungs to understand how they turn into cancer. Researchers will collect tissue samples from 240 adults with these spots using a scope down the airway. The goal is to find clues that could help prevent lung canc…

This study tests whether daily CT scans can help doctors see and protect the ovaries during pelvic radiation in women under 50 with various cancers. The goal is to keep radiation doses to the ovaries low enough to avoid early menopause and infertility. Ten participants will recei…

This study is building an artificial intelligence (AI) system that uses PET/CT scans and patient information to identify different types of lung cancer. The goal is to help doctors tell small cell from non-small cell lung cancer and further classify subtypes without needing a bio…

This study looks at the best times to send messages that encourage physical activity to older adults (65+) who have survived certain cancers and still have chronic pain. Researchers will track activity with a wearable device and ask participants to rate their pain four times a da…

This study aims to develop new ways to find lung cancer earlier by analyzing blood samples with artificial intelligence. Researchers will collect blood from 5,000 people who have suspicious spots on their lungs. The goal is to create tools that help doctors diagnose lung cancer f…

This study is creating a large database of medical information and biological samples from adults with or at risk for many types of cancer, as well as healthy volunteers. The goal is to help researchers better understand what causes cancer, how it progresses, and how to improve p…

This study looks at two ways to remove small lung spots (nodules) in people with lung cancer. One method uses special imaging during surgery (iVATS), the other is standard surgery (VATS). The goal is to see how long each surgery takes, how long patients stay in the hospital, and …

This study aims to collect health information from 12,000 adults with lung or other chest cancers. Researchers want to understand why some people respond better to treatments than others, by looking at factors like genetics, lifestyle, and tumor details. The goal is to improve fu…