LUNG CANCER

This early-stage trial is testing a new drug called BG-60366 in people with advanced non-small cell lung cancer that has a specific genetic change called an EGFR mutation. The drug is designed to find and break down the faulty protein that drives this type of cancer. Researchers …

This early-stage study aims to find a safe and effective dose when combining two drugs (osimertinib and carotuximab) for people with advanced lung cancer that has a specific genetic change (EGFR mutation). Researchers will enroll 60 adults whose cancer has progressed despite prev…

This is a first-in-human safety study testing a new two-part treatment for people with advanced HER2-positive solid tumors that have stopped responding to standard therapies. First, a specially designed virus is injected directly into one tumor to help alert the immune system. A …

This early safety study is testing whether a diabetes drug called dapagliflozin is safe to give to people with early-stage lung cancer before they have surgery. Researchers want to see if taking the pill for 30 days before the operation helps make the surgery more effective by po…

This study is testing whether adding a special gut bacteria supplement (called restorative microbiota therapy) to standard chemotherapy and immunotherapy drugs helps people with advanced lung cancer live longer without their cancer getting worse. About 82 participants will be ran…

This study is testing whether a new oral drug called TNG462 is safe and effective when combined with other cancer drugs for people with advanced pancreatic or non-small cell lung cancer. The trial will involve about 183 adults whose cancers have specific genetic changes (MTAP los…

This study is testing whether a precise, high-dose radiation treatment called stereotactic radiosurgery (SRS) can help people with small cell lung cancer that has spread to the brain. It will measure how many participants are still alive 6 months after receiving the treatment. Th…

This study is testing a new experimental drug called 3H-10000 in people with advanced lung or stomach cancer that cannot be removed by surgery or has spread. The main goals are to find a safe and effective dose and to see if the drug can shrink tumors. The study will enroll about…

This study is testing a freezing treatment called cryoablation for early lung cancer spots found on scans. It's for patients who cannot have or choose not to have standard surgery. Researchers will follow 90 patients for up to 5 years to see if the freezing treatment safely contr…

This study is testing if a blood test can help doctors make better treatment decisions for people with advanced lung cancer. The test looks for tiny bits of cancer DNA in the blood. If the DNA is still found after 6 weeks of standard immunotherapy, the study will see if adding ch…

This study tests whether combining targeted radiation with immunotherapy drugs before surgery can better eliminate lung cancer tumors. It involves 30 adults with stage II-III non-small cell lung cancer who are eligible for surgery. The goal is to see if this combination treatment…

This Canadian study is testing whether a personalized approach to cancer treatment works. It gives the immunotherapy drug atezolizumab to about 200 patients with advanced breast, lung, or other cancers, but only if their tumor's genetic analysis suggests they might respond. The g…

This study is testing a condensed, two-week exercise and education program for current smokers who have COPD and need surgery for suspected lung cancer. The goal is to see if this 'prehab' program is practical and safe to complete quickly before surgery, and if it helps improve f…

This study is testing a new oral drug, PC14586 (rezatapopt), for people with advanced solid tumors that have a specific mutation in a gene called TP53 (Y220C). The main goals are to find a safe and effective dose and to see if the drug can shrink tumors. The trial is enrolling up…

This study is testing a new type of personalized cell therapy called OBX-115 in adults with advanced melanoma or non-small cell lung cancer that has progressed after standard treatments. Doctors take a patient's own immune cells from a tumor, genetically engineer them to be more …

This is the first study in people to test a new oral medication called CID-078 for advanced solid tumors. The main goals are to find a safe dose and see how well the body handles the drug. The study will enroll adults with cancers like triple-negative breast cancer, small cell lu…

This large, late-stage trial is testing whether immediately using aggressive treatments like radiation to destroy all visible cancer spread sites helps people live longer than waiting six months. It's for adults with lung, prostate, or colorectal cancer that has spread to 10 or f…

This study is testing whether adding a new drug called valemetostat to a standard immunotherapy (pembrolizumab) works better than the standard drug alone for people with advanced non-small cell lung cancer. It is for adults who have not had prior treatment for their advanced canc…

This early study is testing the safety of a new cell therapy for adults with advanced lung cancer that has stopped responding to standard treatments. Doctors will collect a patient's own immune cells, modify them in a lab to better target cancer, and then infuse them back into th…

This study is testing a new experimental drug called CNSI-Fe, which is an iron-loaded nanoparticle suspension injected directly into tumors. The goal is to see if it is safe and can help control cancer in people with advanced solid tumors that have stopped responding to standard …

This study is testing a new device that uses pulsed electric fields to destroy lung cancer tumors before they are surgically removed. The goal is to see if this approach is safe and technically feasible. The study is for adults with a single lung tumor between 1.5 and 4 centimete…

This study is testing whether adding a new drug called zipalertinib to standard chemotherapy after lung cancer surgery works better than chemotherapy alone. It's for people with early-stage lung cancer who have specific, less common genetic changes in their tumor. The goal is to …

This study is testing a combination of three drugs for people with non-small cell lung cancer that has spread to the brain and who have not yet received treatment for their advanced cancer. The goal is to see how well this three-drug combo can shrink the tumors in the brain. The …

This study is testing whether a new digital care system can improve quality of life for older adults who have cancer along with other health conditions. It will involve 720 patients aged 70+ with breast, lung, colorectal, or prostate cancer across eight hospitals in France. The m…

This study is testing whether a new, precise radiation planning technique can protect the ovaries in young women (ages 18-50) receiving pelvic radiation for cancers like uterine or rectal cancer. The goal is to prevent radiation from causing early menopause, which can lead to ser…

This study is testing a new oral drug called TNG260, given alone and with the immunotherapy pembrolizumab, for people with advanced solid tumors that have a specific genetic change (STK11 mutation). The main goals are to find a safe and effective dose and to see if the treatment …

This study is for people with a specific type of advanced lung cancer (ALK-positive NSCLC) that has spread to the brain but isn't causing major symptoms. It's comparing two treatment strategies: taking the targeted drug alectinib alone versus taking alectinib plus a precise form …

This study is testing a new radiation therapy approach that uses MRI scans during treatment to adjust radiation beams in real time. Researchers want to see if this method can better target tumors while sparing healthy tissue in patients with various cancers including pancreatic, …

This study is testing a new microwave device called FlexAblate™ to see if it can safely destroy small lung cancer nodules. It is for adults with lung cancer who are not good candidates for surgery or who choose not to have it. Doctors will insert the device through the airway to …

This study tests whether a personalized support program led by nurses can help vulnerable lung cancer patients live longer and feel better. The program includes regular symptom check-ins and a physical training plan. Researchers will compare outcomes for 250 patients who receive …

This study is testing a new support program for cancer survivors who struggle to afford or access healthy food. Researchers will compare 100 patients who receive help from a patient navigator to those getting standard care, to see if the program improves food security, diet quali…

This study is testing whether a support program called CARES helps rural cancer patients start treatment sooner and complete it faster. The program provides navigation help and counseling sessions alongside usual cancer care. Researchers will compare outcomes for 320 patients who…

This study is testing a new oral drug called TNG456, both alone and combined with another cancer drug (abemaciclib), in people with advanced solid tumors that have a specific genetic change called MTAP loss. The main goals are to find safe doses and see if the treatment can shrin…

This study is testing a new drug called FH-006 when given alongside other standard lung cancer treatments. It aims to find the safest and most effective dose and see how well it helps shrink tumors in people with advanced lung cancer that can't be cured with surgery or radiation.…

This study aims to find better treatment combinations for people with non-small cell lung cancer. It will test several new drug combinations against current standard treatments in three different groups of patients: those newly diagnosed with advanced cancer, those whose cancer h…

This early-stage study is testing a new type of personalized immune cell therapy (CAR-T) for people with advanced solid tumors that have a specific marker called CD70. The main goals are to find a safe dose and see how the body handles the treatment. It is for adults with cancers…

This study aims to gather detailed information to make repeat radiation therapy safer for lung cancer survivors whose cancer has returned or who develop a new tumor in the chest. Researchers will follow 500 patients in Denmark to track severe side effects, survival, and quality o…

This study is testing a new treatment called VSV-02 for people with advanced solid tumors who have few or no other treatment options left. VSV-02 is a specially engineered virus designed to both kill cancer cells directly and boost the body's immune system to fight the cancer. Th…

This early-stage study aims to find a safe dose for combining a drug called talazoparib with low-dose chest radiation. It is for people with extensive-stage small cell lung cancer whose disease has not worsened after initial chemotherapy. The main goal is to see how well patients…

This early-stage study is testing a new oral drug called VMD-928, both by itself and combined with an existing immunotherapy (pembrolizumab). It is for adults with advanced solid tumors or lymphoma that have progressed despite available treatments. The main goals are to find safe…

This is a first-in-human study testing a new drug called CLSP-1025 for adults with advanced solid tumors that have a specific genetic change called the p53 R175H mutation. The main goals are to find a safe dose and see if the drug can help control the cancer. The drug works by en…

This early-stage study is testing a new type of personalized cell therapy called GC203 TIL in adults with advanced solid tumors that have stopped responding to standard treatments. Doctors take a patient's own immune cells from a tumor, modify them in a lab to potentially fight c…

This study is testing a new drug called BI 765049, given alone and with another drug called ezabenlimab, for Asian adults with advanced cancers that have stopped responding to standard treatments. The main goals are to find safe doses and see if the treatment can shrink tumors by…

This study is testing if adding a new targeted drug, sotorasib, to standard chemotherapy before surgery is safe and more effective for patients with a specific genetic type of lung cancer. It is for adults with stage IIA-IIIB non-squamous lung cancer that has a KRAS G12C mutation…

This study is testing a new personalized cancer vaccine called LK101, given alongside existing immunotherapy drugs, for people with advanced lung cancer. It is specifically for patients whose cancer has continued to grow despite previous immunotherapy treatment. The main goals ar…

This study is testing a new cancer vaccine made from a patient's own or donated tumor cells. The cells are modified in a lab to train the patient's immune system to attack the cancer, then injected back into the patient. The goal is to see if this approach can help people with ad…

This early-stage study is testing a new drug combination called BMS-986507 in adults with advanced lung or breast cancer that has spread. The main goals are to find a safe dose and see how the body processes the drug, while also looking for early signs that it might help control …

This study is testing a new way to deliver radiation therapy for advanced lung cancer. The goal is to use a special SPECT scan to map which parts of the lung are healthiest and working best, and then avoid giving high radiation doses to those areas. Researchers want to see if thi…

This early-stage study is testing a new type of treatment called CAR-T cell therapy for people with advanced cancers that have a specific marker (CEA) and have stopped responding to standard treatments like chemotherapy. The main goals are to find a safe dose and see if the treat…

This is the first study in people to test a new drug called BL-B01D1. It aims to find a safe dose and see if it can help control advanced cancers that have spread or cannot be removed by surgery. The trial will enroll about 470 adults with various solid tumors, including lung, br…

This study is testing whether a new drug called PF-08634404, when combined with chemotherapy, works better than the current standard treatment (pembrolizumab with chemotherapy) for adults with advanced non-small cell lung cancer. About 1,410 participants will be randomly assigned…

This study is testing whether adding an anti-inflammatory drug called certolizumab to standard chemotherapy before surgery can help shrink lung tumors more effectively. The goal is to see if this combination leads to better outcomes for patients with stage II or III non-small cel…

This study is testing a new type of cell therapy called A2B395 for adults with advanced solid tumors that have spread or returned. The therapy uses modified immune cells designed to specifically kill cancer cells while protecting the patient's healthy cells. The main goals are to…

This study looks back at 400 lung cancer patients who had surgery after receiving drug treatments first. Researchers are comparing traditional open-chest surgery with newer, less invasive techniques. They want to see which approach leads to better recovery and longer survival wit…

This early-stage study is testing a new radioactive drug called Lutetium-177 BL-ARC001 in people with advanced lung, breast, head/neck, and other solid tumors that have stopped responding to standard treatments. The main goals are to find the safest dose, see how the body process…

This study is testing whether tiny radioactive seeds can be safely placed directly into recurrent lung tumors to control cancer growth. Researchers will insert these seeds into tumors of 10 patients with lung cancer that has returned after previous treatment. The main goals are t…

This study is testing whether adding naturopathic doctor-guided care—including personalized diet, supplements, and lifestyle advice—to standard cancer surgery helps patients recover better. It aims to reduce complications, improve quality of life, and potentially help patients li…

This study is testing a new medical device that uses microwave energy to heat and destroy lung cancer tumors. The procedure is done through a thin tube in the airway (bronchoscopy) and aims to be a less invasive alternative to surgical removal. Up to 18 UK patients scheduled for …

This first-in-human study is testing an experimental cancer treatment called IDOV-Immune, which uses a modified virus designed to infect and destroy cancer cells while boosting the immune system. The trial aims to find the safest dose and check for early signs that the treatment …

This study is testing a new type of radiation machine that uses MRI scans to guide treatment in real time. The goal is to see if doctors can more precisely target tumors in the abdomen or chest with intense radiation while better protecting the surrounding healthy organs. The stu…

This study is testing if adding a short, intense course of targeted radiation to standard immunotherapy and chemotherapy helps people with extensive-stage small cell lung cancer live longer without their cancer getting worse. It is for adults newly diagnosed with this aggressive …

This study is testing if an investigational drug called NKTR-255 can help restore the body's immune cells after patients with non-small cell lung cancer complete chemoradiation. The drug will be given alongside the standard immunotherapy durvalumab. Researchers want to see if thi…

This early-stage study is testing a new drug called BL-M07D1 for people with advanced cancers that have a specific marker called HER2. The trial aims to find the safest dose and see if the drug helps control cancer growth in patients who have already tried standard treatments. Re…

This study is testing an experimental drug called patritumab deruxtecan (HER3-DXd) in people with advanced solid tumors that have spread or cannot be removed by surgery. The goal is to see if the drug can shrink tumors and control the disease in people who have already tried at l…

This early-stage trial is testing a new oral drug called RSC-1255 in adults with advanced solid tumors that have stopped responding to standard treatments. The main goals are to find a safe dose and see how well the drug is tolerated, both alone and combined with another medicati…

This study is testing a new type of personalized cell therapy for adults with advanced solid tumors that have come back or spread. The therapy, called Tmod CAR T, is designed to recognize and kill cancer cells while using a built-in safety switch to protect the patient's healthy …

This study is testing whether a new drug called HRS-4508, when combined with other cancer therapies, can help control advanced lung cancer. It's for people whose cancer has continued to grow despite standard treatments. Researchers will measure how well the combination works and …

This study aims to develop a better system for finding early lung cancer and telling it apart from harmless lung nodules. Researchers will test a combination of breath analysis, blood tests, and advanced CT scan analysis on 1,800 participants. The goal is to create a more accurat…

This study is testing a new lung cancer screening program for current and former smokers. It will enroll 1000 people to get yearly low-dose CT scans and blood tests to see if cancer can be found earlier. The goal is to see if this screening approach works well in a public health …

This study is testing whether adding real-time imaging guidance to lung surgery helps surgeons work more efficiently. Researchers will compare two surgical approaches for removing small lung nodules in 200 patients with suspected lung cancer. The goal is to see if the image-guide…

This study is testing a new blood test designed to detect five different cancers (breast, colon, pancreatic, ovarian, and lung) at an early stage. Researchers will analyze tiny particles in the blood using a special light-based technique and artificial intelligence. The goal is t…

This study is testing a new, standardized method for finding lymph nodes in lung tissue removed during cancer surgery. Researchers want to see if this method helps doctors find more lymph nodes than current techniques, which could lead to more accurate cancer staging. More accura…

This study aims to see if a blood test (liquid biopsy) can help doctors assess lung cancer by measuring specific markers called miRNA and DNA methylation. It will compare results from about 1,340 people who either have suspicious lung nodules or are healthy. The goal is to find a…

This study is testing a new, non-invasive way to tell if lung nodules are cancerous. Researchers will collect breath samples from 3,000 people with lung nodules and use chemical analysis and artificial intelligence (AI) to look for patterns. The goal is to create a breath test th…

This study aims to validate a new breath test that looks for cancer markers in exhaled air. It will compare the test's accuracy to standard low-dose CT scans for screening high-risk smokers. The goal is to see if this simpler, cheaper method can help catch lung cancer earlier and…

This study is testing a new type of PET scan to see if it can detect and monitor tissue scarring (fibrosis) caused by radiation therapy. It will enroll 72 adults with lung or pancreatic cancer who are scheduled to receive radiation treatment. The goal is to see if this scan can s…

This study is testing a new imaging technology called full-field optical coherence tomography (FFOCT) on small tissue samples taken during lung biopsies. The goal is to see if this quick, high-resolution imaging can help doctors assess the quality of the biopsy sample in real-tim…

This study aims to understand how well a lung cancer screening program works for people at high risk in Taiwan. It will enroll over 6,600 participants, including former heavy smokers, people with a family history of lung cancer, and those exposed to certain environmental risks li…

This study is testing a new blood test designed to find early signs of a specific type of lung cancer in people who are at risk but cannot get regular CT scans. It aims to enroll 1000 healthy adults of East Asian or Latinx descent who do not currently use tobacco. The test looks …

This study is testing whether mobile low-dose CT scans can effectively detect lung cancer in younger, high-risk smokers. It focuses on people aged 40-54 with a heavy smoking history (30+ pack-years) in North and South Carolina. The goal is to see if starting screening earlier tha…

This study is testing whether artificial intelligence can create PET scan images from regular CT scans to help doctors better diagnose and treat lung cancer. Researchers will enroll 10,000 lung cancer patients to see if these AI-generated images match real PET scans and provide a…

This study is testing whether lung cancer screening using low-dose CT scans is practical and acceptable for Black individuals with a history of smoking. Researchers want to see if this screening approach works well for a group that often doesn't qualify for current screening guid…

This study is testing a new type of PET scan to see if it can better detect and track the spread of non-small cell lung cancer, especially when it has reached the brain. Researchers will compare this new scan to standard imaging methods in about 20 patients. The goal is to see if…

This study is testing whether molecules collected from a person's cough can act as a 'liquid biopsy' to detect early signs of lung cancer and other lung diseases. Researchers will compare cough samples to samples taken during invasive bronchoscopy procedures to see if they provid…

This study aims to find lung cancer early in 1,000 high-risk Mexican adults using annual low-dose CT scans. Participants are people aged 50+ who are heavy smokers, former smokers, exposed to significant wood smoke, or have COPD. The goal is to see if regular scans can detect canc…

This study is testing a new type of imaging scan to see if it can better detect and monitor many different solid tumors. The scan uses a special tracer that attaches to a protein called Trop2, which is often found on cancer cells. Researchers will compare this new scan to standar…

This study is testing a blood test as a first step before a CT scan for lung cancer screening. The goal is to see if the blood test can accurately identify people who are unlikely to have lung cancer, so they might avoid an unnecessary scan. This could reduce radiation exposure a…

This study is observing how well a robotic system works in real hospitals to help doctors locate and take samples from suspicious spots in the lungs. It will follow 3,000 patients who are already scheduled to have this robotic-assisted biopsy procedure. The main goal is to see ho…

This study aims to develop a better, faster way to diagnose lung cancer using artificial intelligence (AI) to analyze blood samples. It will enroll 5,000 people who have a lung nodule found on a screening scan. The goal is to create computer tools that help doctors spot cancer ea…

This study is comparing two different ways to take tissue samples from lung cancer patients during a biopsy procedure. Researchers want to see which method is more likely to collect enough good-quality tissue for advanced genetic testing. The genetic testing helps doctors choose …

This study is collecting real-world information on a robotic system used to biopsy suspicious lung nodules. It will follow 1,200 patients across Europe to see how accurately the system diagnoses lung cancer and how often complications like lung collapse or bleeding occur. The goa…

This study is testing a new combined approach to diagnose and treat early lung cancer. It will enroll 200 patients with small, hazy lung nodules. Doctors will use AI analysis and a heat-based treatment called microwave ablation, along with a tissue biopsy, to try to accurately di…

This study is testing a new artificial intelligence (AI) tool designed to analyze PET/CT scans and patient information. The goal is to help doctors quickly and accurately identify the specific type and genetic features of a patient's lung cancer. Researchers will use data from 5,…

This early-stage study is testing a new type of PET scan designed to detect and measure collagen, the main component of scarring (fibrosis) in the lungs. It aims to see if this scan is safe and can accurately spot and track fibrosis in people with lung cancer, pulmonary fibrosis,…

This study is testing a new blood test designed to detect many types of cancer early, before symptoms appear. It will involve 7,000 people, both with and without cancer, to see if the test can accurately spot cancer signals and identify where in the body the cancer started. The t…

This study is testing a new navigation system called LungVision to help doctors place tiny markers near suspicious lung spots during a bronchoscopy. The markers make it easier for surgeons to find and remove these spots with smaller, more precise cuts, aiming for an accurate diag…

This study aims to validate two new test kits designed to identify which early-stage lung cancer patients are at highest risk of their cancer returning after surgery. Researchers will test these kits on 236 patients who have had their lung tumors completely removed. The goal is t…

This study aims to help more Hispanic smokers get screened for lung cancer. Researchers want to understand what stops people from getting screened and test if a short educational video can encourage screening. About 2,000 Hispanic current and former smokers will watch the video a…

This study is testing whether a special campaign can help more women get screened for lung cancer. The campaign will run in mammography clinics, offering information and referrals to eligible women during their breast cancer screening appointments. Researchers will measure if the…

This large study is testing a digital program called mPATH-Lung to see if it can get more eligible smokers to complete recommended lung cancer screening CT scans. It will enroll 27,000 people and compare different outreach methods, with a special focus on including rural resident…

This study aims to find the best way to encourage people in New Hampshire and Vermont to test their homes for radon, an invisible gas that is a leading cause of lung cancer. Researchers are testing whether a new online educational program, with or without reminder messages, is mo…

This pilot study aims to see if using emergency department visits can help more people get screened for lung cancer. It will test a program that identifies eligible patients and provides education to address common barriers like mistrust or lack of knowledge. The goal is to incre…

This study is testing a campaign called 'Pink & Pearl' to see if it helps more women get screened for lung cancer. Researchers will offer information about lung cancer screening to women who are already getting a mammogram and are eligible based on their age and smoking history. …

This study is testing whether having your regular family doctor recommend annual low-dose CT scans can get more high-risk smokers to participate in lung cancer screening. It aims to see if this doctor-led approach helps detect lung cancer at its earliest, most treatable stages, p…

This study is testing a new centralized support system to help more people in the Bronx get screened for lung cancer. It will involve about 9,460 eligible patients from 24 clinics. The goal is to see if making screening easier to access and follow through with leads to more peopl…

This study is testing whether training cancer doctors and nurses in empathic communication skills can help reduce the feelings of stigma often experienced by lung cancer patients. Over 1,200 participants, including healthcare providers and their patients, will take part. The goal…

This study aims to create and test a new support program designed specifically for older adults living with lung cancer. Researchers will first interview patients, caregivers, and doctors to design the program, then test it with a small group of patients. The goal is to help pati…

This study is testing whether a drug called riluzole can help prevent the memory and thinking problems often called 'chemo brain' in people receiving chemotherapy for various cancers. About 24 adult patients will be randomly assigned to receive either riluzole or a placebo pill w…

This study aims to find the best time to send encouraging messages to help older cancer survivors be more physically active. Researchers will test if receiving a message makes participants more likely to be active in the next hour and if it affects their pain levels over the next…

This study is testing whether a new, long-acting numbing medicine provides better pain relief after lung surgery than the standard version. Researchers will compare pain levels and opioid use in 210 patients who receive either the new extended-release medicine, the standard medic…

This study is testing whether an 8-week home-based rehabilitation program delivered through video calls can help Veterans who recently finished lung cancer treatment. The program aims to reduce common symptoms like shortness of breath, fatigue, and anxiety while improving physica…

This study is testing whether transferring healthy gut bacteria from a donor (fecal microbiota transplantation) can help reduce severe diarrhea and colon inflammation caused by cancer immunotherapy drugs. The trial will enroll 40 patients with various cancers who developed these …

This study is testing which of two nerve-block techniques works better to control pain after major lung cancer surgery. Sixty patients will receive one of the two methods before their operation. The main goal is to see which technique reduces the need for strong painkillers like …

This study is testing if adding high-dose vitamin C given through an IV (intravenous) to standard chemotherapy can improve quality of life and reduce side effects for people with advanced lung cancer. It will involve 90 participants who will be randomly assigned to receive either…

This study compares two different nerve block techniques to manage pain after major chest surgery for lung cancer. Researchers want to see if a newer method called costotransverse foramen block works as well as or better than the standard thoracic paravertebral block. The trial i…

This study is testing a special breathing exercise program designed to help people who have had surgery for lung cancer. Researchers want to see if this training can improve patients' strength, balance, oxygen use during activity, and overall physical activity levels. The study w…

This study compares two different nerve-blocking techniques to manage pain after lung cancer surgery. Researchers will test which method provides better pain relief for 60 patients undergoing chest surgery. The goal is to find safer, more effective ways to control post-surgery pa…

This study is testing if two existing medications can help prevent severe shortness of breath in people with lung cancer and a pre-existing lung scarring disease (ILD) who need radiation therapy. About 98 participants will be randomly assigned to receive either the drugs (N-acety…

This study is testing if a non-drug treatment can help ease a persistent cough that lingers after lung cancer surgery. Researchers are enrolling 84 patients who have had surgery to see if using a special device that delivers gentle electrical pulses to specific points on the skin…

This study is testing whether different types of home exercise can help people with advanced lung cancer who are receiving immunotherapy. Researchers want to see if high-intensity or moderate-intensity workouts improve fitness, reduce treatment side effects, and enhance quality o…

This study is testing a new online program designed to help people with lung cancer manage stress and anxiety while they wait for the results of their routine scans. The program teaches stress management skills and provides support through a website. Researchers will first test t…

This study is testing whether having a structured conversation about a patient's goals and wishes for care during an emergency room visit improves their quality of life. It involves 200 adults with advanced lung or gastrointestinal cancer who are not expected to be cured. Researc…

This study is testing whether using a special high-flow oxygen device during a lung cancer diagnostic procedure leads to fewer breathing problems and shorter procedure times. Researchers will compare the special device to standard oxygen delivery in about 200 adults undergoing a …

This study is testing if an 8-week pulmonary rehabilitation program can help people who have survived advanced non-small cell lung cancer. The program includes exercise training and education, aiming to reduce shortness of breath and fatigue while improving quality of life. Resea…

This study is testing a technique called a 'pleural blood patch' to reduce a common side effect of lung tumor ablation. During ablation, a needle is used to destroy tumors, but it can sometimes puncture the lung, causing it to collapse and requiring a painful chest drain. Researc…

This small pilot study is testing whether regular visits with a trained chaplain can improve spiritual wellbeing and reduce anxiety and depression in people with advanced lung or gastrointestinal cancer. It will compare the chaplain's spiritual care program to informational suppo…

This study is testing a new support program designed to improve quality of life for people living with lung cancer in rural areas. Researchers will compare this personalized program, which includes coaching and education, against standard educational materials. The goal is to see…

This study is testing if adding endurance training to standard physical therapy helps people recover better after lung cancer surgery. It will involve 184 patients who have had a minimally invasive lung resection. The goal is to see if this more intensive rehab improves patients'…

This study is testing whether adding acupuncture to standard anti-nausea medicine helps reduce nausea better for cancer patients undergoing chemotherapy. It will involve 90 patients who are already experiencing nausea despite taking their prescribed anti-sickness drugs. Participa…

This study aims to understand why lung cancer sometimes becomes resistant to immunotherapy treatments. Researchers will collect tumor tissue samples from 50 patients whose cancer has progressed despite receiving immunotherapy. By analyzing these samples, they hope to identify bio…

This study compares how well the cancer drug T-DXd works compared to standard treatments for patients with advanced HER2-positive solid tumors. Researchers will analyze existing medical records from about 105 patients who received either T-DXd in previous trials or standard care …

This study aims to collect detailed genetic information and health records from 25,000 adults who have cancer or are at risk of developing it. Researchers will analyze this data to better understand how cancer develops and to identify potential targets for future treatments. The …

This study is testing whether new computer programs (AI algorithms) can help pathologists diagnose lung and breast cancer more quickly and accurately. Researchers will look back at samples from 600 patients in four countries to see how AI compares to standard lab methods. The goa…

This study aims to understand if a patient's body composition, specifically muscle mass, affects how much chemotherapy they receive and their risk of severe side effects. Researchers will observe 132 adults with advanced non-small cell lung cancer who are starting standard chemot…

This study aims to collect blood and other fluid samples from 3000 people with lung nodules or lung cancer. The goal is to find biological markers that could help doctors diagnose cancer earlier, predict how it will progress, and choose the best treatments. Researchers will compa…

This large international study is collecting information on a new, more precise type of radiation therapy that uses real-time MRI scans to guide treatment. It aims to see if this advanced technology helps people with many types of cancer live longer, better control their tumors, …

This study collects leftover lung tissue from 4,000 patients undergoing surgery for early-stage lung cancer. Researchers analyze these samples to look for specific molecular patterns (like protein and RNA 'fingerprints'). The goal is to learn how these patterns relate to how the …

This study aims to collect detailed information on 12,000 patients with lung and other chest cancers over many years. By tracking their treatments, health, and quality of life, researchers hope to understand why outcomes vary so much between patients. The goal is to use this real…

This study aims to create a library of blood samples from cancer patients and people at high risk for cancer. Researchers will collect these 'liquid biopsies' to help future studies develop better ways to detect cancer early and monitor treatment. The study involves 2,500 partici…

This study is testing a blood test that looks for tiny pieces of tumor DNA to see if it can detect cancer recurrence earlier than standard scans. It aims to enroll 100 adults, including people with various solid tumors and healthy volunteers. The goal is to gather information tha…

This study aims to gather real-world information on how standard, approved lung cancer treatments work for patients aged 70 and older. It will follow 500 participants receiving their first treatment to see how long the treatment works, monitor side effects, and understand its imp…

This study aims to discover the genetic and immune system changes that lead to lung cancer. Researchers will analyze tissue and blood samples from 6000 people who have or are suspected to have lung cancer. The goal is to identify markers that could help detect cancer earlier and …

This study tests whether a virtual assistant or a human trainer is better at teaching lung cancer patients to use home monitoring devices. Researchers will compare how easy each method is for patients to learn from. The goal is to understand which approach works better for helpin…

This study aims to understand if a special care program for lung cancer patients under 50 improves their satisfaction with care and meets their unique needs. Researchers will enroll 75 participants to track their experience, quality of life, and use of support networks over time.…

This study is creating a large international registry to collect real-world data on patients with early-stage lung cancer who undergo a lung-sparing surgery called segmentectomy. It aims to track how well patients do over 3 and 5 years after this specific surgery. The goal is to …

This study is collecting detailed information from 4,000 lung cancer patients over 10 years to build a comprehensive database. Researchers will gather blood samples, tissue samples, and medical images to better understand how lung cancer develops and progresses. The goal is to us…

This study aims to collect blood and tissue samples from people with various cancers to help develop better blood tests. Researchers want to see if these tests can detect tiny amounts of leftover cancer cells after treatment, which might help predict if the cancer could return. P…

This study is building a large, long-term database of health information and biological samples from people with cancer, people at risk for cancer, and healthy volunteers. The goal is to collect this data to help researchers better understand what causes cancer and how to prevent…

This study aims to understand why people react differently to cancer drugs. Researchers will collect blood or cheek swab samples from about 1,100 cancer patients already enrolled in treatment trials at the National Cancer Institute. By analyzing genes, they hope to learn which ge…

This study aims to create a more accurate tool to predict who is at high risk for lung cancer, specifically focusing on people who have never smoked. Researchers will gather information from 10,000 participants, including family history, environmental factors, blood tests, and CT…

This study aims to create a detailed 'atlas' of the earliest cellular changes in the lungs that can lead to cancer. Researchers will enroll 240 high-risk current or former heavy smokers and perform repeated lung examinations over 2-3 years to collect tissue samples. The goal is t…

This study is creating a registry of fluid samples from around the lungs of patients with lung cancer or infections. Researchers will collect these samples during patients' normal medical procedures to build a database for future research. The goal is to help scientists develop b…

This study aims to collect real-world information on how cancer patients experience and report their symptoms from home during treatment. About 25 adults with breast, lung, ovarian, or blood cancers will use an online platform to complete weekly surveys for at least 12 weeks. The…

This study is creating and testing a new questionnaire to measure how consistently lung cancer patients follow their prescribed breathing and exercise rehabilitation plans. Researchers will ask 281 patients in Mexico to fill out the 56-question survey. The goal is to create a rel…

This study is creating a large collection of tissue, blood, and fluid samples from patients with lung diseases like cancer or from lung transplants. The goal is to build a resource for future research to better understand what causes these diseases, how to detect them earlier, an…

This study aims to create and test easy-to-understand educational videos and materials about lung cancer screening, specifically for patients in safety-net healthcare systems. The researchers will work with current and former smokers to adapt the information and then test if the …

This study is a long-term health check-up for people who previously received experimental cancer vaccines in other research trials. It aims to monitor their health for up to 15 years to ensure the vaccines are safe in the long run. Participants will have annual check-ups or phone…

This study aims to improve predictions for how lung cancer patients will respond to treatment. Researchers will combine detailed PET scan images with genetic information from tumor samples to look for patterns. The goal is to create a better tool to forecast a patient's survival …

This study aims to understand how modern, minimally invasive lung cancer surgery affects the heart. Researchers will closely monitor the heart's electrical activity and stress markers in 100 patients before, during, and after their surgery. The goal is to learn if these heart cha…

This study aims to collect blood and other samples from adults with cancer to help scientists better understand how cancer affects the immune system and tumor biology. Participants provide samples for lab analysis, but this is not a treatment study. The goal is to gather knowledg…

This study screens adults with various cancers to see if they qualify for experimental treatments being tested by the National Cancer Institute's Surgery Branch. Participants undergo tests and evaluations to determine their eligibility for specific treatment trials. The study als…

This study aims to understand why many lung cancer patients do not respond to immunotherapy. Researchers will take blood samples from 100 patients and healthy volunteers to analyze specific types of white blood cells called neutrophils. The goal is to learn if certain cells can p…

This study creates a long-term registry of 1500 lung cancer patients treated at a major Italian hospital. Researchers will collect patient data from 2019 to 2035 to understand how different treatments work in real-world practice, track survival rates over 10 years, and identify p…

This study aims to find better ways to predict which lung cancer patients will benefit most from immunotherapy given before surgery. Researchers will follow 100 patients with stage II-IIIB lung cancer who are scheduled for this treatment and surgery. They will analyze blood sampl…

This study aims to identify biological markers (biomarkers) in tissue and sputum samples that could signal the development of lung, head, neck, or esophageal cancers. Researchers are enrolling 700 participants who either have precancerous cell changes, a history of these cancers,…

This study aims to build computer models that can predict how metastatic lung cancer patients will respond to treatments and when resistance might develop. Researchers will collect extensive data from 200 patients receiving standard first-line treatments, tracking their medical, …

This study aims to understand how the bacteria in a patient's gut and lungs might influence how well their lung cancer responds to immunotherapy. Researchers will collect samples from about 48 adults with advanced lung cancer before and during their treatment. The goal is to see …

This study aims to collect blood and tissue samples from people with head, neck, lung, or gastrointestinal cancers. Researchers will analyze these samples to learn how cancer treatments, especially immunotherapies, affect the body's immune system. The goal is to discover better w…

This study aims to understand how common and severe the fear of cancer returning is for people treated for breast or lung cancer. Researchers will survey 200 patients and conduct in-depth interviews to learn about their experiences and needs. The goal is to develop better tools t…

This study aims to collect long-term health information and blood/tissue samples from 730 lung cancer patients treated at Nantes University Hospital. By tracking patients from diagnosis through their entire treatment journey, researchers hope to understand how treatments work in …