LUNG CANCER

This early-stage study tests a new drug called BL-M07D1 in about 280 adults with advanced solid tumors that have the HER2 protein. The goal is to see if the drug is safe and helps shrink tumors. Participants must have tried at least two prior treatments and have a life expectancy…

This study tests a new treatment for people with a specific type of advanced small cell lung cancer (SLFN-11 positive). It combines low-dose radiation, chemotherapy, an immunotherapy drug (sugemalimab), and a targeted drug (olaparib). The goal is to see if this mix is safe and wo…

This study tests a device that uses short electric pulses to destroy lung tumors before they are surgically removed. It involves 25 adults with suspected or confirmed lung cancer who are already scheduled for surgery. The goal is to see if the procedure is safe and feasible.

This study tests a new drug combination (BMS-986507) in 416 adults with advanced lung or breast cancer that has spread or cannot be removed. The main goals are to check safety, find the best dose, and see if the treatment shrinks tumors. Participants must have measurable tumors a…

This study tests a new drug called 3H-10000 in people with advanced lung or stomach cancer that cannot be removed by surgery or has spread. The drug is designed to target and kill cancer cells while limiting harm to healthy cells. The trial aims to find the safest dose and see if…

This early-stage trial tests a new treatment called IDOV-Immune, a virus designed to infect and destroy cancer cells while also boosting the immune system. It is for adults with advanced solid tumors (like colorectal, lung, or breast cancer) that have not responded to standard tr…

This study tests whether adding naturopathic care, a Mediterranean diet, and exercise before and after surgery can improve quality of life and reduce complications for people with lung, stomach, or esophageal cancer. About 20 adults scheduled for curative surgery will receive eit…

This study tests a new type of CAR T cell therapy for adults with advanced solid tumors, including colorectal, pancreatic, lung, ovarian, and mesothelioma cancers. The therapy uses a patient's own immune cells, modified to recognize and attack cancer cells that have lost a specif…

This early-phase study tests a new treatment called GC203 TIL, which uses a patient's own immune cells that are modified in a lab to better attack cancer. The trial enrolls 18 adults with advanced solid tumors (including breast, lung, and gastrointestinal cancers) who have not re…

This early-phase study tests a new radioactive drug (lutetium [177Lu]-BL-ARC001) in 22 adults with advanced lung, breast, head/neck, or other solid tumors that have not responded to standard treatments. The main goals are to check safety, find the best dose, and see if the drug s…

This study tests a new device that delivers a special type of radiation directly into lung tumors that have come back. The goal is to see if it is safe and possible to place these tiny seeds inside the tumor. Ten adults with recurrent lung cancer will take part.

This study tests a new device that uses microwaves to destroy lung cancer nodules. It is for people over 18 who cannot have surgery or choose not to. The device is inserted through the airways to reach the tumor. Researchers will check if the treatment works and is safe over one …

This study tests if axelopran, a drug typically used for opioid-induced constipation, can help control tumor growth in people with advanced breast, lung, pancreas, or prostate cancer. About 34 adults whose cancer has worsened after standard treatment will take axelopran daily for…

This study tests whether adding a pill containing healthy gut bacteria (restorative microbiota therapy) to standard immunotherapy (durvalumab) and chemotherapy can help control advanced non-small cell lung cancer. About 82 people with untreated, advanced lung cancer will receive …

This early-phase trial tests a faster, personalized radiation schedule for people with lung cancer. The goal is to see if giving higher daily doses over fewer days is safe and can better control the tumor. About 45 adults with non-small cell or small cell lung cancer will receive…

This study looks at whether adding Chinese herbal medicine to chemotherapy and immunotherapy can help prevent lung cancer from coming back after surgery. About 367 adults with a certain type of lung cancer will take part over 4 years. The goal is to see if this combination improv…

This study tests a new way of giving chemotherapy and immunotherapy (pembrolizumab) to people with advanced lung or head and neck cancers. Instead of giving both drugs together every time, the treatment alternates between cycles of chemo-immunotherapy and immunotherapy alone. The…

This study tests a personalized cancer vaccine made from patients' own tumor cells. The goal is to train the immune system to fight metastatic cancers like melanoma, breast, lung, and colorectal cancer. Participants receive eight injections over 16 weeks. The study is for adults …

This early-phase trial tests an experimental drug, RSC-1255, alone or with hydroxychloroquine, in adults with advanced solid tumors (e.g., lung, colon, pancreatic cancer, glioblastoma) that have stopped responding to standard treatments. The study has two parts: first, finding a …

This study tests whether a new experimental drug (PF-08634404) combined with chemotherapy works better than the current standard treatment (pembrolizumab plus chemo) for adults with advanced non-small cell lung cancer that has spread. About 1,410 participants will be randomly ass…

This study is testing a new type of radiation therapy called SMART, which uses MRI scans to guide the radiation beam more precisely. The goal is to better target tumors while sparing healthy tissue, potentially improving tumor control and reducing side effects. The trial involves…

This study tests a drug called osimertinib for people with stage III lung cancer that has a specific gene mutation (EGFR). Participants take the drug before and after radiation therapy. The goal is to see if this approach helps control the cancer longer. The study is for 60 adult…

This study tests a new drug called TNG260 combined with an immunotherapy (pembrolizumab) in adults with advanced solid tumors that have a specific genetic change (STK11 mutation). The goal is to find the best dose and see if the combination is safe and can shrink tumors. About 12…

This early-phase trial tests an experimental drug, CLSP-1025, in adults with advanced solid tumors (like lung, colon, or pancreatic cancer) that have a specific change in the p53 gene (R175H) and a certain immune type (HLA-A*02:01). The drug is designed to help the immune system …

This study looks at people with lung cancer that has spread to the brain but causes few or no symptoms. It compares taking the drug alectinib alone versus alectinib plus targeted brain radiation. The goal is to see if delaying radiation keeps the brain cancer under control and av…

This study is for people newly diagnosed with extensive-stage small cell lung cancer, a type that has spread. Researchers want to see if adding focused radiation to the standard treatment of durvalumab and chemotherapy can help people live longer without the cancer getting worse.…

This early-phase study tests a new drug called BL-B01D1 in people with advanced lung cancer and other solid tumors that have spread or cannot be removed. The main goals are to check safety, find the best dose, and see if the drug shrinks tumors. About 470 adults will take part.

This early-stage trial tests a new combination treatment for people with advanced HER2-positive solid tumors (like breast, lung, or stomach cancer). Participants receive an injection of a special virus directly into one tumor to activate the immune system, followed by an infusion…

This study is testing a treatment called cryoablation, which uses extreme cold to freeze and kill lung nodules. It is for 90 people with early-stage lung cancer who cannot have surgery or choose not to. The goal is to see if this freezing method can control the cancer and prevent…

This clinical trial is testing whether new combinations of drugs work better than standard treatments for people with non-small-cell lung cancer. The study includes three groups: people with advanced cancer who haven't been treated yet, those whose cancer has returned after prior…

This study tests whether giving a targeted drug (sotorasib) together with standard chemotherapy before surgery can shrink tumors more effectively in people with a specific genetic mutation (KRAS G12C) in non-squamous non-small cell lung cancer. About 27 adults with stage IIA to I…

This study tests a new drug called CNSI-Fe(II), which is injected directly into tumors. It uses iron to trigger a type of cell death called ferroptosis, aiming to shrink or control advanced solid tumors like lung, pancreas, and colorectal cancer. About 54 adults whose cancers hav…

This study tests a combination of three drugs (datopotamab deruxtecan, carboplatin, and pembrolizumab) in people with non-small cell lung cancer that has spread to the brain and has not been treated before. About 46 adults will receive the drugs every three weeks for four cycles,…

This study tests whether adding a vitamin A-like drug (ATRA) to a platelet-boosting medication (romiplostim N01) works better than the platelet drug alone for cancer survivors whose platelet counts stay low after chemotherapy. About 220 adults with gynecologic, breast, or lung ca…

This early-stage study tests a new treatment called CD70-targeted CAR-T cells in people with advanced solid tumors, including kidney, lung, and ovarian cancers. The therapy uses a patient's own immune cells, modified to recognize and attack cancer cells that have a specific marke…

This study is testing whether a precise type of radiation called stereotactic radiosurgery (SRS) can help people with small cell lung cancer that has spread to the brain. About 62 adults with up to 20 brain tumors will receive SRS, and researchers will track how many are alive af…

This study tests whether giving low-dose radiation and immunotherapy before standard chemotherapy can help shrink tumors in people with stage II to III non-small cell lung cancer. The goal is to make surgery more effective and improve long-term outcomes. About 30 adults who have …

This study tests an experimental treatment called OBX-115 for people with advanced melanoma or non-small cell lung cancer that has spread or come back. The treatment uses a patient's own immune cells (tumor-infiltrating lymphocytes) that are modified to produce a protein (IL15) t…

This early-phase study tests a new treatment for advanced lung cancer that uses a person's own immune cells, modified to better recognize and attack cancer cells. The treatment, called iC9-GD2.CAR.IL-15 T cells, combines antibodies and T cells to target a protein (GD2) found on s…

This study tests a new drug called TNG462, given with other cancer medicines, for people with pancreatic or lung cancer that has a specific genetic change (MTAP loss). The goal is to find safe doses and see if the combination shrinks tumors. About 183 adults with advanced cancer …

This early-phase study tests whether adding carotuximab to the standard drug osimertinib is safe and tolerable for people with advanced EGFR-mutated non-small cell lung cancer. About 60 participants whose cancer has worsened on previous treatments will receive the combination. Th…

This early-stage study tests a new treatment using a patient's own immune cells, engineered to target a protein called CEA found on certain cancer cells. It is for adults with advanced lung, stomach, colon, rectal, esophageal, or pancreatic cancer who have not responded to standa…

This study tests a new drug called FH-006, given alongside other cancer treatments, for people with advanced non-small cell lung cancer. The goal is to find the best dose and see if the combination is safe and helps shrink tumors. About 200 adults aged 18 to 75 who cannot have su…

This small study tests a new technique to mark suspicious lung nodules before surgery. Using a special imaging system, doctors place a tiny marker near the nodule through a breathing tube, avoiding a needle through the chest. The goal is to make it easier for surgeons to find and…

This study tests a new drug called PC14586 (rezatapopt) in people with advanced or spreading solid tumors that have a specific change in the TP53 gene (Y220C mutation). The goal is to see if the drug is safe and works against these cancers. About 300 adults (and some teens after …

This study tests a new drug called HRS-4508 combined with other cancer treatments for people with advanced non-small cell lung cancer that has stopped responding to standard therapy. About 100 adults aged 18 to 75 will participate. The goal is to find the best dose and see if the…

This study tests an experimental drug called patritumab deruxtecan in people with advanced solid tumors that have spread or cannot be removed. The drug targets a protein called HER3 found on some cancer cells. About 740 adults with various cancers like lung, breast, or melanoma w…

This study is testing whether doctors can deliver very high doses of radiation to tumors in the abdomen or chest while limiting harm to nearby organs. It uses a special MRI machine to guide the radiation. About 60 adults with abdominal or lung cancer will take part. The goal is t…

This early-stage study tests an experimental drug called VSV-02 in 6 adults with advanced solid tumors (like melanoma, breast, or lung cancer) who have run out of standard treatments. The drug is given both into a vein and directly into the tumor to see if it can shrink or contro…

This study tests whether adding the investigational drug NKTR-255 to the standard drug durvalumab can help people with advanced non-small cell lung cancer live longer after chemoradiation. About 39 adults will receive the combination to see if it restores immune cells and improve…

This study tests a special radiation method called lattice radiation therapy (LRT) combined with immunotherapy for people with advanced solid tumors that have stopped responding to standard treatments. LRT delivers high doses of radiation to specific spots inside the tumor while …

This study tests a new oral drug, TNG456, in people with advanced solid tumors that have lost a gene called MTAP. The drug works by blocking a protein (PRMT5) that these tumors need to grow. The study has two parts: first, finding the safest dose of TNG456 alone or with abemacicl…

This study tests the drug atezolizumab in about 200 adults with different incurable solid tumors. Researchers use each person's tumor DNA and RNA to see if their cancer might respond to the drug. Participants receive the same dose every 3 weeks, and the study checks if the geneti…

This study tests whether adding valemetostat to the standard immunotherapy pembrolizumab helps people with advanced non-small cell lung cancer that has high PD-L1 levels. About 137 adults who have not had prior treatment for advanced disease will take part. The goal is to see if …

This study tests a new treatment called LK101, given together with standard immunotherapy drugs, for people with advanced lung cancer that has not responded to previous treatments. The goal is to see if the combination is safe and can shrink tumors. About 60 adults with non-small…

This study tests an experimental drug called VMD-928, taken as a pill, either alone or with pembrolizumab (an immunotherapy), in adults with advanced solid tumors or lymphoma that have stopped responding to standard treatments. The goal is to find safe doses and see if the drug c…

This study tests whether adding certolizumab (an anti-inflammatory drug) to standard chemotherapy before surgery can shrink stage II-III lung cancers more than chemo alone. About 60 adults with operable lung cancer will receive the combination, then have surgery to remove any rem…

This study tests a new treatment called A2B395 for adults with advanced solid tumors (like colorectal, lung, breast, and kidney cancers) that have not responded to standard therapy. The treatment uses specially engineered immune cells designed to kill cancer cells while protectin…

This study looks at people with lung, colorectal, or prostate cancer that has spread to up to 10 spots in the body. It compares starting treatment right away versus waiting 6 months to see which approach helps people live longer and maintain quality of life. About 800 participant…

This study tests a flexible microwave probe that can be guided through the airways to destroy small lung cancer nodules (up to 3 cm). Ten people with stage I or II lung cancer will receive this treatment during a bronchoscopy. The goal is to see if the procedure works as planned …

This study tests the safety of dapagliflozin, a drug approved for diabetes and heart failure, when given before surgery to people with early-stage lung adenocarcinoma. The drug targets a protein found at high levels in these cancer cells. About 48 participants will receive the dr…

This early-phase study tests an experimental oral drug called CID-078 in 220 adults with advanced solid tumors that have stopped responding to standard treatments. The goal is to see if the drug is safe and can shrink tumors. It is a first-in-human trial, so the main focus is on …

This study tests whether the drug osimertinib can stop small, hazy spots (called GGNs) in the lungs from growing after surgery for a type of lung cancer. About 43 adults with stage I lung cancer and an EGFR gene mutation will take the pill daily. The goal is to see if the spots s…

This early-stage study is testing the safety of combining the drug talazoparib with low-dose chest radiation in people with extensive-stage small cell lung cancer. Up to 24 participants who have finished initial chemotherapy without their cancer getting worse will take talazopari…

This study tests a new medical device that uses microwave energy to heat and destroy lung cancer tumors. The goal is to see if it is safe and works well. Up to 18 people who are already scheduled for lung surgery will receive this extra procedure first. If successful, this approa…

This early-stage study tests a new drug, QXL138AM, for safety in about 100 people with advanced solid tumors (like ovarian, pancreatic, lung, or breast cancer) or multiple myeloma. Participants must have tried other treatments without success. The study will find the right dose a…

This study tests whether adding chemotherapy to standard immunotherapy (pembrolizumab) can improve outcomes for people with advanced lung cancer. Researchers will use a blood test that detects cancer DNA (ctDNA) to decide when to add chemo. About 230 participants will be enrolled…

This early-phase study tests a new oral drug, DO-2, in adults with advanced solid tumors (like lung cancer) that have a specific MET gene change and no standard treatment options left. The main goal is to check the drug's safety and find the right dose. About 55 participants will…

This study tests whether adding trilaciclib to the standard drug lurbinectedin can lower the risk of dangerous low white blood cell counts (neutropenia) in people with advanced small cell lung cancer that has stopped responding to initial treatment. About 30 adults will receive t…

This study compares a newer, less invasive technique called EBUS-TBNA with standard CT/PET scans to see which more accurately stages lymph nodes in patients with early-stage lung cancer who are scheduled for stereotactic body radiotherapy (SBRT). Accurate staging helps doctors de…

This study aims to create a better way to detect early-stage lung cancer by combining breath analysis, blood tests, and CT scans. Researchers will enroll 1,800 participants, including people with lung cancer, benign nodules, and healthy individuals. The goal is to reduce false al…

This study is testing a new breath test to see if it can find early signs of lung cancer as well as a CT scan. The test collects chemicals in your breath and may be cheaper and easier to use. Researchers will study 3,200 current or former smokers aged 55-74 who are at high risk f…

This study will test 1,000 people in Singapore at risk for lung cancer, including smokers and non-smokers, using low-dose CT scans and blood tests. The goal is to see if this screening approach is practical and accurate for early detection. Results will help shape future screenin…

This study is testing a special PET probe called [68Ga]CBP8 to see if it can detect early signs of tissue damage caused by radiation therapy in people with lung or pancreatic cancer. About 72 participants will get a PET scan before and 3-6 months after radiation. The goal is to f…

This study is testing a lung cancer screening program for current and former smokers aged 45 to 74. Participants will get low-dose CT scans and metabolomics tests to find suspicious lung nodules early. The goal is to see how well the screening works in a public health setting and…

This study is testing a blood test that looks for DNA from lung cancer cells in people who are at risk but cannot get standard lung cancer screening. The test is designed for adults aged 50-80 who are of East Asian, Southeast Asian, or Hispanic/Latinx background and do not curren…

This study is testing a new blood test that uses laser light and artificial intelligence to find signs of five different cancers (breast, colon, pancreatic, ovarian, and lung) at an early stage. Researchers will collect blood samples from 1,400 people aged 45 and older who are su…

This study tests a new imaging agent called [68Ga]CBP8 to see if it can safely detect collagen buildup (scarring) in the lungs of people with pulmonary fibrosis and lung cancer. About 100 healthy volunteers and patients will receive the agent and undergo PET scans. The goal is to…

This study is looking at whether a blood test (liquid biopsy) that measures certain molecules (miRNA and DNA methylation) can help tell if someone has lung cancer. About 1340 adults will take part, including people with lung nodules and healthy controls. The goal is to see if thi…

This study is testing whether a breath test can accurately tell the difference between harmless and cancerous lung nodules. Researchers will collect breath samples from 3,000 adults with lung nodules and use artificial intelligence to analyze the chemicals in their breath. The go…

This study looks at whether biomarkers (substances in the body) can help find lung cancer early. It will screen up to 3,606 people at high or low risk for lung cancer, including smokers and those with suspicious lung nodules. Participants will have yearly CT scans and lab tests t…

This study offers free mobile low-dose CT scans to people aged 40-54 who have smoked heavily (30 pack-years or more) in North and South Carolina. The goal is to find lung cancer at an earlier, more treatable stage. Participants will receive up to three scans over time to track ca…

This study aims to see if synthetic PET images created from standard CT scans can help doctors diagnose and treat lung cancer more accurately. Researchers will collect CT and PET scans from 10,000 people with non-small cell lung cancer and use them to train a computer model. If s…

This study tests an AI tool that looks at routine chest X-rays and medical records to find people at high risk for lung cancer. The AI alerts their doctor to discuss screening CT scans. The goal is to see if this alert increases the number of high-risk patients who get screened w…

This study is testing a new type of PET scan that targets a protein called Trop2, found on many solid tumors. Researchers want to see if this scan can find and measure tumors more accurately than current methods. About 400 adults with various cancers (like lung, bladder, or prost…

This study is testing whether a blood test can be used as a first step to see who really needs a low-dose CT scan for lung cancer. The goal is to avoid unnecessary scans, radiation, and costs for people at high risk, including smokers and those with a family history of lung cance…

This study is testing how well low-dose CT scans can find lung cancer early in people at high risk in Taiwan. It includes three groups: heavy smokers who have quit, people with a family history of lung cancer, and those exposed to pollution or other risks at work or home. About 6…

This study is observing how well the Ion endoluminal system, a robotic tool, can diagnose lung nodules and cancer in real-world use. About 1,200 adults across Europe who need a lung biopsy will take part. The main goal is to see how accurate the system is at getting a clear diagn…

This study looks at whether using telehealth (phone or video visits) can make lung cancer screening easier for people at high risk. Researchers will identify eligible adults aged 50-80 with a heavy smoking history, then offer them low-dose CT scans at a nearby center. The goal is…

This study compares standard bronchoscopy (a lung scope procedure) with and without a special laser imaging tool called nCLE. The goal is to see if nCLE helps doctors place the biopsy needle more accurately, leading to a clear diagnosis more often. About 208 adults with suspiciou…

This study aims to improve how doctors tell if a small lung nodule is cancerous. Researchers will collect fluid from a routine lung exam and analyze DNA in it for cancer signals. The goal is to make the test more sensitive, especially for tiny nodules, so fewer patients need inva…

This study is testing a new radioactive tracer that targets a protein called LRRC15, found on many cancers like pancreatic, breast, lung, and brain tumors. The tracer is used with PET scans to see if it can better detect and stage these cancers compared to standard scans. The stu…

This study tests whether combining a referral to a lung cancer screening program with text message reminders helps more emergency department patients get screened. About 300 people aged 50-80 who smoke or quit recently will take part. The goal is to see if this approach increases…

This study is testing a blood test that looks for DNA signals from 20 different cancers, including lung, breast, and colon cancer. Researchers will see if the test can find cancer early and tell which type it is. In people with lung cancer, the test will also check for any cancer…

This early-phase study tests a new radioactive tracer for PET scans that may help doctors see non-small cell lung cancer that has spread to the brain more clearly. About 20 adults with this type of cancer will receive the tracer and have a PET/CT scan. The goal is to see if this …

This study tests a combined approach for people with ground-glass lung nodules (a type of early lung cancer). Doctors will use microwave ablation to destroy the nodule and take a tissue sample at the same time to confirm the diagnosis. The goal is to see if this one-step method c…

This study tests a special dye that makes cancer cells glow during lung cancer surgery. About 132 adults having lung cancer surgery will receive the dye, and surgeons will use a special camera to see the glow. The goal is to help surgeons find cancer that is hard to see with the …

This study aims to see if artificial intelligence (AI) can help detect lung cancer early in non-smokers who have a parent, sibling, or child with lung cancer. About 3,000 people aged 50-75 who have never smoked will get a low-dose CT scan and blood test. The AI will help doctors …

This study aims to increase lung cancer screening in the Bronx by creating a Central Screening Unit (CSU) that handles all the steps—like checking smoking history and scheduling scans—so busy doctors' offices don't have to. About 9,460 current or former smokers aged 50-77 will be…

This study looks at whether smokers are more likely to get a lung cancer screening CT scan when their regular doctor suggests it. About 500 adults aged 50-74 who smoke or recently quit will be invited to get a low-dose CT scan. The goal is to see how many people actually complete…

This study looks at whether special breathing exercises can help people who have had lung cancer surgery breathe easier, move better, and feel steadier on their feet. About 40 adults aged 18-80 who are cancer-free and recovering from surgery will take part. The goal is to see if …

This study tests a short, pre-surgery exercise and smoking-cessation program for people who smoke and have a lung nodule suspicious for cancer or COPD. About 20 participants will attend two rehab sessions per week before their planned lung treatment. Researchers want to see if th…

This study tests a special program designed to help lung cancer survivors living in rural areas feel better and manage their health. About 300 survivors will either join the program or receive standard information. The goal is to see if the program improves quality of life and he…

This study tests whether adding intravenous vitamin C to standard chemotherapy can improve quality of life for people with incurable non-small cell lung cancer. About 90 adults with stage IIIB or IV cancer will receive either vitamin C or a placebo alongside their usual treatment…

This study tests whether a special care plan, supported by technology, can improve the quality of life for older adults (70+) who have cancer and other health problems. About 720 people with breast, lung, colorectal, or prostate cancer will take part across 8 hospitals in France.…

This study looks at whether pulmonary rehabilitation—a program of exercise and breathing techniques—can improve breathing, fatigue, and quality of life for people with advanced non-small cell lung cancer. About 85 participants will either take part in an 8-week rehab program or r…

This study tests whether adding acupuncture to standard anti-nausea medicine works better than medicine alone for people with nausea caused by chemotherapy. About 90 adults with breast, prostate, lung, gynecologic, colorectal, or metastatic pancreatic cancer will be split into tw…

This study tests whether spiritual care sessions can improve spiritual well-being and reduce anxiety and depression in people with stage IV lung or gastrointestinal cancer. About 36 adults will be randomly assigned to receive either spiritual care or informational support. The go…

This study is testing a program called MyCarePulse and ASCENT to help cancer patients overcome food-related challenges. About 100 adults recently diagnosed with certain cancers will either receive the program or standard care. The goal is to see if the program improves food secur…

This study tests a stress management program for people with lung cancer who are waiting for routine scan results. The program includes coaching calls and online modules to help reduce stress. About 60 adults with lung cancer will participate to see if the program is helpful and …

This study tests whether two medicines—N-acetyl cysteine (a supplement) and dexamethasone (a steroid)—can reduce shortness of breath after radiation therapy for lung cancer in people who also have interstitial lung disease. About 98 participants will receive one or both drugs or …

This study tests a home-based rehab program for 40 veteran lung cancer survivors who finished treatment 1-6 months ago. The program uses video calls and a fitness tracker to help reduce symptoms like shortness of breath, fatigue, and fear of cancer returning. The goal is to impro…

This study compares two types of nerve blocks (RIB and ESPB) to see which one better controls pain after lung cancer surgery. Sixty adults having a thoracotomy will receive one of the blocks, and researchers will measure how much morphine they need in the first 24 hours. The goal…

This study tests whether a couple-based meditation program can improve physical, emotional, and spiritual well-being for people with metastatic lung cancer and their romantic partners. Researchers will enroll 300 couples to see if the program is practical and helpful. The goal is…

This study tests if a special, slow-release painkiller (liposomal bupivacaine) works better than the standard version for controlling pain after lung surgery. About 210 adults having keyhole lung surgery will be randomly assigned to receive one of two painkillers or no nerve bloc…

This study is testing whether a special dietary supplement can help reduce severe side effects from standard cancer treatments like chemotherapy and radiation. It includes 52 adults with head and neck, lung, or rectal cancer. Researchers will compare results with a previous group…

This early-phase study tests whether fecal microbiota transplantation (FMT) can safely reduce severe diarrhea or colon inflammation caused by immune-checkpoint inhibitors in people with genitourinary and other cancers. About 40 participants will receive FMT and be monitored for s…

This study tests whether the drug riluzole can prevent memory and thinking problems (often called 'chemo brain') in people receiving chemotherapy for various cancers. About 24 adults with breast, lung, or other cancers will receive either riluzole or a placebo during their chemo.…

This pilot study tests if brodalumab, a drug approved for autoimmune diseases, can safely reduce severe side effects caused by cancer immunotherapy. About 11 adults with various solid tumors who have immune-related side effects will receive brodalumab. The goal is to see if it lo…

This study looks at whether having a conversation about care goals in the emergency department can improve quality of life for people with advanced lung or gastrointestinal cancer. It involves 200 adults who are at least 18, have advanced cancer, and have certain severe symptoms.…

This study tests whether injecting a small amount of the patient's own blood into the lung lining can prevent air leaks after thermal ablation for lung cancer. About 106 adults scheduled for lung ablation will be randomly assigned to receive either standard care or the extra bloo…

This study tests whether using a SPECT scan to guide radiation therapy can reduce lung damage in people with advanced lung cancer. About 90 patients receiving chemo-radiation will be randomly assigned to standard or SPECT-guided planning. The goal is to see if avoiding highly fun…

This study compares two ways to block pain during lung cancer surgery. One method uses a combination of two nerve blocks, and the other uses a single block. Sixty adults having lung cancer surgery will be randomly assigned to one of the two approaches, and their pain levels will …

This study compares two types of nerve blocks (costotransverse foramen block and thoracic paravertebral block) to control pain after lung cancer surgery. The goal is to see which method reduces the need for morphine and provides longer pain relief. About 70 adults undergoing thor…

This study tests a short supportive program called Pathways to see if it can improve mental health and quality of life for people being treated for advanced lung cancer. About 234 adults with stage 3 or 4 lung cancer who are 3-12 weeks into treatment will take part. Participants …

This study tests a non-invasive treatment called Transcutaneous Acupoint Electrical Stimulation (TAES) to see if it can reduce coughing in people who have had lung cancer surgery. About 84 adults who have had a dry cough for at least two weeks after their operation will receive t…

This study tests whether a nurse-led program that includes symptom tracking, exercise, and help navigating the healthcare system can improve survival and quality of life for vulnerable lung cancer patients. About 250 adults with lung cancer who face extra challenges will be rando…

This study looks at whether using a high flow nasal cannula (a special oxygen device) during a lung cancer procedure called EBUS bronchoscopy can reduce breathing problems and procedure interruptions. About 198 adults having this procedure will be randomly assigned to receive eit…

This study looks at whether a 12-week exercise program at different intensity levels is possible and helpful for people with advanced lung cancer who are already receiving immunotherapy. Researchers will track how many participants complete the exercise sessions and measure immun…

This study compares two types of minimally invasive surgery—robotic-assisted and video-assisted—for people with early-stage non-small cell lung cancer. The goal is to see which approach leads to better quality of life and recovery. About 512 adults across Europe will take part, a…

This study tests whether using an incentive spirometer—a device that encourages deep breathing—can lower the risk of lung inflammation (pneumonitis) in people with advanced lung cancer receiving chemotherapy and radiation. About 100 participants will use the device 10 times every…

This study looks at whether adding endurance training (like cycling) to standard physical therapy helps people recover better after minimally invasive lung cancer surgery. About 184 adults having lung surgery will be randomly assigned to standard rehab or standard rehab plus extr…

This study looks at whether a computer-based virtual agent or a real person is better at teaching lung cancer patients how to use devices at home to check their weight, blood pressure, heart rate, temperature, and oxygen levels. About 36 adults with solid tumors will be randomly …

This study looks at how minimally invasive lung cancer surgery affects the heart's electrical activity. Researchers will monitor 100 adult patients before, during, and after surgery to see if temporary changes occur. The goal is to better understand heart stress from this procedu…

This study is for people with advanced cancers who are taking targeted treatments for months or years. Researchers will interview 75 participants to understand their experiences and needs. The goal is to find better ways to support patients living with chronic cancer treatments.

This study aims to develop a new 4D-MRI imaging technique that creates 3D movies of the lungs and liver during breathing. The goal is to help doctors better target tumors in cancer patients receiving radiation therapy, especially when tumors move with breathing. The study will te…

This study is collecting information from 600 people with early-stage lung cancer who are having a type of surgery called pulmonary segmentectomy. Participants fill out questionnaires before surgery, a few weeks after, and 6 months later. The goal is to learn how many people rema…

This study looks at CT scans from 2,000 people with early-stage lung cancer to see if computer models can better predict biopsy results and treatment outcomes. Researchers will review medical records and use data from a national screening trial. The goal is to improve how doctors…

This study aims to find the genetic and immune system changes that cause lung cancer to start and grow. Researchers will collect tissue samples from 6,000 people who have or are suspected of having lung cancer. The goal is to better understand the disease, not to test a new treat…

This study aims to create a more accurate way to predict lung cancer risk in people who have never smoked. Researchers will collect information from 10,000 participants aged 50-80 who have a family history of lung cancer. They will use questionnaires, blood tests for specific ant…

This study tests whether a large language model (a type of AI) can help junior doctors write more accurate and efficient cancer treatment reports. 40 junior doctors will be split into two groups: one uses AI assistance, the other uses traditional methods. Their reports will be sc…

This study collects blood and other samples from adults with cancer to learn how certain immune cells change before and after chemotherapy. Researchers will also analyze genes in the samples and link them to patient health details. The study does not provide any treatment, but pa…

This study compares different outreach methods to see which works best for getting people at high risk for lung cancer to complete a screening CT scan. It includes 27,000 participants, focusing on racial/ethnic minorities and rural residents. The goal is to find the most effectiv…

This study is developing and testing two new kits that aim to predict if early-stage lung cancer will come back after surgery. About 236 adults with stage IA to IIIA lung adenocarcinoma who had their tumor fully removed will provide tissue and blood samples. The goal is to see ho…

This study tests whether teaching oncology care providers empathic communication skills can reduce the stigma lung cancer patients often feel during medical visits. Over 1,200 doctors, nurse practitioners, and physician assistants across the U.S. will be trained and evaluated usi…

This study is creating a huge collection of medical information and biological samples from adults with or at risk for many types of cancer, as well as healthy volunteers. The goal is to help researchers better understand cancer causes, improve early detection, and develop person…

This study is looking at whether tiny particles in the blood, called extracellular vesicles, can help predict nerve damage caused by chemotherapy. About 120 adults with certain cancers will give blood samples and answer questions before, during, and after chemo. The goal is to fi…

This study aims to collect blood samples (liquid biopsies) from 2,500 people with cancer or at high risk for cancer, along with their medical information. The samples will be stored in a research bank for future studies to improve how we detect, monitor, and treat cancer. Partici…

This study looks at how many breast and lung cancer patients have a severe fear that their cancer will return. Researchers will interview 200 patients to understand their experiences and what kind of support they need. The goal is to find better ways to identify and help those wh…

This study aims to improve how doctors find and diagnose lung cancer early. Researchers will collect blood samples from 5,000 people who have suspicious spots on their lungs. They will use artificial intelligence to analyze the blood and CT scans, hoping to create a tool that cat…

This study is testing a new imaging method called full-field optical coherence tomography (FFOCT) on small lung biopsy samples. The goal is to see if FFOCT can give the same information as the standard lab analysis, but faster. About 20 adults with lung cancer or sarcoidosis who …

This study enrolls up to 9,600 adults with various solid tumors (like breast, lung, or prostate cancer) to donate blood and leftover tissue samples. Researchers will use these samples to develop and improve tests that look for tiny bits of cancer DNA in the blood, which could hel…

This study is collecting information from 200 people with advanced lung cancer to build computer models that can predict how well a treatment will work. Researchers will gather medical, imaging, and lifestyle data to understand why some patients respond to therapy while others do…

This study is collecting health information and biological samples from 730 adults newly diagnosed with lung cancer. Researchers aim to track how patients respond to treatments in real-world settings, including those often excluded from clinical trials. The goal is to better unde…

This study looks at how a person's body composition, especially their fat-free mass (muscle), relates to side effects from chemotherapy in advanced lung cancer. Researchers will track 132 patients to see if adjusting the chemo dose based on muscle mass can reduce toxicity. The go…

This study looks at when to send messages to encourage physical activity in older adults (65+) who have survived certain cancers and live with chronic pain. Researchers will track activity levels and pain ratings to find the best timing for these prompts. The goal is to learn how…

This study screens up to 7,000 adults with cancers like melanoma, lung, or colorectal cancer to see if they qualify for experimental treatments developed by the National Cancer Institute's Surgery Branch. These treatments involve taking a patient's own immune cells, growing them …

This study is creating a new questionnaire to measure how well people with lung cancer follow their breathing rehabilitation program. About 281 Mexican patients will fill out the 56-question scale. The goal is to make sure the tool is accurate and reliable, so doctors can better …

This study follows up with people who previously took part in cancer vaccine studies using gene therapy. It does not provide new treatment but tracks their health yearly for 15 years to watch for any long-term side effects. Up to 750 participants with various cancers are included…

This study looks at different types of immune cells called neutrophils in the blood of people with lung cancer. Researchers want to see if certain neutrophil types are linked to how the cancer grows or resists treatment. About 100 adults with advanced lung cancer, plus healthy vo…

This study is a large registry that will follow 8,000 cancer patients who receive radiation therapy guided by an MR-Linac, a machine that combines an MRI scanner with a radiation beam. The goal is to see if this technology helps people live longer, controls tumors better, and imp…

This study looks at whether DNA from blood, sputum, lung fluid, and breath can help track non-small cell lung cancer before and after surgery. About 210 adults having surgery to remove their cancer will provide samples over 24 months. The goal is to see if these tests are practic…

This study looks at 48 adults with advanced lung cancer who are starting immunotherapy. Researchers will collect samples from the lungs, stool, and blood before and after 8 weeks of treatment. The goal is to see if certain bacteria in the gut or airways are linked to how well the…

This study aims to gather information from cancer patients (breast, lung, ovarian, multiple myeloma, or AML) who use a remote symptom monitoring system during their routine treatment. Participants will complete weekly surveys about their symptoms for at least 12 weeks. The goal i…

This study is gathering information from 180 lung cancer patients to understand how malnutrition and metabolism affect their health. Researchers will look at factors like genetics, gut bacteria, and tumor details to create personalized nutrition recommendations. The goal is to im…

This study collects fluid from around the lungs (pleural fluid) from people with lung cancer, breast cancer, or lung infections. The goal is to create a large registry of samples and health data for future research. No new treatments or procedures are tested—only standard care sa…

This study is testing a decision aid to help people decide whether to get screened for lung cancer. The tool is designed for patients in a safety-net healthcare system. Researchers will enroll 360 current or former smokers aged 50-80 who have no history of lung cancer. The goal i…

This study looks at two ways to remove small lung nodules in people with lung cancer. One method uses special imaging during surgery (iVATS), while the other is the standard VATS technique. Researchers will measure how long each surgery takes, how long patients stay in the hospit…

This study looks at whether a campaign called Pink & Pearl can encourage more women who are at risk for lung cancer to get screened. Researchers will track how many women complete lung cancer screening after seeing the campaign during their mammogram visit. The goal is to find be…

This study collects tumor tissue from 50 adults with lung cancer whose disease has worsened while on immunotherapy. Researchers will analyze the samples to learn why the treatment stopped working. The goal is to better understand resistance mechanisms, not to provide direct treat…

This study is collecting blood, tissue, and other samples from 7,000 people with different cancers to look for tiny bits of cancer DNA that may remain after treatment. The goal is to learn how to detect cancer early if it comes back. Participants' test results may help guide thei…

This study tests if a new type of MRI scan, using an inhaled gas called hyperpolarized xenon-129, can help doctors identify and predict common side effects of radiation therapy in lung cancer patients. About 70 people will take part, including both healthy volunteers and lung can…

This study is testing an artificial intelligence (AI) tool that estimates a person's risk of developing lung cancer in the next 3 years. Researchers will enroll 400 adults aged 50-80 who are current or former heavy smokers. Participants will receive their risk result, and the stu…

This study is testing whether an AI system can accurately identify different types of lung cancer using PET/CT scans and patient information like age, smoking history, and tumor markers. The goal is to tell small cell from non-small cell lung cancer and further classify subtypes …

This study collects blood or cheek swab samples from 1,100 cancer patients to look for genetic differences that might affect how their bodies process cancer treatments. The goal is to understand why some people have more side effects or get less benefit from therapy. Participants…

This study looks at why Hispanic current and former smokers may not get screened for lung cancer. Researchers will give 2000 participants an educational video and then ask them questions. The goal is to find better ways to help more people get this important screening.

This study observes 110 adults with head/neck, lung, or rectal cancer to track changes in their nutrition and body composition during standard cancer treatments. Researchers measure daily food intake, muscle mass, and strength over time. The goal is to gather information that wil…

This study is for people with lung or chest cancers that have come back or are new, and who have already had radiation before. Researchers want to see how safe and effective a second round of high-dose radiation is by tracking side effects and survival in 500 participants. The go…

This study tests a new way to predict how well your lungs will work after lung cancer surgery. Doctors use a 3D CT scan to create a virtual model of your lungs and simulate the surgery beforehand. The goal is to improve safety and help plan recovery. About 60 adults with non-smal…

This study looks at whether combining PET scan images with genetic testing can better predict how well lung cancer treatments will work and how long patients may survive. Researchers will study 120 adults with non-small cell lung cancer. The goal is to create a more accurate tool…

This study looks at whether tissue samples taken during a routine lung biopsy (called EBUS-TBNA) can be used to analyze gene changes in lung cancer. The goal is to see if these gene changes can help predict which treatments—like surgery, chemo, or radiation—will work best for eac…

This study looks at 400 people with non-small cell lung cancer who had pre-treatment (like chemo or immunotherapy) and then needed a specific type of lung surgery called sleeve lobectomy. Researchers want to see if a less invasive surgery (using small cuts and a camera) works as …

This study observes how pathologists currently diagnose lung and breast cancer, and tests whether artificial intelligence (AI) can help make the process faster and more accurate. Researchers will look at tissue samples from 600 adults suspected of having these cancers. The goal i…

This study will screen 1,000 people in Mexico aged 50 or older who are at high risk for lung cancer—including heavy smokers, former smokers, and those exposed to wood smoke—using low-dose CT scans each year for 3 years. The goal is to find lung cancer at an early stage when it's …

This study is creating a large database of blood samples, tumor tissue, and medical images from 4,000 people with lung cancer. Researchers will follow participants for up to 10 years to collect information that can be used for future studies. The goal is to better understand lung…

This study creates a registry of 1500 lung cancer patients treated at one hospital. Researchers will collect data from 2019 to 2035 to understand survival, how the disease progresses, and how well treatments work in real life. The goal is to use this information to improve future…

This study follows 500 adults aged 70 and older who are starting their first treatment for non-small cell lung cancer. Researchers will collect information on how well the treatments work, side effects, and quality of life. The goal is to learn more about what happens in everyday…

This study compares two ways of taking tissue samples from lung tumors to see which one gives better material for genetic testing. About 250 adults with suspected lung cancer will be randomly assigned to get either a standard needle biopsy or a newer freezing technique. The goal …

This study looks at ways to encourage people to test their homes for radon, a radioactive gas that can cause lung cancer. Researchers will test an online tool and reminder messages to see if they help more people request and use free radon test kits. The study involves 172 adults…

This study looks at whether a special care program helps younger adults (under 50) with lung cancer feel more satisfied with their care. Researchers will also ask about the needs of patients and their families, and see if joining peer support groups makes a difference. About 75 p…

This study is creating a large collection of blood and other biological samples from 3,000 people with lung nodules or lung cancer. Researchers will use these samples to identify new biomarkers that could improve how we diagnose, predict outcomes, and choose treatments for lung c…

This study aims to see if low-dose CT scans are a good way to screen for lung cancer in Black individuals aged 50-80 who have smoked. Researchers will enroll 900 participants to check how many people agree to join and how well the scans find cancer. The goal is to improve early d…

This study tests a program called CARES that provides advocacy, resources, education, and support to rural cancer patients. The goal is to see if it helps them start treatment sooner after diagnosis and finish it faster. The study will include 320 adults with solid tumors like lu…

This study aims to create a program that helps older adults with lung cancer address concerns related to aging, such as managing symptoms and connecting with specialists. In the first phase, patients, caregivers, and providers give feedback on the program. In the second phase, ol…

This study looks at whether a special campaign called Pink & Pearl can help more women who are at risk for lung cancer get screened. About 5,500 women ages 50 to 80 who come for mammograms at Christian Hospital will be included. Researchers will track how many get referred and co…

This study is testing a web-based tool called CARE that gives cancer patients information about treatment costs, health insurance, and financial help. About 430 adults with gynecologic, prostate, lung, or colorectal cancer will use the tool to see if it reduces financial stress a…

This observational study tracks 2,400 lung cancer patients treated with immune checkpoint inhibitors to understand how often blood clots (in veins or arteries) occur and what raises that risk. Researchers will compare patients who develop clots with those who don't, looking for b…

This study tests whether a patient navigation program helps more Black adults who are at high risk for lung cancer complete their lung cancer screening. Researchers will enroll 675 people and track how many get a low-dose CT scan. The goal is to see if having a guide through the …

This study aims to develop a simple, non-invasive test for lung diseases like cancer by analyzing cough samples. Researchers will collect coughs, mouthwash, and lung fluid from 2,000 adults to see if genetic material from the lungs can be detected in breath. The goal is to create…

This study looks at sputum and tissue samples from 700 people with or without precancerous changes in the airways. The goal is to find biomarkers—biological clues—that may help detect lung, head and neck, or esophageal cancer earlier. Participants provide samples during routine p…

This study is creating a large database of 10,000 lung cancer patients who received radiotherapy. Researchers will collect information on tumor control, side effects, and quality of life to build models that predict outcomes. The goal is to use these models to select the best tre…

This study aims to understand how lung tumors burn sugar for fuel using a special MRI scan and a natural sugar solution. About 200 adults with suspected lung cancer who need surgery will take part. The goal is to develop a method to see tumor metabolism, not to treat the disease.

This study looks at whether a new, step-by-step method for examining lung tissue after surgery can find more lymph nodes than the usual approach. Finding more lymph nodes helps doctors stage lung cancer more accurately and decide if extra treatment like chemotherapy is needed. Ab…

This study aims to collect and analyze genetic information from 25,000 adults who either have cancer or are at risk of developing it. Researchers will look at tumor DNA and other health records to better understand what drives different cancers. The goal is to find new ways to de…

This study collects blood, tumor, and other tissue samples from up to 1,250 people with head and neck, lung, or gastrointestinal cancers. Researchers will analyze these samples to learn how different cancer treatments affect the immune system, identify who might develop side effe…

This research study collects and analyzes lung tumor samples from 4,000 people with early-stage non-small cell lung cancer who are having surgery. The goal is to find unique patterns in RNA and proteins (molecular fingerprints) that may help predict cancer recurrence and survival…

This study looks at whether certain genetic markers in blood and tumor samples can predict how well immunotherapy works before surgery for non-small cell lung cancer. Researchers will collect samples from 100 people with stage II-IIIB lung cancer who are scheduled to receive immu…

This study collects blood, urine, sputum, and lung tissue from 4,000 adults at high risk for lung cancer. Researchers will analyze these samples to find DNA changes and other molecular markers that could predict cancer behavior. The goal is to learn how lung cancer develops and t…

This study collects tissue samples from 7,000 adults with lung cancer, COPD, lung transplants, or other chest diseases. The samples are stored in a repository to help researchers better understand how these diseases start, how to diagnose them early, and how to improve treatment.…

This study tests whether the emergency department can be used to identify people at high risk for lung cancer and help them get screened. Researchers will screen patients for social needs and offer a tailored program to encourage lung cancer screening. The goal is to see if this …

This study is testing whether a blood test that looks for tumor DNA (ctDNA) can find cancer returning sooner than standard scans. Researchers will follow 100 people with various solid tumors to see if early detection leads to better treatment options. The goal is to improve how w…

This study is creating a detailed atlas of pre-cancerous spots in the lungs to understand how they turn into cancer. Researchers will collect tissue samples from 240 adults with these spots using a scope down the airway. The goal is to find clues that could help prevent lung canc…

This study aims to collect health information from 12,000 adults with lung or other chest cancers. Researchers want to understand why some people respond better to treatments than others, by looking at factors like genetics, lifestyle, and tumor details. The goal is to improve fu…