LUNG CANCER

This study tests a new drug called BMS-986507, alone or with other cancer medicines, in adults with advanced lung or breast cancer that has spread. The goal is to check safety, side effects, and how well the drugs work. About 416 participants will receive different combinations t…

This study tests an experimental treatment called OBX-115 for people with advanced melanoma or non-small cell lung cancer that has spread or stopped responding to standard therapy. OBX-115 uses a patient's own immune cells (tumor-infiltrating lymphocytes) that are modified in the…

This study tests a new drug called rezatapopt (PC14586) in people with advanced solid tumors that have a specific TP53 Y220C mutation. The drug is designed to reactivate the p53 protein, which normally helps stop cancer growth. The trial will also test rezatapopt combined with th…

This study tests a new device that uses microwave energy to destroy lung tumors during a bronchoscopy, before the patient has surgery to remove the tumor. The goal is to see if the device is safe and works well in 30 people with confirmed lung cancer who are already scheduled for…

This trial investigates whether specially engineered T cells can safely target and fight lung cancer. Participants have advanced or relapsed lung cancer and receive a single infusion of their own T cells that have been trained to recognize cancer-specific markers. The study aims …

This early-phase trial tests an experimental drug called RSC-1255, given alone or with hydroxychloroquine, in people with advanced solid tumors (like lung, colon, or pancreatic cancer) who have run out of standard options. The study has two parts: first, finding a safe dose, and …

This study tests whether adding AGuIX gadolinium-based nanoparticles to standard brain radiation can better control brain metastases that are at high risk of coming back. About 134 adults with certain cancers (like melanoma, lung, breast, or colorectal) that have spread to the br…

This early-phase study tests a new treatment called TNhYP218 CAR T cells for people with solid tumors that have high levels of a protein called mesothelin, including mesothelioma. Participants' own immune cells are collected, modified in a lab to better attack cancer, and then gi…

This early study tests a new device that places tiny radioactive seeds directly into lung tumors that have come back after previous treatment. The seeds release a special type of radiation that spreads through the tumor. The goal is to see if the procedure is safe and possible in…

This early-stage trial is testing a new type of immune cell therapy for people with advanced cancers that have a specific protein called KK-LC-1. The cancers being studied include stomach, breast, cervical, and lung cancer. Participants will receive chemotherapy followed by a sin…

This study tests a new treatment using a patient's own immune cells, called CAR T cells, that are specially designed to target and kill solid tumor cells while leaving healthy cells unharmed. It is for adults with certain advanced cancers, including lung, colon, pancreatic, ovari…

This study tests whether adding the investigational drug NKTR-255 to the standard immunotherapy durvalumab can help restore immune cells after chemoradiation in people with advanced non-small cell lung cancer. About 39 adults will receive the combination and be followed for overa…

This study tests whether stereotactic radiosurgery (SRS), a precise form of radiation, can effectively treat brain metastases in people newly diagnosed with small cell lung cancer that has spread to the brain. About 62 participants will receive SRS, and researchers will track how…

This study tests whether a simple blood test that measures cancer DNA (ctDNA) can help doctors decide when to add chemotherapy to the standard immunotherapy drug pembrolizumab for people with advanced lung cancer. About 230 participants will be enrolled. The goal is to see if thi…

This study tests whether a new experimental drug called PF-08634404, given with chemotherapy, works better than the current standard treatment (pembrolizumab plus chemo) for adults with advanced non-small cell lung cancer. About 1,410 participants will be randomly assigned to rec…

This study tests whether lower doses of chemotherapy can effectively control lung cancer in patients aged 70+ or those with other health problems. About 280 participants will receive pre-set reduced chemo doses to see if tumors shrink while causing fewer side effects. The goal is…

This study is testing a precise type of radiation called stereotactic body proton therapy (SBPT) for people with early-stage non-small cell lung cancer who cannot have surgery or choose not to. About 65 participants will receive targeted proton beams in a few high-dose sessions. …

This phase 2 trial is testing an experimental drug called patritumab deruxtecan (HER3-DXd) in 740 people with advanced solid tumors, including melanoma, lung, breast, and other cancers. The drug is given by IV every three weeks. The main goal is to see if the drug shrinks tumors.…

This study looks at whether adding Chinese herbal medicine to standard chemotherapy and immunotherapy can help prevent lung cancer from coming back after surgery. About 367 adults with a certain type of lung cancer (driver gene negative, stage Ib to IIIb) will take part. The goal…

This study tests a new oral drug, TNG462, combined with other treatments for people with pancreatic or non-small cell lung cancer that has lost the MTAP gene and, in some cases, has a RAS mutation. The trial has two phases: first to find the safest dose, then to see how well the …

This study is for adults with certain cancers (like breast, lung, or ovarian) that are in complete remission but have persistently low platelet counts from past chemotherapy. It tests whether adding a vitamin A derivative (ATRA) to a standard platelet-boosting drug works better t…

This early-phase trial tests whether adding carotuximab to the standard drug osimertinib is safe for people with advanced EGFR-mutated non-small cell lung cancer. About 60 participants whose cancer has progressed on prior treatments will receive both drugs. The main goal is to fi…

This study tests a new treatment for people with a specific type of advanced small cell lung cancer (SLFN-11 positive). The treatment combines low-dose radiation, chemotherapy, an immunotherapy drug (sugemalimab), and a targeted drug (olaparib). The goal is to see if this combina…

This study tests if axelopran, a drug used for opioid-induced constipation, can slow tumor growth in people with advanced breast, lung, pancreas, or prostate cancer. About 34 adults whose cancer has worsened after standard treatment will take axelopran daily for up to a year. Res…

This study is testing a new way to give chemotherapy and immunotherapy for people with advanced lung or head and neck cancers. Instead of giving both treatments together every time, the plan alternates cycles of chemo plus immunotherapy with immunotherapy alone. The goal is to se…

This study tests whether the drug osimertinib can stop small, hazy spots (called GGNs) in the lungs from growing after surgery for a specific type of lung cancer. About 43 adults with early-stage lung cancer and an EGFR mutation will take a daily pill for one year. The goal is to…

This phase 2 trial tests a new radiation technique called lattice radiation therapy (LRT) combined with immunotherapy in 30 people with advanced solid tumors that have not responded to standard treatments. LRT delivers high doses of radiation to small spots inside the tumor while…

This study tests a new device that uses microwave energy to heat and destroy lung tumors. 18 people with lung cancer who are already scheduled for surgery will receive this ablation first. The goal is to see if the device is safe and can effectively kill the tumor, which might on…

This early-stage trial tests a new drug called QXL138AM in about 100 people with advanced solid tumors (like ovarian, pancreatic, or lung cancer) or multiple myeloma. The drug is designed to help the immune system attack cancer cells. The main goal is to check safety and find the…

This study tests a new drug called TNG456, alone or with another drug (abemaciclib), in people with advanced cancers that have lost a gene called MTAP. The trial has two parts: first finding a safe dose, then testing how well it shrinks tumors. Up to 191 adults with lung cancer, …

This study tests a flexible microwave ablation probe that can be guided through a bronchoscope to destroy small lung cancer nodules (up to 3 cm) before surgical removal. Ten people with stage I-II lung cancer will receive the ablation during a bronchoscopy, and the treated tissue…

This phase 2 trial tests an experimental drug called FH-006 combined with other cancer treatments in 200 people with advanced non-small cell lung cancer. The goal is to see if the combination is safe and can shrink tumors. Researchers will also determine the best dose for future …

This study is testing a new device called the FlexAblate Microwave Ablation System that uses heat from microwaves to destroy small lung cancer nodules. It is for people who cannot have surgery or choose not to. The trial will check if the device safely and completely treats the t…

This study looks at whether people with lung cancer that has spread to the brain can safely delay radiation therapy. Participants take alectinib, a targeted drug, either alone or with focused radiation. The goal is to see if starting with just the drug keeps the brain cancer unde…

This study tests a drug called osimertinib for people with a specific type of stage III lung cancer that cannot be removed by surgery. Participants take the drug before and after radiation therapy. The goal is to see if this approach helps control the cancer longer. The study is …

This phase 1 trial tests a personalized, accelerated radiation therapy for locally advanced lung cancer. The radiation dose is tailored to each patient's tumor size and location, aiming to deliver a higher dose in fewer sessions. The study will enroll 45 adults with non-small cel…

This early-stage study is testing a new drug called DO-2 in people with advanced solid tumors (like lung cancer) that have a specific genetic change (MET mutation) and have run out of standard treatments. The main goal is to check the drug's safety and how the body processes it. …

This Phase 2 trial tests whether adding trilaciclib to the chemotherapy drug lurbinectedin can reduce severe neutropenia (a dangerous drop in white blood cells) in people with small cell lung cancer that has spread. About 30 participants will receive both drugs intravenously. The…

This Phase 1 trial tests a new drug called BL-M07D1 in 280 adults with advanced HER2-positive cancers, including breast, lung, and stomach cancers. The study aims to find safe doses and check for early signs of tumor shrinkage. Participants must have tried at least two prior trea…

This study tests a device that uses short electric pulses to destroy lung tumors before they are surgically removed. It involves 25 adults with suspected or confirmed lung cancer who are already scheduled for surgery. The goal is to see if the procedure is safe and can successful…

This early-stage trial tests whether a stool transplant (FMT) can help cancer patients who develop severe diarrhea or colon inflammation from immune-checkpoint inhibitor drugs. About 40 patients with various cancers will receive the transplant via colonoscopy. The main goal is to…

This early-stage study tests the safety of combining the drug talazoparib with low-dose chest radiation in people with extensive-stage small cell lung cancer that has not worsened after initial chemotherapy. About 24 participants will receive talazoparib pills daily during radiat…

This study is for people newly diagnosed with extensive-stage small cell lung cancer that has spread. Researchers want to see if adding a precise, high-dose radiation treatment (ablative radiation) to the standard combination of durvalumab (an immunotherapy) and chemotherapy (car…

This Phase 1 trial tests IDOV-Immune, a genetically engineered virus designed to infect and destroy cancer cells while boosting the immune system. It is for adults with advanced solid tumors (like colorectal, pancreatic, or lung cancer) that have not responded to standard treatme…

This study tests a new drug called CNSI-Fe(II), which is injected directly into tumors. It uses iron to trigger a type of cell death called ferroptosis, aiming to control advanced solid tumors like lung, pancreas, and colorectal cancers. The trial involves 54 adults whose current…

This study tests whether using a SPECT scan to map healthy, working lung tissue can help doctors aim radiation away from those areas during treatment for advanced lung cancer. The goal is to reduce lung damage and side effects like breathing problems. About 90 people with lung ca…

This study tests whether a diabetes drug called dapagliflozin is safe to give before surgery in people with early-stage lung adenocarcinoma. About 48 participants will take the drug for a short time before their planned surgery. The goal is to see if the drug can help make surger…

This early-phase trial is testing a new drug called CLSP-1025 in about 90 adults with advanced solid tumors (like lung, colon, or breast cancer) that have a specific p53 mutation (R175H). The drug works by directing the body's immune cells to attack cancer cells carrying this mut…

This early-stage trial tests a new combination treatment for people with advanced HER2-positive solid tumors (like breast, lung, or stomach cancer). Participants receive an injection of a special virus directly into one tumor to help the immune system attack cancer, followed by a…

This early-phase study tests a new treatment for people with advanced lung cancer that has not responded to standard therapies. The treatment uses a patient's own immune cells (T cells) that are modified in a lab to better recognize and attack cancer cells. The main goal is to fi…

This phase 3 trial tests whether treating 1 to 10 metastatic tumors right away with precise radiation improves survival compared to waiting 3 months. It includes 800 adults with lung, colorectal, or prostate cancer that has spread to a few spots. Participants are randomly assigne…

This phase 3 trial is testing whether a personalized program of supplements (vitamin D, mushroom extract, fish oil, probiotics, and whey protein) plus lifestyle coaching can improve recovery and quality of life for people undergoing surgery for lung, stomach, or esophageal cancer…

This study tests whether ciprofol, a newer sedative, can reduce heart injury after lung surgery compared to the standard drug propofol. About 1,058 adults aged 45–80 having video-assisted lung surgery will be randomly assigned to receive one of the two drugs during anesthesia. Th…

This early-phase study tests a new drug called BL-B01D1 in people with advanced lung cancer or other solid tumors that have spread or cannot be removed. The main goals are to check the drug's safety, find the best dose, and see if it helps shrink tumors. About 470 adults will tak…

This early-phase study tests a new treatment called PTC13, which uses specially engineered immune cells (CAR-T cells) to attack cancer cells that have a protein called CEA. The study includes 18 adults with advanced colorectal, stomach, pancreatic, or other solid tumors that have…

This study is testing an anti-PD-1 antibody (a type of immunotherapy) alone or combined with low-dose decitabine and/or standard chemotherapy in people whose cancers have come back or not responded to treatment. The trial includes patients with several cancer types, such as lymph…

This study tests a new drug called 3H-10000, which is an antibody-drug conjugate designed to target and kill cancer cells. It is for people with advanced lung or stomach cancer that cannot be removed by surgery or has spread. The trial will enroll 170 participants to find the saf…

This study tests a procedure called cryoablation, which uses extreme cold to freeze and destroy lung nodules that are early-stage cancer. It is for people who cannot have surgery due to age or health issues. The trial will enroll 90 participants and follow them for up to 5 years …

This early-stage study tests an experimental oral drug called DPTX3186 in 40 adults with advanced solid tumors (like colorectal, gastric, lung, or triple-negative breast cancer) that are linked to a specific cell signal called Wnt. These participants have no other approved treatm…

This early-phase study tests a radioactive drug called lutetium BL-ARC001 in 22 people with advanced lung, breast, head and neck, or other solid tumors that have stopped responding to standard therapies. The drug is given by IV infusion over a 6-week cycle. The main goals are to …

This study tests a combination of two experimental drugs, ZGGS18 and ZG005, in people with advanced solid tumors (cervical, liver, neuroendocrine, or lung cancer) that no longer respond to standard treatments. The main goals are to check safety, find the best dose, and see if the…

This phase 2 trial is testing whether giving a combination of low-dose radiation, stereotactic body radiotherapy (SBRT), the immunotherapy drug tislelizumab, and standard chemotherapy before surgery can improve outcomes for people with stage II to III non-small cell lung cancer. …

This study tests whether early, personalized nutritional support and a simple home exercise program can prevent weight loss and improve quality of life in 200 adults with lung, colorectal, ovarian, or pancreatic cancer starting palliative chemotherapy. Participants receive guidan…

This Phase 2 trial is testing a new drug called HRS-4508, given as a tablet, together with other anticancer drugs (SHR-A1811 and/or Adebrelimab) in 100 adults with advanced non-small cell lung cancer that has not responded to standard treatments. The main goals are to check safet…

This study tests an experimental drug called VMD-928, taken as a pill, either alone or with another cancer drug (pembrolizumab). It is for adults with advanced solid tumors or lymphoma that have not responded to or are no longer controlled by available treatments. The goal is to …

This early-phase study tests a new treatment called GC203 TIL for people with advanced solid tumors (cancers in organs like the breast, lung, or gut) that have not responded to standard therapies. The treatment uses a patient's own immune cells, which are modified in a lab to bet…

This study tests a personalized vaccine called LK101, made from a patient's own tumor markers, combined with standard immunotherapy drugs (pembrolizumab, durvalumab, or tislelizumab) in 60 adults with advanced lung cancer. The goal is to see if the combination is safe and can hel…

This early-stage trial is testing a new drug called VSV-02 in 6 people with advanced solid tumors (like melanoma, breast, or lung cancer) who have no good treatment options left. VSV-02 is a modified virus that is injected into a vein and directly into the tumor, aiming to kill c…

This study tests an experimental drug called TNG260 combined with an immunotherapy (pembrolizumab) in people with advanced solid tumors that have a specific gene change (STK11 mutation). The goal is to find the best dose and see if the combination is safe and can shrink tumors. A…

This master trial is testing a new radiation technique called SMART, which uses MRI to guide and adapt radiation beams in real time. The goal is to deliver high doses precisely to tumors while protecting nearby organs. The study enrolls adults with various cancers (pancreas, lung…

This study tests whether adding certolizumab (an anti-inflammatory drug) to standard chemotherapy and immunotherapy helps shrink stage II-III lung cancer more effectively before surgery. About 60 adults with operable lung cancer will receive the combination, then have their tumor…

This study tests whether adding valemetostat to the standard immunotherapy pembrolizumab works better than pembrolizumab alone for people with advanced non-small cell lung cancer that has high PD-L1 levels. About 137 adults who have not had prior treatment will participate. The g…

This early-stage study is testing a new treatment called CEA-targeted CAR-T cells for people with advanced solid tumors like lung, stomach, colon, rectal, esophageal, or pancreatic cancer that have not responded to standard therapies. The treatment uses a patient's own immune cel…

This early-stage trial tests a new type of immunotherapy called CD70-targeted CAR-T cells in people with advanced solid tumors, including kidney, lung, ovarian, and thyroid cancers. The treatment involves taking a patient's own immune cells, engineering them to recognize and atta…

This early-phase trial tests a personalized vaccine made from a patient's own tumor cells or donor cells. The cells are modified and killed in the lab, then injected under the skin to train the immune system to attack the cancer. The study includes 50 adults with metastatic melan…

This phase 2 trial is testing a combination of three drugs—datopotamab deruxtecan, carboplatin, and pembrolizumab—in 46 people with non-small cell lung cancer that has spread to the brain and who have not had prior treatment for those brain tumors. The goal is to see how well the…

This study tests the immunotherapy drug atezolizumab in 200 people with advanced solid tumors (breast, lung, GI, and others). Researchers use each person's tumor DNA to see if it predicts a response. Participants get the same dose every 3 weeks. The goal is to see if DNA analysis…

This study tests a new navigation system called LungVision to help doctors mark suspicious lung nodules before surgery. The system uses augmented fluoroscopy and ultrasound to guide a small marker to the nodule. The goal is to make marking easier and less invasive than current me…

This early-stage trial tests an experimental oral drug called CID-078 in 220 adults with advanced solid tumors that have not responded to standard treatments. The study is split into two parts: first, finding a safe dose, and then checking if the drug shrinks tumors. It is a firs…

This study tests whether taking special gut bacteria capsules (RMT) alongside standard chemotherapy and immunotherapy can help control advanced lung cancer. About 82 people with untreated non-small cell lung cancer will receive either RMT or a placebo. The goal is to see if the b…

This study tests A2B395, a donor-derived CAR T-cell therapy designed to target cancer cells while sparing healthy ones. It is for adults with advanced solid tumors like colorectal, lung, or breast cancer that have lost a specific immune marker. The trial has two phases: first to …

This study tests whether doctors can deliver very high doses of radiation to tumors in the abdomen or chest using an MRI-guided machine, while limiting harm to nearby organs. About 60 people with abdominal or lung cancer will take part. The main goal is to see if the treatment ca…

This study is testing a new blood test called EXoPred that uses artificial intelligence and laser technology to find tiny particles from cancer cells. The goal is to detect breast, colon, pancreatic, ovarian, and lung cancers at an early stage. Researchers will enroll 1,400 peopl…

This study is testing a lung cancer screening program for smokers aged 45 to 74. It uses low-dose CT scans and metabolomics to find lung nodules and reduce false negatives. The goal is to improve early detection and help smokers quit. 1,000 participants will be followed in a publ…

This study looks at whether community pharmacists can help more people get screened for lung cancer. It will enroll 300 adults aged 50-77 who are current or former heavy smokers. Participants can choose a simple blood test or a CT scan to check for early signs of lung cancer. The…

This study is testing whether low-dose CT scans can help find lung cancer early in people at high risk. About 20,000 adults aged 50-74 who are current or former heavy smokers will get a CT scan at the start, then again after 1 and 3 years. The goal is to see how many lung cancers…

The NIMBLE study is testing whether blood-based biomarkers can accurately distinguish between cancerous and non-cancerous lung nodules. Researchers will analyze blood samples from 1,800 patients referred with a lung nodule, looking at protein markers, epigenetic smoking markers, …

This study tests an FDA-approved AI software that analyzes CT scans of lung nodules to estimate cancer risk. 300 adults aged 35-89 with newly found lung nodules will be randomly assigned to have their doctors use the AI tool or not. The goal is to see if the AI helps doctors mana…

This study is testing a new type of PET scan that uses special radioactive tracers to find and map solid tumors in the body. The tracers target a protein called Trop2, which is often found on cancer cells. Researchers will enroll 400 people with various cancers (including bladder…

This Phase 3 trial tests a fluorescent dye called abenacianine that makes lung cancer cells glow under a special camera during surgery. About 132 people having lung cancer surgery will receive the dye. The goal is to see if the dye helps surgeons find tumors that are hard to see …

This study compares two ways to take tissue samples from small lung spots found during screening. One method uses standard forceps, the other uses a freezing probe (cryo biopsy) to get larger samples. The goal is to see if cryo biopsies give a clearer diagnosis with fewer complic…

This study is testing whether combining low-dose CT scans with blood-based biomarker tests can improve lung cancer screening in high-risk people. It will enroll 1,000 participants in Singapore, including both smokers and non-smokers. The goal is to see if this approach is practic…

This study tests an AI tool that looks at routine chest X-rays and medical records to find people at high risk for lung cancer. The AI alerts their doctor to discuss lung cancer screening. The goal is to see if this alert helps more high-risk people get a lung cancer screening CT…

This study is looking for biomarkers—clues in the body—that could help find lung cancer early. Over 3,600 participants, including people at high and low risk for lung cancer, will provide samples and undergo CT scans. The goal is to see if these biomarkers can spot tumors before …

This study is testing whether a minimally invasive procedure called EBUS-TBNA is more accurate than standard CT/PET scans for checking if lung cancer has spread to lymph nodes in the chest. The goal is to better select patients for a precise type of radiation therapy (SBRT). Abou…

This study tests whether giving emergency department patients who are at high risk for lung cancer a direct referral to a screening program, plus text message reminders, increases the number who get screened. About 300 eligible adults will be randomly assigned to either basic inf…

This study is testing a new radioactive imaging agent that targets a protein called LRRC15, found on many cancer cells. Researchers will use PET scans to see if this agent can better detect and stage cancers like pancreatic, breast, lung, and others. The trial includes 26 healthy…

This study aims to see if analyzing DNA from fluid left over after a lung nodule biopsy can better detect cancer. About 60 adults with small lung nodules (20 mm or less) will have a standard bronchoscopy, and the leftover fluid will be tested for cancer-related DNA changes. If su…

This study looks at whether offering lung cancer screening through telehealth (phone or video visits) can help more high-risk people get tested. Researchers will identify eligible smokers aged 50-80, confirm their eligibility by phone, and schedule either an in-person or teleheal…

This study compares standard bronchoscopy (using a thin tube to look at the lungs) with and without an additional laser-based microscope called nCLE. The microscope helps doctors see if the sampling needle is in the right spot before taking tissue. About 208 adults with suspiciou…

This study is testing whether an artificial intelligence (AI) blood test and risk model can help find lung cancer early in people at high risk. Researchers will enroll 400 adults aged 50-80 who smoke or recently quit. Some will get the AI blood test, others an AI analysis of thei…

This early-stage trial is testing a new radioactive tracer called 68Ga-FXX489 (NNS309) for PET/CT scans. The goal is to see if it can safely and accurately detect tumors and their spread in 30 adults with suspected cancer. Researchers will measure how the tracer moves through the…

This study is testing whether certain biomarkers in blood and lung tissue can help doctors tell if a lung nodule is cancer, predict the risk of cancer coming back after surgery, and monitor for late recurrence. Researchers will follow 250 people with suspicious lung nodules or re…

This study tests whether adding a freezing biopsy (cryobiopsy) to the standard needle biopsy improves diagnosis of lung cancer that has spread to the chest. About 240 adults with suspicious chest lymph nodes will get both procedures. The goal is to see if the combo finds cancer m…

This study is testing whether an artificial intelligence program can help detect lung cancer early in non-smokers aged 50 to 75 who have a close family member with lung cancer. About 3,000 participants will get a low-dose CT scan of their chest, and the AI will analyze the images…

This study is testing whether an artificial intelligence (AI) system can accurately identify different types of lung cancer by analyzing PET/CT scans and patient information like age, smoking history, and tumor markers. Researchers aim to improve how doctors distinguish between s…

This early-phase study is testing a new imaging agent called [68Ga]CBP8 to see if it can safely and accurately detect collagen buildup (scarring) in the lungs. Researchers will compare scans from healthy volunteers, lung cancer patients, and people with pulmonary fibrosis. The go…

This early-phase study is testing a new radioactive tracer for PET scans that may better detect non-small cell lung cancer that has spread to the brain. About 20 adults with this type of lung cancer and brain metastases will receive the tracer and undergo imaging. The goal is to …

This study tests a special PET probe called [68Ga]CBP8 to see if it can detect tissue damage caused by radiation therapy in people with lung or pancreatic cancer. About 72 participants will get a PET scan before and 3-6 months after radiation. The goal is to find early signs of r…

This study is testing two new diagnostic kits that use blood samples or tumor tissue to predict if early-stage lung cancer will come back after surgery. Researchers will enroll 236 people with stage IA to IIIA lung cancer who have had their tumor fully removed. The goal is to see…

This study looks at whether a quick swallowing test done by a physical therapist can reliably detect vocal cord paralysis after major lung cancer surgery, compared to the standard scope exam. About 72 adults having lung surgery will take a swallowing test and a scope test right a…

This study is testing whether a breath test can detect lung cancer early in people at high risk. Researchers will collect breath samples from 3,200 current or former smokers aged 55-74 and compare the results to standard low-dose CT scans. If the breath test works well, it could …

This study is testing a new blood test that uses NMR technology to spot lung inflammation caused by immunotherapy drugs. The goal is to catch this serious side effect early, so doctors can treat it quickly. The study will include 60 people with lung cancer who are on immunotherap…

This study is testing a new way to screen for early lung cancer using a combination of breath analysis, blood tests, and CT scans. Researchers aim to reduce the high rate of false positives from CT scans alone. They will enroll 1,800 participants, including people with lung cance…

This study looks at whether people with unexplained weight loss who are at high risk for lung cancer are more likely to develop the disease. Researchers will use low-dose CT scans and blood tests to screen 409 participants over one year. The goal is to see if adding weight loss t…

This study is testing whether a blood test (liquid biopsy) can be used as a first step to screen for lung cancer in high-risk people, before deciding if they need a low-dose CT scan. The goal is to reduce unnecessary scans, radiation exposure, and healthcare costs. The study will…

This study uses mobile low-dose CT scans to screen for lung cancer in people aged 40-54 who have a heavy smoking history (30 pack-years or more). Participants in North and South Carolina will get up to three scans over time. The goal is to see if screening younger high-risk smoke…

This study is testing a blood test that looks for DNA signals from 20 different cancers, including lung, breast, and colon cancer. Researchers will see if the test can find cancer early, detect any cancer left after treatment, and catch a relapse before it shows up on scans. The …

This study tests a new radioactive probe called 68Ga-PFA2 for PET scans. It targets a protein called annexin A2, which is found at high levels in many cancers and helps them spread. Researchers want to see if this probe can find metastases in lung cancer patients better than curr…

This study will give yearly low-dose CT scans to 1,000 people in Mexico who are at high risk for lung cancer—including heavy smokers, former smokers, and those exposed to wood smoke. The goal is to see if regular screening can find lung cancer at an earlier, more treatable stage.…

This observational study is testing whether a breath test can accurately tell the difference between benign and malignant lung nodules. Researchers will analyze volatile organic compounds (VOCs) in the exhaled breath of 3,000 people with lung nodules. The goal is to develop an AI…

This pilot study is testing whether it's practical to add an abdominal CT scan to the standard lung cancer screening for people aged 55-70 who have smoked. The goal is to see if this extra scan can detect kidney cancer, abdominal aortic aneurysms, and kidney stones without slowin…

This study is testing a new imaging technique called full-field optical coherence tomography (FFOCT) to examine small lung biopsy samples taken during bronchoscopy. Researchers want to see if FFOCT can provide results that match standard lab analysis, potentially allowing faster …

This study is testing a new blood test that looks for pieces of tumor DNA (EGFR mutations) to screen for lung cancer in healthy people aged 50-80 who are of East Asian, Southeast Asian, or Hispanic/Latinx background and do not currently smoke. The goal is to find lung cancer earl…

This study tests whether synthetic PET images, created from standard CT scans using artificial intelligence, can accurately diagnose and guide treatment for lung cancer. Researchers will enroll 10,000 people with non-small cell lung cancer to see if this new method matches the qu…

This study will test a method that combines microwave ablation (using heat to destroy lung nodules) with a biopsy (taking a tissue sample) to diagnose ground-glass lung cancer. Researchers plan to enroll 200 people with small lung nodules who cannot or choose not to have surgery.…

This study is testing a new blood test called Nu.Q to see if it can accurately tell the difference between harmless and cancerous lung nodules. Researchers will collect blood from 500 people who have lung nodules found on CT scans and compare the test results with the final diagn…

This study tests whether injecting a near-infrared dye called indocyanine green (ICG) around a lung tumor can help surgeons see the tumor and the first lymph node it drains to during surgery. About 100 adults having lung surgery will receive the dye, and a special camera will det…

This study will give low-dose CT scans to over 6,600 people in Taiwan who are at high risk for lung cancer due to heavy smoking, family history, or environmental exposures like air pollution. The goal is to see how many people agree to screening and how many lung cancers are foun…

Lung cancer is the top cancer killer of Veterans, often found too late to cure. This trial tests whether giving doctors personalized prediction tools and dashboards can increase lung cancer screening rates among 23,520 high-risk Veterans. The goal is to catch cancer earlier and r…

This study tests whether combining electroacupuncture (a type of acupuncture with mild electric pulses) with a standard nausea drug can prevent vomiting after lung cancer surgery. The trial will include 204 high-risk patients undergoing thoracoscopic surgery. The main goal is to …

This trial tests whether sending text message reminders encourages more high-risk adults to complete a lung cancer screening CT scan. Researchers will enroll 27,000 people aged 50-77 who smoke or recently quit, focusing on minority and rural communities. The goal is to see if sim…

This phase 2 trial tests whether riluzole, a drug already approved for ALS, can prevent the cognitive problems (often called 'chemo brain') that many cancer patients face during chemotherapy. The study will enroll 24 adults with various cancers who are about to start chemotherapy…

This study tests a new centralized screening unit at Montefiore-Einstein to help more people in the Bronx get screened for lung cancer. The unit will identify eligible smokers, educate them, and guide them through the screening process. Researchers hope this will lead to earlier …

This study looks at whether smokers aged 50-74 are more likely to get a low-dose CT scan for lung cancer when their family doctor recommends it. Researchers will track how many people complete the scan within one year. The goal is to catch lung cancer early in high-risk smokers.

This study tests whether cancer patients can complete a supervised exercise program from home using video calls. The program includes resistance training with dumbbells and aerobic exercise. Researchers want to see if this approach is practical and helps patients maintain functio…

This study tests whether acupuncture at specific points before and after lung cancer surgery can improve sleep and reduce long-term pain. About 316 patients will receive either real or sham acupuncture alongside standard care. The goal is to see if this simple, low-risk treatment…

This study tests whether a therapy called Meaning-Centered Psychotherapy for Latinos (MCP-L) can help reduce anxiety and depression in 300 Latino patients with advanced cancer. Participants receive either MCP-L or standard cognitive behavioral therapy over about 3 months. The goa…

This Phase 2 trial tests a drug called ASCA101 in 135 adults with solid tumors (colorectal, ovarian, or lung cancer) who have cachexia—a condition causing severe weight loss and muscle wasting. Participants receive either ASCA101, an active control (Megace), or a placebo for 12 w…

This study tests a navigation program for cancer patients starting immunotherapy. The program helps with essential needs like food, transportation, and housing, and tracks side effects. Researchers want to see if this support helps patients continue their treatment and improves t…

This study tests a program called ICCAN that gives cancer patients extra help with social and economic needs, like finding resources and monthly check-ins. Researchers want to see if this support helps patients complete their cancer treatment and improves their quality of life, c…

This study tests whether a telehealth education program, called Surgery School, helps people prepare for lung or major abdominal cancer surgery. Participants will watch videos and talk with a clinician online before their operation. The goal is to see if this reduces breathing pr…

This study tests a program to help long-term lung cancer survivors feel more socially connected and improve their quality of life. Thirty survivors will be randomly assigned to either the program or a comparison group. The program uses techniques from cognitive behavioral therapy…

This study tests whether a 20-minute exercise session on a stationary bike, done right before each radiotherapy treatment, is practical and safe for people with stage I-III non-small cell lung cancer. About 30 participants will try the program, and researchers will track how many…

This study tests whether a combination of two drugs, fosrolapitant and palonosetron, plus a steroid, can prevent nausea and vomiting caused by chemotherapy and immunotherapy in people with esophageal or lung cancer. About 120 participants will receive the drug before each chemo c…

This study tests whether doing breathing exercises at home can help reduce heart and lung side effects in people being treated for breast, head/neck, or lung cancer. The exercises are designed to strengthen breathing muscles and may be easier than regular aerobic exercise for pat…

This study tests whether adding acupuncture and acupressure to standard anti-nausea medicine can better reduce chemotherapy-induced nausea. About 90 cancer patients with ongoing nausea will be split into two groups: one gets the extra acupuncture, the other gets medicine alone. T…

This study tests whether wearing a virtual reality (VR) headset during daily radiation therapy can help manage anxiety in people with prostate, breast, lung, or head and neck cancer. About 54 patients will use a Meta Quest 2 headset during their treatments, and researchers will t…

This study tests a new way to plan radiation therapy for people with stage 3 lung cancer. The method uses CT ventilation imaging to identify and avoid the healthiest parts of the lungs during treatment. Researchers want to see if this approach helps patients maintain a better qua…

This study tests whether an artificial intelligence (AI) system can improve recovery after lung cancer surgery. About 868 patients from 20 hospitals will be randomly assigned to either standard care or standard care plus an AI tool that tracks symptoms, activity, and recovery pro…

This study tests a personalized self-management program to help cancer survivors on immune checkpoint inhibitors better handle side effects and reduce anxiety or depression. About 400 adults with breast, colon, lung, skin, or rectal cancer who recently started immunotherapy will …

This pilot study tests whether brodalumab, a drug used for autoimmune conditions like psoriasis, can safely reduce immune-related side effects caused by cancer immunotherapy. About 11 adults with advanced solid tumors who developed these side effects will receive brodalumab injec…

This study tests a brief program called Pathways, designed to help people with advanced lung cancer set personal goals and improve their mental health and quality of life during treatment. About 234 participants will be randomly assigned to receive either the Pathways program or …

This study tests whether a tablet-based video program can help rural cancer patients better understand their care and feel more coordinated. About 40 adults with early-stage breast, lung, or colon cancer living in rural Vermont will be randomly assigned to receive the videos righ…

This study explores whether a couple-based meditation program can improve quality of life for people with stage IV lung cancer and their romantic partners. Researchers will enroll 300 couples to attend meditation sessions and complete questionnaires about their health, mood, and …

This study looks at whether 12 weeks of different exercise programs can help people with advanced lung cancer who are already receiving immunotherapy. The goal is to see if exercise is safe and doable, and if it can improve immune markers. About 30 adults with non-small cell lung…

This study tests whether using an incentive spirometer—a device that encourages deep breathing—can lower the risk of lung inflammation (pneumonitis) in people with advanced lung cancer receiving chemotherapy and radiation. About 100 participants will use the device 10 times every…

This study looks at whether pulmonary rehabilitation—a program of exercise and breathing techniques—can improve breathing, fatigue, and quality of life for people with advanced non-small cell lung cancer. Half of the 85 participants will do an 8-week rehab program, while the othe…

This study is testing a jelly-based nutritional supplement in 52 people with head and neck, lung, or rectal cancer who are receiving standard cancer treatments like chemo or radiation. The supplement contains ingredients like arginine, omega-3, and olive oil, and is taken twice d…

This study compares a long-acting painkiller (liposomal bupivacaine) to a standard one (bupivacaine hydrochloride) for numbing nerves between the ribs during lung surgery. About 210 adults having keyhole lung surgery will be randomly assigned to one of three groups: the long-acti…

This study tests a short, pre-surgery rehab program for people who smoke and have a lung nodule that may be cancer. About 20 participants will do breathing exercises and get help to stop smoking. The goal is to see if this program is practical and can improve fitness, reduce symp…

This study compares two ultrasound-guided nerve blocks—rhomboid intercostal block and erector spinae plane block—for pain control after lung cancer surgery. Sixty adults undergoing thoracotomy will receive one of the two blocks with bupivacaine. Researchers will measure morphine …

This study tests two different ways to numb nerves around the chest to control pain after lung cancer surgery. Sixty adults having lung cancer surgery will be randomly assigned to one of two nerve block techniques. The goal is to see which method provides better pain relief durin…

This study tests whether spiritual care sessions can improve spiritual wellbeing, reduce anxiety and depression, and increase satisfaction with care for people with stage IV lung or gastrointestinal cancer. About 36 adults will be randomly assigned to receive either spiritual car…

This study tests whether N-acetyl cysteine (NAC) and a short course of steroids can reduce severe shortness of breath after lung radiation in people with both lung cancer and interstitial lung disease. About 98 participants will receive either NAC or placebo, plus either steroids…

This study tests whether telephone-based physical activity coaching can improve physical function in adults aged 65 and older who are having lung cancer surgery, as well as their family caregivers. Participants will either receive regular coaching calls or track their own activit…

This study looks at whether a 6-month home exercise and nutrition program can improve thinking and physical abilities in cancer survivors aged 65 and older, along with their support person. About 1,500 participants will be assigned to either a virtually supervised or unsupervised…

This study tests two types of nerve blocks to see which one better prevents shoulder pain after lung surgery. 75 adults with lung cancer scheduled for open-lung surgery will receive either an interscalene block, an anterior suprascapular block, or standard epidural pain relief. T…

This study tests a special program designed to help people living in rural areas who have had lung cancer. The program focuses on improving quality of life, reducing stigma, and helping survivors stay engaged with their healthcare. About 300 participants will be randomly assigned…

This study is testing a program called MyCarePulse and ASCENT to help cancer patients overcome food-related challenges. About 100 adults recently diagnosed with certain cancers will either receive the program or standard care. The goal is to see if the program improves food secur…

This study tests whether combining virtual reality with pleasant smells can lower pain and anxiety in people recovering from heart or lung surgery. About 80 adults scheduled for cardiothoracic surgery will either receive the VR-and-scent therapy or standard care. The goal is to s…

This study tests a six-week program of morning bright light exposure combined with moderate walking for people with lung or esophageal cancer. The goal is to see if it can improve sleep-wake rhythms, reduce physical and emotional symptoms, and boost quality of life. Two hundred p…

This study is testing a stress management program designed for people with lung cancer who are waiting for routine scan results. The program includes a short orientation, self-guided web modules with stress management exercises, and coaching calls. Researchers want to see if the …

This study tests a program for older adults (65+) with cancer and mild memory issues, along with their spouse or caregiver. Over six video sessions, the pair learns strategies to manage challenges. The goal is to see if the program reduces distress and improves quality of life. A…

This study tests a program called CARES that provides nurse navigators and counselors to rural cancer patients. The goal is to see if this support helps patients start and finish treatment more quickly and improves their quality of care. About 320 adults with solid tumors like lu…

This study tests whether injecting a patient's own blood into the lung lining (a pleural blood patch) can prevent air leaks after thermal ablation for lung cancer. About 106 adults scheduled for lung ablation will be randomly assigned to receive the blood patch or not. The main g…

This study tests whether a special breathing exercise program can improve oxygen use, balance, and physical activity in people who have had lung cancer surgery. Forty adults aged 18-80 who are in remission will do breathing training with a device for 4 weeks, then add functional …

This study tests two different nerve blocks to control pain after lung cancer surgery. 70 adults will receive either a costotransverse foramen block or a thoracic paravertebral block, both using the numbing drug bupivacaine. The goal is to see which block reduces the need for mor…

This study tests a home-based telerehabilitation program for veterans who have completed treatment for early-stage lung cancer. The program lets participants choose from exercises to reduce shortness of breath, fatigue, or anxiety. Researchers hope to improve quality of life and …

This study tests whether adding intravenous vitamin C to standard chemotherapy can improve quality of life for people with advanced non-small cell lung cancer. About 90 adults with incurable lung cancer will receive either vitamin C or a placebo alongside their usual treatment. T…

This study tests whether training emergency room doctors in palliative care can improve quality of life for patients with advanced lung or gastrointestinal cancer. About 200 participants will be split into two groups: one gets standard ER care, the other gets care from a doctor t…

This study tests whether a nurse-led program that includes regular symptom check-ins, guidance, and exercise can improve survival and quality of life for 250 vulnerable lung cancer patients. Participants will be randomly assigned to receive this extra support or standard care. Th…

This study aims to create a brief behavioral intervention for older adults (60+) with lung cancer, addressing aging-specific concerns like depression, anxiety, pain, and shortness of breath. In the first phase, patients, caregivers, and providers give feedback on the program. In …

This study looks at whether using a high-flow nasal cannula (a special oxygen device) during a lung cancer procedure called EBUS bronchoscopy can reduce breathing problems and procedure interruptions. About 198 adults having this procedure will be randomly assigned to receive eit…

This study tests whether adding daily cycling to standard physical therapy helps people recover faster after minimally invasive lung cancer surgery. 184 participants will be randomly assigned to either standard rehab or standard rehab plus 20 minutes of stationary cycling. The ma…

This study tests whether transcutaneous acupoint electrical stimulation (TAES) can improve chronic cough in 84 people who had lung cancer surgery. TAES delivers mild electrical pulses to acupuncture points on the skin, aiming to mimic acupuncture without needles. Researchers will…

This study aims to collect tumor, normal tissue, and blood samples from up to 1559 people with cancers of the lung, esophagus, or pleura. Researchers will analyze genetic and epigenetic changes to better understand these diseases and identify potential markers for future treatmen…

This study is looking for genetic clues that might tell doctors whether immunotherapy will work well before lung cancer surgery. Researchers will collect blood and tumor samples from 100 people with stage II-IIIB non-small cell lung cancer. They will test for two types of genetic…

This study is observing how well the Ion endoluminal system, a robotic tool, works for lung nodule biopsies and localization in everyday medical practice across Europe. Researchers will track 1,200 adults to see how often the tool correctly diagnoses lung nodules and how often co…

This study is testing a web-based tool called CARE that gives cancer patients information about treatment costs, health insurance, and financial resources. About 430 adults with gynecologic, prostate, lung, or colorectal cancer will use the tool to see if it helps them feel more …

This study collects blood and tumor tissue samples from people with head and neck or lung cancers to find biological markers that indicate low oxygen levels within tumors. Low-oxygen tumors tend to be more aggressive and resistant to standard treatments like radiation and chemoth…

This study is building a huge registry of information and biological samples from adults with or at risk for many types of cancer, as well as healthy volunteers. Researchers will use this resource to study what causes cancer and how to better prevent, detect, and treat it. The re…

This study watches for heart changes in 150 adults receiving chest radiation for lung, esophageal, breast, or thymus cancer. Researchers will check heart markers, electrical activity, and immune cells at the end of treatment and up to 3 months later. The goal is to find early sig…

This study aims to collect blood, urine, tumor samples, and health data from up to 1,000 people with malignant mesothelioma or other cancers that express a protein called mesothelin. Participants will be followed over time to track the course of their disease. The goal is to buil…

This study is collecting tumor tissue and blood samples from 800 people with lung cancer to look for changes in a gene pathway called EGFR. The goal is to better understand the DNA mutations that drive the disease. No new treatment is being tested; instead, researchers hope to id…

This study aims to safely collect health information like heart rate and activity levels from cancer patients using devices like smartphones and wearables. Researchers will use this data to learn more about how it relates to cancer diagnosis, treatment response, and risk factors.…

This study is collecting detailed genetic and health information from 500 people with various cancers, including breast, lung, and leukemia. The goal is to create a shared database that helps researchers develop more personalized treatments. Participants provide samples and data,…

This study screens adults with certain cancers (like melanoma, lung, or colorectal cancer) to see if they qualify for experimental treatments being tested by the NCI Surgery Branch. These treatments involve taking a patient's own immune cells, growing them in a lab, and giving th…

This study is a registry that gathers information from 250 people with lung cancer or cancer that has spread to the lungs. Participants will have their tumors treated with a robotic scope inserted through the mouth to burn the tumor. The goal is to learn how well this procedure w…

This study is looking at whether low-dose CT scans can find lung cancer early in people who have a parent, sibling, or child with lung cancer. The study includes 1,520 people aged 50 to 75, both smokers and non-smokers. Researchers want to see how many cases of lung cancer are fo…

This study is testing whether a special MRI scan using an inhaled gas called hyperpolarized xenon-129 can help doctors identify and predict lung damage caused by radiation therapy in lung cancer patients. The gas is breathed in instead of being injected like a typical contrast dy…

This study looks at how different lung cancer screening habits (like too much, too little, or just right) affect whether the cancer is caught early. About 5,390 newly diagnosed lung cancer patients will share their medical history and screening records. The goal is to find the be…

This study aims to collect and analyze tumor samples from 10,000 adults with advanced solid cancers (like breast, lung, or colon cancer) to create a province-wide gene database. The goal is to help doctors identify which targeted drugs or clinical trials might work best for each …

This study provides long-term follow-up for people who previously received gene therapy or other immunotherapy for cancers like prostate, liver, breast, colon, or lung cancer. Participants will have annual health check-ups or phone calls for up to 15 years to monitor for any long…

This study is a registry that will follow 600 people with early-stage lung cancer who undergo a surgery called segmentectomy. Participants will fill out questionnaires about their health before surgery, shortly after, and six months later. The goal is to measure how long people l…

This study collects blood and other biospecimens from adults with cancer to analyze immune-suppressing cells and genetic changes. Up to 1,750 participants will provide samples before and after chemotherapy. The goal is to better understand how cancer affects the immune system, bu…

This study is testing whether a patient navigation program can increase the number of people who complete lung cancer screening. The study will enroll 675 Black or African-American adults who are at high risk for lung cancer due to smoking history. Participants will receive guida…

This study gathers information from the medical records of 75,000 adults treated for lung cancer at 38 French hospitals. Researchers will look at patient details, tumor types, and treatments given over time. The goal is to understand how care has evolved and what outcomes patient…

This study looks at whether lung ultrasound can detect emphysema (a type of lung damage) as well as CT scans do. About 1,600 people with or without emphysema will get both an ultrasound and a CT scan. The goal is to find patterns on ultrasound that match the damage seen on CT, wh…

This study will review health records of 60,000 adults with lung cancer in Alberta and Ontario to understand current treatments, survival rates, and healthcare costs. It aims to describe real-world patterns rather than test a new treatment. No direct benefit to participants, but …

This study is building a large collection of blood, tumor tissue, and fecal samples from 500 people with lung cancer. Researchers will track how patients respond to standard treatments and look for biological clues that predict success or failure. The goal is to better understand…

This study is testing a new technology that uses x-rays to track lung tumors during radiation therapy, without needing to implant markers in the lung. About 30 people with early-stage lung cancer or a few lung metastases will take part. The goal is to see if the markerless tracki…

This pilot study tests whether using CT ventilation imaging can more accurately predict lung function after lung cancer surgery compared to the standard method. Researchers will compare predictions from CT scans with actual lung function tests in 15 surgical candidates. If succes…

This study tests a new tool called TRTRM that predicts which older cancer patients are at high risk for severe side effects from treatment. Researchers will use the tool to adjust drug doses and monitoring for patients aged 65 and older with solid tumors. The goal is to see if th…

This study looks at whether a campaign called Pink & Pearl can increase lung cancer screening among women who are already getting mammograms. Researchers will track how many eligible women get screened and what factors help or hinder the process. About 279 women aged 50-80 with a…

This study tests a new type of CT scan that pauses during irregular breathing to get clearer images for lung cancer radiation planning. It involves 30 adults with lung cancer who will receive one extra scan during their usual treatment simulation. The goal is to see if this metho…

Cancer patients face a higher risk of blood clots during chemotherapy, but it's hard to know who is most at risk. This study will measure clotting-related biomarkers in the blood of 380 patients with ovarian, lung, stomach, or pancreatic cancer at four points during their treatme…

This study tests a new way to predict how well your lungs will work after lung cancer surgery. Doctors will use 3D CT scans to create a virtual model of your lungs and simulate the surgery beforehand. The goal is to see if this method is more accurate than current techniques, hel…

This study enrolls 7,000 people with various cancers who have had or will have treatment aimed at a cure. Researchers collect blood, tissue, urine, and saliva samples over time to look for tiny bits of cancer DNA left behind. The goal is to find any remaining cancer as early as p…

This study is for people with advanced cancers who are taking long-term targeted treatments. Researchers want to learn about their experiences through interviews. The goal is to find better ways to support these patients. The study is currently recruiting 75 participants.

This study looks at whether a small sample taken from lung cancer patients during a routine biopsy (called EBUS-TBNA) can be used to analyze genes that predict how well treatments like chemotherapy or surgery might work. Researchers plan to enroll 400 adults with confirmed or sus…

This study is testing a new imaging method called 4D-MRI that creates 3D movies of the lungs and liver as a person breathes. The goal is to help doctors better track tumor movement during radiation therapy, making treatment more precise. Researchers will test this in healthy volu…

This study is testing whether a quick, non-invasive test that measures heart rate and breathing patterns before thoracic surgery can help predict which patients are more likely to have complications after the operation. Researchers will enroll 130 adults undergoing major chest su…

This study aims to develop a better way to image lung tumors using MRI and a natural, slightly modified sugar solution. Researchers will look at how tumors burn sugar for fuel by analyzing tumor samples after surgery. The goal is to understand the metabolic pathways of lung cance…

This study is testing whether tiny particles in the blood, called extracellular vesicles, can predict nerve damage caused by chemotherapy. Researchers will follow 120 adults with various cancers who are receiving specific chemo drugs. Participants give blood samples and answer qu…

This study looks at how often lung cancer patients on immune checkpoint inhibitors develop blood clots (in veins or arteries) and what factors increase that risk. Researchers will follow 2,400 adults with lung cancer who are starting immunotherapy, comparing those who get clots w…

This study collects blood, urine, sputum, and lung tissue from 4,000 adults at high risk for lung cancer. Researchers analyze these samples to find DNA changes and other markers that could signal cancer early. The goal is to better understand how lung cancer develops and to find …

This study looks at how adults aged 70 and older with non-small cell lung cancer are treated in everyday medical practice. Researchers will track 500 participants to understand which treatments work best, how safe they are, and how they affect quality of life. The goal is to gath…

This study is creating a large database of 10,000 lung cancer patients who received radiation therapy. Researchers will collect information on tumor control, side effects, and quality of life to build models that predict outcomes. The goal is to use these models to select the bes…

This study looks at whether DNA from blood, sputum, lung fluid, and breath can help find genetic changes in non-small cell lung cancer. Researchers will collect samples from 210 patients before and after surgery, then follow them for 24 months to check for cancer return. The goal…

This study is gathering information from 10,000 people with lung cancer or other chest tumors. Researchers want to learn more about the disease, how it is treated, and what affects a person's outlook. No new treatments are being tested—the goal is to collect data to help improve …

This study looks at CT scans from 2,000 people to see if computer models can better predict how lung cancer will respond to treatment. Researchers will review past patient records and data from a national screening trial. The goal is to improve screening and treatment decisions f…

This study collects tumor samples from 150 lung cancer patients to grow miniature versions called organoids in the lab. Researchers will test how these organoids respond to chemotherapy and targeted drugs, and compare that to how the patient's actual tumor responds. They will als…

This study enrolls 75 lung cancer patients under age 50 to see if a dedicated care program improves their satisfaction and well-being. Participants fill out surveys over five years about their needs, quality of life, and experience with peer support. The goal is to understand wha…

This study collects blood or cheek swab samples from 1,100 cancer patients at the National Cancer Institute to analyze genetic differences that may influence how their bodies process cancer treatments. The goal is to understand why some patients experience more side effects or le…

This study compares two types of minimally invasive lung cancer surgery: robotic-assisted (RATS) and video-assisted (VATS). It will follow 512 patients across Europe to see which technique leads to better quality of life and recovery. The goal is to help surgeons and patients mak…

This study follows 110 adults with head and neck, lung, or rectal cancer to see how their nutrition and body composition change during standard cancer treatments. Researchers will measure food intake, muscle mass, and strength over time. The goal is to gather data that could late…

This study tests whether a large language model (AI) can help junior doctors write more accurate and efficient cancer treatment reports. Forty doctors will be split into two groups: one using AI assistance, the other using traditional methods. The reports will be scored by expert…

This study tests a personalized 'open lung' breathing method during lung cancer surgery to see if it prevents low oxygen levels better than standard care. The method adjusts air pressure based on each patient's lung stiffness. 120 adults scheduled for lung cancer removal will be …

This study will analyze the genes of 25,000 adults who have cancer or are at risk for it. Researchers will use advanced testing to find genetic changes linked to cancer and track health records over time. The goal is to learn more about cancer biology and discover new ways to per…

This study is collecting data from 180 lung cancer patients to understand their nutritional and metabolic status. Researchers will analyze factors like genetics and gut bacteria to create a model that can recommend personalized diets. The goal is to improve quality of life and ou…

This study tests whether a special training program can help cancer doctors communicate more empathetically with lung cancer patients. Many lung cancer patients feel judged or stigmatized during medical visits, which can harm their well-being and care. The training teaches doctor…

This study is building a large collection of blood, urine, saliva, and other samples from 3000 people with lung nodules or lung cancer. Researchers hope to find biological markers that can help diagnose lung cancer earlier, predict how the disease will progress, and guide treatme…

This study tests a standardized technique for finding lymph nodes in lung tissue removed during surgery. Researchers want to see if this method finds more nodes and improves cancer staging. About 160 adults with lung cancer who are having a lobectomy will take part. The goal is t…

This observational study tracks 500 lung cancer patients receiving a second round of high-dose radiation to the chest. Researchers will collect data on side effects and survival to find safer ways to deliver repeat radiation. The goal is to help doctors personalize treatment and …

This study is a large registry that will follow about 8,000 cancer patients who receive radiation therapy using a special machine called an MR-Linac, which combines an MRI scanner with a radiation beam. The goal is to learn how well this technology works for different cancers, in…

This study looks at different types of neutrophils (a kind of immune cell) in the blood of people with lung cancer. Researchers want to see if certain neutrophil types are linked to tumor growth and resistance to immunotherapy. They will compare blood samples from 100 lung cancer…

This study aims to collect health information from 12,000 adults with lung or other chest cancers. Researchers want to understand why some people respond better to treatment than others, even when their cancer stage is the same. By gathering data from routine care, they hope to i…

This study tests three different methods of numbing the chest (paravertebral block) to see which provides the best pain relief after video-assisted lung surgery. Researchers will check how much sensation is lost in the chest area using ice and a special filament. The goal is to f…

This study aims to see if low-dose CT scans are a good way to screen for lung cancer in Black individuals aged 50-80 who have smoked. Researchers will enroll 900 participants to check how many people join the study and how well the scans find cancer. The goal is to improve early …

This study looks at whether a campaign called Pink & Pearl can help more women get screened for lung cancer. About 5,500 women aged 50-80 who get mammograms at Christian Hospital will take part. Researchers will track how many complete lung cancer screening and how long it takes,…

This study is gathering information from 25 adults with breast, lung, ovarian, multiple myeloma, or acute myeloid leukemia who are on active treatment. Participants fill out a short online survey each week for at least 12 weeks to report how they are feeling. The goal is to build…

This study is testing whether a blood test that looks for tumor DNA (ctDNA) can find cancer returning earlier than standard scans. About 100 people with different solid tumors will give blood samples after treatment. The goal is to see if early detection can lead to better treatm…

This study looks at tumor samples from 500 adults with lung or other chest cancers to find out why some treatments stop working. Researchers will study genetic changes in the cancer cells. The goal is to learn how to better choose the next treatment for each person.

This study is testing whether a monthly blood test can predict dangerous blood clots in people with certain cancers (lung, pancreatic, stomach, or brain). Cancer patients are at high risk for clots, which can be deadly. Researchers will follow 200 participants for 12 months, taki…

This study is creating a risk prediction model for lung cancer in people who have never smoked. Researchers will enroll 10,000 participants aged 50-80 with a family history of lung cancer. They will collect data from questionnaires, blood tests for autoantibodies and genetic mark…

This study collects samples and health information from 2,000 people with lung nodules to find the best way to detect lung cancer early. Participants must have a nodule at least 5mm wide and plan to have a biopsy, PET scan, or follow-up within 7 months. The goal is to improve how…

This study tests a new way to increase lung cancer screening in people at high risk. Researchers will use the emergency department to identify eligible patients and offer them extra help to get a low-dose CT scan. The goal is to see if this approach works better than standard car…

This study compares two ways to take tissue samples from lung cancer patients: standard needle biopsy (EBUS-TBNA) and a newer freezing technique (cryobiopsy). The goal is to see which method provides enough tissue for genetic testing, which helps doctors choose the best treatment…

This study is testing a decision aid to help people decide whether to get screened for lung cancer. The tool is designed for patients in a safety-net healthcare system. Researchers will enroll 360 current or former smokers aged 50-80 to see if the aid is safe and helpful.

This study looks at ways to encourage homeowners and renters in New Hampshire and Vermont to test their homes for radon, a radioactive gas that can cause lung cancer. In the first phase, participants join focus groups to share their views on radon testing. In the second phase, pa…

This study collects blood and tissue samples from 2,000 people being tested or treated for lung cancer. The samples are stored for future research into earlier detection, better treatments, and prevention strategies. No direct benefit is offered to participants, but the bank coul…

This study collects blood, tumor, and other tissue samples from up to 1,250 people with head and neck, lung, or gastrointestinal cancers. Researchers want to understand how the immune system changes during cancer treatments, especially immunotherapies. Participants donate samples…

This study looks at how common severe fear of cancer recurrence is among people treated for breast or lung cancer. Researchers will survey 200 patients and interview 40 of them to understand their experiences and what kind of support they need. The goal is to find better ways to …

This study is collecting blood and tumor samples from 730 newly diagnosed lung cancer patients at Nantes University Hospital. Researchers will follow patients from diagnosis until death to understand how treatments work in real life, especially for patients often left out of clin…

This study is building a large collection of blood, tissue, and fluid samples from 7,000 people with lung cancer, other chest diseases, or lung transplants. The goal is to help researchers learn more about what causes these diseases, how to find them early, and how to treat them …

This study collects blood and leftover tissue samples from 9,600 people with various cancers, including breast, lung, and pancreatic cancer. Researchers will use these samples to improve tests that look for cancer DNA in the blood. The goal is to better detect if cancer returns o…

This study looks at the best times to send messages that encourage physical activity to older cancer survivors (65+) who have chronic pain. About 50 participants will wear an activity tracker and rate their pain four times a day using a smartphone app. The goal is to see if certa…

This study aims to develop a simple, non-invasive way to detect lung diseases like cancer, asthma, and COPD by analyzing DNA and proteins from cough samples. Researchers will collect cough specimens from 2000 adults, including smokers and non-smokers, and compare them to samples …

This study looks at whether measuring a patient's energy reserve (fitness) before major cancer surgery can help predict how well they recover. Researchers will use a special exercise test to measure gas exchange and see if it relates to complications after surgery. The goal is to…

This study tests whether special MRI scans with xenon gas can show which parts of the lung work best. Doctors then aim to aim radiation away from those healthy areas during lung cancer treatment. The goal is to learn if this approach reduces lung damage and helps breathing. About…

This study looks at 400 lung cancer patients who had chemotherapy or immunotherapy before surgery. Researchers compare two surgical techniques: minimally invasive (using small cuts and a camera) versus traditional open chest surgery. The goal is to see which approach leads to bet…

This study creates a registry of 1500 lung cancer patients to track their health over 10 years. Researchers will collect information on survival, how the disease changes, and how well treatments work in real life. The goal is to learn more about lung cancer to improve future care…

This study looks at how a person's fat-free mass (like muscle) affects the dose and side effects of the chemotherapy drug carboplatin in patients with advanced non-small cell lung cancer. Researchers will track 132 patients to see if body composition is linked to toxicity. The go…

Researchers in Mexico are developing a questionnaire to measure how well lung cancer patients follow their respiratory rehabilitation program. The study will enroll 281 adults with lung cancer who are currently in rehab. Participants will fill out a 56-item scale, and the researc…

This study is collecting data from 200 people with advanced lung cancer to build computer models that could predict how well a treatment will work. Researchers will gather information from tumor biopsies, blood and urine samples, and patient questionnaires about quality of life a…

This study is testing a new tool called CANoPy that predicts whether a cancer patient will develop long-term nerve pain. Researchers will follow 625 adults with breast, gynecological, colorectal, or lung cancer as they undergo treatments like chemotherapy or surgery. By collectin…

This study looks at 48 adults with advanced lung cancer who are about to start immunotherapy. Researchers will collect samples from the lungs, stool, and blood before and after treatment to see if certain bacteria are linked to better outcomes. The goal is to understand why some …

This study aims to create a large collection of blood samples from 2,500 people with or at high risk for cancer. Researchers will use these samples to study liquid biopsies, which are blood tests that may help detect cancer, track treatment response, and spot recurrence. Particip…

This study looks at how the bacteria in your gut might influence diarrhea caused by cancer treatments. Researchers will follow 150 adults starting cancer therapy, collecting stool and blood samples to analyze gut microbiome changes. The goal is to better understand why some peopl…

This study is building a large database of blood samples, tumor samples, and scans from 4,000 people with lung cancer. Researchers will follow participants for up to 10 years to collect information that can help future studies. The goal is to better understand lung cancer and imp…

This study tracks 100 cancer survivors aged 18–74 to see how common muscle loss (sarcopenia) and cognitive problems ('chemo brain') are after treatment. Participants undergo physical and mental assessments. The goal is to better understand these long-term side effects and guide p…

This study looks at whether mucus plugs in the airways of COPD patients lead to lung fibrosis (scarring). Researchers will collect lung tissue and mucus from 20 people during lung cancer surgery and compare those with and without COPD. The goal is to understand the link and find …

This study compares two surgical methods for removing small lung nodules (spots) in 200 adults with lung cancer. One method uses a special image-guided marker to help the surgeon find the spot; the other is standard surgery. The goal is to see how long each surgery takes and how …

This study looks at how cancer treatment impacts the work life and overall well-being of 400 men, ages 21 to 70, who have been newly diagnosed with solid tumors like colorectal, lung, or head and neck cancer. Participants will fill out questionnaires about their work hours, finan…

This study aims to find genetic and immune changes that help lung cancer start and grow. Researchers will collect tissue samples from 6,000 people with lung cancer or suspicious lung masses. The goal is to better understand the disease, not to test a new treatment.

This study collects pleural fluid (fluid around the lungs) and medical information from patients with known or suspected lung cancer or lung infections. The goal is to build a registry of samples that researchers can use to develop better tests and treatments in the future. Parti…

This study tests whether a short educational video can encourage Hispanic current and former smokers to get screened for lung cancer. Researchers will enroll 2,000 people aged 50-80 who smoke or quit recently. Participants watch the video and answer surveys to identify barriers a…

This study collects samples from 320 people, including those with solid cancers (like lung, colon, or pancreatic cancer) and those undergoing lung cancer screening, to look for cancer cells and DNA in blood, urine, and bone marrow. The goal is to learn how cancer spreads and find…

This study collects and analyzes lung tissue from 4,000 people having surgery for early-stage non-small cell lung cancer. Researchers look for unique RNA and protein patterns (fingerprints) in the samples. The goal is to link these fingerprints to how the cancer behaves, such as …

This research study collects sputum and tissue samples from 700 people with precancerous changes or certain cancers (lung, head and neck, esophageal). The goal is to find biomarkers—biological signs—that could help understand or detect these cancers earlier. Participants include …

This study is looking at whether a blood test (called a liquid biopsy) can help detect lung cancer. Researchers will collect blood samples from 1,340 people, some with lung nodules and some without, to measure specific molecules called miRNA and DNA methylation. The goal is to se…

This study looks at whether combining PET scan images with genetic testing can better predict how well non-small cell lung cancer patients will respond to treatment and how long they might survive. Researchers will analyze scans and tumor samples from 120 adults. The goal is to c…

This study looks at whether a quick ultrasound of the thigh muscle can detect muscle loss (sarcopenia) in people who have finished cancer treatment. Researchers will compare the ultrasound results with a standard whole-body scan (DEXA) in 55 adults aged 18-74 with certain cancers…

This study looks at how modern, minimally invasive lung cancer surgery affects the heart's electrical signals. Researchers will monitor 100 adults before, during, and after surgery to see if temporary changes occur. The goal is to better understand the heart stress caused by the …

This study collects tumor samples from 50 lung cancer patients whose disease has worsened while on immunotherapy. The goal is to analyze the tissue for clues about why the treatment stopped working. No new drug is being tested; instead, researchers hope to better understand resis…