Poop pills? stool transplants may ease immunotherapy side effects
NCT ID NCT04038619
First seen Nov 18, 2025 · Last updated Jun 22, 2026 · Updated 28 times
Summary
This early-stage trial tests whether a stool transplant (FMT) can help cancer patients who develop severe diarrhea or colon inflammation from immune-checkpoint inhibitor drugs. About 40 patients with various cancers will receive the transplant via colonoscopy. The main goal is to see if it is safe and can reduce gut symptoms within two weeks.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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M D Anderson Cancer Center
RECRUITINGHouston, Texas, 77030, United States
Contact Phone: •••-•••-••••
Contact
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
fecal microbiota transplantation (stool transplant)
What this could lead to
If it works, this could offer a new way to manage severe diarrhea and colon inflammation caused by cancer immunotherapy, helping patients stay on their cancer treatment.
What could go wrong
This is a very early Phase 1 trial with only 40 participants, so it is not yet proven. The procedure involves a colonoscopy and carries risks like infection or worsening symptoms.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.