DIARRHEA

This early-stage study tests a new vaccine called IVT Shigella-04 to see if it is safe and helps the immune system fight Shigella bacteria, a major cause of severe diarrhea. About 60 healthy adults aged 18 to 49 will receive two shots of either the vaccine or a placebo. Researche…

This early-stage trial tests whether a stool transplant (FMT) can help cancer patients who develop severe diarrhea or colon inflammation from immune-checkpoint inhibitor drugs. About 40 patients with various cancers will receive the transplant via colonoscopy. The main goal is to…

This study tests how the drug rifaximin (Xifaxan) works in children aged 6 to 11 with acute diarrhea likely caused by bacteria. Half the children get the drug plus oral rehydration therapy, the other half get rehydration alone. Researchers want to see if adding the drug helps dia…

This early-stage trial tests whether SER-155, a mix of 16 live bacteria taken by mouth, can safely treat severe diarrhea and colon inflammation caused by cancer immunotherapy. The study will enroll 15 adults who have developed these side effects. The main goal is to check safety,…

This study tests whether daily supplements of lactoferrin and lysozyme, proteins found in milk, can prevent severe diarrhea and improve nutrition in children aged 6-24 months who were hospitalized with diarrhea and malnutrition. Six hundred children in Kenya will receive one of t…

This study tests a program called CHoBI7, which teaches handwashing, water treatment, and safe water storage to diarrhea patients and their families in Bangladesh hospitals. Researchers want to see if this program reduces diarrhea and improves hygiene behaviors compared to standa…

This study aims to see if a 7-day water, sanitation, and hygiene program can reduce cholera infections in neighborhoods where a cholera patient lives. About 3,140 people will take part, focusing on homes without running water. The program provides practical tools and education to…

This Phase 2 study tests whether brenipatide, given as an injection under the skin, can safely reduce abdominal pain and improve stool consistency in adults with diarrhea-predominant irritable bowel syndrome (IBS-D). About 531 participants will receive either the drug or a placeb…

This study tests whether a daily probiotic supplement called BioAmicus Complete can help infants with colic, constipation, diarrhea, and eczema. 140 babies will receive either the probiotic drops or a placebo (sunflower oil) for 25 days. Researchers will track changes in stool, c…

This study is testing whether a fecal transplant from a carefully selected donor can reduce symptoms in people with moderate to severe IBS. The donor stool has low levels of certain proteins that may trigger IBS. 43 participants will receive the transplant during a colonoscopy an…

This early-phase study at Mayo Clinic tests whether adding the medication mirtazapine to a low-FODMAP diet improves symptoms of irritable bowel syndrome with diarrhea (IBS-D) better than diet alone. About 20 adults aged 18-70 will take either mirtazapine or a placebo while follow…

This study tests whether fecal microbiota transplantation (FMT) capsules can help people with diarrhea and colitis caused by immune checkpoint inhibitor cancer treatment. About 20 adults with melanoma or kidney cancer will receive either FMT or placebo capsules alongside their st…

This study looks at two common IV fluids given to children aged 6 months to 5 years who are dehydrated from a stomach bug. The goal is to see if one type helps restore normal blood chemistry faster than the other. Doctors choose the fluid as part of normal care, and the research …

This study looks at people who have had their entire colon removed and their small intestine connected directly to their rectum. Researchers want to understand how common and how severe bowel symptoms like diarrhea, urgency, and leakage are after this surgery, and how these sympt…