DIARRHEA

This early-stage study is testing a new vaccine called IVT Shigella-04 to prevent Shigella infections, which cause severe diarrhea. The trial involves 60 healthy adults aged 18 to 49 who will receive either the vaccine or a placebo. The main goal is to check the vaccine's safety …

This study looks at whether adding the antibiotic rifaximin to standard oral rehydration therapy helps children aged 6 to 11 with bacterial diarrhea get better faster. About 54 children will either receive rifaximin plus rehydration or rehydration alone for 3 days. Researchers wi…

This study tests whether adding milk proteins (lactoferrin and lysozyme) to the daily food of malnourished children aged 6-24 months can prevent severe diarrhea and help them recover nutritionally. The 600 participants in Kenya will receive the supplement for 6 months after leavi…

This study tests whether a 7-day water, sanitation, and hygiene program can reduce cholera infections in households near a person with cholera. Researchers will enroll about 3,140 people living in these high-risk areas. The goal is to see if this quick, targeted approach can stop…

This early-phase study tests whether fecal microbiota transplantation (FMT) can safely reduce severe diarrhea or colon inflammation caused by immune-checkpoint inhibitors in people with genitourinary and other cancers. About 40 participants will receive FMT and be monitored for s…

This study tests whether fecal microbiota transplantation (FMT) capsules can help people with diarrhea and colitis caused by immune checkpoint inhibitors, a common side effect of cancer treatment. Twenty adults with melanoma or kidney cancer will receive either FMT or placebo cap…

This study tests whether a fecal transplant from a carefully selected donor can reduce symptoms in people with irritable bowel syndrome (IBS) who have high gut protein breakdown activity. About 43 adults with moderate to severe IBS will receive the transplant during a colonoscopy…

This study tests an experimental drug called brenipatide for adults with irritable bowel syndrome with diarrhea (IBS-D). The goal is to see if it safely reduces daily belly pain and improves stool consistency compared to a placebo. About 531 participants will receive injections u…

This early study tests a live bacterial treatment called SER-155 for people who have diarrhea and colon inflammation from cancer immunotherapy. The goal is to see if it is safe and can reduce symptoms without needing strong immune-suppressing drugs. About 15 adults will take SER-…

This study is testing if adding the medication mirtazapine to a special low-FODMAP diet helps people with IBS-D feel better than using the diet alone. It will involve about 20 adults with IBS-D to see if the combination reduces symptoms like abdominal pain, diarrhea, and bloating…

This study observes 30 adults who had their colon removed and their rectum reconnected. Researchers will track bowel symptoms like diarrhea, urgency, and leakage, and how these affect quality of life. The goal is to better understand and manage these common post-surgery issues. N…

This study looks at why some people with Alpha-Gal syndrome get stomach pain, diarrhea, or vomiting after eating pork. Researchers will give 30 adults pork with and without a certain sugar (alpha-gal) in a blinded test to see if it triggers an allergic reaction. They will also me…