Could a common antidepressant plus a special diet tame IBS diarrhea?

NCT ID NCT06684470

Recruiting now Symptom relief Sponsor: Mayo Clinic Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This early-phase study at Mayo Clinic tests whether adding the medication mirtazapine to a low-FODMAP diet improves symptoms of irritable bowel syndrome with diarrhea (IBS-D) better than diet alone. About 20 adults aged 18-70 will take either mirtazapine or a placebo while following the diet. The goal is to see if the combo reduces abdominal pain, bloating, and diarrhea.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Mirtazapine (a neuromodulator) and a low-FODMAP diet
What this could lead to: If it works, this could point toward a more effective way to manage IBS with diarrhea by combining diet changes with medication.
What could go wrong: This is a very early, small pilot study with only 20 people. Results may not apply to everyone, and mirtazapine can cause side effects like drowsiness and weight gain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

diarrheal disease irritable bowel syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DIARRHEA IBS (IRRITABLE BOWEL SYNDROME)

Contacts and locations

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Locations

Mayo Clinic
RECRUITING

Jacksonville, Florida, 32224, United States

Contact Email: •••••@•••••

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