Could a common antidepressant plus a special diet tame IBS diarrhea?
NCT ID NCT06684470
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-phase study at Mayo Clinic tests whether adding the medication mirtazapine to a low-FODMAP diet improves symptoms of irritable bowel syndrome with diarrhea (IBS-D) better than diet alone. About 20 adults aged 18-70 will take either mirtazapine or a placebo while following the diet. The goal is to see if the combo reduces abdominal pain, bloating, and diarrhea.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Mirtazapine (a neuromodulator) and a low-FODMAP diet
What this could lead to
If it works, this could point toward a more effective way to manage IBS with diarrhea by combining diet changes with medication.
What could go wrong
This is a very early, small pilot study with only 20 people. Results may not apply to everyone, and mirtazapine can cause side effects like drowsiness and weight gain.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Mayo Clinic
RECRUITINGJacksonville, Florida, 32224, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••