Diarrheal disease

This early-stage study tests a new vaccine called IVT Shigella-04 to see if it is safe and helps the immune system fight Shigella bacteria, a major cause of severe diarrhea. About 60 healthy adults aged 18 to 49 will receive two shots of either the vaccine or a placebo. Researche…

This large Phase 3 trial tests whether VE303, a capsule containing 8 harmless bacteria, can prevent repeat Clostridioides difficile (C. diff) infections. About 852 people who have had at least one prior C. diff infection will take VE303 or a placebo for 14 days. The main goal is …

This study looks at whether giving antibiotics to children with a certain type of Shigella infection (non-dysentery watery diarrhea) helps them recover faster and grow better. About 700 children in Bangladesh and Zambia will receive either azithromycin or a placebo. Researchers w…

This early-stage trial tests whether a stool transplant (FMT) can help cancer patients who develop severe diarrhea or colon inflammation from immune-checkpoint inhibitor drugs. About 40 patients with various cancers will receive the transplant via colonoscopy. The main goal is to…

This study tests how the drug rifaximin (Xifaxan) works in children aged 6 to 11 with acute diarrhea likely caused by bacteria. Half the children get the drug plus oral rehydration therapy, the other half get rehydration alone. Researchers want to see if adding the drug helps dia…

This early-stage trial tests whether SER-155, a mix of 16 live bacteria taken by mouth, can safely treat severe diarrhea and colon inflammation caused by cancer immunotherapy. The study will enroll 15 adults who have developed these side effects. The main goal is to check safety,…

This study tests whether daily supplements of lactoferrin and lysozyme, proteins found in milk, can prevent severe diarrhea and improve nutrition in children aged 6-24 months who were hospitalized with diarrhea and malnutrition. Six hundred children in Kenya will receive one of t…

This study tests whether whole genome sequencing (looking at all DNA) finds more answers than whole exome sequencing (looking at just the protein-making parts) for children with long-lasting diarrhea and gut problems. About 180 children will be randomly assigned to one test or th…

This study will collect capsule endoscopy images from 10,000 patients to train an artificial intelligence system to detect bowel diseases, Crohn's disease, celiac disease, chronic diarrhea, and tumors. The goal is to improve diagnostic accuracy and reduce the time doctors spend r…

This study tests a program called CHoBI7, which teaches handwashing, water treatment, and safe water storage to diarrhea patients and their families in Bangladesh hospitals. Researchers want to see if this program reduces diarrhea and improves hygiene behaviors compared to standa…

This study tests whether providing targeted water, sanitation, and hygiene (WASH) supplies and education to households of cholera patients can reduce the spread of diarrhea. About 2,900 people in South Kivu, DRC, will take part. The goal is to see if these simple measures can pre…

This study aims to see if a 7-day water, sanitation, and hygiene program can reduce cholera infections in neighborhoods where a cholera patient lives. About 3,140 people will take part, focusing on homes without running water. The program provides practical tools and education to…

This study tests whether taking probiotics can prevent severe diarrhea in women with HER2-positive breast cancer who are treated with neratinib. About 308 participants will be randomly assigned to receive either probiotics or a placebo for six weeks, alongside standard diarrhea p…

This Phase 2 study tests whether brenipatide, given as an injection under the skin, can safely reduce abdominal pain and improve stool consistency in adults with diarrhea-predominant irritable bowel syndrome (IBS-D). About 531 participants will receive either the drug or a placeb…

This study tests whether repeated magnetic pulses to the brain (rTMS) can reduce abdominal pain and diarrhea in people with diarrhea-predominant irritable bowel syndrome (IBS-D). 46 adults will receive either real or sham rTMS for 20 minutes daily over 3 weeks. Researchers will a…

This study tests whether a daily probiotic supplement called BioAmicus Complete can help infants with colic, constipation, diarrhea, and eczema. 140 babies will receive either the probiotic drops or a placebo (sunflower oil) for 25 days. Researchers will track changes in stool, c…

This study is testing whether a fecal transplant from a carefully selected donor can reduce symptoms in people with moderate to severe IBS. The donor stool has low levels of certain proteins that may trigger IBS. 43 participants will receive the transplant during a colonoscopy an…

This study tests whether adding amino acids to the standard rehydration drink can help children aged 6 months to 5 years recover faster from acute gastroenteritis (stomach flu). About 72 kids with mild to moderate diarrhea will receive either the fortified drink or standard oral …

This study is testing whether a supplement containing butyrate and polyphenols can improve gut health and reduce digestive discomfort like bloating, gas, and abdominal pain. Researchers will enroll 124 adults aged 25-70 who report regular gut issues. Participants will take either…

This early-phase study at Mayo Clinic tests whether adding the medication mirtazapine to a low-FODMAP diet improves symptoms of irritable bowel syndrome with diarrhea (IBS-D) better than diet alone. About 20 adults aged 18-70 will take either mirtazapine or a placebo while follow…

This study tests whether fecal microbiota transplantation (FMT) capsules can help people with diarrhea and colitis caused by immune checkpoint inhibitor cancer treatment. About 20 adults with melanoma or kidney cancer will receive either FMT or placebo capsules alongside their st…

This study aims to collect medical data and biological samples (blood, urine, stool, and tissue) from up to 4,000 adults with known or suspected gastrointestinal diseases. Participants receive standard medical care at the NIH, and any extra samples or leftover tissue from procedu…

This study compares two methods of accessing the radial artery in the wrist for coronary angiography: the standard approach versus an ultrasound-guided distal approach. Researchers will enroll 1,400 patients who need this heart procedure to see if ultrasound guidance reduces the …

This study looks at two common IV fluids given to children aged 6 months to 5 years who are dehydrated from a stomach bug. The goal is to see if one type helps restore normal blood chemistry faster than the other. Doctors choose the fluid as part of normal care, and the research …

This study in Bauchi, Nigeria, is testing whether giving free Oral Rehydration Salts (ORS) and zinc directly to homes can increase how often these treatments are used for children under 5 with diarrhea. Over 100,000 children are taking part, with some areas receiving the medicine…

This study looks at people who have had their entire colon removed and their small intestine connected directly to their rectum. Researchers want to understand how common and how severe bowel symptoms like diarrhea, urgency, and leakage are after this surgery, and how these sympt…

This study tests whether community demonstrations and local chlorine redemption points can increase household water treatment in rural Nigeria. Researchers will compare 20 communities receiving the intervention with 10 control communities. The goal is to see if this approach impr…

This study follows 368 mothers and their babies in Zimbabwe from pregnancy until the child turns 3. Researchers want to understand how malnutrition, poor water and sanitation, and gut problems affect child growth, infections, and development. They will measure gut bacteria, immun…

This study looks at 60 children with congenital diarrhea and enteropathy (CODE) in China. Researchers will collect medical history, blood, and stool samples to find biological markers and build a risk prediction model. No new treatment is being tested; the goal is to better under…