Diarrheal disease

This study tests a new vaccine called Shigella4V, designed to protect against shigellosis, a severe diarrheal disease. Researchers are giving the vaccine to healthy adults, children, and 9-month-old infants to check its safety and whether it triggers a strong immune response. Dif…

This study tested a new vaccine designed to protect against severe diarrhea caused by Shigella bacteria. The vaccine was first given to adults in Europe, then to adults, children, and infants in Africa. Researchers checked for side effects and measured immune responses to find th…

This study tested an experimental vaccine (CssBA+dmLT) to see if it can prevent moderate-to-severe diarrhea caused by ETEC bacteria, a common cause of traveler's diarrhea. About 72 healthy adults received either the vaccine or a placebo, then were exposed to the bacteria in a con…

This study tested a new vaccine called Shigella4V2 to protect infants against shigellosis, a severe diarrheal disease. Researchers gave the vaccine to 110 healthy 9-month-old babies to check its safety and how well it triggers an immune response. The goal is to find the best dose…

This early-stage study tested a new oral vaccine designed to protect against two bacteria that cause severe diarrhea: Shigella and ETEC. Fifty-three healthy adults received the vaccine to check for side effects and to see if it triggers an immune response. The goal is to develop …

This study tested a new Shigella vaccine in 200 healthy African infants to see if it can prevent severe diarrhea. The vaccine was given in two doses, and researchers measured immune responses and safety. The trial is now complete, and results will show whether this approach is pr…

This study tested a new vaccine called ShigETEC in healthy adults and children in Bangladesh. The vaccine aims to protect against two bacteria that cause severe diarrhea: Shigella and ETEC. Researchers gave three doses of the vaccine or a placebo to 196 participants to check if i…

This study tested whether a daily dose of Travelan (IMM-124E) tablets could prevent moderate-to-severe diarrhea in healthy adults deliberately infected with ETEC bacteria, a common cause of travelers' diarrhea. Sixty-three volunteers took either Travelan or a placebo for 7 days. …

This study tested a treatment called RBX2660 (REBYOTA) for people with recurrent Clostridioides difficile infection. The treatment is made from healthy human stool bacteria and was given during a colonoscopy. The goal was to see if this delivery method is safe and works well. For…

This early-phase study tested a combination of three oral drugs (irinotecan, temozolomide, and cefixime) in 30 children whose high-risk neuroblastoma had come back or not responded to standard treatment. The goal was to find the safest dose of irinotecan when given with the other…

This study tested whether an oral rehydration solution (ORS) with added calcium works better than standard ORS for adults with severe watery diarrhea, including cholera. Researchers measured stool output, diarrhea duration, and other symptoms in 396 adults. The goal is to find a …

This large study in rural India trained village health workers to diagnose and treat common illnesses like high blood pressure, diarrhea, pneumonia, malaria, asthma, and COPD. Over 72,000 adults aged 16-60 from 80 tribal villages took part. The goal was to reduce deaths by at lea…

This study tested whether a low-cost food storage cabinet called a "meatsafe" could reduce diarrhea in children aged 6 to 24 months in low-income areas of Dhaka, Bangladesh. Researchers compared households that received the cabinet and food safety education to those that did not.…

This study tested whether tranexamic acid, a drug that helps blood clot, can lower the chance of infection after gastrointestinal surgery. Over 3,300 adults at higher risk for complications took part. The goal was to see if the drug reduces surgical site infections compared to a …

This phase II trial tested the drug isatuximab in 43 patients with AL amyloidosis that had come back or stopped responding to treatment. Isatuximab is a monoclonal antibody that may help stop abnormal protein buildup. The study measured how well the drug reduced disease markers a…

This study tested whether teaching mothers to wash their hands and add chlorine to household water can prevent diarrhea in children under 5. Over 800 children in central Ethiopia took part, with some families receiving handwashing education, some getting water chlorination suppli…

This study tested whether specially built houses (Star Homes) could reduce malaria, respiratory infections, and diarrhea in children under 13 in rural Tanzania. Over 1,100 children lived either in a Star Home or a traditional mud house. The Star Homes have screened windows, solar…

This study tested three types of Sawyer water filters in nearly 10,000 households in Ciudad Victoria, Mexico. The goal was to see if using these filters reduces diarrhea and other waterborne illnesses. Researchers tracked self-reported health changes over time after giving househ…

This study tested whether a teacher-led hygiene campaign in primary schools in Lagos, Nigeria, could improve handwashing and prevent diarrhea, undernutrition, and pneumonia in children. Over 3,500 children from schools with clean water and toilets took part. Researchers measured …

This study tests whether acupuncture using tiny, semi-permanent needles can prevent diarrhea caused by the chemotherapy drug irinotecan in children with solid tumors. About 22 children will receive the acupuncture during their second round of chemo, and researchers will measure p…

This study tested health and wellness products to see if they could improve common stomach issues like gas, bloating, diarrhea, and constipation. About 500 adults from across the U.S. took part. Participants took either the product or a placebo (a dummy pill) and reported their s…

This study followed 18 people in Spain with idiopathic pulmonary fibrosis (IPF) or other progressive lung scarring who were taking nintedanib (OFEV) and had developed diarrhea. The goal was to see if the diarrhea could be controlled after 12 weeks while staying on the full dose. …

This study tested a 12-week online mind-body program for adults with chronic conditions like heart failure, cancer, and liver disease. The program included mindful movement, meditation, breathwork, and coping skills. Researchers measured changes in anxiety, depression, fatigue, a…

This study tested a probiotic (BB-12 with LGG) in 123 children with autism and stomach problems. The goal was to see if different doses are safe and can improve behavior and gut health. Researchers tracked side effects, behavior changes, and gut bacteria over 56 days of treatment…

This study tested three different eating plans in 135 adults with irritable bowel syndrome with diarrhea (IBS-D) to see which best reduces stomach pain, bloating, and other symptoms. Participants followed either a low-FODMAP diet, a Tritordeum-based diet (a special type of wheat)…

This study tested the drug crofelemer in 93 adults with chronic diarrhea of unknown cause (not related to HIV). The goal was to see if the drug reduces stool frequency and improves consistency, and to find out which diagnostic tests are most useful. Results may help doctors bette…

This study tested whether adding racecadotril to standard rehydration therapy helps children aged 3 months to 5 years with acute watery diarrhea. 200 hospitalized children received either racecadotril or a placebo alongside standard care. The goal was to see if the drug reduces s…

This study looked at whether a food supplement containing GABA and Melissa can help improve quality of life and reduce belly discomfort in people with diarrhea-predominant irritable bowel syndrome (IBS-D). Twenty adults with IBS-D took the supplement, and researchers measured cha…

This study tested whether a mix of two probiotics (Lactobacillus acidophilus and Limosilactobacillus reuteri) could shorten diarrhea in children aged 1 to 6 with acute infectious diarrhea. 145 children were randomly assigned to receive the probiotics or a placebo. Researchers mea…

This completed study tested two dietary supplements—a butyrate formulation and a butyrate plus polyphenol formulation—against a placebo in 143 adults with frequent gut issues. The goal was to see if these supplements improve gut health, reduce gut permeability, and ease digestive…

This study tested whether colesevelam, a drug used for high cholesterol, can safely reduce diarrhea in people with multiple myeloma who take lenalidomide. 25 participants received colesevelam for 4 weeks. The goal was to see if diarrhea improved to a mild level or better. The stu…

This pilot study tested whether giving ondansetron (Zofran) before drinking bowel-cleansing liquid helps children have a cleaner colon and feel less sick. 41 kids aged 2 to 20 took either ondansetron or a placebo before their colonoscopy. The study measured bowel cleanliness and …

This completed pilot trial tested two postbiotic supplements (ABB S3 and ABB C22) in 100 hospitalized patients with diarrhea or gut symptoms from tube feeding. The goal was to see if these nutritional supplements could ease symptoms like diarrhea, vomiting, and improve stool cons…

This study compared giving zinc alone versus zinc plus a probiotic yeast (Saccharomyces boulardii) to 276 children under 5 with acute watery diarrhea. Researchers measured how long it took for diarrhea and vomiting to stop. The goal was to see if the combination treatment speeds …

This study looked at how chemotherapy affects the gut microbiome in 40 people with non-Hodgkin's lymphoma. Researchers collected stool samples to analyze changes in gut bacteria after treatment. The goal was to better understand why chemotherapy causes digestive problems like dia…

This study looked at 30 adults with Alpha-Gal syndrome, a condition where eating red meat causes allergic reactions. Participants ate cooked ground pork with or without a sugar called alpha-gal, then researchers checked for allergic reactions, gut symptoms, and changes in immune …

This completed study looked at 41 children with intestinal epithelial dysplasia (also called tufting enteropathy), a rare gut condition. Researchers collected blood and skin samples to find the genes and mutations responsible for the disease. The goal was to better understand the…

This study tested a mobile app called OASES that guides nurses and clinical officers in rural Uganda through emergency care steps for severe diarrhea, breathing problems, and seizures. About 15 clinicians used the app during simulated patient scenarios to see if it helped them fo…

This study examined 288 children aged 2 to 5 in France, Africa, and South America to see if low vitamin C levels are more common in those with diarrhea. Researchers compared vitamin C in the blood of children with diarrhea to healthy children of the same age and sex. The goal is …