Could a simple tablet stop Travelers' diarrhea before it starts?

NCT ID NCT05933525

Completed Disease control Sponsor: Immuron Ltd. Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether a daily dose of Travelan (IMM-124E) tablets could prevent moderate-to-severe diarrhea in healthy adults deliberately infected with ETEC bacteria, a common cause of travelers' diarrhea. Sixty-three volunteers took either Travelan or a placebo for 7 days. Researchers measured how many people developed severe diarrhea and how much stool they produced. The goal is to find a simple, safe way to protect travelers from this unpleasant illness.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Travelan (IMM-124E) tablets
What this could lead to: If it works, this could provide a simple daily pill to prevent travelers' diarrhea caused by ETEC bacteria.
What could go wrong: This is a small Phase 2 trial with only 63 participants, so results may not apply to everyone. The study is completed but not yet published, so we don't know if it worked.

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Conditions

The condition(s) this trial relates to.

diarrheal disease dysentery escherichia coli infection intestinal infectious disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DIARRHEA INFECTIOUS DIARRHEA TRAVELERS DIARRHEA

Contacts and locations

Locations

Pharmaron Clinical Pharmacology Center

Baltimore, Maryland, 21201, United States

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