Zofran may ease nasty bowel prep for children needing colonoscopy
NCT ID NCT05439772
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This pilot study tested whether giving ondansetron (Zofran) before drinking bowel-cleansing liquid helps children have a cleaner colon and feel less sick. 41 kids aged 2 to 20 took either ondansetron or a placebo before their colonoscopy. The study measured bowel cleanliness and symptoms like pain, bloating, nausea, and vomiting.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- ondansetron (Zofran)
- What this could lead to
- If it works, ondansetron could make bowel preparation for colonoscopy more comfortable for children by reducing nausea and vomiting.
- What could go wrong
- This is a small pilot study with only 41 participants, so results may not apply to all children. Ondansetron can rarely cause heart rhythm problems in those with certain conditions.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
SUNY Downstate University Hospital of Brooklyn
Brooklyn, New York, 11203, United States
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