Could an extra flu shot shield vulnerable kids?
NCT ID NCT03277703
First seen Aug 06, 2026 · Last updated Aug 07, 2026 · Updated 1 time
Summary
This trial tests whether giving children with autoimmune diseases (like inflammatory bowel disease or rheumatologic conditions) an extra booster dose of the flu vaccine improves their immune response compared to a single dose. These children take immunosuppressive medications that may weaken vaccine effectiveness. The study will compare flu antibody levels and flu illness rates between children receiving one or two doses, with all participants receiving two doses in the second year.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Influenza vaccine (booster dose strategy)
- What this could lead to
- If effective, a booster flu shot could offer stronger protection against flu for children with autoimmune conditions who are on immunosuppressive therapies.
- What could go wrong
- The trial is small and early, and the immune response may still be weaker than in healthy children. There is also a risk of side effects from the extra vaccine dose.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Clinical Research Center
East Setauket, New York, 11733, United States
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