Crohn disease

This study watches how well IL-23 inhibitors work for adults with active Crohn's disease in everyday clinics. About 665 people will get treatment chosen by their doctor and be checked at 12 and 52 weeks. The main goal is to see how many reach remission (symptom-free) by week 12, …

This phase 3 study tests a drug called afimkibart in 600 people with moderate-to-severe Crohn's disease. Participants receive either the drug or a placebo to see if it can reduce symptoms and gut inflammation. The trial is double-blind, meaning neither patients nor doctors know w…

This study tests if the drug vorinostat is safe and can help people with moderate-to-severe Crohn's disease by reducing gut inflammation. Participants who respond well may then receive a maintenance treatment with ustekinumab for up to two years. The goal is to control symptoms a…

This study will follow 100 people in Saudi Arabia with moderate to severe Crohn's disease or ulcerative colitis who are starting guselkumab. Researchers will measure how long patients continue the treatment in real-world clinics, along with early symptom improvements. No new drug…

This trial tests whether using ultrasound during surgery to choose where to cut the bowel leads to better outcomes for people with Crohn's disease. About 44 adults with Crohn's disease affecting the last part of the small intestine will be randomly assigned to have their surgery …

This phase 3 trial tests duvakitug, an injected drug, in about 980 adults with moderate to severe Crohn's disease who haven't improved with other treatments. The study is double-blind and placebo-controlled, meaning some participants get the drug and some get a dummy shot. The go…

This phase 2 trial tests a drug called DISC-0974 in 21 adults with inflammatory bowel disease (IBD) who also have anemia caused by inflammation. The study aims to see if the drug safely raises hemoglobin levels compared to a placebo. Participants receive injections of either DISC…

This study looks at whether taking a mix of probiotics (good bacteria) can change the gut microbiome of children and teens aged 5-18 with inflammatory bowel disease (IBD). About 40 participants will be randomly assigned to take probiotics or a placebo, then switch after a period.…

This study tests whether increasing the dose of guselkumab can help people with Crohn's disease who don't get better with standard doses. About 210 adults with active Crohn's will receive guselkumab, and after 12 weeks, those who haven't responded will get a higher dose more ofte…

This phase 3 trial is testing a drug called tulisokibart in about 1,200 people with moderate-to-severe Crohn's disease who haven't had success with other treatments. The drug is given by IV or injection and aims to reduce symptoms and heal the gut lining. The study compares tulis…

This study is testing the drug vedolizumab (Entyvio) in 400 adults with moderate to severe ulcerative colitis or Crohn's disease. Participants first receive the drug through an IV for 6 weeks, then switch to injections under the skin for the rest of the year. The main goal is to …

This phase 2 trial is testing four different drugs—risankizumab, trosunilimab, lutikizumab, and ABBV-8736—in about 540 adults with moderate to severe Crohn's disease. The goal is to see if these targeted therapies can reduce inflammation and improve symptoms. Participants will re…

This study follows 40 children with Crohn's disease or ulcerative colitis who developed severe psoriasis from anti-TNF drugs and switched to ustekinumab. Researchers will check if their digestive symptoms stay controlled and if their skin improves after 3-6 months. The goal is to…

This study tests upadacitinib (RINVOQ), a daily oral medication, in 110 children aged 2 to 18 with moderate to severe Crohn's disease who haven't improved with other treatments. The trial has three parts: an initial 12-week open-label phase, a 52-week double-blind maintenance pha…

This study tests the long-term safety and effectiveness of mirikizumab in 150 children and adolescents with moderate-to-severe ulcerative colitis or Crohn's disease. Participants who completed earlier mirikizumab studies can join. The trial lasts about 172 weeks and aims to see i…

This pilot study tests two stem cell treatments for anal fistulas in people with Crohn's disease. One uses donor stem cells (Alofisel), the other uses stem cells from the patient's own fat. The goal is to see which works better at closing the fistula. The study plans to enroll 20…

This study tracks 250 people with moderate-to-severe Crohn's disease who are switching to either upadacitinib or risankizumab after a first treatment didn't work well enough. Researchers will see if these drugs help patients achieve remission without needing steroids over 18 mont…

This study tests whether a special medical food called LH VIOLA, taken as a partial replacement for regular meals, can help people with Crohn's disease or ulcerative colitis who are at risk of malnutrition maintain or regain weight and muscle strength. About 146 participants will…

This study tests whether adding the weight-loss drug tirzepatide to the Crohn's drug mirikizumab helps people with moderate-to-severe Crohn's disease who are also overweight or have obesity. About 290 adults will receive either mirikizumab alone or mirikizumab plus tirzepatide. T…

This study tests an experimental pill called MORF-057 (zotemtegrast) in 385 adults with moderate-to-severe Crohn's disease. The drug works by blocking a protein that drives gut inflammation. Participants will receive one of three doses of the drug or a placebo for 14 weeks to see…

This study tests whether capsules containing freeze-dried healthy donor gut bacteria can take root in the intestines of people with Crohn's disease. Researchers will check if the bacteria engraft in the ileum and colon, and explore changes in symptoms and inflammation. The trial …

This phase 3 study tests whether duvakitug can help people with moderate-to-severe Crohn's disease maintain remission. About 751 participants who responded to prior treatment will receive either duvakitug or a placebo injection for up to 40 weeks, with an option to continue in an…

This study looks at the long-term safety of a drug called vedolizumab given as a shot under the skin to children and teenagers with ulcerative colitis or Crohn's disease. About 70 participants who did well on the drug in an earlier study will keep getting it, while those who didn…

This pilot study tests a new procedure for people with Crohn's disease who have anal fistulas that haven't healed with standard treatments. Doctors take a small amount of fat from the patient's belly, process it mechanically in the same surgery, and inject it into the fistula tra…

This study tests whether stem cells from a donor can help control Crohn's disease, a chronic gut condition causing pain and diarrhea. About 46 adults will receive either stem cells or a placebo through IV infusions over 16 weeks. Researchers will track symptom changes and side ef…

This study is for people who have both an autoimmune disease (like rheumatoid arthritis, lupus, or multiple sclerosis) and an advanced cancer that has spread or cannot be removed by surgery. It tests the safety and effectiveness of the immunotherapy drug nivolumab, given alone or…

This study is checking the long-term safety of guselkumab, a biologic drug given as a shot, in children with moderate to severe Crohn's disease, ulcerative colitis, or juvenile psoriatic arthritis. About 196 kids who already completed a prior guselkumab study and benefited from i…

This study tests an experimental drug called SAR441566 in 260 adults with moderate to severe Crohn's disease. Participants will receive different doses of the drug or a placebo for up to 52 weeks to see if it reduces gut inflammation and improves symptoms. The goal is to find a s…

This study follows 50 people with moderate to severe Crohn's disease or ulcerative colitis to see how long they stay on guselkumab in real-world settings. Researchers will measure treatment persistence and early symptom improvements using patient diaries. The goal is to understan…

This phase 3 trial tests a drug called afimkibart in 100 children aged 2-17 with moderate-to-severe Crohn's disease. The goal is to see if it can help children feel better and heal their intestines. Participants will receive the drug as an IV infusion or injection, and researcher…

This study tests a new drug called RO7790121 (Afimkibart) in people with moderate-to-severe Crohn's disease. The goal is to see if the drug can reduce symptoms and heal the gut lining better than a placebo. About 425 adults who have not responded well to other treatments will tak…

This study tests a new medicine, JNJ-78934804, against an existing drug (guselkumab) in 460 people with moderate-to-severe Crohn's disease. The goal is to see if the new drug can reduce symptoms and heal the gut lining better at 48 weeks. Participants must have had Crohn's for at…

This study tests whether adding a low dose of upadacitinib (a JAK inhibitor) to a standard TNF inhibitor (like infliximab or adalimumab) works better than simply increasing the dose of the TNF inhibitor alone for people with moderate-to-severe Crohn's disease. About 312 adults wh…

This early-stage trial tests BDHK-2009, an experimental tablet for inflammatory bowel diseases like ulcerative colitis and Crohn's disease. The study involves 68 healthy adults aged 18 to 55 to see if the drug is safe and how the body handles it. Participants receive either a sin…

This study tests the safety of giving a second injection of a patient's own frozen fat-derived cells (stromal vascular fraction) to treat anal fistulas that didn't heal in a previous trial. About 25 adults with Crohn's disease who still have active fistulas will receive the injec…

This study will follow 500 people with Crohn's disease or ulcerative colitis who are starting guselkumab, a biologic drug. Researchers will measure how many achieve remission and how the treatment affects daily life, including fatigue and work productivity. The goal is to underst…

This study tests whether guselkumab works better than risankizumab for people with moderate to severe Crohn's disease. About 530 adults will receive one of the two drugs and be followed for a year. The goal is to see which drug leads to deeper remission, meaning fewer symptoms an…

This study tracks 220 adults with moderate-to-severe ulcerative colitis or Crohn's disease who are starting guselkumab, a biologic drug. Researchers will measure how many achieve remission (symptom control) and whether they can stop steroids. The goal is to see how well the drug …

This study tests whether guselkumab can help people with Crohn's disease whose current treatment (ustekinumab) has stopped working. Crohn's disease causes severe gut inflammation. About 78 Chinese adults with active Crohn's will receive guselkumab and be followed for 48 weeks to …

This study tests whether the experimental drug icotrokinra can reduce symptoms and gut inflammation in people with moderate-to-severe Crohn's disease. About 1,092 adults will receive either the drug or a placebo for up to 40 weeks. The goal is to see if the drug can bring about r…

This phase 2 study is testing two new drugs — mirikizumab (given by IV or injection) and LY4395089 (a pill) — in 60 adults with moderately to severely active ulcerative colitis or Crohn's disease. The goal is to see if these treatments are safe and can help control the disease. T…

This study tests whether adding a new drug (LY4395089) to an existing treatment (mirikizumab) works better than mirikizumab alone for adults with moderate-to-severe Crohn's disease. About 60 participants will be followed for 62 weeks to check safety and how well the combination r…

This study tests tirzepatide, a drug used for diabetes, in 60 adults with Crohn's disease who have active inflammation in the small bowel despite other treatments. The goal is to see if tirzepatide can heal the gut lining better than switching to another standard biologic therapy…

This study tests a new strategy to prevent Crohn's disease from returning after bowel surgery. Instead of waiting 6 months for a colonoscopy, doctors will use a simple stool test at 3 months to decide if treatment needs to be stepped up earlier. The goal is to reduce the number o…

This study tests a drug called guselkumab in 120 children with moderate to severe Crohn's disease. The goal is to see if it can reduce symptoms and heal the gut lining over 52 weeks. Participants must have active Crohn's confirmed by endoscopy. This is a phase 3 trial, meaning it…

This study tests whether mirikizumab, an injected drug that blocks IL-23, can reduce inflammatory strictures (narrowed areas) in the small bowel caused by Crohn's disease. About 60 adults with at least one stricture will receive the drug and be monitored with MRI and symptom scor…

This study tests a bone marrow transplant from a family donor for children under 21 with severe non-cancer blood disorders like sickle cell disease, bone marrow failure, or immune problems. The goal is to see if the transplant can replace the diseased cells with healthy donor cel…

This study tests risankizumab, a drug already used in adults, in children aged 2 to 18 with moderate to severe Crohn's disease. About 110 kids will receive the drug intravenously then by injection over several years. The goal is to see if it safely reduces symptoms and gut inflam…

This study tests if the drug mirikizumab can heal damage deep in the gut wall in people with Crohn's disease. About 75 adults with active symptoms and inflammation seen on MRI will receive the drug. The main goal is to see if the gut shows at least 25% improvement after 24 weeks.

This study tests whether giving two drugs together (vedolizumab and upadacitinib) for 12 weeks works better than vedolizumab alone to reduce bowel inflammation and ulcers in adults with moderate to severe Crohn's disease. About 396 participants will receive the combo or a placebo…

This phase 3 trial tests mirikizumab, an injected drug, in 90 children with moderate-to-severe Crohn's disease. The study looks at whether the drug can improve symptoms and heal the gut lining over 52 weeks. Participants receive mirikizumab during a 12-week induction period, then…

This study follows 900 children ages 6-17 who are newly diagnosed with Crohn's disease and starting anti-TNF therapy. Researchers will track healing of the intestine using blood tests, stool samples, colonoscopy, and MRI over one year. The goal is to understand why some children …

This study follows 200 adults with Crohn's disease or ulcerative colitis who are prescribed Zymfentra as part of their regular care. Participants answer online surveys about their bowel habits for one year to see if symptoms improve. The goal is to understand how effective this m…

This study tests the long-term safety of an oral drug called zasocitinib (TAK-279) in adults with moderate to severe Crohn's disease or ulcerative colitis. Participants who responded to the drug in earlier studies can continue treatment for up to 3 years. The main goal is to see …

This study looks at whether a special liquid diet called exclusive enteral nutrition (EEN) can help adults with active Crohn's disease feel better and reduce inflammation. About 300 participants will use EEN as their main treatment for 12 weeks. Researchers will check remission r…

This study looks at the long-term safety of a medicine called tulisokibart for people with moderate to severe Crohn's disease or ulcerative colitis. It is an extension study, meaning participants must have already taken tulisokibart in a previous study. The main goal is to see ho…

This study tests whether a newer surgical method called Kono-S anastomosis can better prevent Crohn's disease from returning after bowel surgery compared to the standard side-to-side technique. About 600 adults with Crohn's disease needing bowel resection will be randomly assigne…

This study tests an experimental treatment called DB-3Q, made from stem cell particles, for people with Crohn's disease who have painful tunnels (fistulas) near the anus. About 36 adults will receive either the treatment or a placebo to see if it safely closes the fistulas and im…

This study looks at how children and teenagers with moderate to severe ulcerative colitis or Crohn's disease process a drug called vedolizumab when given as a shot under the skin. About 70 participants who already responded to vedolizumab given through a vein will receive the sho…

This study tests an experimental drug called TQH3906 in adults with moderate-to-severe ulcerative colitis or Crohn's disease. About 135 participants will receive either the drug or a placebo for 12 weeks to see if it safely reduces inflammation and improves symptoms. The goal is …

This study tests an oral drug called TAK-279 (Zasocitinib) in 268 adults with moderate-to-severe Crohn's disease who haven't responded well to other treatments. Participants take one of three doses or a placebo daily for 12 weeks to see if it reduces gut inflammation and ulcers, …

This study is for children with ulcerative colitis or Crohn's disease who already completed a previous vedolizumab trial. It aims to see how safe the drug is over a longer period. About 240 kids will receive vedolizumab infusions or be observed without treatment. Researchers will…

This study tests a medicine called vedolizumab in children and teens with moderate to severe Crohn's disease. The goal is to see if the drug can reduce inflammation and keep symptoms under control over the long term. Participants first receive three infusions over six weeks, then…

This study looks at 220 adults with Crohn's disease whose symptoms returned while on adalimumab. Half will get a higher dose of adalimumab, and the other half will switch to vedolizumab. The goal is to see which approach leads to better control of the disease after 24 weeks, usin…

This study tests whether a computer program that calculates a personalized dose of infliximab based on blood tests can help children with Crohn's disease achieve deep remission better than standard dosing. About 180 children and young adults (ages 6–22) newly diagnosed with Crohn…

This study tests whether adding a special diet (Crohn's Disease Exclusion Diet) to the standard drug infliximab helps children with Crohn's disease feel better and stay in remission longer. About 140 children starting infliximab will be randomly assigned to receive the diet plus …

This study tests an experimental oral drug called obefazimod in 212 adults with moderate-to-severe Crohn's disease who haven't responded well to other treatments. Participants receive either obefazimod or a placebo daily for 12 weeks (induction), then up to 40 more weeks (mainten…

This study is testing whether a Mediterranean-like diet called Nordiet can improve gut health and reduce inflammation in 160 teens and adults with Crohn's disease or ulcerative colitis. Participants will follow the diet for four weeks while researchers check changes in gut bacter…

This study is testing an interleukin-23 monoclonal antibody, a drug that blocks a key inflammatory protein, in 200 adults with moderate to severe Crohn's disease or ulcerative colitis. Participants receive the drug and are followed for 54 weeks to see if they can achieve remissio…

This study looks at how well newer inflammatory bowel disease (IBD) medications work in children whose previous anti-TNF treatment stopped working or didn't help. About 1,100 kids with Crohn's disease or ulcerative colitis will answer questions about their symptoms and health ove…

This study tests whether acupuncture can reduce the number of flare-ups in people with Crohn's disease who are currently in remission. About 106 participants will receive either real or sham acupuncture over several months. The goal is to see if this ancient practice can help kee…

This study looks at whether early surgery or waiting and trying biologic drugs first is better for people with Crohn's disease who have bowel blockages. About 138 participants will be randomly assigned to either have surgery soon or receive biologic therapy. The goal is to see wh…

This study looks at whether replacing a normal diet with specialized milkshakes for 6 weeks can improve how well biologic drugs work in children aged 6-18 with active Crohn's disease. About 90 participants will either follow their normal diet or drink the milkshakes alongside the…

This pilot study tests whether the weight-loss drug tirzepatide (Zepbound) combined with a Mediterranean diet can help control mild Crohn's disease. Twenty-four adults with Crohn's who are already on biologic therapy and have a BMI of 27 or higher will receive either tirzepatide …

This study tests whether adding a special diet (Crohn's Disease Exclusion Diet) to standard medication helps children with unstable Crohn's disease have fewer flare-ups over a year. About 120 kids aged 6-17 will be randomly assigned to either diet plus medication or medication al…

This phase 2 trial is testing an experimental drug called SAR442970 in about 99 adults with moderate to severe Crohn's disease. Participants will receive either the drug or a placebo as a shot under the skin. The main goal is to see if the drug can improve the appearance of the g…

This study tests whether combining guselkumab with JAK inhibitors (upadacitinib or tofacitinib) can help people with inflammatory bowel disease that hasn't improved with other treatments. About 80 participants will receive the drug combination and be monitored for 12 and 52 weeks…

This study looks at whether a drug called guselkumab can help people with moderate to severe Crohn's disease who did not improve or could not tolerate another drug called ustekinumab. About 60 adults will receive guselkumab and be followed for 52 weeks. The main goal is to see ho…

This study compares two treatments for children aged 6-18 with Crohn's disease: one group gets infliximab alone, another gets immunosuppressives alone, and a third gets both. The goal is to see which approach leads to more kids achieving remission (feeling better and showing heal…

This study is testing whether combining two different biologic drugs can better control moderate to severe Crohn's disease. One hundred adults will first receive either vedolizumab plus adalimumab or vedolizumab plus ustekinumab. Those who respond well will then switch to vedoliz…

This study tests whether removing extra tissue (the mesentery) during standard Crohn's surgery is safe and helps prevent the disease from returning. About 30 adults with Crohn's disease who are already on biotherapy will undergo this procedure. The main goal is to see if the surg…

This Phase 2 study is testing two new drugs, MT-501 and MT-201, in 140 adults with moderate-to-severe Crohn's disease or ulcerative colitis. The goal is to see if these treatments are safe and can improve symptoms and gut healing. Researchers will monitor side effects and measure…

This study tests whether improving nutrition before surgery reduces complications in people with inflammatory bowel disease (IBD). About 150 adults scheduled for intestinal surgery will receive a nutrition specialist and special shakes. Researchers will track hospital stay length…

This study looks at two drugs, guselkumab and ustekinumab, in 100 adults with moderate-to-severe Crohn's disease that has caused narrowing (strictures) in the bowel. The goal is to see which drug better controls symptoms and improves imaging results over 52 weeks. Participants co…

This study is testing whether the drug ustekinumab (Stelara) can help people with moderate-to-severe Crohn's disease who also have bowel strictures (narrowing of the intestine). About 239 participants will receive ustekinumab and be followed for a year. The goal is to see if the …

This early-stage trial tests whether statins, a common cholesterol medicine, can prevent strictures (narrowing) in the gut for adults with Crohn's disease. About 20 participants will take either statins or a placebo daily for 6-12 months after surgery. Researchers will check for …

This program provides children and teenagers with moderate to severe ulcerative colitis or Crohn's disease continued access to vedolizumab, a medication given through a vein, after they finish a related study. It is for those who still benefit from the treatment and have no good …

This study tests whether taking a daily prebiotic supplement for 8 weeks can improve gut health and reduce inflammation in people with ulcerative colitis. Researchers will collect stool samples and track symptoms in 70 adults. The goal is to see if prebiotics can help manage the …

This study tests whether combining two drugs—upadacitinib and ustekinumab—works better than just increasing the dose of ustekinumab alone for people with Crohn's disease who didn't get enough help from standard treatment. About 214 adults with active Crohn's will be randomly assi…

This study follows about 240 people in Japan with moderate to severe Crohn's disease who are taking upadacitinib, an approved drug. Researchers will track side effects and how well the drug controls the disease over up to 64 weeks. The goal is to see how the drug works in everyda…

This study tests a stem cell transplant for people aged 13-28 with severe Crohn's disease that hasn't responded to other treatments. Doctors take the patient's own blood stem cells, then use high-dose therapy to wipe out overactive immune cells before returning the stem cells. Th…

This Canadian study is testing whether switching to the drug guselkumab (Tremfya) can help people with inflammatory bowel disease (IBD) who didn't respond well enough to ustekinumab. Researchers will track symptoms, test results, and overall health in 200 participants over one ye…

This study compares quality of life in adults with Crohn's disease during a flare when treated either with standard care or an adapted Crohn's disease exclusion diet plus partial enteral nutrition. The diet limits certain foods and uses a nutritional drink (Modulen) to help contr…

This study tests whether a diet that removes refined and intolerant foods can help people with Crohn's disease stay in remission after bowel surgery. Researchers will track quality of life and nutrition in 35 participants. The goal is to create a practical dietary plan for Chines…

This program offers early access to upadacitinib (Rinvoq) for people with Crohn's disease, ulcerative colitis, certain types of arthritis, or atopic dermatitis who have no other suitable treatments and cannot join ongoing clinical trials. A doctor must decide if the potential ben…

This study tests whether adding a special diet called the Crohn's Disease Exclusion Diet (CDED) to standard anti-TNF therapy can improve outcomes for people with active Crohn's disease or ulcerative colitis. Eighty adults starting anti-TNF drugs will be randomly assigned to eithe…

This study tests whether removing a larger portion of the mesentery (the tissue that connects the intestine to the abdominal wall) during surgery for Crohn's disease can reduce the chance of the disease coming back. 204 adults with Crohn's disease limited to the ileocecal area wi…

This study tests whether treating Crohn's disease with a goal of healing the entire gut wall (seen on ultrasound) leads to better results than treating based on symptoms and blood tests alone. About 304 adults with moderate to severe Crohn's will be split into two groups and foll…

This study tracks 50 children and adults with non-malignant disorders like immune deficiencies and anemias who receive a stem cell transplant after a reduced-intensity chemotherapy regimen. The goal is to see if this approach improves survival and reduces severe graft-versus-host…

This study is testing whether people with Crohn's disease or ulcerative colitis who are in deep remission can safely reduce their dose of the biologic drug ustekinumab. Participants will either switch from injections every 4 weeks to every 8 weeks, or from every 8 weeks to every …

This early study tests whether injecting stem cells from donated fat tissue can help heal complex anal fistulas in people with Crohn's disease who haven't gotten better with standard treatments. Nine adults will receive the stem cell injection and be followed for six months to ch…

This study tests whether high-dose chemotherapy followed by a stem cell transplant can help people with severe Crohn's disease that hasn't responded to other treatments. It includes up to 20 children and adults aged 10 to 60. The goal is to see if the approach is safe and can red…

This study is testing a less intense chemotherapy and radiation regimen before a stem cell transplant for children and young adults up to age 55 with non-cancerous blood disorders like immune deficiencies, anemias, and metabolic diseases. The goal is to see if this gentler prepar…

This study tests an experimental cell therapy called TRX103 for people with moderate to severe Crohn's disease that hasn't improved with standard treatments. About 39 adults will receive TRX103 along with a low dose of a chemotherapy drug to prepare the body. The main goal is to …

This study tests whether fecal microbiota transplants (FMT) given as capsules can safely improve symptoms in people newly diagnosed with rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, Crohn's disease, or ulcerative colitis. Two hundred participants will receiv…

This study will follow about 4,000 people who have received a fecal microbiota transplant (FMT) — a procedure that transfers gut bacteria from a healthy donor to restore balance in the gut. It aims to see how well FMT works over 3 months, 1 year, and 5 years for conditions like r…

This study is testing whether a smartphone app called SMART-IBD can help teenagers with inflammatory bowel disease (IBD) remember to take their medications and manage their symptoms. About 70 teens aged 13-17 will either use the full app with reminders and challenges or just a si…

This study tests whether a daily cranberry supplement can help restore healthy gut bacteria in adults with Crohn's disease. Fifty participants will take either the cranberry supplement or a placebo for 10 weeks. Researchers will track changes in gut bacteria, inflammation, and sy…

This study tests whether adding a structured coping skills program to standard biologic medication improves emotional well-being and disease remission in people with early Crohn's disease. 170 adults with active Crohn's for less than 5 years will receive either the coping program…

This study follows 275 Crohn's disease patients in Japan who receive darvadstrocel, a stem cell injection, for complex anal fistulas. Researchers will monitor side effects and whether fistulas close over 36 months. The goal is to see if this treatment is safe and works in real-wo…

This study tests a new surgery for people with Crohn's disease in the last part of the small intestine. The surgery removes the diseased section and nearby fatty tissue, then reconnects the bowel in a special way (Kono-S anastomosis). The goal is to see if this lowers the chance …

This phase 3 trial tests the drug vedolizumab in 408 adults in China with moderate-to-severe Crohn's disease. Participants receive IV infusions of vedolizumab or a placebo over several weeks. The goal is to see if vedolizumab can reduce symptoms like abdominal pain and diarrhea, …

This study is for people with active Crohn's disease that hasn't improved with standard treatments. Participants will receive a stem cell transplant followed by a drug called vedolizumab to help keep the disease in remission. The goal is to see if this combination can reduce symp…

This study tests whether adding diet advice and stress management sessions to standard advanced therapy helps people with Crohn's disease or ulcerative colitis reach remission. About 160 adults with active IBD will be split into four groups, each receiving different combinations …

This study is testing whether adding the antifungal drug fluconazole to standard IL-23 therapy helps people with mild to moderate Crohn's disease. About 120 adults will be randomly assigned to receive either fluconazole or a placebo alongside their usual treatment. The main goal …

This study is testing whether a remote monitoring app can help people with active inflammatory bowel disease (Crohn's or ulcerative colitis) spend more time in remission. About 290 adults whose disease is flaring will use the app to track symptoms and health data. The goal is to …

This study tests a new drug called BCD-261 in 204 adults with moderate to severe active Crohn's disease who haven't improved with standard treatments. Participants receive either a low, medium, or high dose of BCD-261 or a placebo by injection. The goal is to see if the drug can …

This study is testing a new stool test that measures calprotectin, a protein that signals inflammation in the gut. The goal is to see if the test can help doctors diagnose Crohn's disease or ulcerative colitis and tell them apart from irritable bowel syndrome. About 220 adults wi…

This study compares a new imaging technique called Texture and Colour Enhancement Imaging (TXI) with standard white light during colonoscopy in 219 people with inflammatory bowel disease (IBD). The goal is to see if TXI finds more dysplastic (precancerous) lesions. Each patient w…

This study is developing an artificial intelligence system that analyzes CT and MRI scans to diagnose and predict outcomes for digestive diseases like Crohn's disease, ulcerative colitis, and intestinal tuberculosis. Researchers are using data from 21 hospitals in China to train …

This study is testing a device called the AlgometRx Nociometer to see if it can measure inflammation in children with inflammatory bowel disease (IBD). The device checks how different nerve fibers respond, which may give doctors a clearer picture of disease activity. Researchers …

This study is testing a special PET/MR scan that uses a radioactive tracer to detect scar tissue in the bowel of people with Crohn's disease. The goal is to see if the scan can tell the difference between scarred (fibrotic) strictures and inflamed ones, which would help doctors d…

This study will collect capsule endoscopy images from 10,000 patients to train an artificial intelligence system to detect bowel diseases, Crohn's disease, celiac disease, chronic diarrhea, and tumors. The goal is to improve diagnostic accuracy and reduce the time doctors spend r…

This early-phase study tests whether a special PET scan tracer, Ga68-FAPI-46, can detect early fibrosis (scarring) in the small bowel of people with Crohn's disease. About 45 participants will be divided into those with known strictures and those without, to compare scan results.…

This pilot study tests a new device called the Retro-TCE capsule, which is a small camera attached to a string that is inserted into the lower gut to take pictures without needing sedation. The study will enroll 30 people, including healthy volunteers and those with Lynch syndrom…

This study is testing whether a shorter, abbreviated MRI scan (called MRE) works just as well as the standard, longer scan for detecting inflammation and damage in the bowel of people with Crohn's disease. Researchers will enroll 300 children and adults who already need an MRE as…

This study tests whether starting biologic drugs only after seeing signs of Crohn's disease on a colonoscopy is as good as starting them right after surgery to prevent the disease from coming back. About 292 adults with Crohn's who had bowel surgery will be randomly assigned to o…

This study is testing a web-based tool that estimates a person's risk of developing Crohn's disease based on their lifestyle and family history. Researchers will enroll 80 healthy people who have a parent or sibling with inflammatory bowel disease. Participants will receive perso…

This study tests an oral drug called EXL01 to see if it can prevent Crohn's disease from coming back after bowel surgery. About 80 adults who recently had surgery for Crohn's will receive either EXL01 or a placebo for up to 24 weeks. Doctors will use a camera to check the bowel f…

This study tests whether combining repetitive transcranial magnetic stimulation (rTMS) with an anti-inflammatory diet can reduce constipation and improve quality of life in people with Crohn's disease. Fifty patients aged 40-60 will be split into two groups: one gets both rTMS an…

This study tests whether morning bright light therapy can help people with Crohn's disease or ulcerative colitis by reducing gut leaks and inflammation. About 30 adults with stable medication will use a light box each morning for 8 weeks. Researchers will check changes in gut bar…

Many people with Crohn's disease still have belly pain, bloating, or irregular bowel habits even when their disease is not active. This study tests whether a low dose of amitriptyline, a medication already used for irritable bowel syndrome, can safely reduce those symptoms. One h…

This pilot study tests whether the MyIBDDiet app helps people with inflammatory bowel disease (IBD) learn about and follow an anti-inflammatory diet. Forty adults with IBD who are not in a flare will use the app for 30 to 60 days and complete surveys about its ease of use and the…

This study tests a smartphone app called COBMINDEX that teaches stress-reduction techniques to people with Crohn's disease. Researchers want to see if using the app improves wellbeing, fatigue, and pain as much as working with a human therapist. The trial will enroll 200 adults w…

This study tests whether morning light therapy can improve sleep timing and reduce symptoms in people with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. Sixty-eight adults with active IBD symptoms will either use a light therapy device at hom…

This study tests whether a ketogenic (low-carb, high-fat) or carnivore (all meat) diet can improve quality of life and reduce symptoms in adults with inflammatory bowel disease (Crohn's or ulcerative colitis) or rheumatoid arthritis. Participants are randomly assigned to one of t…

This study tests whether far-infrared (fIR) light therapy is safe and can ease symptoms in people with Crohn's disease. Forty participants will receive 10 weekly sessions of fIR at different intensities or a sham treatment. Researchers will monitor side effects, symptom scores, a…

This study tests whether using virtual reality (VR) can safely reduce abdominal pain in people with Crohn's disease who are not currently experiencing active inflammation. Researchers at Mayo Clinic will enroll 15 participants to see if VR improves pain and quality of life over 1…

This study looks at whether a single educational session about the benefits of exercise can help people with Crohn's disease or ulcerative colitis (IBD) become more physically active. The goal is to reduce fatigue, improve digestion, and enhance quality of life. About 71 adults w…

This study tests whether a low dose of Interleukin-2 (IL-2) can safely reduce symptoms in people with moderate-to-severe Crohn's disease. About 30 participants aged 12 to 80 will receive the drug to find the best dose that works with the fewest side effects. The goal is to improv…

This study looks at whether people with moderate-to-severe inflammatory bowel disease (IBD) need to take a steroid (dexamethasone) before each infliximab infusion to prevent allergic reactions. Researchers will compare those who get the steroid routinely with those who only get i…

This study looks at whether a low sulfur diet can reduce ongoing symptoms like belly pain and diarrhea in people whose Crohn's disease is otherwise quiet. Twenty adults with Crohn's in remission will either follow a low sulfur diet or their usual diet for 8 weeks. Participants wo…

This study tests whether a 12-week personalized aerobic exercise program, done at home with telemedicine guidance, can improve fitness, disease control, and quality of life in adults with inactive or mildly active inflammatory bowel disease (IBD). Twenty-eight participants will e…

This study looks at whether a 12-week remote exercise program can improve quality of life for people with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. About 72 adults with IBD will use a smartphone app to follow guided physical activities at…

This study aims to learn more about how diseases related to blood clots, the immune system, and blood vessels start and change over time. Researchers will enroll up to 1,000 people aged 5 and older, including those with these conditions, their healthy relatives, and healthy volun…

This study looks at how children with Crohn's disease or ulcerative colitis burn energy at rest. Researchers will measure resting energy expenditure using a special breathing test and compare it to standard formulas. The goal is to see if energy use is linked to disease activity …

This study is checking how common chronic kidney disease is in children with inflammatory bowel disease (IBD), like Crohn's disease or ulcerative colitis. Researchers will look at medical records from 600 children with IBD and compare them to children without IBD. The goal is to …

This study uses a homemade device with electrodes placed on the belly to record electrical signals from the stomach and intestines. Researchers will compare these signals in healthy volunteers, people with Crohn's disease (with or without fibrosis), and people with functional gas…

This study looks for better ways to detect lung inflammation and infections early in people who have received a stem cell transplant from a donor. About 40 participants aged 5 to 70 will get regular lung scans, breathing tests, blood draws, and a procedure where a tube collects f…

This study collects small tissue samples (biopsies) from people undergoing routine endoscopy and grows them into mini-organs called organoids in the lab. These organoids mimic the real intestine and help researchers understand diseases like Crohn's and ulcerative colitis. The goa…

This study compares the gut microbiome—bacteria, fungi, and viruses—in people with Crohn's disease, with or without arthritis, and healthy controls. Researchers aim to find microbial biomarkers linked to arthritis in Crohn's patients. No treatment is given; it is purely observati…

This study aims to learn how the immune system controls inflammation in the gut for people with Crohn's disease or ulcerative colitis. Up to 1,000 participants aged 0 to 75 will receive standard medical care and may provide blood, tissue, or white blood cell samples. No experimen…

This study aims to collect medical data and biological samples (blood, urine, stool, and tissue) from up to 4,000 adults with known or suspected gastrointestinal diseases. Participants receive standard medical care at the NIH, and any extra samples or leftover tissue from procedu…

This study investigates whether advanced treatments for Crohn's disease also improve sleep quality. Adults with active Crohn's who are about to start a new advanced therapy will wear a Fitbit Inspire 3 for five days at three different times: before treatment, at week 4, and at we…

This study looks at proteins and bacteria in the gut of people with Crohn's disease compared to healthy individuals. Researchers will analyze samples from colonoscopies to understand what goes wrong in Crohn's. The goal is to find new ways to diagnose and treat the disease. 40 ad…

This study is looking for genetic clues that might predict how well people with inflammatory bowel disease (IBD) will respond to a common treatment called anti-TNF therapy. Researchers will collect blood samples from 40 patients who have not used anti-TNF before and track their r…

This study uses health insurance claims data from Korea to count how many children under 18 have Crohn's disease or ulcerative colitis, and how their treatment changes as they grow. Researchers will look at patterns of medication use, hospital visits, and costs over several years…

This study tests whether a simple blood test that reads epigenetic markers can help doctors pick the best biologic drug (ustekinumab or vedolizumab) for adults with active Crohn's disease. 378 participants will be randomly assigned to either have their treatment guided by this te…

This study looks at whether a protein in the blood called LRG can accurately show how active Crohn's disease or ulcerative colitis is in the gut. Researchers will compare LRG levels with standard endoscopic and symptom scores in 100 European adults. If successful, LRG could becom…

This study is tracking over 25,000 people with inflammatory bowel disease (IBD) to understand why many continue to have abdominal pain even when their disease is in remission. Researchers will use questionnaires, blood and stool samples, heart rate recordings, and genetic data to…

This study is testing an educational tool designed for people with melanoma who also have an autoimmune disease and are considering treatment with immune checkpoint inhibitors. Researchers want to see if the tool is easy to use and helpful for both patients and healthcare provide…

This study will compare kidney function in 3,000 adults with Crohn's disease or ulcerative colitis to 3,000 adults without these conditions. Participants will provide blood and urine samples and have a kidney ultrasound. The goal is to learn how common kidney problems are in IBD …

This study is looking at whether a substance in the blood called LRG can help doctors tell how active ulcerative colitis or Crohn's disease is in the gut. Researchers will measure LRG levels in 300 people who might have these conditions and compare them with what is seen during a…

This study looks at how much energy, water, and waste are used during different types of bowel imaging tests for people with ulcerative colitis or Crohn's disease. The goal is to see if a simple, non-invasive ultrasound can be a greener alternative to colonoscopy and CT scans. Ab…

This study follows 153 people aged 60 and older with inflammatory bowel disease (IBD) to see how disease activity affects frailty. Researchers will also check whether frailty raises the risk of hospitalization or death. Participants will have their frailty, IBD symptoms, and over…

This study looks at the long-term safety of the drug ustekinumab compared to other biologic treatments in adults with Crohn's disease or ulcerative colitis. Researchers will use health records from the Department of Defense to track rates of cancer, serious infections, and other …

This study tests whether drinking 1.5 liters of water before an MRI scan can give doctors clear images of the small bowel in people with Crohn's disease, compared to the standard polyethylene glycol (PEG) prep. About 194 participants will be randomly assigned to water or PEG, and…

This study aims to identify biological markers that can predict how patients with inflammatory bowel disease (IBD) will respond to a type of medication called TNF-alpha inhibitors. Researchers will collect blood and tissue samples from 100 adults, including healthy controls and I…

This study follows 575 Crohn's disease patients who have had ileocecal resection surgery. Researchers collect blood, tissue, and microbiome samples to classify the disease and identify factors that predict recurrence. The goal is to improve prevention and treatment strategies for…

This study collects tissue, blood, and stool samples from 200 children with inflammatory bowel disease (IBD) or other gut disorders. Researchers will use a cutting-edge technique called spatial transcriptomics to map gene activity directly inside gut tissue. The goal is to better…

This study follows 420 adults with Crohn's disease who are in deep remission to see if a non-invasive intestinal ultrasound can predict when symptoms will return. Participants get regular ultrasounds over 18 months, and researchers compare those who relapse to those who don't. Th…

This study follows 450 adults who have early signs of inflammatory bowel disease (Crohn's or ulcerative colitis) found during routine colon cancer screening, but who have no symptoms yet. Researchers will collect blood, stool, and tissue samples over time to see how the disease p…

This study looks at how chronic perianal conditions like fistulas and abscesses impact a person's sexual health and body image—something often overlooked by doctors. Researchers will survey 60 adults using questionnaires to measure these effects and identify gaps in communication…

This study looks at how the bacteria and diet of pregnant women with inflammatory bowel disease (IBD) may influence gut inflammation in their babies. Researchers will collect samples from 80 mothers and infants over a year to track gut microbes and diet. The goal is to find patte…

This study is testing a tool called B-COMPASS that uses a 22-question survey to predict whether people will follow their prescribed treatments. Researchers will enroll 3100 adults with cardiovascular, endocrine, immune, nerve, cancer, or rare diseases across Europe. The goal is t…

This study observes how doctors use a treat-to-target strategy for people with Crohn's disease or ulcerative colitis in routine care. Researchers will review medical records of 2000 adults over 24 months to see if adjusting treatment based on disease activity improves outcomes. N…

This pilot study is testing how well two common pain relievers—acetaminophen (Tylenol) and ibuprofen (Advil)—work for period cramps in women with Crohn's disease. Twenty-four women will take each drug for two menstrual cycles and report their symptoms. The main goal is to see if …

This study looks at how gut bacteria change the energy use of immune cells in people with inflammatory bowel disease (IBD) and healthy adults. Researchers will give healthy volunteers a short course of antibiotics to alter their gut bacteria, then measure immune cell metabolism u…

This study looks at whether measuring infliximab levels in saliva is as good as measuring it in blood for children with inflammatory bowel disease (IBD). Fifteen children starting infliximab will provide saliva and blood samples during routine visits. The goal is purely to gather…

This study is testing whether a simple ultrasound can accurately measure muscle loss in people with inflammatory bowel disease (Crohn's or colitis). Currently, doctors use CT scans to check for muscle wasting, but CT involves radiation and is not always available. Researchers wil…

This early-phase study at Stanford University is testing whether the statin drug rosuvastatin changes bile acid levels and gut bacteria in people with primary sclerosing cholangitis (PSC), a liver disease with no cure. Researchers will enroll 15 adults with PSC and inflammatory b…

This study is creating a large registry of 800 people receiving biologic medications for immune conditions like autoimmune diseases and primary immune deficiencies. Researchers will collect blood samples and health data to better understand how these treatments work and who respo…

This study looks at how nutrition and body composition (like muscle and fat) impact the health of people with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. Researchers will follow 300 participants starting new medical treatments or having sur…

This study follows 300 adults with Crohn's disease who are starting standard treatments like vedolizumab or IL-23 blockers. Researchers will track how quickly patients feel improvements in pain, fatigue, and daily functioning using simple questionnaires. The goal is to better und…

This study follows 945 women with Crohn's disease or ulcerative colitis to see how pregnancy affects their condition. Researchers will track disease flares during pregnancy, after childbirth, and during breastfeeding. The goal is to better understand the link between IBD and preg…

This study surveys 400 adults with inflammatory bowel disease (IBD) from two medical centers to understand how social factors like insurance, income, and support affect medication adherence and quality of life. Researchers focus on Hispanic and Black patients, who often have wors…

This study is testing whether two dietary supplements, Goodphyte IB Defense and Goodphyte Immunity, are acceptable and easy for adults with chronic diseases like IBD, hypertension, anemia, or multiple sclerosis to take. Researchers will also check if the supplements improve how w…

This study interviews 60 children aged 10-17 with inflammatory bowel disease (Crohn's or colitis) to learn what makes it easier or harder for them to be physically active. Participants fill out two questionnaires and talk one-on-one with a researcher. No treatment or exercise pro…

This study aims to find new markers in the blood that can detect an imbalance of gut bacteria linked to inflammatory bowel disease (IBD). Researchers will compare 60 people with IBD and 60 people without IBD by collecting stool, blood, and tissue samples. The goal is to develop a…

This study aims to create a standardized quality system for confocal enteroscopy, a technique that lets doctors see cells in real time during a small bowel exam. Researchers will enroll 600 people aged 18-70 who need small bowel endoscopy, along with certified gastroenterologists…

This study tracks 1,400 adults with Crohn's disease across multiple hospitals in China to understand how common hard-to-treat cases are and how well current treatments work. Researchers will compare patients who respond poorly to therapy with those who do better, and look for fac…

This study looks at whether the unique mix of bacteria and fungi in the gut can predict how well Crohn's disease patients will respond to treatment. Researchers will collect stool, blood, and tissue samples from 100 adults during routine colonoscopies and track their health for a…

This study tests a new 3D visualization tool called vEUA that helps surgeons see fistulas more clearly before operating on people with perianal Crohn's disease. About 30 adults who need surgery for fistulas or abscesses will be randomly assigned to standard care or care with the …

This research study collects health information from 10,000 people with brain inflammation conditions like Long COVID, ME/CFS, and autoimmune diseases. Participants use a smartphone app to share symptoms, health history, and wearable data. The goal is to find disease subtypes and…

This study from Aarhus University is looking at how common magnesium deficiency is in people with Crohn's disease, ulcerative colitis, ileostomy, or bile acid diarrhea. Magnesium is important for muscles, nerves, and heart health, but standard blood tests may miss a deficiency. T…

This study is a large registry that will follow 10,000 people with inflammatory bowel disease (IBD) in Germany over many years. Its goal is to collect real-world information on how well treatments work, how the disease changes over time, and how it affects patients' daily lives. …

The PLANET study is looking at whether tiny plastic particles in our environment can trigger gut inflammation and raise the risk of inflammatory bowel disease (IBD). Researchers will measure microplastics in stool samples from pregnant women, their healthy relatives, and people w…

This study looks at how common exocrine pancreatic insufficiency (EPI) is in people with active Crohn's disease who are starting a biologic therapy. EPI means the pancreas doesn't make enough enzymes to digest food properly. Researchers will check for EPI at the start of treatmen…

This study explores how traditional Chinese medicine tools, such as tongue and pulse diagnosis, can help identify unique features of inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. Researchers will compare 30 people with IBD to 30 healthy volun…

This study looks at whether a toxin called deoxynivalenol (DON), found in grains, might be a risk factor for inflammatory bowel disease (IBD). Researchers will measure DON levels in 100 people—some with Crohn's disease and others without IBD—to see how the body processes it. The …

This study is testing whether robotic surgery is a practical option for people with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. Researchers will compare robotic surgery to standard laparoscopic surgery in 100 adults to see which approach wo…

This study looks at how well the drug guselkumab works in adults with Crohn's disease. Researchers will use intestinal ultrasound and blood tests to measure response over one year. The goal is to find better ways to track treatment success without invasive procedures. About 90 pa…

This study collects tissue and blood samples from 300 people with autoimmune diseases like Crohn's, multiple sclerosis, and celiac disease. Researchers aim to identify the specific targets of immune cells (T cells) that cause inflammation. The goal is to discover new targets for …

This study follows 216 adults with inflammatory bowel disease (IBD) who are in remission. They wear a wrist monitor and fill out sleep questionnaires for one year to see if changes in sleep quality can predict when a flare-up will happen. The goal is to find early warning signs o…

This study looks at how immune cells and inflammatory molecules differ in people with migraine, especially those who also have autoimmune diseases like multiple sclerosis, rheumatoid arthritis, or endometriosis. Researchers will compare blood samples from 396 women to measure reg…

This study looks at whether teaching children and teens with inflammatory bowel disease (IBD) about ultra-processed foods (like packaged snacks and sugary drinks) can help them eat less of them. About 120 participants will complete online food diaries and receive either nutrition…

This study involves about 50 adults with Crohn's disease who have a permanent ileostomy (a surgically created opening in the belly to pass waste). The goal is to create new tools—a patient questionnaire and an endoscopic scoring system—to accurately measure disease activity in th…

This study uses MRI scans to look at bone marrow fat in teenagers newly diagnosed with Crohn's disease, comparing them to healthy teens. The goal is to understand if Crohn's affects bone health early on. Researchers will also measure bone density using other imaging methods. The …

This study is testing a new device called a wireless thermal capsule, which is swallowed and measures temperature as it travels through the digestive tract. The goal is to see if it can reliably detect small temperature changes that might indicate inflammation from diseases like …

This study is for adults in South Korea with ulcerative colitis or Crohn's disease who are already taking vedolizumab injections. Researchers will look at medical records to track side effects and how well the treatment works. No new medicine or treatment is given—this is just an…

This study aims to understand why Crohn's disease often returns after surgery by examining specific immune cells that respond to a protein called IL-23. Researchers will collect tissue samples from 40 patients with Crohn's disease during routine colonoscopies, before and after 12…

This study looks at whether microplastics are found more often in children with inflammatory bowel disease (IBD) compared to healthy children. Researchers will collect samples of tissue, blood, urine, and stool from 40 children during routine endoscopy. No treatment is given—the …

This study tests a new imaging method using a special dye (FAPI) to detect bowel scarring in people with Crohn's disease. Scarring affects up to half of patients and often leads to surgery, but current tests can't spot it early. The study will involve 30 adults starting biologic …

This study is a large registry that will collect information from over 4,000 people with Crohn's disease or ulcerative colitis in Argentina. Doctors will record details about patients' diagnosis, treatments, and any safety issues like infections. The goal is to better understand …

This study is collecting health data, voice recordings, and biological samples from 100 IBD patients in Luxembourg (part of a larger 800-person study across Europe). Researchers hope to find patterns that can predict when a patient's treatment needs to change. The goal is to use …

This study is looking at why the immune system attacks the gut in people with celiac disease and other immune-related gut disorders. Researchers will collect blood and tissue samples from 200 adults to study immune cells and genes. The goal is to better understand what goes wrong…

This study aims to find out how often men with inflammatory bowel disease (IBD) have HPV infection in their mouth and anal area. Researchers will collect swab samples from 384 men with Crohn's disease or ulcerative colitis and test for HPV and abnormal cell changes. The goal is t…

This study follows 48 adults with active Crohn's disease or ulcerative colitis who are starting biologic or JAK inhibitor therapy. Researchers use a quick, painless bioelectrical impedance scan to measure muscle mass and other body composition changes at the start, 24 weeks, and …