Could a common cholesterol drug unlock secrets of a rare liver disease?
NCT ID NCT05912387
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-phase study at Stanford University is testing whether the statin drug rosuvastatin changes bile acid levels and gut bacteria in people with primary sclerosing cholangitis (PSC), a liver disease with no cure. Researchers will enroll 15 adults with PSC and inflammatory bowel disease, giving them a daily 20 mg statin pill. The goal is to understand the disease better, not to treat it directly.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Rosuvastatin (a statin drug, 20 mg tablet once daily)
- What this could lead to
- If successful, this study could reveal how statins change bile acids and gut bacteria in PSC, pointing toward new treatment approaches for this liver disease.
- What could go wrong
- This is a very small, early-phase pilot study with only 15 participants. It is designed to gather information, not to test a treatment, so results may not lead to any direct benefit for patients.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Stanford University
RECRUITINGStanford, California, 94305, United States
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