INFLAMMATORY BOWEL DISEASES

This study looks at how well newer inflammatory bowel disease (IBD) medications work in children whose previous treatment (anti-TNF drugs) stopped working or didn't help. About 1,100 kids with Crohn's disease or ulcerative colitis will answer questions about their symptoms and pr…

This study tests whether dapagliflozin, a drug already used for diabetes, can help people with mild to moderate ulcerative colitis (a type of inflammatory bowel disease). The goal is to reduce gut inflammation and improve symptoms like diarrhea and abdominal pain. About 50 adults…

This study is testing whether transplanting healthy stool bacteria into people with ulcerative colitis can help control the disease. It involves 85 adults with active colitis who will receive either the transplant or a placebo. The goal is to see if this approach is worth testing…

This study tests whether taking frozen capsules containing healthy donor stool (or filtered stool) can safely help people with mild-to-moderate ulcerative colitis reach remission. About 129 adults who have not responded to standard treatments will take the capsules or a placebo f…

This study tests whether pentoxifylline, a drug usually used for blood flow problems, can safely reduce symptoms in people with mild-to-moderate ulcerative colitis. Researchers will measure changes in disease activity and quality of life over the trial period. The study aims to e…

This study tests whether adding the antifungal drug fluconazole to standard IL-23 therapy helps people with Crohn's disease feel better. About 120 adults with mild to moderate Crohn's will receive either fluconazole or a placebo alongside their usual treatment. The main goal is t…

This study looks at how well and how safely the drug mirikizumab works over a long period (about 3 years) in children and teenagers with moderate-to-severe ulcerative colitis or Crohn's disease. Participants must have already been in a previous mirikizumab study and may continue …

This study tests an experimental drug called MORF-057 in 385 adults with moderate to severe Crohn's disease. Participants will receive one of three doses or a placebo to see if the drug can reduce gut inflammation and improve symptoms. The goal is to find a safer, more convenient…

This study looks at whether checking and improving nutrition before surgery can lower the risk of problems like infections or bleeding in people with inflammatory bowel disease (IBD). About 150 adults having intestinal surgery will be offered nutritional shakes and support. The g…

This study tests whether long-acting antibodies, given alone or together, can safely reduce inflammation and improve symptoms in adults with moderate-to-severe ulcerative colitis. About 645 participants will receive the treatment through an IV infusion followed by regular shots. …

This study tests a new tool: a capsule about the size of a fish oil pill attached to a string that takes pictures inside the lower gut. It is inserted without sedation and moves slowly upward using a motor. The goal is to see if it can get clear images of the lower GI tract in 30…

This study is testing a web-based tool that gives personalized risk estimates for Crohn's disease to people who have a close family member with the condition. The goal is to see if learning their personal risk motivates them to make healthy lifestyle and diet changes that might p…

This study looks at whether eating more fermented foods like yogurt, kimchi, and sauerkraut can reduce gut inflammation and improve daily life for people with mild to moderate ulcerative colitis. About 21 adults with the condition will add these foods to their diet for a period o…

This study tests a virtual group program that teaches teens with IBD coping skills and uses heart rate biofeedback to help manage stress. About 128 participants aged 13-18 will be randomly assigned to the program or a waitlist. The goal is to see if the program reduces anxiety, d…

This study tests whether virtual reality (VR)-guided therapy can help manage pain for people hospitalized with inflammatory bowel disease (IBD). About 40 participants will try the VR program and report if it's helpful and easy to use. The goal is to see if this approach is a prac…

This study tests whether far-infrared (fIR) therapy is safe and can help ease symptoms in people with Crohn's disease. Forty adults with active Crohn's will receive 10 sessions of either one of three intensities of fIR or a placebo treatment. Researchers will track side effects, …

This study looks at whether a toxin called deoxynivalenol (DON), often found in grains, might be a risk factor for inflammatory bowel disease (IBD). Researchers will measure DON levels in 100 adults—some with Crohn's disease and some without—to see how the body processes it and h…

This study looks at whether a simple, painless ultrasound of the intestines can predict when Crohn's disease will come back in patients who are currently in deep remission. Researchers will follow 420 adults for 18 months to see who relapses and compare their ultrasound results. …

This study looks at how statins, a common cholesterol medicine, change bile acids and gut bacteria in people with primary sclerosing cholangitis (PSC), a rare liver disease with no cure. Researchers will collect samples from 15 adults with PSC to understand the disease better. Th…

This study collects DNA samples from 1200 adults receiving routine care at the University of Chicago. Researchers test for genetic differences that could affect how patients respond to certain medications, including risk of side effects. The results are shared with their doctors,…

This study looks at how nutrition and body composition (like muscle mass) influence treatment results in people with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. Researchers will follow 300 patients starting new medical therapies or undergoi…

This study uses health records to learn how many children under 18 in Korea develop Crohn's disease or ulcerative colitis each year, and how many are living with these conditions. Researchers will also track what treatments children receive, how their treatment changes as they gr…

This study is collecting health information and samples from 100 people with inflammatory bowel disease (IBD) who are changing their treatment. Researchers will use artificial intelligence to analyze this data and find patterns that could predict when a treatment change is needed…

This study looks at how natural cannabis compounds (phytocannabinoids) affect immune cells from 100 people with chronic inflammatory diseases like rheumatoid arthritis, lupus, and inflammatory bowel disease. Researchers will take blood samples and expose the cells to different ca…

This study aims to understand why the immune system attacks the gut in conditions like celiac disease, autoimmune enteropathy, and inflammatory bowel disease. Researchers will analyze immune cells from 200 adult participants to uncover the mechanisms behind these diseases. The go…

This study is creating a large database to collect information about people with rare diseases like amyloidosis, sarcoidosis, and many others. Researchers will track participants' health, treatments, and outcomes over time to better understand these conditions. The goal is to imp…

This study looks at how social factors like insurance and medication adherence affect quality of life in people with inflammatory bowel disease (IBD), focusing on Hispanic and Black patients. Researchers will survey 400 adults with IBD to understand these links. The goal is to fi…

This study is testing a new medical device that measures how nerves respond to inflammation in children with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. The device checks three types of nerve fibers to help doctors better understand disease…

This study is looking at whether the unique mix of bacteria and fungi in the gut can help predict how well a person with Crohn's disease will respond to treatment. Researchers will collect stool, blood, and tissue samples from 100 adults in British Columbia during routine colonos…

This study tests a new wireless pill that measures temperature inside the gut. The goal is to see if it can help detect diseases like Crohn's disease. Ten healthy adults will swallow the capsule and researchers will check if it sends accurate temperature readings.

This study looks at whether robotic surgery is a good option for people with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. About 100 adults having minimally invasive surgery for IBD will take part. The goal is to see if robotic surgery is tec…

This study aims to create a large collection of blood and tissue samples from people with autoimmune diseases like lupus and scleroderma. Researchers will use these samples to learn more about how these diseases work, identify markers for diagnosis, and discover clues for future …