New antibody cocktail aims to tame ulcerative colitis

NCT ID NCT07012395

Recruiting now Disease control Sponsor: Spyre Therapeutics, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 29, 2026 · Updated 8 times

Summary

This Phase 2 trial is testing three long-acting antibodies, alone or in combination, for people with moderate-to-severe ulcerative colitis. The study will enroll 645 adults to see if these treatments can reduce inflammation and lead to remission. Participants receive the antibodies through an IV infusion followed by regular shots under the skin.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: long-acting antibodies (SPY001, SPY002, SPY003)
What this could lead to: If successful, this could lead to a new treatment option that helps control ulcerative colitis with fewer doses, improving quality of life.
What could go wrong: This is an early Phase 2 trial, so results are uncertain. The antibodies may not work better than placebo, and side effects are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

colitis inflammatory bowel disease ulcerative colitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COLITIS COLITIS, ULCERATIVE INFLAMMATORY BOWEL DISEASES ULCERATIVE COLITIS

Contacts and locations

Show contact details

Study contacts

Contact

Email: •••••@•••••

Locations

029
RECRUITING

Miami, Florida, 33165, United States
040
RECRUITING

Chapel Hill, North Carolina, 27599, United States
Site 002
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San Antonio, Texas, 78229, United States
Site 003
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Boston, Massachusetts, 02114, United States
Site 004
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Seattle, Washington, 98195, United States
Site 005
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Garland, Texas, 75246, United States
Site 006
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Kansas City, Kansas, 66160, United States
Site 007
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Kissimmee, Florida, 34741, United States
Site 008
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Southlake, Texas, 76092, United States
Site 009
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Webster, Texas, 77598, United States
Site 011
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Glen Burnie, Maryland, 21061, United States
Site 012
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Lancaster, California, 93534, United States
Site 013
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Cedar Park, Texas, 78613, United States
Site 016
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Winston-Salem, North Carolina, 27103, United States
Site 017
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Kingsport, Tennessee, 37663, United States
Site 019
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Tacoma, Washington, 98405, United States
Site 023
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La Jolla, California, 92037, United States
Site 024
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Canoga Park, California, 91304, United States
Site 025
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Providence, Rhode Island, 02904, United States
Site 028
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Rochester, Minnesota, 55905, United States
Site 030
RECRUITING

Louisville, Kentucky, 40202, United States
Site 033
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Colorado Springs, Colorado, 91304, United States
Site 035
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Marrero, Louisiana, 70072, United States
Site 037
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New York, New York, 10065, United States
Site 038
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Chicago, Illinois, 60637, United States
Site 041
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Durham, North Carolina, 27710, United States
Site 083
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London, Ontario, G8H 3P7, Canada
Site 084
RECRUITING

Toronto, Ontario, M5G1X5, Canada
Site 085
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Greater Sudbury, P3C1X3, Canada
Site 086
RECRUITING

London, N6K 1M6, Canada
Site 102
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Lujan de Cuyo, Mendoza Province, 5505, Argentina
Site 103
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Rosario, Sant Fe, 2000, Argentina
Site 104
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San Miguel de Tucumán, Tucumán Province, 4000, Argentina
Site 105
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La Plata, Buenos Aires, 1900, Argentina
Site 121
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Porto Alegre, Rio Grande do Sul, 90160-093, Brazil
Site 122
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Porto Alegre, Rio Grande do Sul, 90035-903, Brazil
Site 123
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Brasília, Federal District, 70200-730, Brazil
Site 125
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Caxias do Sul, Rio Grande do Sul, 95070-560, Brazil
Site 126
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Passo Fundo, Rio Grande do Sul, 99010-260, Brazil
Site 127
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Santos, São Paulo, 11075-900, Brazil
Site 128
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Santo André, São Paulo, 09080-110, Brazil
Site 129
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Consolação, São Paulo, 01307-002, Brazil
Site 130
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São José do Rio Preto, São Paulo, 15015-110, Brazil
Site 131
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Campinas, São Paulo, 13086045, Brazil
Site 133
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Goiânia, Goiás, 74535-170, Brazil
Site 134
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Passo Fundo, Rio Grande do Sul, 99010-120, Brazil
Site 136
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Juiz de Fora, Minas Gerais, 36033-318, Brazil
Site 137
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Teresina, Piauí, 64.049-550, Brazil
Site 152
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Santiago, Santiago Metropolitan, 8320000, Chile
Site 153
RECRUITING

Osorno, Los Lagos Region, 5290000, Chile
Site 173
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Tlajomulco de Zúñiga, Jalisco, 45645, Mexico
Site 174
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Saltillo, Coahuila, 25050, Mexico
Site 175
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Celaya, Guanajuato, 38000, Mexico
Site 202
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Heidelberg, 3084, Australia
Site 203
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Melbourne, 3004, Australia
Site 204
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Liverpool, 2170, Australia
Site 206
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South Brisbane, 4101, Australia
Site 207
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Woolloongabba, 4102, Australia
Site 208
RECRUITING

Concord, 2139, Australia
Site 262
RECRUITING

New Delhi, National Capital Territory of Delhi, 110002, India
Site 265
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Sūrat, 395002, India
Site 266
RECRUITING

Kochi, 682040, India
Site 268
RECRUITING

Jaipur, 302004, India
Site 270
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Hyderabad, 500032, India
Site 281
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Shinjuku-Ku, Tokyo, 169-0073, Japan
Site 282
RECRUITING

Chuo Ku, Osaka, 540-0006, Japan
Site 283
RECRUITING

Tsu, Mie-ken, 514-8507, Japan
Site 284
RECRUITING

Okayama, 703-851, Japan
Site 285
RECRUITING

Sendai, 981-3213, Japan
Site 286
RECRUITING

Saga, 849-8501, Japan
Site 287
RECRUITING

Sendai, Miyagi, 983-8520, Japan
Site 288
RECRUITING

Osaka, 545-8586, Japan
Site 290
RECRUITING

Ōita, Oita Prefecture, 870-0823, Japan
Site 291
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Kobe, 650-0015, Japan
Site 292
RECRUITING

Shiwa-gun, Iwate, 028-3695, Japan
Site 293
RECRUITING

Urayasu-shi, 279-0021, Japan
Site 294
RECRUITING

Chikushino-shi, Fukuoka, 818-8502, Japan
Site 295
RECRUITING

Bunkyō-Ku, Tokyo, 113-8519, Japan
Site 296
RECRUITING

Minato-Ku, Tokyo, 108-8642, Japan
Site 297
RECRUITING

Sakura, Chiba, 285-8741, Japan
Site 299
RECRUITING

Kashiwa, Chiba, 277-0871, Japan
Site 300
RECRUITING

Yokohama, Kanagawa, 232-0024, Japan
Site 303
RECRUITING

Nara, 630-8581, Japan
Site 304
RECRUITING

Maebashi, Gunma, 371-8511, Japan
Site 351
RECRUITING

Seoul, 03722, South Korea
Site 352
RECRUITING

Seoul, 06591, South Korea
Site 353
RECRUITING

Wŏnju, 26426, South Korea
Site 354
RECRUITING

Daegu, 40404, South Korea
Site 355
RECRUITING

Daejeon, 34943, South Korea
Site 356
RECRUITING

Seoul, 03312, South Korea
Site 357
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Busan, 48108, South Korea
Site 358
RECRUITING

Daegu, 42415, South Korea
Site 359
RECRUITING

Suwon, 16247, South Korea
Site 360
RECRUITING

Seoul, 07985, South Korea
Site 361
RECRUITING

Daegu, 42601, South Korea
Site 362
RECRUITING

Seoul, 6351, South Korea
Site 391
RECRUITING

Taipei, 100225, Taiwan
Site 392
RECRUITING

Chiayi City, 600, Taiwan
Site 393
RECRUITING

Taoyuan City, 333, Taiwan
Site 394
RECRUITING

Changhua, 500, Taiwan
Site 395
RECRUITING

Kaohsiung City, 833401, Taiwan
Site 396
RECRUITING

Taichung, 404327, Taiwan
Site 397
RECRUITING

Taipei, 104, Taiwan
Site 421
RECRUITING

Amman, 11942, Jordan
Site 422
RECRUITING

Irbid, 21110, Jordan
Site 423
RECRUITING

Irbid, 22110, Jordan
Site 424
RECRUITING

Amman, 11196, Jordan
Site 425
RECRUITING

Amman, 11194, Jordan
Site 426
RECRUITING

Irbid, 22110, Jordan
Site 441
RECRUITING

Beersheba, 8410101, Israel
Site 442
RECRUITING

Nahariya, 2210001, Israel
Site 443
RECRUITING

Haifa, 31048, Israel
Site 444
RECRUITING

Jerusalem, 9103102, Israel
Site 445
RECRUITING

Beer Yaaqov, 7033001, Israel
Site 446
RECRUITING

Jerusalem, 9112001, Israel
Site 463
RECRUITING

Linz, 4021, Austria
Site 471
RECRUITING

Ghent, 9000, Belgium
Site 472
RECRUITING

Roeselare, 9000, Belgium
Site 474
RECRUITING

Sint-Niklaas, Osst-Vlaanderen, 9100, Belgium
Site 475
RECRUITING

Bruges, 8310, Belgium
Site 476
RECRUITING

Ghent, Osst-Vlaanderen, 9000, Belgium
Site 481
RECRUITING

Banja Luka, 78 000, Bosnia and Herzegovina
Site 483
RECRUITING

Sarajevo, 71000, Bosnia and Herzegovina
Site 484
RECRUITING

Mostar, 88000, Bosnia and Herzegovina
Site 492
RECRUITING

Sofia, 1343, Bulgaria
Site 494
RECRUITING

Gorna Oryahovitsa, 5100, Bulgaria
Site 495
RECRUITING

Sofia, 1463, Bulgaria
Site 498
RECRUITING

Rousse, 7002, Bulgaria
Site 499
RECRUITING

Sofia, 1407, Bulgaria
Site 521
RECRUITING

Osijek, 31000, Croatia
Site 524
RECRUITING

Zagreb, 10000, Croatia
Site 531
RECRUITING

Brno, 615 00, Czechia
Site 534
RECRUITING

Ostrava, 702 00, Czechia
Site 536
RECRUITING

Klatovy, 33901, Czechia
Site 537
RECRUITING

Pardubice, 532 03, Czechia
Site 538
RECRUITING

Prague, 150 00, Czechia
Site 551
RECRUITING

Nantes, 44300, France
Site 555
RECRUITING

Marseille, 13015, France
Site 556
RECRUITING

Pierre-Bénite, 69310, France
Site 557
RECRUITING

Nice, 06200, France
Site 558
RECRUITING

Saint-Etienne, 42270, France
Site 581
RECRUITING

Tbilisi, 0102, Georgia
Site 582
RECRUITING

Tbilisi, 0159, Georgia
Site 583
RECRUITING

Tbilisi, 01444, Georgia
Site 584
RECRUITING

Kutaisi, 4600, Georgia
Site 585
RECRUITING

Tbilisi, 0180, Georgia
Site 586
RECRUITING

Tbilisi, 0144, Georgia
Site 587
RECRUITING

Tbilisi, 0159, Georgia
Site 588
RECRUITING

Tbilisi, 0114, Georgia
Site 589
RECRUITING

Marneuli, 3000, Georgia
Site 590
RECRUITING

Tbilisi, 0178, Georgia
Site 602
RECRUITING

Kiel, 24105, Germany
Site 603
RECRUITING

Ulm, 89081, Germany
Site 604
RECRUITING

Berlin, 14163, Germany
Site 606
RECRUITING

Berlin, 10117, Germany
Site 607
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Dachau, 85221, Germany
Site 608
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Leipzig, 04103, Germany
Site 609
RECRUITING

Munich, 81377, Germany
Site 610
RECRUITING

Frankfurt am Main, 60590, Germany
Site 611
RECRUITING

Brandenburg an der Havel, 14770, Germany
Site 631
RECRUITING

Chaïdári, 124 62, Greece
Site 632
RECRUITING

Athens, 115 27, Greece
Site 634
RECRUITING

Athens, 10676, Greece
Site 635
RECRUITING

Athens, Attica, 11527, Greece
Site 651
RECRUITING

Budapest, H-1088, Hungary
Site 652
RECRUITING

Székesfehérvár, H-8000, Hungary
Site 654
RECRUITING

Békéscsaba, H-5600, Hungary
Site 655
RECRUITING

Budapest, H-1062, Hungary
Site 656
RECRUITING

Budapest, H-1083, Hungary
Site 671
RECRUITING

Segrate, Milan, 20132, Italy
Site 672
RECRUITING

Negrar, 37024, Italy
Site 673
RECRUITING

Legnano, Milan, 20025, Italy
Site 674
RECRUITING

Rozzano, Milan, 20089, Italy
Site 675
RECRUITING

Turin, 10128, Italy
Site 676
RECRUITING

San Donato Milanese, Milan, 20097, Italy
Site 677
RECRUITING

Padova, 35128, Italy
Site 679
RECRUITING

Pavia, Lombardy, 27100, Italy
Site 680
RECRUITING

Turin, Piedmont, 10126, Italy
Site 681
RECRUITING

Rome, 00168, Italy
Site 682
RECRUITING

Castellana Grotte, Bari, 70013, Italy
Site 683
RECRUITING

Bologna, 40138, Italy
Site 703
RECRUITING

Vilnius, LT-08406, Lithuania
Site 704
RECRUITING

Klaipėda, LT-92288, Lithuania
Site 711
RECRUITING

Chisinau, MD2025, Moldova
Site 712
RECRUITING

Chisinau, MD2025, Moldova
Site 713
RECRUITING

Chisinau, MD2005, Moldova
Site 714
RECRUITING

Chisinau, MD2025, Moldova
Site 715
RECRUITING

Chisinau, MD2068, Moldova
Site 731
RECRUITING

Warsaw, 04-501, Poland
Site 732
RECRUITING

Bydgoszcz, 85-794, Poland
Site 733
RECRUITING

Szczecin, 71-685, Poland
Site 734
RECRUITING

Wroclaw, 53-149, Poland
Site 735
RECRUITING

Katowice, 40-748, Poland
Site 736
RECRUITING

Rzeszów, 35-326, Poland
Site 737
RECRUITING

Szczecin, 71-434, Poland
Site 738
RECRUITING

Wroclaw, 52-416, Poland
Site 739
RECRUITING

Warsaw, 00--710, Poland
Site 740
RECRUITING

Poznan, 60-309, Poland
Site 741
RECRUITING

Warsaw, 02-786, Poland
Site 742
RECRUITING

Wroclaw, 54-239, Poland
Site 743
RECRUITING

Opole, 45-819, Poland
Site 744
RECRUITING

Sopot, 81-756, Poland
Site 745
RECRUITING

Staszów, 28-2200, Poland
Site 747
RECRUITING

Wroclaw, 53-611, Poland
Site 748
RECRUITING

Krakow, 31-501, Poland
Site 749
RECRUITING

Katowice, 40-600, Poland
Site 750
RECRUITING

Warsaw, 57-300, Poland
Site 751
RECRUITING

Warsaw, 00-189, Poland
Site 752
RECRUITING

Tychy, 43-100, Poland
Site 753
RECRUITING

Bydgoszcz, 85-2299, Poland
Site 754
RECRUITING

Warsaw, 02-172, Poland
Site 781
RECRUITING

Bucharest, 020125, Romania
Site 782
RECRUITING

Cluj-Napoca, 400061, Romania
Site 783
RECRUITING

Bucharest, 011273, Romania
Site 784
RECRUITING

Bucharest, 014142, Romania
Site 786
RECRUITING

Constanța, 900161, Romania
Site 788
RECRUITING

Timișoara, 300239, Romania
Site 801
RECRUITING

Zrenjanin, 23000, Serbia
Site 802
RECRUITING

Belgrade, 11000, Serbia
Site 803
RECRUITING

Belgrade, 11080, Serbia
Site 805
RECRUITING

Niš, 18 000, Serbia
Site 806
RECRUITING

Užice, 31000, Serbia
Site 807
RECRUITING

Belgrade, 11000, Serbia
Site 821
RECRUITING

Prešov, 080 01, Slovakia
Site 822
RECRUITING

Košice, 040 13, Slovakia
Site 823
RECRUITING

Bratislava, 811 09, Slovakia
Site 825
RECRUITING

Zvolen, 960 01, Slovakia
Site 831
RECRUITING

Seville, 41013, Spain
Site 832
RECRUITING

Santiago de Compostela, A Coruna, 15702, Spain
Site 834
RECRUITING

Madrid, 28031, Spain
Site 835
RECRUITING

Gijón, 33394, Spain
Site 836
RECRUITING

Ourense, 32005, Spain
Site 837
RECRUITING

Madrid, 28222, Spain
Site 838
RECRUITING

Lugo, 27003, Spain
Site 851
RECRUITING

Sankt Gallen, 9007, Switzerland
Site 852
RECRUITING

Basel, 4031, Switzerland
Site 853
RECRUITING

Bern, 3012, Switzerland
Site 861
RECRUITING

Mersin, 33110, Turkey (Türkiye)
Site 862
RECRUITING

Trabzon, 61080, Turkey (Türkiye)
Site 863
RECRUITING

Sakarya, 54290, Turkey (Türkiye)
Site 864
RECRUITING

Izmir, 35575, Turkey (Türkiye)
Site 865
RECRUITING

Sanliurfa, 63300, Turkey (Türkiye)
Site 866
RECRUITING

İzmit, 41380, Turkey (Türkiye)
Site 867
RECRUITING

Istanbul, 34093, Turkey (Türkiye)
Site 901
RECRUITING

Lutsk, 43005, Ukraine
Site 902
RECRUITING

Kyiv, 02002, Ukraine
Site 903
RECRUITING

Kyiv, 04210, Ukraine
Site 904
RECRUITING

Kyiv, 02091, Ukraine
Site 905
RECRUITING

Kyiv, 03037, Ukraine
Site 906
RECRUITING

Ivano-Frankivsk, 76008, Ukraine
Site 907
RECRUITING

Vinnytsia, 21029, Ukraine
Site 908
RECRUITING

Vinnytsia, 21009, Ukraine
Site 909
RECRUITING

Lviv, 79010, Ukraine
Site 910
RECRUITING

Vinnytsia, 21028, Ukraine
Site 911
RECRUITING

Kyiv, 04107, Ukraine
Site 912
RECRUITING

Lviv, 79059, Ukraine
Site 913
RECRUITING

Kyiv, 04050, Ukraine
Site 914
RECRUITING

Poltava, 36011, Ukraine
Trial Site 804
RECRUITING

Belgrade, 11 000, Serbia

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