COLITIS, ULCERATIVE

This study tests an experimental drug called MK-8690 for people with moderate to severe ulcerative colitis, a condition causing gut inflammation. About 100 adults will receive either the drug or a placebo to see if it helps achieve remission (fewer symptoms and healed gut lining)…

This study tests an experimental drug called SAR441566 in about 204 adults with moderate-to-severe ulcerative colitis, a chronic bowel disease causing inflammation and symptoms like diarrhea and bleeding. The goal is to see if different doses can help patients achieve remission (…

This study tests an oral medication called etrasimod in children aged 2 to 12 with moderate to severe ulcerative colitis. The goal is to see if it can safely reduce inflammation and bring about remission over 52 weeks. Participants who finish may continue treatment for up to 5 ye…

This study tests a new treatment called MH002, which contains live bacteria to help repair the gut in people with mild-to-moderate ulcerative colitis. About 204 adults whose current medication isn't working well enough will receive either MH002 or a placebo for 12 weeks. The goal…

This study tests an oral medication called ozanimod in 120 children aged 12-17 with moderate-to-severe ulcerative colitis who haven't improved with standard treatments. The goal is to see if the drug can safely bring the disease into remission (no symptoms) and keep it there. Par…

This study follows 360 adults aged 18-65 with moderate to severe ulcerative colitis who are prescribed etrasimod as part of their normal care. Researchers will track symptom changes—like stool frequency and rectal bleeding—over 52 weeks using health questionnaires completed onlin…

This study looks at how well guselkumab works for Chinese patients with moderate-to-severe ulcerative colitis who have never taken biologic medicines. Researchers will track 200 participants over 48 weeks to see if their symptoms improve in everyday medical practice. The goal is …

This study looks at the long-term safety of tulisokibart, a medicine for moderate to severe Crohn's disease and ulcerative colitis. People who already took tulisokibart in an earlier study can join. Researchers will track side effects and how well people tolerate the drug over ti…

This study tracks 220 adults with moderate-to-severe ulcerative colitis or Crohn's disease who are starting guselkumab, a biologic drug. Researchers will measure how many patients achieve remission (symptom control) and whether they can stop using steroids. The goal is to see how…

This study follows 400 people with Crohn's disease or ulcerative colitis who are starting guselkumab, a biologic drug. Researchers will measure how many achieve remission and how the drug affects fatigue, quality of life, and daily activities. The goal is to see how well the trea…

This observational study follows 300 adults with moderate to severe ulcerative colitis who are prescribed etrasimod as part of their routine care. Researchers will track symptoms like stool frequency and rectal bleeding over 52 weeks to see how well the drug works in real life. P…

This study is checking the safety and effectiveness of the drug Jyseleca (filgotinib) in Korean patients with rheumatoid arthritis or ulcerative colitis. About 2040 people will take the drug as prescribed by their doctor, and researchers will track side effects and how well the d…

This study looks at the long-term safety of a drug called guselkumab in children with moderate to severe Crohn's disease, ulcerative colitis, or juvenile psoriatic arthritis. About 196 kids who have already benefited from guselkumab in a previous study will continue receiving it.…

This program offers early access to the drug etrasimod for people with ulcerative colitis who have not improved with at least three other treatments. It is designed for individual patients with no other options. The goal is to help control the disease when standard therapies have…

This study tests whether long-acting antibodies, given alone or together, can safely reduce inflammation and improve symptoms in adults with moderate-to-severe ulcerative colitis. About 645 participants will receive the treatment through an IV infusion followed by regular shots. …

This study tests whether a carefully designed diet can change the gut bacteria of people with active ulcerative colitis and reduce disease activity. Researchers will enroll 20 adults with active UC to follow the diet and track changes in their gut microbiome and symptoms. The goa…

This study is testing a new oral medication called icotrokinra for adults and adolescents with moderate-to-severe ulcerative colitis, a chronic inflammatory bowel disease. The main goal is to see if the drug can safely bring the disease into remission and keep it under control ov…

This study looks at why many people with ulcerative colitis have trouble sleeping and how that affects their disease. Researchers will track sleep quality, gut bacteria, and nerve activity in 152 patients. The goal is to understand the connection between the gut and brain to impr…

This study looks at whether two dietary supplements, Goodphyte IB Defense and Goodphyte Immunity, are easy for adults with chronic conditions like IBD, hypertension, multiple sclerosis, or anemia to take regularly. Researchers will also check if these supplements help the body ab…

This study looks at how often people with Crohn's disease, ulcerative colitis, an ileostomy, or bile acid diarrhea have low magnesium levels. Magnesium is important for muscles, nerves, and heart health, but standard blood tests may miss a deficiency. Researchers will compare dif…

This observational study looks at the long-term safety of the drug ustekinumab compared to other biologic treatments in adults with Crohn's disease or ulcerative colitis. Researchers will analyze health records from the Department of Defense to track rates of cancer, serious infe…

This study is testing a new medical device that measures how nerves respond to inflammation in children with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. The device checks three types of nerve fibers to help doctors better understand disease…